d8dbf16edc1c3e16544702ecb90aec6d pmc_9913166.pdf 93e2e6345f8deac7bc96d10d699cae8c50d661e5 pmc_9913166.pdf 0317d4581765ef3465a3ddc614c714df12e14a4a8d50f67ce77a01d20e725de9 pmc_9913166.pdf Title: Clinical Presentation, Management, and Evolution of Lymphomas in Patients with Inflammatory Bowel Disease: An ENEIDA Registry Study Subject: An increased risk of lymphoma has been described in patients with inflammatory bowel disease (IBD). The aims of our study were to determine the clinical presentation, the previous exposure to immunosuppressive and biologic therapies, and the evolution of lymphomas in patients with IBD. IBD patients with diagnosis of lymphoma from October 2006 to June 2021 were identified from the prospectively maintained ENEIDA registry of GETECCU. We identified 52 patients (2.4 cases of lymphoma/1000 patients with IBD; 95% CI 1.8–3.1). Thirty-five were men (67%), 52% had ulcerative colitis, 60% received thiopurines, and 38% an anti-TNF drug before lymphoma diagnosis. Age at lymphoma was lower in those patients treated with thiopurines (53 17 years old) and anti-TNF drugs (47 17) than in those patients not treated with these drugs (63 12; p < 0.05). Five cases had relapse of lymphoma (1.7 cases/100 patient-years). Nine patients (17%) died after 19 months (IQR 0–48 months). Relapse and mortality were not related with the type of IBD or lymphoma, nor with thiopurines or biologic therapies. In conclusion, most IBD patients had been treated with thiopurines and/or anti-TNF agents before lymphoma diagnosis, and these patients were younger at diagnosis of lymphoma than those not treated with these drugs. Relapse and mortality of lymphoma were not related with these therapies. Keywords: inflammatory bowel disease; lymphoma; thiopurines; anti-TNF Author: Ivan Guerra, Luis Bujanda, Miriam Mañosa, Isabel Pérez-Martínez, María José Casanova, Luisa de la Peña, Marina de Benito, Montserrat Rivero, Pilar Varela, Lorena Bernal, Ana Carolina Franco, Yolanda Ber, Marta Piqueras, Carlos Tardillo, Ángel Ponferrada, Sonsoles Olivares, Alfredo J. Lucendo, Pau Gilabert, Mónica Sierra Ausín, María Bellart, Amaia Herrarte, Margalida Calafat, Ruth de Francisco, Javier P. Gisbert, Jordi Guardiola, Eugeni Domènech and Fernando Bermejo Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Feb 1 11:15:38 2023 CET ModDate: Wed Feb 1 11:32:58 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 585100 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JCZEAA+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 DUFXDP+VnURWPalladioL Type 1 Custom yes yes no 15 0 WSWPYS+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 OWNDDG+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 MUAYQA+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 LGTZLE+CMSY10 Type 1 Builtin yes yes no 69 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 90 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 94 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 98 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 102 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-12 02:31:15 CEST RepresentationInformation: pmc_9913166.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-30 02:16:09 CEST Size: 585100 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 264 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Data Source Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Variables of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Immunosuppressive and Biological Treatments before Lymphoma Diagnosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Diagnosis of Lymphoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Treatment of Lymphoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Treatment and Evolution of IBD after Lymphoma Diagnosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Relapse of Lymphoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Mortality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Info: Title: Clinical Presentation, Management, and Evolution of Lymphomas in Patients with Inflammatory Bowel Disease: An ENEIDA Registry Study Author: Ivan Guerra, Luis Bujanda, Miriam Mañosa, Isabel Pérez-Martínez, María José Casanova, Luisa de la Peña, Marina de Benito, Montserrat Rivero, Pilar Varela, Lorena Bernal, Ana Carolina Franco, Yolanda Ber, Marta Piqueras, Carlos Tardillo, Ángel Ponferrada, Sonsoles Olivares, Alfredo J. Lucendo, Pau Gilabert, Mónica Sierra Ausín, María Bellart, Amaia Herrarte, Margalida Calafat, Ruth de Francisco, Javier P. Gisbert, Jordi Guardiola, Eugeni Domènech and Fernando Bermejo Subject: An increased risk of lymphoma has been described in patients with inflammatory bowel disease (IBD). The aims of our study were to determine the clinical presentation, the previous exposure to immunosuppressive and biologic therapies, and the evolution of lymphomas in patients with IBD. IBD patients with diagnosis of lymphoma from October 2006 to June 2021 were identified from the prospectively maintained ENEIDA registry of GETECCU. We identified 52 patients (2.4 cases of lymphoma/1000 patients with IBD; 95% CI 1.8 3.1). Thirty-five were men (67%), 52% had ulcerative colitis, 60% received thiopurines, and 38% an anti-TNF drug before lymphoma diagnosis. Age at lymphoma was lower in those patients treated with thiopurines (53 17 years old) and anti-TNF drugs (47 17) than in those patients not treated with these drugs (63 12; p < 0.05). Five cases had relapse of lymphoma (1.7 cases/100 patient-years). Nine patients (17%) died after 19 months (IQR 0 48 months). Relapse and mortality were not related with the type of IBD or lymphoma, nor with thiopurines or biologic therapies. In conclusion, most IBD patients had been treated with thiopurines and/or anti-TNF agents before lymphoma diagnosis, and these patients were younger at diagnosis of lymphoma than those not treated with these drugs. Relapse and mortality of lymphoma were not related with these therapies. Keywords: inflammatory bowel disease; lymphoma; thiopurines; anti-TNF Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Feb 01 11:15:38 CET 2023 ModDate: Wed Feb 01 11:32:58 CET 2023 ID: 0x28a845100dd1814ff19830f78af50621, 0x28a845100dd1814ff19830f78af50621 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: WSWPYS+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 241 FontDescriptor: FontName: WSWPYS+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LGTZLE+CMSY10 FontSubset: true FirstChar: 6 LastChar: 6 FontDescriptor: FontName: LGTZLE+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: OWNDDG+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: OWNDDG+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JCZEAA+VnURWPalladioL-Bold FontSubset: true FirstChar: 129 LastChar: 226 FontDescriptor: FontName: JCZEAA+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MUAYQA+URWPalladioL-Ital FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: MUAYQA+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DUFXDP+VnURWPalladioL FontSubset: true FirstChar: 161 LastChar: 226 FontDescriptor: FontName: DUFXDP+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 79, 281, 152, 290 Annotation: Subtype: Link Rect: 34, 270, 113, 278 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 152, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 115, 630, 126, 643 Annotation: Subtype: Link Rect: 215, 630, 226, 643 Annotation: Subtype: Link Rect: 387, 630, 398, 643 Annotation: Subtype: Link Rect: 208, 617, 219, 631 Annotation: Subtype: Link Rect: 302, 617, 313, 631 Annotation: Subtype: Link Rect: 491, 617, 502, 631 Annotation: Subtype: Link Rect: 235, 605, 246, 618 Annotation: Subtype: Link Rect: 427, 605, 438, 618 Annotation: Subtype: Link Rect: 218, 592, 230, 605 Annotation: Subtype: Link Rect: 412, 592, 423, 605 Annotation: Subtype: Link Rect: 505, 592, 516, 605 Annotation: Subtype: Link Rect: 132, 579, 143, 593 Annotation: Subtype: Link Rect: 110, 17, 261, 28 Annotation: Subtype: Link Rect: 410, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 402, 87, 421 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 270, 477, 277, 486 ActionDest: 116 Annotation: Subtype: Link Rect: 277, 477, 284, 486 ActionDest: 116 Annotation: Subtype: Link Rect: 243, 440, 250, 448 ActionDest: 116 Annotation: Subtype: Link Rect: 359, 427, 366, 436 ActionDest: 116 Annotation: Subtype: Link Rect: 549, 402, 556, 411 ActionDest: 116 Annotation: Subtype: Link Rect: 412, 364, 419, 373 ActionDest: 116 Annotation: Subtype: Link Rect: 419, 364, 426, 373 ActionDest: 116 Annotation: Subtype: Link Rect: 427, 364, 434, 373 ActionDest: 116 Annotation: Subtype: Link Rect: 526, 225, 533, 234 ActionDest: 116 Annotation: Subtype: Link Rect: 371, 111, 378, 121 ActionDest: 116 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 511, 698, 518, 707 ActionDest: 116 Annotation: Subtype: Link Rect: 164, 645, 241, 657 Annotation: Subtype: Link Rect: 357, 647, 364, 657 ActionDest: 116 Annotation: Subtype: Link Rect: 364, 647, 371, 657 ActionDest: 116 Annotation: Subtype: Link Rect: 229, 622, 236, 631 ActionDest: 116 Annotation: Subtype: Link Rect: 235, 343, 242, 355 ActionDest: 73 Annotation: Subtype: Link Rect: 472, 343, 479, 355 ActionDest: 76 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 552, 327, 559, 339 ActionDest: 79 Page: Sequence: 5 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 458, 506, 465, 518 ActionDest: 82 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 354, 657, 366, 666 ActionDest: 116 Annotation: Subtype: Link Rect: 261, 620, 273, 629 ActionDest: 116 Annotation: Subtype: Link Rect: 315, 481, 327, 490 ActionDest: 116 Annotation: Subtype: Link Rect: 328, 481, 340, 490 ActionDest: 119 Annotation: Subtype: Link Rect: 378, 444, 390, 453 ActionDest: 119 Annotation: Subtype: Link Rect: 233, 356, 245, 365 ActionDest: 119 Annotation: Subtype: Link Rect: 544, 306, 556, 315 ActionDest: 119 Annotation: Subtype: Link Rect: 441, 293, 453, 302 ActionDest: 119 Annotation: Subtype: Link Rect: 301, 256, 308, 264 ActionDest: 116 Annotation: Subtype: Link Rect: 423, 230, 430, 239 ActionDest: 116 Annotation: Subtype: Link Rect: 430, 230, 442, 239 ActionDest: 119 Annotation: Subtype: Link Rect: 443, 230, 455, 239 ActionDest: 119 Annotation: Subtype: Link Rect: 518, 218, 530, 227 ActionDest: 119 Annotation: Subtype: Link Rect: 549, 130, 556, 139 ActionDest: 116 Annotation: Subtype: Link Rect: 544, 105, 556, 114 ActionDest: 119 Annotation: Subtype: Link Rect: 485, 67, 497, 76 ActionDest: 119 Annotation: Subtype: Link Rect: 498, 67, 510, 76 ActionDest: 119 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 267, 723, 279, 732 ActionDest: 119 Annotation: Subtype: Link Rect: 449, 698, 461, 707 ActionDest: 119 Annotation: Subtype: Link Rect: 544, 673, 556, 682 ActionDest: 119 Annotation: Subtype: Link Rect: 376, 635, 383, 644 ActionDest: 116 Annotation: Subtype: Link Rect: 450, 610, 462, 619 ActionDest: 119 Annotation: Subtype: Link Rect: 462, 610, 474, 619 ActionDest: 119 Annotation: Subtype: Link Rect: 427, 585, 439, 594 ActionDest: 119 Annotation: Subtype: Link Rect: 208, 547, 220, 556 ActionDest: 119 Annotation: Subtype: Link Rect: 319, 434, 330, 443 ActionDest: 119 Annotation: Subtype: Link Rect: 331, 434, 343, 443 ActionDest: 119 Annotation: Subtype: Link Rect: 343, 434, 355, 443 ActionDest: 119 Annotation: Subtype: Link Rect: 544, 409, 556, 418 ActionDest: 119 Annotation: Subtype: Link Rect: 315, 384, 327, 393 ActionDest: 119 Annotation: Subtype: Link Rect: 274, 271, 285, 280 ActionDest: 119 Annotation: Subtype: Link Rect: 286, 271, 298, 280 ActionDest: 119 Annotation: Subtype: Link Rect: 298, 271, 310, 280 ActionDest: 119 Annotation: Subtype: Link Rect: 433, 246, 445, 255 ActionDest: 119 Annotation: Subtype: Link Rect: 375, 196, 387, 205 ActionDest: 119 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 59, 416, 96, 426 Annotation: Subtype: Link Rect: 471, 392, 508, 403 Annotation: Subtype: Link Rect: 233, 358, 271, 368 Annotation: Subtype: Link Rect: 277, 358, 313, 368 Annotation: Subtype: Link Rect: 399, 323, 437, 334 Annotation: Subtype: Link Rect: 407, 288, 445, 299 Annotation: Subtype: Link Rect: 451, 288, 487, 299 Annotation: Subtype: Link Rect: 104, 254, 142, 265 Annotation: Subtype: Link Rect: 144, 220, 182, 230 Annotation: Subtype: Link Rect: 95, 185, 133, 196 Annotation: Subtype: Link Rect: 104, 151, 142, 161 Annotation: Subtype: Link Rect: 148, 151, 184, 161 Annotation: Subtype: Link Rect: 59, 116, 96, 126 Annotation: Subtype: Link Rect: 359, 81, 397, 92 Annotation: Subtype: Link Rect: 403, 81, 439, 92 Annotation: Subtype: Link Rect: 489, 58, 526, 69 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 514, 710, 551, 721 Annotation: Subtype: Link Rect: 239, 676, 277, 687 Annotation: Subtype: Link Rect: 382, 641, 420, 652 Annotation: Subtype: Link Rect: 426, 641, 462, 652 Annotation: Subtype: Link Rect: 488, 629, 525, 640 Annotation: Subtype: Link Rect: 469, 618, 506, 629 Annotation: Subtype: Link Rect: 95, 596, 133, 606 Annotation: Subtype: Link Rect: 207, 561, 244, 571 Annotation: Subtype: Link Rect: 157, 527, 194, 537 Annotation: Subtype: Link Rect: 519, 503, 557, 514 Annotation: Subtype: Link Rect: 59, 492, 95, 502 Annotation: Subtype: Link Rect: 232, 457, 269, 468 Annotation: Subtype: Link Rect: 275, 457, 311, 468 Annotation: Subtype: Link Rect: 381, 445, 560, 456 Annotation: Subtype: Link Rect: 56, 434, 440, 445 Annotation: Subtype: Link Rect: 480, 422, 560, 433 Annotation: Subtype: Link Rect: 56, 411, 116, 422 Annotation: Subtype: Link Rect: 346, 388, 383, 399 Annotation: Subtype: Link Rect: 350, 353, 388, 364 Annotation: Subtype: Link Rect: 376, 330, 414, 341 Annotation: Subtype: Link Rect: 340, 296, 378, 307 Annotation: Subtype: Link Rect: 152, 262, 190, 272 Annotation: Subtype: Link Rect: 322, 238, 360, 249 Annotation: Subtype: Link Rect: 366, 238, 402, 249 Annotation: Subtype: Link Rect: 363, 215, 401, 226 Annotation: Subtype: Link Rect: 407, 215, 443, 226 Annotation: Subtype: Link Rect: 440, 181, 478, 192 Annotation: Subtype: Link Rect: 484, 181, 520, 192 Annotation: Subtype: Link Rect: 425, 158, 462, 169 Annotation: Subtype: Link Rect: 469, 158, 505, 169 Checksum: 856b67ba Type: CRC32 Checksum: d8dbf16edc1c3e16544702ecb90aec6d Type: MD5 Checksum: 93e2e6345f8deac7bc96d10d699cae8c50d661e5 Type: SHA-1