e79f2b522a9c48f576bebfa13c540879 pmc_9897054.pdf 3d7064877d8ae7ba1431244c14ca6bb8f664df25 pmc_9897054.pdf cb856183f945665370a09c4a167b9ede02dfa2cb2e7c888533b48cc9159615e4 pmc_9897054.pdf Title: LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors Subject: Introduction: The association of polymorphisms in molecules involved in the immune response (checkpoint inhibitors) with the clinical outcome after allogeneic transplantation (alloHSCT) has been described Keywords: LAG3: lymphocyte activation gene 3, graft-versus-host disease, allogeneic transplant, immune response, checkpoint molecules Author: David Cruz; Rocío Rodríguez-Romanos; Marta González-Bartulos; Irene García-Cadenas; Rafael de la Cámara; Inmaculada Heras; Ismael Buño; Nazly Santos; Natàlia Lloveras; Pilar Velarde; Esperanza Tuset; Carmen Martínez; Marcos González; Guillermo F. Sanz; Christelle Ferrá; Antonia Sampol; Rosa Coll; Jose A. Pérez-Simón; Javier López-Jiménez; Manuel Jurado; David Gallardothe GvHD/Immunotherapy Working Party of the Spanish Group of Hematopoietic Transplant (GETH) Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Jan 20 06:11:56 2023 CET ModDate: Fri Jan 20 06:12:12 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.389 x 841.663 pts Page rot: 0 File size: 1085536 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EBKAOM+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 507 0 EBKAPN+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 508 0 EBKAPO+AdvPSA18C Type 1C WinAnsi yes yes no 509 0 EBKAPP+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 514 0 EBKBAA+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 515 0 EBKBBA+AdvPSA323 Type 1C WinAnsi yes yes no 516 0 EBKBCB+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 520 0 EBKCBL+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 523 0 EBKCBM+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 524 0 EBKCFO+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 153 0 EBKCFP+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 165 0 EBKCGP+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 168 0 EBKCHA+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 154 0 EBKCFM+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 160 0 EBKCFN+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 161 0 EBKCJB+AdvOT46dcae81 Type 1C WinAnsi yes yes no 171 0 EBKCKB+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 173 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 174 0 EBKEGI+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 178 0 EBKGKK+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 182 0 EBKGLK+AdvTT58d178b9+03 Type 1C Custom yes yes yes 181 0 EBKGLL+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 180 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-11 02:34:32 CEST RepresentationInformation: pmc_9897054.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-06 02:16:32 CEST Size: 1085536 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B27' cannot be found Offset: 1071407 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B28' cannot be found Offset: 1071407 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 578 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Patients and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: LAG3 genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: LAG3 genotype distribution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: LAG3 genotype of the donor and clinical outcome after allogeneic hematopoietic transplant from HLA-identical sibling donors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Interaction between LAG3 and PDCD1 genotypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Info: Title: LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors Author: David Cruz; Rocío Rodríguez-Romanos; Marta González-Bartulos; Irene García-Cadenas; Rafael de la Cámara; Inmaculada Heras; Ismael Buño; Nazly Santos; Natàlia Lloveras; Pilar Velarde; Esperanza Tuset; Carmen Martínez; Marcos González; Guillermo F. Sanz; Christelle Ferrá; Antonia Sampol; Rosa Coll; Jose A. Pérez-Simón; Javier López-Jiménez; Manuel Jurado; David Gallardothe GvHD/Immunotherapy Working Party of the Spanish Group of Hematopoietic Transplant (GETH) Subject: Introduction: The association of polymorphisms in molecules involved in the immune response (checkpoint inhibitors) with the clinical outcome after allogeneic transplantation (alloHSCT) has been described Keywords: LAG3: lymphocyte activation gene 3, graft-versus-host disease, allogeneic transplant, immune response, checkpoint molecules Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Jan 20 06:11:56 CET 2023 ModDate: Fri Jan 20 06:12:12 CET 2023 ID: 0x3dc464a2b720506f24d2abe896d85d7e, 0x68d4392db671be43b255e34a58da1766 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: 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