808fb32d3aabda58d3ac32b7bb29855b pmc_9931739.pdf 91beffdeec1d70ffe1554103b10b50edd77489cb pmc_9931739.pdf 3085e03597d0f4146cb806a05734c2e5033cee8cae59e978a7aa5434403af0d9 pmc_9931739.pdf Title: Lymphangioleiomyomatosis: Searching for potential biomarkers Subject: Background: Vascular endothelial growth factor-D (VEGF-D) is the most commonly used biomarker for diagnosing lymphangioleiomyomatosis (LAM). Keywords: lymphangioleiomyomatosis, biomarkers, serum, metalloproteinases, VEGF-D, diagnose Author: Eva Revilla-López Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Fri Jan 27 11:28:51 2023 CET ModDate: Fri Jan 27 12:07:55 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1409342 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KSUZAT+MinionPro-Regular Type 1 Custom yes yes no 27 0 SUFYGY+MuseoSans-700 Type 1 Custom yes yes no 28 0 JNDIHR+MuseoSans-300 Type 1 Custom yes yes no 29 0 VCTIZF+MuseoSans-300Italic Type 1 Custom yes yes no 34 0 SKYOPU+MuseoSans-500 Type 1 Custom yes yes no 35 0 ZYUAEV+RBLMI Type 1 Builtin yes yes no 36 0 HFLPXP+MTSYN Type 1 Builtin yes yes no 37 0 DJUXLU+MinionPro-It Type 1 Custom yes yes no 103 0 VIEYGG+MinionPro-Bold Type 1 Custom yes yes no 148 0 CTKQBK+MuseoSans-500Italic Type 1 Custom yes yes no 166 0 OUQERI+MTSYB Type 1 Builtin yes yes no 167 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-12 02:30:49 CEST RepresentationInformation: pmc_9931739.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-23 02:11:33 CET Size: 1409342 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 470 FreeObjects: 3 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Lymphangioleiomyomatosis: Searching for potential biomarkers Children: Item: Title: 1. Introduction Item: Title: 2. Materials and methods Children: Item: Title: 2.1. Subjects and clinical data Item: Title: 2.2. Blood collection and storage Item: Title: 2.3. MMP-2, MMP-9, endostatin, FGF acidic, PIGF, thrombospondin-2, VEGF-D, VEGF- R3, angiopoietin-1, PDGF-AA, vWF, KL-6, and CA-125 assays Item: Title: 2.4. Statistical analysis Item: Title: 3. Results Children: Item: Title: 3.1. Distribution of serum biomarkers between groups Item: Title: 4. Discussion Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Conflict of interest Item: Title: Publisher's note Item: Title: Supplementary material Item: Title: References Info: Title: Lymphangioleiomyomatosis: Searching for potential biomarkers Author: Eva Revilla-López Subject: Background: Vascular endothelial growth factor-D (VEGF-D) is the most commonly used biomarker for diagnosing lymphangioleiomyomatosis (LAM). Keywords: lymphangioleiomyomatosis, biomarkers, serum, metalloproteinases, VEGF-D, diagnose Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Fri Jan 27 11:58:51 CET 2023 ModDate: Fri Jan 27 12:37:55 CET 2023 ID: 0x1b347af3d2fadcf83a38d5e0b04d8964, 0x941ee61596608c43a98f8370dffe17a1 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VCTIZF+MuseoSans-300Italic FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: VCTIZF+MuseoSans-300Italic Flags: Symbolic FontBBox: -245, -210, 1030, 883 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: SKYOPU+MuseoSans-500 FontSubset: true FirstChar: 3 LastChar: 243 FontDescriptor: FontName: SKYOPU+MuseoSans-500 Flags: Symbolic FontBBox: -121, -210, 1088, 892 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZYUAEV+RBLMI FontSubset: true FirstChar: 58 LastChar: 62 FontDescriptor: FontName: ZYUAEV+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: VIEYGG+MinionPro-Bold FontSubset: true FirstChar: 49 LastChar: 121 FontDescriptor: FontName: VIEYGG+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HFLPXP+MTSYN FontSubset: true FirstChar: 0 LastChar: 14 FontDescriptor: FontName: HFLPXP+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: CTKQBK+MuseoSans-500Italic FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: CTKQBK+MuseoSans-500Italic Flags: Symbolic FontBBox: -249, -210, 1047, 892 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DJUXLU+MinionPro-It FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: DJUXLU+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OUQERI+MTSYB FontSubset: true FirstChar: 6 LastChar: 6 FontDescriptor: FontName: OUQERI+MTSYB Flags: Symbolic FontBBox: -16, -935, 1043, 896 FontFile: true Font: BaseFont: KSUZAT+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 233 FontDescriptor: FontName: KSUZAT+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: SUFYGY+MuseoSans-700 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: SUFYGY+MuseoSans-700 Flags: Symbolic FontBBox: -125, -210, 1126, 902 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JNDIHR+MuseoSans-300 FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: JNDIHR+MuseoSans-300 Flags: Symbolic FontBBox: -118, -210, 1088, 883 FontFile: true EncodingDictionary: Differences: true XMP: lymphangioleiomyomatosis, biomarkers, serum, metalloproteinases, VEGF-D, diagnose pdfTeX-1.40.16 1.5 application/pdf fmed-10-1079317.tex Lymphangioleiomyomatosis: Searching for potential biomarkers Background: Vascular endothelial growth factor-D (VEGF-D) is the most commonly used biomarker for diagnosing lymphangioleiomyomatosis (LAM). Eva Revilla-López Victoria Ruiz de Miguel Manuel López-Meseguer Cristina Berastegui Meritxell Boada-Pérez Alberto Mendoza-Valderrey Marta Arjona-Peris Marta Zapata-Ortega Victor Monforte Carlos Bravo Antonio Roman Susana Gómez-Ollés Berta Sáez-Giménez 2023-01-27T15:58:51+05:30 lymphangioleiomyomatosis biomarkers serum metalloproteinases VEGF-D diagnose 2023-01-27T15:58:51+05:30 2023-01-27T16:37:55+05:30 2023-01-27T16:37:55+05:30 LaTeX with hyperref package uuid:6200a39b-1dc9-4b62-a759-00ae46c90ae4 uuid:bf9396b6-662c-40db-9840-a9021732ad44 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 41, 799, 210, 815 Annotation: Subtype: Link Rect: 440, 806, 521, 815 Annotation: Subtype: Link Rect: 440, 797, 539, 806 Annotation: Subtype: Link Rect: 440, 786, 552, 797 Annotation: Subtype: Link Rect: 41, 710, 118, 727 Annotation: Subtype: Link Rect: 55, 379, 148, 387 Annotation: Subtype: Link Rect: 62, 303, 90, 310 Annotation: Subtype: Link Rect: 90, 303, 126, 310 Annotation: Subtype: Link Rect: 126, 303, 161, 310 Annotation: Subtype: Link Rect: 161, 303, 187, 310 Annotation: Subtype: Link Rect: 41, 293, 67, 301 Annotation: Subtype: Link Rect: 207, 678, 553, 724 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 119, 699, 125, 707 ActionDest: 312 Annotation: Subtype: Link Rect: 122, 663, 128, 670 ActionDest: 312 Annotation: Subtype: Link Rect: 44, 626, 51, 634 ActionDest: 312 Annotation: Subtype: Link Rect: 53, 626, 59, 634 ActionDest: 312 Annotation: Subtype: Link Rect: 268, 577, 274, 585 ActionDest: 312 Annotation: Subtype: Link Rect: 280, 577, 286, 585 ActionDest: 312 Annotation: Subtype: Link Rect: 280, 552, 286, 560 ActionDest: 312 Annotation: Subtype: Link Rect: 101, 528, 107, 536 ActionDest: 312 Annotation: Subtype: Link Rect: 83, 516, 89, 524 ActionDest: 312 Annotation: Subtype: Link Rect: 44, 479, 51, 487 ActionDest: 312 Annotation: Subtype: Link Rect: 275, 467, 286, 475 ActionDest: 312 Annotation: Subtype: Link Rect: 91, 430, 102, 438 ActionDest: 312 Annotation: Subtype: Link Rect: 190, 394, 201, 401 ActionDest: 312 Annotation: Subtype: Link Rect: 224, 345, 235, 353 ActionDest: 312 Annotation: Subtype: Link Rect: 100, 320, 110, 328 ActionDest: 312 Annotation: Subtype: Link Rect: 262, 308, 273, 316 ActionDest: 312 Annotation: Subtype: Link Rect: 275, 308, 286, 316 ActionDest: 312 Annotation: Subtype: Link Rect: 206, 186, 217, 194 ActionDest: 312 Annotation: Subtype: Link Rect: 277, 174, 288, 182 ActionDest: 312 Annotation: Subtype: Link Rect: 44, 149, 55, 157 ActionDest: 312 Annotation: Subtype: Link Rect: 81, 113, 91, 120 ActionDest: 312 Annotation: Subtype: Link Rect: 75, 101, 86, 108 ActionDest: 312 Annotation: Subtype: Link Rect: 488, 447, 498, 455 ActionDest: 312 Annotation: Subtype: Link Rect: 414, 376, 425, 384 ActionDest: 312 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 206, 95, 239, 106 ActionDest: 163 Annotation: Subtype: Link Rect: 306, 369, 389, 380 ActionDest: 163 Annotation: Subtype: Link Rect: 317, 357, 346, 368 ActionDest: 163 Annotation: Subtype: Link Rect: 306, 178, 342, 189 ActionDest: 193 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 226, 96, 260, 107 ActionDest: 193 Annotation: Subtype: Link Rect: 348, 59, 382, 70 ActionDest: 193 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 184, 494, 214, 505 ActionDest: 221 Annotation: Subtype: Link Rect: 232, 494, 291, 505 ActionDest: 312 Annotation: Subtype: Link Rect: 41, 482, 77, 493 ActionDest: 312 Annotation: Subtype: Link Rect: 80, 482, 86, 493 ActionDest: 312 Annotation: Subtype: Link Rect: 345, 725, 378, 736 ActionDest: 221 Annotation: Subtype: Link Rect: 306, 474, 339, 485 ActionDest: 259 Annotation: Subtype: Link Rect: 380, 317, 391, 325 ActionDest: 312 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 44, 122, 55, 129 ActionDest: 312 Annotation: Subtype: Link Rect: 60, 122, 71, 129 ActionDest: 312 Annotation: Subtype: Link Rect: 114, 122, 124, 129 ActionDest: 312 Annotation: Subtype: Link Rect: 203, 122, 213, 129 ActionDest: 312 Annotation: Subtype: Link Rect: 92, 109, 103, 117 ActionDest: 312 Annotation: Subtype: Link Rect: 161, 109, 171, 117 ActionDest: 312 Annotation: Subtype: Link Rect: 353, 85, 364, 93 ActionDest: 312 Annotation: Subtype: Link Rect: 329, 61, 339, 69 ActionDest: 312 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 76, 433, 87, 441 ActionDest: 312 Annotation: Subtype: Link Rect: 69, 373, 80, 381 ActionDest: 312 Annotation: Subtype: Link Rect: 275, 313, 286, 321 ActionDest: 312 Annotation: Subtype: Link Rect: 66, 229, 77, 237 ActionDest: 344 Annotation: Subtype: Link Rect: 173, 205, 183, 213 ActionDest: 344 Annotation: Subtype: Link Rect: 109, 145, 115, 153 ActionDest: 312 Annotation: Subtype: Link Rect: 120, 145, 130, 153 ActionDest: 344 Annotation: Subtype: Link Rect: 192, 145, 203, 153 ActionDest: 344 Annotation: Subtype: Link Rect: 116, 86, 122, 93 ActionDest: 312 Annotation: Subtype: Link Rect: 460, 739, 471, 747 ActionDest: 312 Annotation: Subtype: Link Rect: 485, 620, 495, 628 ActionDest: 344 Annotation: Subtype: Link Rect: 326, 608, 336, 616 ActionDest: 344 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 316, 598, 553, 609 Annotation: Subtype: Link Rect: 303, 586, 409, 597 Annotation: Subtype: Link Rect: 155, 387, 233, 396 Annotation: Subtype: Link Rect: 160, 343, 258, 352 Annotation: Subtype: Link Rect: 191, 307, 288, 316 Annotation: Subtype: Link Rect: 120, 280, 197, 288 Annotation: Subtype: Link Rect: 253, 108, 292, 117 Annotation: Subtype: Link Rect: 51, 101, 93, 109 Annotation: Subtype: Link Rect: 78, 72, 165, 81 Annotation: Subtype: Link Rect: 514, 494, 553, 503 Annotation: Subtype: Link Rect: 313, 487, 358, 494 Annotation: Subtype: Link Rect: 530, 438, 553, 447 Annotation: Subtype: Link Rect: 313, 430, 380, 439 Annotation: Subtype: Link Rect: 456, 402, 547, 411 Annotation: Subtype: Link Rect: 337, 374, 445, 382 Annotation: Subtype: Link Rect: 387, 345, 477, 354 Annotation: Subtype: Link Rect: 337, 310, 436, 318 Annotation: Subtype: Link Rect: 470, 281, 553, 290 Annotation: Subtype: Link Rect: 313, 274, 326, 281 Annotation: Subtype: Link Rect: 319, 238, 413, 246 Annotation: Subtype: Link Rect: 301, 202, 386, 209 Annotation: Subtype: Link Rect: 515, 172, 553, 181 Annotation: Subtype: Link Rect: 313, 166, 349, 173 Annotation: Subtype: Link Rect: 333, 109, 439, 117 Annotation: Subtype: Link Rect: 476, 80, 553, 89 Annotation: Subtype: Link Rect: 313, 74, 323, 80 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 459, 806, 553, 814 Annotation: Subtype: Link Rect: 112, 746, 227, 754 Annotation: Subtype: Link Rect: 350, 746, 456, 754 Annotation: Subtype: Link Rect: 541, 715, 553, 724 Annotation: Subtype: Link Rect: 313, 707, 407, 715 Annotation: Subtype: Link Rect: 471, 676, 553, 685 Annotation: Subtype: Link Rect: 313, 670, 323, 677 Annotation: Subtype: Link Rect: 41, 26, 111, 34 Annotation: Subtype: Link Rect: 505, 26, 553, 34 Checksum: 98c45b7f Type: CRC32 Checksum: 808fb32d3aabda58d3ac32b7bb29855b Type: MD5 Checksum: 91beffdeec1d70ffe1554103b10b50edd77489cb Type: SHA-1