d841345dca4f65b08f3da09dca5d41ca pmc_9963792.pdf 51dccbd51b2116c4ba0f239decac0f76454b3572 pmc_9963792.pdf 33b765f288ddd35d5bc9d31ccac96920cae10d905d54a7537d9626f5b9ec976d pmc_9963792.pdf Title: The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease Subject: Interleukin 17 (IL-17) is an effector cytokine that plays a key role in the pathogenesis of both psoriasis and metabolic-associated fatty liver disease (MAFLD), a condition that is more prevalent and severe in patients with psoriasis. In liver inflammation, IL-17 is mainly produced by CD4+ T (TH17) and CD8+ T cells (Tc17), although numerous other cells (macrophages, natural killer cells, neutrophils and T cells) also contribute to the production of IL-17. In hepatocytes, IL-17 mediates systemic inflammation and the recruitment of inflammatory cells to the liver, and it is also implicated in the development of fibrosis and insulin resistance. IL-17 levels have been correlated with progression from MAFLD to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Clinical trials have shown that inhibiting IL-17A in patients with psoriasis could potentially contribute to the improvement of metabolic and liver parameters. A better understanding of the key factors involved in the pathogenesis of these chronic inflammatory processes could potentially lead to more efficient treatment for both psoriasis and MAFLD, and help to develop holistic strategies to improve the management of these patients. Keywords: psoriasis; metabolic-associated fatty liver disease; MAFLD; IL-17; IL-17A Author: Antonio Olveira, Salvador Augustin, Salvador Benlloch, Javier Ampuero, Jorge Alonso Suárez-Pérez, Susana Armesto, Eva Vilarrasa, Isabel Belinchón-Romero, Pedro Herranz, Javier Crespo, Francisco Guimerá, Lara Gómez-Labrador, Víctor Martín and José Manuel Carrascosa Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Feb 2 07:26:01 2023 CET ModDate: Thu Feb 2 07:32:50 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1238667 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CMFVHJ+VnURWPalladioL Type 1 Custom yes yes no 10 0 ASHNOE+EURM10 Type 1 Builtin yes yes no 15 0 JWVCCY+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 YBUYPG+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 FPDEUL+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 PJCGLK+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 EICKBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 86 0 EICKBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 89 0 EICKCA+PalatinoLinotype TrueType WinAnsi yes yes no 95 0 EICKCB+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 98 0 EICKCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 104 0 EICKMA+PalatinoLinotype TrueType MacRoman yes yes no 107 0 EICKBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 121 0 EICKBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 124 0 EICKCA+PalatinoLinotype TrueType WinAnsi yes yes no 130 0 EICKCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 133 0 EICKMA+PalatinoLinotype TrueType MacRoman yes yes no 136 0 EICKBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 153 0 EICKBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 156 0 EICKCA+PalatinoLinotype TrueType WinAnsi yes yes no 162 0 EICKCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 165 0 EICKMA+PalatinoLinotype TrueType MacRoman yes yes no 168 0 DXWSGT+CMSY10 Type 1 Builtin yes yes no 175 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-15 02:40:39 CET RepresentationInformation: pmc_9963792.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-02 02:17:03 CET Size: 1238667 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 474 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Role of IL-17 in Systemic Inflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: IL-17 as the Key Effector Cytokine Link between Psoriasis and MAFLD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Role of IL-17 in MAFLD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Info: Title: The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease Author: Antonio Olveira, Salvador Augustin, Salvador Benlloch, Javier Ampuero, Jorge Alonso Suárez-Pérez, Susana Armesto, Eva Vilarrasa, Isabel Belinchón-Romero, Pedro Herranz, Javier Crespo, Francisco Guimerá, Lara Gómez-Labrador, Víctor Martín and José Manuel Carrascosa Subject: Interleukin 17 (IL-17) is an effector cytokine that plays a key role in the pathogenesis of both psoriasis and metabolic-associated fatty liver disease (MAFLD), a condition that is more prevalent and severe in patients with psoriasis. In liver inflammation, IL-17 is mainly produced by CD4+ T (TH17) and CD8+ T cells (Tc17), although numerous other cells (macrophages, natural killer cells, neutrophils and T cells) also contribute to the production of IL-17. In hepatocytes, IL-17 mediates systemic inflammation and the recruitment of inflammatory cells to the liver, and it is also implicated in the development of fibrosis and insulin resistance. IL-17 levels have been correlated with progression from MAFLD to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Clinical trials have shown that inhibiting IL-17A in patients with psoriasis could potentially contribute to the improvement of metabolic and liver parameters. A better understanding of the key factors involved in the pathogenesis of these chronic inflammatory processes could potentially lead to more efficient treatment for both psoriasis and MAFLD, and help to develop holistic strategies to improve the management of these patients. 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