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based on a recombinant RBD fusion heterodimer of SARS-CoV-2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Recombinant RBD fusion heterodimer expression and characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Recombinant RBD fusion heterodimer antigen immunogenicity in BALB/c mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: RBD-specific binding and neutralizing antibody titers on PHH-1V vaccination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: RBD-specific cellular immune response on PHH-1V vaccination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Recombinant RBD fusion heterodimer antigen immunogenicity and efficacy against SARS-CoV-2 Wuhan/D614G in K18-hACE2 mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Recombinant RBD fusion heterodimer antigen immunogenicity and efficacy against different SARS-CoV-2 VoCs in K18-hACE2 mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Immunogenicity and efficacy of PHH-1V against SARS-CoV-2 Beta variant (B.1.351) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Immunogenicity and efficacy of PHH-1V against SARS-CoV-1 Delta variant (B.1.617.2) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Immunogenicity and efficacy of PHH-1V against SARS-CoV-1 Omicron variant (BA.1) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Safety of the recombinant RBD fusion heterodimer antigen after vaccination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Limitations of the study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Supplemental information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: STAR★Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: Key resources table 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MCJCDN+Helvetica-Bold FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: MCJCDN+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MCIPLG+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 83 LastChar: 110 FontDescriptor: FontName: MCIPLG+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MCIPMH+AdvPSA5BC FontSubset: true FirstChar: 37 LastChar: 222 FontDescriptor: FontName: MCIPMH+AdvPSA5BC Flags: Nonsymbolic FontBBox: -156, -239, 1135, 791 FontFile3: true Encoding: MacRomanEncoding XMP: application/pdf doi:10.1016/j.isci.2023.106126 Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2 Antonio Barreiro Antoni Prenafeta Gregori Bech-Sabat Mercè Roca Eva Perozo Mur Ricard March Luis González-González Laia Madrenas Júlia Corominas Alex Fernández Alexandra Moros Manuel Cañete Mercè Molas Thais Pentinat-Pelegrin Clara Panosa Alberto Moreno Ester Puigvert Molas Eva Pol Vilarrassa Jordi Palmada Carme Garriga Teresa Prat Cabañas Javier Iglesias-Fernández Júlia Vergara-Alert Cristina Lorca-Oró Núria Roca Leira Fernández-Bastit Jordi Rodon Mònica Pérez Joaquim Segalés Edwards Pradenas Silvia Marfil Benjamin Trinité Raquel Ortiz Bonaventura Clotet Julià Blanco Jorge Díaz Pedroza Rosa Ampudia Carrasco Yaiza Rosales Salgado Jordina Loubat-Casanovas Sara Capdevila Larripa Julia Garcia Prado Jordi Barretina Marta Sisteré-Oró Paula Cebollada Rica Andreas Meyerhans Laura Ferrer Health sciences Immune response Immunology Microbiology ISCIENCE, 26 (2023) 106126. doi:10.1016/j.isci.2023.106126 The Author(s) journal ISCIENCE © 2023 The Author(s). 2589-0042 26 3 17 March 2023 2023-03-17 106126 106126 10.1016/j.isci.2023.106126 https://doi.org/10.1016/j.isci.2023.106126 2010-04-23 true 10.1016/j.isci.2023.106126 elsevier.com 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