93105d143ea503f66a948a564784159d pmc_9842712.pdf 2ca86fccc6fb79a7adc0422b7aedf1e4ea2ebb53 pmc_9842712.pdf 63111aba2e624bc75a9bae9a1a6f69c4fdfd5307370bee262765676d2f157534 pmc_9842712.pdf Title: Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 Subject: Nature Communications, doi:10.1038/s41467-023-35854-0 Keywords: Author: Javier Garcia-Pardo Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Jan 16 04:10:27 2023 CET ModDate: Mon Jan 16 15:13:15 2023 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 3061124 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HJAKFH+AdvOTdd63dae3+20 Type 1C WinAnsi yes yes no 62 0 HJAKJH+AdvOT0c200bf0 Type 1C WinAnsi yes yes no 420 0 HJAKMH+AdvOT511ca30e.B Type 1C WinAnsi yes yes no 64 0 HJAJCI+AdvOT13119950 Type 1C WinAnsi yes yes no 97 0 HJAJCJ+AdvOT89719618 Type 1C WinAnsi yes yes no 65 0 HJAJCK+AdvOTa2fa4214.B Type 1C WinAnsi yes yes no 739 0 HJAJCL+AdvOTa2fa4214.B+fb Type 1C Custom yes yes yes 740 0 HJAKFF+AdvOTdd63dae3 Type 1C WinAnsi yes yes no 69 0 HJAKFG+AdvOTdd63dae3+fb Type 1C Custom yes yes yes 71 0 HJAKOH+AdvOTdd63dae3+03 Type 1C Custom yes yes yes 61 0 HJAKOI+AdvOT3d287b35.B Type 1C WinAnsi yes yes no 63 0 HJAKOL+AdvOTcc1f6510.I Type 1C WinAnsi yes yes no 66 0 HJAKPM+AdvOTdd63dae3+22 Type 1C Custom yes yes no 67 0 HJAKOJ+AdvOT70e1938e Type 1C WinAnsi yes yes no 68 0 HJAKOK+AdvOT70e1938e+fb Type 1C Custom yes yes yes 70 0 HJAPCF+AdvOT3d287b35.B+fb Type 1C Custom yes yes yes 93 0 HJAPCG+AdvOT3d287b35.B+20 Type 1C WinAnsi yes yes no 94 0 HJANJM+Arial-BoldMT Type 1C WinAnsi yes yes no 95 0 HJAOHI+ArialMT Type 1C Custom yes yes yes 96 0 Calibri Type 1C WinAnsi yes no no 147 0 HJBMDI+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 256 0 HJCCBF+AdvOTcc1f6510.I+03 Type 1C Custom yes yes yes 395 0 HJCCCF+AdvOTdd63dae3+21 Type 1C WinAnsi yes yes no 396 0 HJCCEH+AdvOT0c200bf0+20 Type 1C WinAnsi yes yes no 421 0 HJCCEI+AdvOT0c200bf0+fb Type 1C Custom yes yes yes 422 0 HJCCDG+AdvOT23e3f5cb.I Type 1C WinAnsi yes yes no 423 0 HJCCHI+AdvOT13119950+20 Type 1C WinAnsi yes yes no 436 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-18 02:39:51 CET RepresentationInformation: pmc_9842712.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-26 02:12:19 CET Size: 3061124 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR59' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR56' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found Offset: 2575041 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR58' cannot be found Offset: 2575041 MIMEtype: application/pdf PDFMetadata: Objects: 851 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: hnRNPDLs localize at the nucleus and exon 6 is key for their compartmentalization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: hnRNPDL-2 forms stable and non-toxic amyloid fibrils Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Cryo-EM structure determination of hnRNPDL-2 amyloid fibrils Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Structural features of hnRNPDL-2 amyloid fibrils Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Disease-causative hereditary mutations in the hnRNPDL-2 fibril structure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: hnRNPDL-2 amyloid fibrils bind nucleic acids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Cell culture, plasmids and cell lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Cell transfection and immunoblotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Protein expression and purification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Fibril formation and in’vitro aggregation kinetics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Ultracentrifugation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Immunolabelling and negative staining electron microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Cryo-EM sample preparation and data collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Helical reconstruction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Model building and refinement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Fibril stability and solvation free energy calculations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: In vivo cell imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Gel Electrophoretic Mobility Shift Binding Assays (EMSA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Fluorescent RNA/DNA-binding assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Cytotoxicity assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Info: Title: Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 Author: Javier Garcia-Pardo Subject: Nature Communications, doi:10.1038/s41467-023-35854-0 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Jan 16 04:40:27 CET 2023 ModDate: Mon Jan 16 15:13:15 CET 2023 ID: 0xfa1c75bdf06f0604c9b46509aa3df940, 0x608918f5c605143ad8a9c362ea465653 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 46 ImageHeight: 40 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 160 ImageHeight: 129 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 52 ImageHeight: 21 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 144 ImageHeight: 69 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 137 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 52 ImageHeight: 21 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 223 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 153 ImageHeight: 48 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 99 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 153 ImageHeight: 87 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4 ImageHeight: 12 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 137 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 56 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 56 ImageHeight: 4 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 24 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 99 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 55 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 153 ImageHeight: 24 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 12 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 137 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 13 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 23 ImageHeight: 4 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1990 ImageHeight: 1276 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 123 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 157 ImageHeight: 67 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 21 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 124 ImageHeight: 66 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 99 ImageHeight: 19 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 153 ImageHeight: 49 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 176 ImageHeight: 80 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 191 ImageHeight: 27 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1951 ImageHeight: 2124 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 173 ImageHeight: 80 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 9 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1965 ImageHeight: 1836 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 203 ImageHeight: 105 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1941 ImageHeight: 2047 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Fonts: Type1: Font: BaseFont: HJAKMH+AdvOT511ca30e.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: HJAKMH+AdvOT511ca30e.B Flags: Nonsymbolic FontBBox: -41, -218, 979, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJBMDI+AdvOT8608a8d1 FontSubset: true FirstChar: 181 LastChar: 181 FontDescriptor: FontName: HJBMDI+AdvOT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAJCJ+AdvOT89719618 FontSubset: true FirstChar: 35 LastChar: 124 FontDescriptor: FontName: HJAJCJ+AdvOT89719618 Flags: Nonsymbolic FontBBox: -20, -218, 927, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAKOL+AdvOTcc1f6510.I FontSubset: true FirstChar: 46 LastChar: 111 FontDescriptor: FontName: HJAKOL+AdvOTcc1f6510.I Flags: Nonsymbolic FontBBox: -218, -218, 1020, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAKPM+AdvOTdd63dae3+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: HJAKPM+AdvOTdd63dae3+22 Flags: Nonsymbolic FontBBox: -62, -250, 1083, 885 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HJAKOJ+AdvOT70e1938e FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: HJAKOJ+AdvOT70e1938e Flags: Serif, Nonsymbolic FontBBox: -114, -218, 989, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAKFF+AdvOTdd63dae3 FontSubset: true FirstChar: 37 LastChar: 246 FontDescriptor: FontName: HJAKFF+AdvOTdd63dae3 Flags: Serif, Nonsymbolic FontBBox: -93, -218, 979, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAKOK+AdvOT70e1938e+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HJAKOK+AdvOT70e1938e+fb Flags: Symbolic FontBBox: 9, 0, 854, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJAKFG+AdvOTdd63dae3+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HJAKFG+AdvOTdd63dae3+fb Flags: Symbolic FontBBox: 19, 0, 812, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJCCBF+AdvOTcc1f6510.I+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HJCCBF+AdvOTcc1f6510.I+03 Flags: Symbolic FontBBox: -104, -208, 895, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJCCCF+AdvOTdd63dae3+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: HJCCCF+AdvOTdd63dae3+21 Flags: Nonsymbolic FontBBox: -31, -145, 1125, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Calibri Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAPCF+AdvOT3d287b35.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HJAPCF+AdvOT3d287b35.B+fb Flags: Symbolic FontBBox: 0, 0, 875, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJAPCG+AdvOT3d287b35.B+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: HJAPCG+AdvOT3d287b35.B+20 Flags: Nonsymbolic FontBBox: -187, -145, 1395, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJANJM+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: HJANJM+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAOHI+ArialMT FontSubset: true FirstChar: 2 LastChar: 197 FontDescriptor: FontName: HJAOHI+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJAJCI+AdvOT13119950 FontSubset: true FirstChar: 38 LastChar: 237 FontDescriptor: FontName: HJAJCI+AdvOT13119950 Flags: Nonsymbolic FontBBox: -31, -218, 947, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAJCK+AdvOTa2fa4214.B FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: HJAJCK+AdvOTa2fa4214.B Flags: Serif, Nonsymbolic FontBBox: -125, -218, 989, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAKJH+AdvOT0c200bf0 FontSubset: true FirstChar: 38 LastChar: 246 FontDescriptor: FontName: HJAKJH+AdvOT0c200bf0 Flags: Nonsymbolic FontBBox: -10, -208, 906, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAJCL+AdvOTa2fa4214.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HJAJCL+AdvOTa2fa4214.B+fb Flags: Symbolic FontBBox: 0, 0, 864, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJCCEH+AdvOT0c200bf0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: HJCCEH+AdvOT0c200bf0+20 Flags: Nonsymbolic FontBBox: -229, -104, 1083, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJCCEI+AdvOT0c200bf0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HJCCEI+AdvOT0c200bf0+fb Flags: Symbolic FontBBox: 19, 0, 604, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJCCDG+AdvOT23e3f5cb.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: HJCCDG+AdvOT23e3f5cb.I Flags: Nonsymbolic FontBBox: -62, -208, 947, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJCCHI+AdvOT13119950+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: HJCCHI+AdvOT13119950+20 Flags: Nonsymbolic FontBBox: -229, -104, 1156, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAKOH+AdvOTdd63dae3+03 FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: HJAKOH+AdvOTdd63dae3+03 Flags: Symbolic FontBBox: -156, -197, 833, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJAKFH+AdvOTdd63dae3+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: HJAKFH+AdvOTdd63dae3+20 Flags: Nonsymbolic FontBBox: -197, -125, 1322, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJAKOI+AdvOT3d287b35.B FontSubset: true FirstChar: 45 LastChar: 124 FontDescriptor: FontName: HJAKOI+AdvOT3d287b35.B Flags: Serif, Nonsymbolic FontBBox: -125, -218, 1000, 958 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-023-35854-0 Javier Garcia-Pardo Andrea Bartolomé-Nafría Antonio Chaves-Sanjuan Marcos Gil-Garcia Cristina Visentin Martino Bolognesi Stefano Ricagno Salvador Ventura Springer US Nature Communications, doi:10.1038/s41467-023-35854-0 Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 Springer 2023-01-16T15:13:15+01:00 2023-01-16T08:40:27+05:30 2023-01-16T15:13:15+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:158f67cf-6806-4ab2-b51d-4c1ebe7a8c3a uuid:26206ed0-c3f1-4069-8fa6-6d6c33d8f264 default 1 converted uuid:1b3e32aa-0edd-47b0-8d18-f57b4733fd40 converted to PDF/A-2b pdfToolbox 2023-01-16T08:41:15+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 300, 552, 301, 561 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 300, 552, 301, 561 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 550, 310, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 300, 550, 309, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 550, 310, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 425, 552, 426, 561 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 425, 552, 426, 561 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 434, 550, 435, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 425, 550, 434, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 434, 550, 435, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 322, 539, 323, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 322, 539, 323, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 331, 538, 332, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 322, 538, 331, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 331, 538, 332, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 423, 539, 425, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 423, 539, 425, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 432, 538, 433, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 424, 538, 432, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 432, 538, 434, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 295, 527, 296, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 295, 527, 296, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 525, 305, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 295, 525, 304, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 525, 305, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 390, 527, 392, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 390, 527, 392, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 399, 525, 400, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 390, 525, 399, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 399, 525, 400, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 496, 527, 498, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 496, 527, 498, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 505, 525, 506, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 496, 525, 505, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 505, 525, 506, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 212, 116, 217 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 118, 212, 121, 217 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 213, 191, 215, 196 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 238, 187, 242, 195 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 173, 169, 176, 174 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 220, 116, 223, 121 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 512, 255, 515, 260 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 464, 234, 467, 239 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 489, 212, 491, 217 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 494, 212, 499, 217 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 549, 202, 553, 207 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 554, 202, 559, 207 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 527, 159, 531, 164 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 532, 159, 537, 164 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 525, 137, 530, 142 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 531, 137, 535, 142 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 342, 116, 345, 121 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: -2, 479, 50, 511 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 38, 486, 50, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 38, 490, 40, 500 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 38, 490, 40, 500 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 192, 48, 282, 55 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 210, 726, 215, 731 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 216, 726, 220, 731 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 163, 694, 168, 699 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 76, 673, 81, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 287, 523, 292, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 58, 501, 63, 506 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 271, 491, 277, 496 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 369, 62, 377 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 271, 347, 274, 355 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 290, 341, 292, 346 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 180, 144, 183, 152 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 174, 79, 177, 88 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 351, 694, 354, 699 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 381, 572, 386, 580 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 420, 544, 425, 549 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 426, 544, 431, 549 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 351, 519, 355, 527 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 378, 519, 383, 527 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 447, 476, 452, 484 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 436, 454, 440, 463 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 457, 433, 461, 441 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 370, 401, 375, 409 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 530, 283, 535, 291 Flags: Print AppearanceDictionary: true Destination: 161 Annotation: Subtype: Link Rect: 444, 148, 449, 153 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 531, 101, 536, 109 Flags: Print AppearanceDictionary: true Destination: 135 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 273, 159, 275, 164 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 197, 116, 200, 121 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 326, 148, 331, 153 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 332, 148, 337, 153 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 380, 73, 383, 78 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 386, 73, 391, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 433, 58, 437, 66 Flags: Print AppearanceDictionary: true Destination: 161 Annotation: Subtype: Link Rect: 491, 47, 495, 56 Flags: Print AppearanceDictionary: true Destination: 161 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 63, 79, 67, 88 Flags: Print AppearanceDictionary: true Destination: 161 Annotation: Subtype: Link Rect: 93, 79, 97, 88 Flags: Print AppearanceDictionary: true Destination: 161 Annotation: Subtype: Link Rect: 357, 52, 362, 57 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 363, 52, 368, 57 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 87, 105, 92, 110 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 62, 483, 67 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 55, 168, 59, 172 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 60, 168, 65, 172 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 81, 737, 87, 742 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 615, 223, 623 Flags: Print AppearanceDictionary: true Destination: 161 Annotation: Subtype: Link Rect: 241, 583, 246, 591 Flags: Print AppearanceDictionary: true Destination: 161 Annotation: Subtype: Link Rect: 270, 523, 273, 528 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 289, 480, 294, 485 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 58, 465, 61, 473 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 240, 465, 245, 473 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 268, 465, 273, 473 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 247, 401, 252, 409 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 260, 379, 265, 388 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 101, 315, 106, 323 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 252, 287, 254, 292 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 257, 287, 260, 292 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 187, 255, 192, 260 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 120, 197, 125, 206 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 283, 154, 287, 163 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 86, 101, 90, 109 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 520, 673, 522, 678 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 366, 609, 369, 613 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 505, 587, 510, 592 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 511, 587, 517, 592 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 500, 523, 504, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 506, 523, 511, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 512, 523, 518, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 412, 512, 417, 517 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 418, 512, 423, 517 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 547, 469, 552, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 553, 469, 559, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 548, 394, 553, 399 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 554, 394, 559, 399 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 465, 234, 470, 239 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 471, 234, 475, 239 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 428, 180, 431, 185 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 486, 137, 492, 142 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 451, 116, 456, 121 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 459, 116, 464, 121 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 381, 62, 386, 67 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 356, 228, 362, 232 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 459, 98, 463, 103 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 257, 673, 262, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 262, 619, 268, 624 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 198, 598, 204, 603 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 114, 534, 119, 539 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 250, 501, 254, 506 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 290, 501, 294, 506 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 198, 459, 203, 464 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 352, 223, 356 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 79, 330, 82, 335 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 73, 319, 79, 324 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 234, 309, 239, 314 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 240, 309, 245, 314 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 169, 298, 174, 303 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 190, 212, 193, 217 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 194, 169, 197, 174 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 160, 84, 163, 89 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 474, 737, 480, 742 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 360, 651, 364, 656 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 332, 587, 337, 592 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 494, 561, 499, 570 Flags: Print AppearanceDictionary: true Destination: 161 Annotation: Subtype: Link Rect: 550, 555, 553, 560 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 554, 555, 559, 560 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 325, 534, 330, 539 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 421, 523, 426, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 448, 480, 454, 485 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 553, 469, 559, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 497, 437, 502, 442 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 428, 223, 430, 228 Flags: Print AppearanceDictionary: true Destination: 403 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 159, 716, 165, 721 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 528, 277, 533, 281 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 359, 255, 364, 260 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 558, 244, 561, 249 Flags: Print AppearanceDictionary: true Destination: 403 Annotation: Subtype: Link Rect: 366, 234, 372, 239 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 422, 159, 427, 164 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 377, 52, 382, 57 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 384, 52, 389, 57 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 474, 52, 480, 57 Flags: Print AppearanceDictionary: true Destination: 424 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 141, 658, 158, 666 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 42, 647, 88, 655 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 42, 626, 95, 634 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 225, 587, 231, 592 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 288, 523, 292, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 62, 501, 67, 506 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 122, 501, 127, 506 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 465, 72, 473 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 178, 427, 183, 431 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 158, 394, 163, 399 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 223, 298, 227, 303 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 247, 266, 252, 271 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 157, 244, 162, 249 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 326, 641, 331, 646 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 517, 416, 522, 421 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 510, 287, 516, 292 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 409, 58, 425, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 445, 58, 491, 66 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 240, 733, 292, 741 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 104, 711, 126, 720 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 132, 711, 151, 720 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 157, 711, 175, 720 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 181, 711, 204, 720 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 711, 246, 720 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 306, 465, 467, 473 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 358, 421, 366 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 456, 187, 561, 195 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 176, 365, 184 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 89b8934e Type: CRC32 Checksum: 93105d143ea503f66a948a564784159d Type: MD5 Checksum: 2ca86fccc6fb79a7adc0422b7aedf1e4ea2ebb53 Type: SHA-1