b7822c7b5234e10085a2b6c5fe25e823 pmc_9960033.pdf 5d39a102c9a1daca65252394cf85da6fcb6f7d86 pmc_9960033.pdf 2d08df0e7196674b56621815cfdddf0be4c3adbcaede5eebddae7aade154dcdd pmc_9960033.pdf Title: Efficacy and Safety of JAK1 Inhibitor Abrocitinib in Atopic Dermatitis Subject: Abrocitinib is a JAK1 selective inhibitor recently approved for the treatment of moderate-to-severe atopic dermatitis in adults. It has demonstrated efficacy and safety in several clinical trials, both in children and adults, in monotherapy, and compared with dupilumab. The expected EASI-75 response rate estimates at week 12 are 62.9% (95% CrI 42.5–79.9%) for abrocitinib 200 mg and 43.0% (95% CrI 24.8–64.0%) for abrocitinib 100 mg. Abrocitinib has shown a faster effect than dupilumab as regards early alleviation of itch. Because of the incomplete target selectivity of JAK inhibitors, when abrocitinib treatment is considered, laboratory screening is necessary, latent tuberculosis must be screened for, active infections are a contraindication, and special caution must be exerted in treating elderly patients and those predisposed to thromboembolic events. Even though recent meta-analyses of clinical trials have not shown that atopic dermatitis, or its treatment with JAK inhibitors or dupilumab, modify the risk of deep venous thrombosis or pulmonary embolism, long-term follow-up studies will better define the safety profile of abrocitinib. Keywords: abrocitinib; jak inhibitor; JAK1; atopic dermatitis Author: Helena Iznardo, Esther Roé, Esther Serra-Baldrich and Lluís Puig Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jan 24 01:21:54 2023 CET ModDate: Tue Jan 24 01:24:39 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 552846 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MWHIBA+VnURWPalladioL Type 1 Custom yes yes no 10 0 JAOIIZ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 WILYYO+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 CPUQHS+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 AKXRSZ+EURB10 Type 1 Builtin yes yes no 28 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 IAFAOG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 ANOLDD+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 84 0 ANOLMB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 90 0 GOCQIR+EURM10 Type 1 Builtin yes yes no 98 0 HCPSKZ+CMSY10 Type 1 Builtin yes yes no 105 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-29 02:30:15 CEST RepresentationInformation: pmc_9960033.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-09 02:13:57 CET Size: 552846 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 371 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: JAK1 Inhibition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Abrocitinib: Pharmacokinetics and Pharmacodynamics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Abrocitinib: Efficacy and Safety Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Abrocitinib vs. Placebo in Monotherapy: JADE MONO-1, MONO-2, and JADE REGIMEN Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Abrocitinib vs. Dupilumab or Placebo with Topical Therapy: JADE COMPARE and JADE EXTEND Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Abrocitinib with Topical Therapy in Teenagers: JADE TEEN Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Abrocitinib vs. Dupilumab with Topical Treatment: JADE DARE Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Other Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Comparison with Other AD Therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Efficacy and Safety of JAK1 Inhibitor Abrocitinib in Atopic Dermatitis Author: Helena Iznardo, Esther Roé, Esther Serra-Baldrich and Lluís Puig Subject: Abrocitinib is a JAK1 selective inhibitor recently approved for the treatment of moderate-to-severe atopic dermatitis in adults. It has demonstrated efficacy and safety in several clinical trials, both in children and adults, in monotherapy, and compared with dupilumab. The expected EASI-75 response rate estimates at week 12 are 62.9% (95% CrI 42.5 79.9%) for abrocitinib 200 mg and 43.0% (95% CrI 24.8 64.0%) for abrocitinib 100 mg. Abrocitinib has shown a faster effect than dupilumab as regards early alleviation of itch. Because of the incomplete target selectivity of JAK inhibitors, when abrocitinib treatment is considered, laboratory screening is necessary, latent tuberculosis must be screened for, active infections are a contraindication, and special caution must be exerted in treating elderly patients and those predisposed to thromboembolic events. Even though recent meta-analyses of clinical trials have not shown that atopic dermatitis, or its treatment with JAK inhibitors or dupilumab, modify the risk of deep venous thrombosis or pulmonary embolism, long-term follow-up studies will better define the safety profile of abrocitinib. 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