0d2f76423db1e568a0da5b9eceb0856d pmc_9899209.pdf 8f06143cc0fc01d783f3493f35e3a68af119a1b9 pmc_9899209.pdf 57a7bf2e936e5dd7c4a6e757d1f648f906bd6f2b2fdfd1610d827c20d0e41150 pmc_9899209.pdf Title: Coordinated local RNA overexpression of complement induced by interferon gamma in myositis Subject: Scientific Reports, https://doi.org/10.1038/s41598-023-28838-z Author: Maria Casal-Dominguez Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Feb 4 08:44:23 2023 CET ModDate: Sat Feb 4 10:03:21 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1325558 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XFTTRM+Wingdings-Regular Type 1C WinAnsi yes yes yes 284 0 MinionPro-Regular Type 1C Custom yes no yes 33 0 SJZZLY+TimesNewRomanPS-BoldMT CID TrueType Identity-H yes yes yes 285 0 DJTXJC+Corbel-Bold CID TrueType Identity-H yes yes yes 34 0 DKMIJC+Corbel-BoldItalic CID TrueType Identity-H yes yes yes 125 0 Corbel2 TrueType WinAnsi yes no yes 35 0 SKMTLY+Corbel CID TrueType Identity-H yes yes yes 36 0 Corbel3 CID TrueType Identity-H yes no yes 329 0 Corbel4 TrueType WinAnsi yes no yes 40 0 MinionPro-It Type 1C Custom yes no yes 71 0 STTAGY+ArialMT Type 1C WinAnsi yes yes no 81 0 MinionPro-Bold Type 1C Custom yes no yes 82 0 VTDURS+Helvetica Type 1C WinAnsi yes yes no 103 0 VTDURS+Helvetica2 Type 1C WinAnsi yes yes no 124 0 VTDURS+MinionPro-Regular2 Type 1C Custom yes yes no 149 0 VTDURS+MTMI Type 1C Custom yes yes no 150 0 VTDURS+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 151 0 VTDURS+MTMI2 Type 1C Custom yes yes no 152 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-11 02:34:30 CEST RepresentationInformation: pmc_9899209.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-04-22 02:23:54 CEST Size: 1325558 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 367 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Coordinated local RNA overexpression of complement induced by interferon gamma in myositis Children: Item: Title: Methods Children: Item: Title: Patients. Item: Title: Standard protocol approvals and patient consent. Item: Title: RNA sequencing. Item: Title: Single-nuclei RNA-sequencing. Item: Title: Single-cell RNA-sequencing. Item: Title: Culture of differentiating human skeletal muscle myoblasts and treatment with different types of interferon. Item: Title: Statistical and bioinformatic analysis. Item: Title: Results Children: Item: Title: Differential expression of complement proteins in the different types of IM. Item: Title: Correlation of complement expression with myositis activity. Item: Title: Different cell types coordinately express various complement genes. Item: Title: Local complement expression in IM correlates with IFNγ pathway activation. Item: Title: Discussion Item: Title: References Item: Title: Acknowledgements Info: Title: Coordinated local RNA overexpression of complement induced by interferon gamma in myositis Author: Maria Casal-Dominguez Subject: Scientific Reports, https://doi.org/10.1038/s41598-023-28838-z Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Feb 04 09:14:23 CET 2023 ModDate: Sat Feb 04 10:03:21 CET 2023 ID: 0xf025aeb390086cc9d2f54725332119e7, 0xe337f1a5721c0766f46225eda5933608 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 48 ImageHeight: 946 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: DJTXJC+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: SKMTLY+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: DKMIJC+Corbel-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: SJZZLY+TimesNewRomanPS-BoldMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: STTAGY+ArialMT FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: STTAGY+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VTDURS+MinionPro-Regular2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: VTDURS+MinionPro-Regular2 Flags: Symbolic, AllCap FontBBox: 0, 0, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VTDURS+MTMI FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: VTDURS+MTMI Flags: Symbolic FontBBox: 0, -199, 551, 671 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VTDURS+Helvetica FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: VTDURS+Helvetica Flags: Nonsymbolic FontBBox: -951, -481, 1446, 1122 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: VTDURS+MTMI2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: VTDURS+MTMI2 Flags: Symbolic FontBBox: 0, -199, 551, 671 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: XFTTRM+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XFTTRM+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: VTDURS+Helvetica2 FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: VTDURS+Helvetica2 Flags: Nonsymbolic FontBBox: -951, -481, 1446, 1122 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: VTDURS+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: VTDURS+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: DKMIJC+Corbel-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DKMIJC+Corbel-BoldItalic Flags: Symbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Font: BaseFont: HYMTSU+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HYMTSU+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: DJTXJC+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DJTXJC+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: SJZZLY+TimesNewRomanPS-BoldMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SJZZLY+TimesNewRomanPS-BoldMT Flags: Serif, Symbolic FontBBox: -558, -328, 2000, 1056 FontFile2: true XMP: 2023-02-04T13:14:23+05:30 Springer 2023-02-04T10:03:21+01:00 2023-02-04T10:03:21+01:00 application/pdf https://doi.org/10.1038/s41598-023-28838-z Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-023-28838-z Coordinated local RNA overexpression of complement induced by interferon gamma in myositis Maria Casal-Dominguez Iago Pinal-Fernandez Katherine Pak Sandra Muñoz-Braceras Jose C. Milisenda Jiram Torres-Ruiz Stefania Dell′Orso Faiza Naz Gustavo Gutierrez-Cruz Yaiza Duque-Jaimez Ana Matas-Garcia Laura Valls-Roca Gloria Garrabou Ernesto Trallero-Araguas Brian Walitt Lisa Christopher-Stine Thomas E. Lloyd Julie J. Paik Jemima Albayda Andrea Corse Josep Maria Grau Albert Selva-O’Callaghan Andrew L. Mammen 10.1038/s41598-023-28838-z 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-023-28838-z 10.1038/s41598-023-28838-z 2045-2322 journal Scientific Reports This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2010-04-23 true 10.1038/s41598-023-28838-z noindex springer.com springerlink.com VoR uuid:422ef58a-c16b-43de-9c85-00d3700b5ecc uuid:b4d9f5c0-cd05-43c3-ac0e-4b65b731e8c5 default 1 converted uuid:b4de5696-5d9e-486d-a783-d3376edb12d5 converted to PDF/A-2b pdfToolbox 2023-02-04T13:15:19+05:30 converted uuid:3b893ad4-af76-4a76-956c-8b0c079b6d1e converted to PDF/A-2b pdfToolbox 2023-02-04T13:16:24+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 262, 253, 265, 241 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 455, 243, 458, 231 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 428, 223, 431, 211 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 433, 223, 435, 211 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 527, 193, 530, 181 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 533, 193, 536, 181 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 481, 675, 556, 658 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 249, 724, 252, 712 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 253, 724, 256, 712 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 456, 714, 459, 702 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 460, 714, 463, 702 Flags: Print AppearanceDictionary: true Destination: 136 Annotation: Subtype: Link Rect: 466, 714, 472, 702 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 221, 694, 227, 682 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 269, 582, 275, 570 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 511, 582, 517, 570 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 190, 408, 196, 396 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 199, 408, 204, 396 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 385, 346, 391, 334 Flags: Print AppearanceDictionary: true Destination: 171 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 352, 510, 357, 498 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 497, 510, 502, 498 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 504, 510, 509, 498 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 198, 348, 202, 336 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 311, 348, 316, 336 Flags: Print AppearanceDictionary: true Destination: 89 Annotation: Subtype: Link Rect: 547, 338, 552, 326 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 314, 298, 318, 286 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 174, 258, 178, 246 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 283, 258, 287, 246 Flags: Print AppearanceDictionary: true Destination: 89 Annotation: Subtype: Link Rect: 276, 206, 281, 194 Flags: Print AppearanceDictionary: true Destination: 99 Annotation: Subtype: Link Rect: 174, 166, 178, 154 Flags: Print AppearanceDictionary: true Destination: 99 Thumb: true Page: Sequence: 4 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 315, 202, 319, 190 Flags: Print AppearanceDictionary: true Destination: 99 Thumb: true Page: Sequence: 6 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 537, 723, 543, 711 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 546, 723, 552, 711 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 445, 713, 451, 701 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 285, 683, 289, 671 Flags: Print AppearanceDictionary: true Destination: 111 Thumb: true Page: Sequence: 8 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 357, 714, 361, 702 Flags: Print AppearanceDictionary: true Destination: 130 Annotation: Subtype: Link Rect: 224, 452, 230, 440 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 377, 442, 383, 430 Flags: Print AppearanceDictionary: true Destination: 171 Annotation: Subtype: Link Rect: 489, 432, 495, 420 Flags: Print AppearanceDictionary: true Destination: 171 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 499, 241, 554, 229 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 231, 259, 219 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 201, 443, 189 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 358, 91, 517, 79 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 4f89698e Type: CRC32 Checksum: 0d2f76423db1e568a0da5b9eceb0856d Type: MD5 Checksum: 8f06143cc0fc01d783f3493f35e3a68af119a1b9 Type: SHA-1