8b5edbfc8a5db024dccd4f7ada36c953 pmc_9962801.pdf cc150f7a9749f4e5f1ddaa7c221a79a7548152bf pmc_9962801.pdf 538c90d4fac8c0c521f9a0dd4193e56647220b62535721412966bc1ea21c4cab pmc_9962801.pdf Title: Intracranial Granular Cell Tumours in Three Dogs: Atypical Magnetic Resonance Imaging Features and Immunohistochemical Study Subject: Intracranial granular cell tumours (GCT) are uncommon neoplasms of uncertain cellular origin that are rarely reported in dogs. This case series describes three aged dogs that presented with neurological signs in which magnetic resonance (MR) imaging revealed plaquelike extra-axial lesions that were hypointense on T2-weighted (T2w) images. The surgical biopsy of the lesions and necropsies were followed by histochemical characterisation with periodic acid–Schiff (PAS) staining and immunohistochemistry with ubiquitin, S-100, and SOX-10 to elucidate the cellular origin. The immunohistochemical study indicated that these intracranial GCTs were not of Schwann cell origin. In conclusion, GCTs should be considered a differential diagnosis of intracranial, extra-axial hypointense brain lesions on T2w MR images. Keywords: granular cell tumour; magnetic resonance imaging; immunohistochemistry; brain; dog Author: Clàudia Mayor, Judit Verdés, Jaume Alomar, Rosa Novellas, Martí Pumarola and Sònia Añor Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Feb 9 05:23:49 2023 CET ModDate: Thu Feb 9 06:33:33 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3887102 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KJRTQU+VnURWPalladioL Type 1 Custom yes yes no 10 0 HHLPDC+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 JMTWUR+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 SJCARL+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 PBGZAA+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 CTCXDQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 71 0 ENHMMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 86 0 ENHMMO+PalatinoLinotype TrueType WinAnsi yes yes no 89 0 ENHMNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 92 0 ENHMMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 110 0 ENHMMO+PalatinoLinotype TrueType WinAnsi yes yes no 113 0 ENHMNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 116 0 ENHONF+TimesNewRoman CID TrueType Identity-H yes yes yes 119 0 ENHMMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 140 0 ENHMMO+PalatinoLinotype TrueType WinAnsi yes yes no 143 0 ENHMNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 146 0 ENHMMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 161 0 ENHMMO+PalatinoLinotype TrueType WinAnsi yes yes no 164 0 ENHMNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 167 0 ENHONF+TimesNewRoman CID TrueType Identity-H yes yes yes 170 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-11 02:34:08 CET RepresentationInformation: pmc_9962801.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-09 02:13:51 CET Size: 3887102 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 333 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Case Presentation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Case 1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Case 2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Case 3 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Histopathological and Immunohistochemical Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Info: Title: Intracranial Granular Cell Tumours in Three Dogs: Atypical Magnetic Resonance Imaging Features and Immunohistochemical Study Author: Clàudia Mayor, Judit Verdés, Jaume Alomar, Rosa Novellas, Martí Pumarola and Sònia Añor Subject: Intracranial granular cell tumours (GCT) are uncommon neoplasms of uncertain cellular origin that are rarely reported in dogs. This case series describes three aged dogs that presented with neurological signs in which magnetic resonance (MR) imaging revealed plaquelike extra-axial lesions that were hypointense on T2-weighted (T2w) images. The surgical biopsy of the lesions and necropsies were followed by histochemical characterisation with periodic acid Schiff (PAS) staining and immunohistochemistry with ubiquitin, S-100, and SOX-10 to elucidate the cellular origin. The immunohistochemical study indicated that these intracranial GCTs were not of Schwann cell origin. In conclusion, GCTs should be considered a differential diagnosis of intracranial, extra-axial hypointense brain lesions on T2w MR images. 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