8808afd6aa3662a11d6a70d3a35d6a87  pmc_9881265.pdf
838b0fbbeecf83d62b1d5558effa311496b53410  pmc_9881265.pdf
31364174f44695c697e2677d7a4e90525843873d04798c20222a25b02caf6508  pmc_9881265.pdf

Title:          Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia
Subject:        BMC Neuroscience, https://doi.org/10.1186/s12868-023-00775-7
Keywords:       Ischemic stroke; Proteome; Transcriptome; Sex; Diabetes; Age
Author:         Laura Ramiro 
Creator:        Adobe InDesign 15.1 (Windows)
Producer:       Adobe PDF Library 15.0; modified using iTextSharp™ 5.5.14-SNAPSHOT ©2000-2020 iText Group NV (AGPL-version); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Fri Jan 27 08:02:19 2023 CET
ModDate:        Fri Jan 27 09:25:09 2023 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          15
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      2316488 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     45  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     49  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     47  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  no     748  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes    123  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     46  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     48  0
UBNDFY+MTSY                          Type 1C           Custom           yes yes yes     50  0
USAKWV+WarnockPro-It                 Type 1C           WinAnsi          yes yes yes     51  0
TOZYOB+STIXMath-Regular              Type 1C           WinAnsi          yes yes yes     66  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    532  0
MyriadPro-SemiboldIt                 Type 1C           Custom           yes no  yes     83  0
WMXDPB+MyriadPro-LightIt             Type 1C           WinAnsi          yes yes yes    124  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-03-16 02:35:18 CET
 RepresentationInformation: pmc_9881265.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-02-09 02:15:41 CET
  Size: 2316488
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 843
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia
      Children: 
       Item: 
        Title: Abstract 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Study design
         Item: 
          Title: Animals
         Item: 
          Title: Transient middle cerebral artery occlusion (MCAO) model
         Item: 
          Title: Brain collection and extraction of protein and RNA
         Item: 
          Title: Transcriptomics study
         Item: 
          Title: Proteomics study
         Item: 
          Title: Bioinformatics and statistical analyses
          Children: 
           Item: 
            Title: Transcriptomics data
           Item: 
            Title: Proteomics data
           Item: 
            Title: Integrative analyses
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Transcriptomics results
          Children: 
           Item: 
            Title: Differentially expressed genes
           Item: 
            Title: Integrative analysis of transcriptomic results
         Item: 
          Title: Proteomics results
          Children: 
           Item: 
            Title: Integrative analysis of proteomic results
       Item: 
        Title: Discussion
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia
    Author: Laura Ramiro 
    Subject: BMC Neuroscience, https://doi.org/10.1186/s12868-023-00775-7
    Keywords: Ischemic stroke; Proteome; Transcriptome; Sex; Diabetes; Age
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iTextSharp™ 5.5.14-SNAPSHOT ©2000-2020 iText Group NV (AGPL-version); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Fri Jan 27 08:32:19 CET 2023
    ModDate: Fri Jan 27 09:25:09 CET 2023
   ID: 0x63c289ccc381d140e38aa5e85e53171d, 0x3233190a8fc52894244c24613773284d
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 42
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 82
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1595
      ImageHeight: 683
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1600
      ImageHeight: 2481
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1961
      ImageHeight: 799
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UBNDFY+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: UBNDFY+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TOZYOB+STIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: TOZYOB+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: USAKWV+WarnockPro-It
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: USAKWV+WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular2
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WMXDPB+MyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WMXDPB+MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2023-01-27T12:32:19+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2023-01-27T09:25:09+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2023-01-27T09:25:09+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iTextSharp™ 5.5.14-SNAPSHOT ©2000-2020 iText Group NV (AGPL-version); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Ischemic stroke; Proteome; Transcriptome; Sex; Diabetes; Age</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s12868-023-00775-7</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Neuroscience, https://doi.org/10.1186/s12868-023-00775-7</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Ischemic stroke</rdf:li>
               <rdf:li>Proteome</rdf:li>
               <rdf:li>Transcriptome</rdf:li>
               <rdf:li>Sex</rdf:li>
               <rdf:li>Diabetes</rdf:li>
               <rdf:li>Age</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Laura Ramiro </rdf:li>
               <rdf:li>Júlia Faura </rdf:li>
               <rdf:li>Alba Simats </rdf:li>
               <rdf:li>Paula García-Rodríguez </rdf:li>
               <rdf:li>Feifei Ma </rdf:li>
               <rdf:li>Luna Martín </rdf:li>
               <rdf:li>Francesc Canals </rdf:li>
               <rdf:li>Anna Rosell </rdf:li>
               <rdf:li>Joan Montaner </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12868-023-00775-7</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s12868-023-00775-7</prism:url>
         <prism:doi>10.1186/s12868-023-00775-7</prism:doi>
         <prism:issn>1471-2202</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BMC Neuroscience</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12868-023-00775-7</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:42938cc7-0296-4fc2-93b2-028608a96be0</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:99897fa8-a923-421a-a6fb-eda8d1ca7d55</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:42938cc7-0296-4fc2-93b2-028608a96be0</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-01-27T12:34:22+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:bd879570-feb6-40cf-9df7-8ebe17854c64</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-01-27T12:34:57+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 68, 330, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 68, 530, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 60, 276, 52
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 267, 358, 255
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 396, 207, 400, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 407, 207, 412, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 372, 159, 377, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 382, 159, 387, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 219, 680, 224, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 180, 656, 185, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 221, 644, 226, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 232, 644, 237, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 251, 548, 261, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 162, 512, 172, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 137, 500, 147, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 152, 500, 162, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 174, 476, 184, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 258, 464, 268, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 275, 464, 285, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 59, 392, 69, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 59, 272, 69, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 75, 272, 85, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 337, 488, 347, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 458, 368, 468, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 395, 320, 405, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 145, 692, 155, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 85, 404, 95, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 89, 272, 99, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 415, 512, 424, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 308, 512, 318, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 404, 488, 414, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 479, 368, 489, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 523, 332, 533, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 386, 80, 396, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 231, 657, 241, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 275, 621, 285, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 163, 453, 173, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 275, 405, 285, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 275, 369, 285, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 209, 309, 218, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 223, 309, 233, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 147, 285, 156, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 59, 273, 69, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 339, 381, 344, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 504, 237, 508, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 345, 225, 350, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 276
      Annotation: 
       Subtype: Link
       Rect: 338, 129, 348, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 507, 81, 512, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 195, 371, 200, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 145, 323, 150, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 187, 263, 192, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 330, 323, 335, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
     Thumb: true
    Page: 
     Sequence: 8
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 259, 200, 269, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 275, 200, 285, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 206, 152, 216, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 259, 128, 269, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 275, 128, 285, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 461, 393, 471, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 477, 393, 487, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 473, 177, 483, 165
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 489, 177, 499, 165
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 171, 681, 181, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 187, 681, 197, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 99, 645, 109, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 115, 645, 125, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 261, 621, 271, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 59, 585, 69, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 228, 573, 238, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 143, 537, 153, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 59, 465, 69, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 77, 465, 87, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 244, 441, 254, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 258, 441, 268, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 87, 309, 97, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 93, 273, 102, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 108, 273, 118, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 262, 177, 272, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 362, 645, 372, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 376, 645, 386, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 523, 621, 533, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 454, 501, 464, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 336, 465, 346, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 507, 453, 517, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 523, 453, 533, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 437, 321, 447, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 453, 321, 463, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 406, 201, 416, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 458, 105, 468, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 473, 105, 483, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 681, 69, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 223, 645, 233, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 239, 645, 249, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 87, 561, 97, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 101, 561, 111, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 115, 513, 125, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 224, 405, 234, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 240, 405, 250, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 234, 333, 243, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 103, 285, 113, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 239, 237, 249, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 182, 177, 192, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 459, 465, 469, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 475, 465, 485, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 335, 189, 345, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
      Annotation: 
       Subtype: Link
       Rect: 351, 189, 361, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 299
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 248, 138, 281, 129
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 129, 156, 120
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 442, 499, 449, 491
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 452, 499, 459, 491
       Flags: Print
       AppearanceDictionary: true
       Destination: 405
      Annotation: 
       Subtype: Link
       Rect: 319, 105, 436, 97
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 362, 78, 495, 70
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 685, 173, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 163, 640, 286, 632
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 631, 94, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 147, 595, 260, 587
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 208, 568, 280, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 559, 141, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 171, 541, 281, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 532, 105, 524
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 141, 487, 286, 479
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 248, 469, 281, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 460, 163, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 133, 433, 283, 425
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 424, 78, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 89, 343, 218, 335
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 307, 288, 299
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 298, 283, 290
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 289, 101, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 193, 217, 282, 209
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 208, 109, 200
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 676, 505, 668
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 649, 513, 641
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 432, 631, 530, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 451, 559, 530, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 550, 345, 542
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 523, 536, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 337, 487, 464, 479
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 511, 469, 533, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 460, 410, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 424, 513, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 397, 418, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 506, 370, 528, 362
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 361, 411, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 337, 334, 457, 326
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 506, 316, 528, 308
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 307, 423, 299
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 472, 289, 526, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 280, 392, 272
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 181, 457, 173
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 505, 200, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 478, 288, 470
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 469, 126, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 178, 451, 287, 443
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 442, 105, 434
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 173, 415, 283, 407
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 406, 93, 398
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 161, 379, 280, 371
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 208, 361, 280, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 352, 110, 344
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 212, 334, 284, 326
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 325, 122, 317
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 89, 298, 227, 290
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 162, 271, 286, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 262, 93, 254
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 103, 244, 231, 236
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 217, 286, 209
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 208, 174, 200
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 140, 181, 284, 173
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 170, 145, 279, 137
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 136, 105, 128
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 109, 289, 101
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 100, 89, 92
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 492, 649, 538, 641
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 640, 431, 632
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 337, 613, 481, 605
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 568, 502, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 343, 533, 335
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 334, 346, 326
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 376, 307, 475, 299
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 488, 253, 534, 245
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 244, 379, 236
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 350, 199, 464, 191
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 2fcc663e
   Type: CRC32
  Checksum: 8808afd6aa3662a11d6a70d3a35d6a87
   Type: MD5
  Checksum: 838b0fbbeecf83d62b1d5558effa311496b53410
   Type: SHA-1