3ecdc323d9c7a2204835578f8881f4eb pmc_9913539.pdf 9f8cf87eac23541e326d70d20ba4cb2961f8f765 pmc_9913539.pdf 0f0b6cf005c6d0ede0aaeca1b9d20aefe777efd3b2a12a5544c73a5de4b1954f pmc_9913539.pdf Title: Outcomes Following Autologous Fat Grafting in Patients with Sequelae of Head and Neck Cancer Treatment Subject: A single-center retrospective study was designed to assess the outcomes of autologous fat grafting for improving surgery- and radiotherapy-related sequelae in 40 patients with head and neck cancer. All patients underwent surgical resection of primary tumors and radiotherapy (50–70 Gy) and were followed over 12 months after fat grafting. Eligibility for fat grafting procedures included complete remission after at least 3 years of oncological treatment. The cervical and paramandibular regions were the most frequently treated areas. Injected fat volumes ranged between 7.5 and 120 mL (mean: 23 mL). Esthetic improvement was obtained in 77.5% of patients, being significant in 17.5%, and functional improvement in 89.2%, being significant in 29.7% of patients. Minor complications occurred in three patients. There was a high degree of satisfaction regarding esthetic improvement, global satisfaction, and 92.5% of patients would recommend the procedure. This study confirms the benefits of fat grafting as a volumetric correction reconstructive strategy with successful cosmetic and functional outcomes in patients suffering from sequelae after head and neck cancer treatment. Keywords: autologous fat grafting; head and neck cancer; radiotherapy; reconstruction; sequelae; quality of life Author: Jorge Masià-Gridilla, Javier Gutiérrez-Santamaría, Iago Álvarez-Sáez, Jorge Pamias-Romero, Manel Saez-Barba and Coro Bescós-Atin Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Jan 28 07:02:14 2023 CET ModDate: Sat Jan 28 07:05:04 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1951103 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VJCWAR+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 POBRAG+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 JNYUUQ+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 SZXRFY+CMSY10 Type 1 Builtin yes yes no 23 0 ARIQJE+VnURWPalladioL Type 1 Custom yes yes no 27 0 YRKSID+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 94 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 98 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 102 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 114 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 118 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 122 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 138 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 142 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 146 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 158 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 162 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 166 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 182 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 186 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 190 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 194 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-08 02:27:29 CEST RepresentationInformation: pmc_9913539.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-30 02:15:52 CEST Size: 1951103 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 333 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Design and Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Fat Grafting and Surgical Procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Evaluation and Follow-Up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Info: Title: Outcomes Following Autologous Fat Grafting in Patients with Sequelae of Head and Neck Cancer Treatment Author: Jorge Masià-Gridilla, Javier Gutiérrez-Santamaría, Iago Álvarez-Sáez, Jorge Pamias-Romero, Manel Saez-Barba and Coro Bescós-Atin Subject: A single-center retrospective study was designed to assess the outcomes of autologous fat grafting for improving surgery- and radiotherapy-related sequelae in 40 patients with head and neck cancer. All patients underwent surgical resection of primary tumors and radiotherapy (50 70 Gy) and were followed over 12 months after fat grafting. Eligibility for fat grafting procedures included complete remission after at least 3 years of oncological treatment. The cervical and paramandibular regions were the most frequently treated areas. Injected fat volumes ranged between 7.5 and 120 mL (mean: 23 mL). Esthetic improvement was obtained in 77.5% of patients, being significant in 17.5%, and functional improvement in 89.2%, being significant in 29.7% of patients. Minor complications occurred in three patients. There was a high degree of satisfaction regarding esthetic improvement, global satisfaction, and 92.5% of patients would recommend the procedure. This study confirms the benefits of fat grafting as a volumetric correction reconstructive strategy with successful cosmetic and functional outcomes in patients suffering from sequelae after head and neck cancer treatment. 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