11d12f480ee241b86381add0b17cd2f1 pmc_9865491.pdf b3e45afa008acb5d7c48cc3dd482130ac0960224 pmc_9865491.pdf cceec880fdfbeff3d56ca13dd0ded289ee16b40303a63eef62541ec478238ca1 pmc_9865491.pdf Title: Importance of Water Transport in Mammalian Female Reproductive Tract Subject: Aquaporins (AQPs) are involved in water homeostasis in tissues and are ubiquitous in the reproductive tract. AQPs are classified into classical aquaporins (AQP0, 1, 2, 4, 5, 6 and 8), aquaglycerolporins (AQP3, 7, 9, and 10) and superaquaporins (AQP11 and 12). Nine AQPs were described in the mammalian female reproductive tract. Some of their functions are influenced by sexual steroid hormones. The continuous physiological changes that occur throughout the sexual cycle, pregnancy and parturition, modify the expression of AQPs, thus creating at every moment the required water homeostasis. AQPs in the ovary regulate follicular development and ovulation. In the vagina and the cervix, AQPs are involved mainly in lubrication. In the uterus, AQPs are mostly mediated by estradiol and progesterone to prepare the endometrium for possible embryo implantation and fetal development. In the placenta, AQPs are responsible for the fluid support to the fetus to maintain fetal homeostasis that ensures correct fetal development as pregnancy goes on. This review is focused on understanding the role of AQPs in the mammalian female reproductive tract during the sexual cycle of pregnancy and parturition. Keywords: aquaporins; female reproductive tract; reproduction; placenta; water homeostasis Author: Lluis Ferré-Dolcet and Maria Montserrat Rivera del Alamo Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jan 11 11:34:36 2023 CET ModDate: Wed Jan 11 11:38:08 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 907978 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 DDMOHK+VnURWPalladioL Type 1 Custom yes yes no 15 0 XAYYQB+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 QKUUKQ+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 RLTIDH+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 CTCXDQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 FNIMMF+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 73 0 FNIMNG+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 79 0 FNIMNH+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 85 0 FNIMNI+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 91 0 FNIMNJ+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 94 0 FNIMNK+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 97 0 FNIMMF+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 109 0 FNIMNG+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 115 0 FNIMNH+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 121 0 FNIMNI+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 127 0 FNIMNJ+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 130 0 FNIMNK+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 133 0 DVCMRV+CMSY10 Type 1 Builtin yes yes no 143 0 CKBPVA+EURM10 Type 1 Builtin yes yes no 156 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-02 02:36:21 CET RepresentationInformation: pmc_9865491.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-26 02:11:35 CET Size: 907978 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 525 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Aquaporins and Reproduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Molecular Structure, Function, and Location of Aquaporins (AQPs) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: AQPs in the Female Reproductive Tract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: AQPs in the Ovary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: AQPs in the Vagina and Cervix Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: AQPs in the Uterus Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: AQPs in the Placenta Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Info: Title: Importance of Water Transport in Mammalian Female Reproductive Tract Author: Lluis Ferré-Dolcet and Maria Montserrat Rivera del Alamo Subject: Aquaporins (AQPs) are involved in water homeostasis in tissues and are ubiquitous in the reproductive tract. AQPs are classified into classical aquaporins (AQP0, 1, 2, 4, 5, 6 and 8), aquaglycerolporins (AQP3, 7, 9, and 10) and superaquaporins (AQP11 and 12). Nine AQPs were described in the mammalian female reproductive tract. Some of their functions are influenced by sexual steroid hormones. The continuous physiological changes that occur throughout the sexual cycle, pregnancy and parturition, modify the expression of AQPs, thus creating at every moment the required water homeostasis. AQPs in the ovary regulate follicular development and ovulation. In the vagina and the cervix, AQPs are involved mainly in lubrication. In the uterus, AQPs are mostly mediated by estradiol and progesterone to prepare the endometrium for possible embryo implantation and fetal development. In the placenta, AQPs are responsible for the fluid support to the fetus to maintain fetal homeostasis that ensures correct fetal development as pregnancy goes on. This review is focused on understanding the role of AQPs in the mammalian female reproductive tract during the sexual cycle of pregnancy and parturition. 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