d4764b5ad968f28c086efd8552ed30eb  pmc_9954482.pdf
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95debe0cb7b48a08f5e8ec8e25ace251ab78b28fdc694cece2a87b7351f70d49  pmc_9954482.pdf

Title:          Depression in Major Neurodegenerative Diseases and Strokes: A Critical Review of Similarities and Differences among Neurological Disorders
Subject:        Depression and anxiety are highly prevalent in most neurological disorders and can have a major impact on the patient’s disability and quality of life. However, mostly due to the heterogeneity of symptoms and the complexity of the underlying comorbidities, depression can be difficult to diagnose, resulting in limited recognition and in undertreatment. The early detection and treatment of depression simultaneously with the neurological disorder is key to avoiding deterioration and further disability. Although the neurologist should be able to identify and treat depression initially, a neuropsychiatry team should be available for severe cases and those who are unresponsive to treatment. Neurologists should be also aware that in neurodegenerative diseases, such as Alzheimer’s or Parkinson’s, different depression symptoms could develop at different stages of the disease. The treatment options for depression in neurological diseases include drugs, cognitive-behavioral therapy, and somatic interventions, among others, but often, the evidence-based efficacy is limited and the results are highly variable. Here, we review recent research on the diagnosis and treatment of depression in the context of Alzheimer’s disease, Parkinson’s disease, and strokes, with the aim of identifying common approaches and solutions for its initial management by the neurologist.
Keywords:       depression; dementia; Alzheimer’s disease; Parkinson’s disease; stroke; SSRIs; SNRIs; vortioxetine
Author:         Javier Pagonabarraga, Cecilio Álamo, Mar Castellanos, Samuel Díaz and Sagrario Manzano
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      Title: Introduction 
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      Title: Depression in Neurological Diseases: Common Aspects 
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      Title: Overview of Depression in Alzheimer’s Disease 
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      Title: Overview of Depression in Parkinson’s Disease 
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      Title: Overview of Depression in Stroke 
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      Title: Pharmacological Treatment of Depression in Major Neurodegenerative Diseases and Stroke 
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        Title: Common Therapeutic Approaches 
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      Title: Non-Pharmacological Treatment of Depression in Major Neurodegenerative Diseases and Stroke 
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    Title: Depression in Major Neurodegenerative Diseases and Strokes: A Critical Review of Similarities and Differences among Neurological Disorders
    Author: Javier Pagonabarraga, Cecilio Álamo, Mar Castellanos, Samuel Díaz and Sagrario Manzano
    Subject: Depression and anxiety are highly prevalent in most neurological disorders and can have a major impact on the patient’s disability and quality of life. However, mostly due to the heterogeneity of symptoms and the complexity of the underlying comorbidities, depression can be difficult to diagnose, resulting in limited recognition and in undertreatment. The early detection and treatment of depression simultaneously with the neurological disorder is key to avoiding deterioration and further disability. Although the neurologist should be able to identify and treat depression initially, a neuropsychiatry team should be available for severe cases and those who are unresponsive to treatment. Neurologists should be also aware that in neurodegenerative diseases, such as Alzheimer’s or Parkinson’s, different depression symptoms could develop at different stages of the disease. The treatment options for depression in neurological diseases include drugs, cognitive-behavioral therapy, and somatic interventions, among others, but often, the evidence-based efficacy is limited and the results are highly variable. Here, we review recent research on the diagnosis and treatment of depression in the context of Alzheimer’s disease, Parkinson’s disease, and strokes, with the aim of identifying common approaches and solutions for its initial management by the neurologist.
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