4897044c486b64e600b03a5b6d561c38 pmc_9913503.pdf 1f956f0d7323127c2e9b37d98a124e898af364b2 pmc_9913503.pdf 772bb83bf3574f471fd79b681ef8a6b9a8e6f501dcfc8c2d26c6868436e7ef3b pmc_9913503.pdf Title: Epidemiology, Diagnosis and Management of Penile Cancer: Results from the Spanish National Registry of Penile Cancer Subject: Introduction: Penile cancer (PC) is a rare malignancy with an overall incidence in Europe of 1/100,000 males/year. In Europe, few studies report the epidemiology, risk factors, clinical presentation, and treatment of PC. The aim of this study is to present an updated outlook on the aforementioned factors of PC in Spain. Materials and Methods: A multicentric, retrospective, observational epidemiological study was designed, and patients with a new diagnosis of PC in 2015 were included. Patients were anonymously identified from the Register of Specialized Care Activity of the Ministry of Health of Spain. All Spanish hospitals recruiting patients in 2015 were invited to participate in the present study. We have followed a descriptive narration of the observed data. Continuous and categorical data were reported by median (p25th–p75th range) and absolute and relative frequencies, respectively. The incidence map shows differences between Spanish regions. Results: The incidence of PC in Spain in 2015 was 2.55/100,000 males per year. A total of 586 patients were identified, and 228 patients from 61 hospitals were included in the analysis. A total of 54/61 (88.5%) centers reported 5 new cases. The patients accessed the urologist for visually-assessed penile lesions (60.5%), mainly localized in the glans (63.6%). Local hygiene, smoking habits, sexual habits, HPV exposure, and history of penile lesions were reported in 48.2%, 59.6%, 25%, 13.2%, and 69.7%. HPV-positive lesions were 18.1% (28.6% HPV-16). The majority of PC was squamous carcinoma (95.2%). PC was cT2 in 45.2% (103/228) cases. At final pathology, PC was pT2 in 51% of patients and pN1 in 17% of cases. The most common local treatment was partial penectomy (46.9% cases). A total of 47/55 (85.5%) inguinal lymphadenectomies were open. Patients with pN1 disease were treated with chemotherapy in 12/39 (40.8%) of cases. Conclusions: PC incidence is relatively high in Spain compared to other European countries. The risk factors for PC are usually misreported. The diagnosis and management of PC are suboptimal, encouraging the identification of referral centers for PC management. Keywords: penile cancer; cancer; epidemiology; incidence Author: Ángel Borque-Fernando, Josep Maria Gaya, Luis Mariano Esteban-Escaño, Juan Gómez-Rivas, Rodrigo García-Baquero, Fernando Agreda-Castañeda, Andrea Gallioli, Paolo Verri, Francisco Javier Ortiz-Vico, Balig Fawwaz Amir-Nicolau, Ignacio Osman-Garcia, Pedro Gil-Martínez, Miguel Arrabal-Martín, Álvaro Gómez-Ferrer Lozano, Felix Campos-Juanatey, Félix Guerrero-Ramos and Josè Rubio-Briones Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Jan 19 08:16:30 2023 CET ModDate: Thu Jan 19 08:33:16 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 963176 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XOBIIF+VnURWPalladioL Type 1 Custom yes yes no 10 0 HQZGAU+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 TTJVMF+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 NTALXJ+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 IKKWKP+CMSY10 Type 1 Builtin yes yes no 28 0 JFUQEY+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 84 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 88 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 92 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 96 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 113 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 117 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 121 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 125 0 NUUXUW+VnURWPalladioL-Italic Type 1 Custom yes yes no 152 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-17 02:31:27 CEST RepresentationInformation: pmc_9913503.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-04-22 02:23:49 CEST Size: 963176 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 284 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Patient Recruitment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Objective Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Clinics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Histology and Staging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Management Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Info: Title: Epidemiology, Diagnosis and Management of Penile Cancer: Results from the Spanish National Registry of Penile Cancer Author: Ángel Borque-Fernando, Josep Maria Gaya, Luis Mariano Esteban-Escaño, Juan Gómez-Rivas, Rodrigo García-Baquero, Fernando Agreda-Castañeda, Andrea Gallioli, Paolo Verri, Francisco Javier Ortiz-Vico, Balig Fawwaz Amir-Nicolau, Ignacio Osman-Garcia, Pedro Gil-Martínez, Miguel Arrabal-Martín, Álvaro Gómez-Ferrer Lozano, Felix Campos-Juanatey, Félix Guerrero-Ramos and Josè Rubio-Briones Subject: Introduction: Penile cancer (PC) is a rare malignancy with an overall incidence in Europe of 1/100,000 males/year. In Europe, few studies report the epidemiology, risk factors, clinical presentation, and treatment of PC. The aim of this study is to present an updated outlook on the aforementioned factors of PC in Spain. Materials and Methods: A multicentric, retrospective, observational epidemiological study was designed, and patients with a new diagnosis of PC in 2015 were included. Patients were anonymously identified from the Register of Specialized Care Activity of the Ministry of Health of Spain. All Spanish hospitals recruiting patients in 2015 were invited to participate in the present study. We have followed a descriptive narration of the observed data. Continuous and categorical data were reported by median (p25th p75th range) and absolute and relative frequencies, respectively. The incidence map shows differences between Spanish regions. Results: The incidence of PC in Spain in 2015 was 2.55/100,000 males per year. A total of 586 patients were identified, and 228 patients from 61 hospitals were included in the analysis. A total of 54/61 (88.5%) centers reported 5 new cases. The patients accessed the urologist for visually-assessed penile lesions (60.5%), mainly localized in the glans (63.6%). Local hygiene, smoking habits, sexual habits, HPV exposure, and history of penile lesions were reported in 48.2%, 59.6%, 25%, 13.2%, and 69.7%. HPV-positive lesions were 18.1% (28.6% HPV-16). The majority of PC was squamous carcinoma (95.2%). PC was cT2 in 45.2% (103/228) cases. At final pathology, PC was pT2 in 51% of patients and pN1 in 17% of cases. The most common local treatment was partial penectomy (46.9% cases). A total of 47/55 (85.5%) inguinal lymphadenectomies were open. Patients with pN1 disease were treated with chemotherapy in 12/39 (40.8%) of cases. Conclusions: PC incidence is relatively high in Spain compared to other European countries. The risk factors for PC are usually misreported. The diagnosis and management of PC are suboptimal, encouraging the identification of referral centers for PC management. 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