e742312c29d9cd55381617e3985df156 pmc_9964424.pdf 8193c033d38c8e16b61d8d8c23062c82eb337e15 pmc_9964424.pdf 659c6806db963e0d9a9cfaae322e3ca0acd81166cef5471b2a82ea222bf8f8e6 pmc_9964424.pdf Title: Determinants of Depressive Symptoms in People Living with HIV: Findings from a Population-Based Study with a Gender Perspective Subject: Depressive symptoms are common among people living with HIV (PLWH). The aim of this study was to identify the determinants of depressive symptoms in PLWH in Spain. A total of 1060 PLWH participated in this cross-sectional study and completed the Patient Health Questionnaire-9. The odds ratios for the presence of depressive symptoms were analyzed in a multivariable logistic regression model, including sociodemographic data, comorbidities, health-related behaviors, and social-environment-related variables. We found an overall prevalence of depressive symptoms of 21.42%; by subgroup, namely men, women, and transgender persons, prevalence was 18.13%, 32.81%, and 37.14%, respectively. Moreover, social isolation (OR = 1.05 [CI, 1.02–1.08]) and poor physical and mental quality of life (OR = 1.06 [CI, 1.02–1.09] and OR = 1.13 [CI, 1.09–1.17], respectively) were associated with depressive symptoms. As protective factors, we identified serodisclosure to more people (vs. none; OR = 0.39 [CI, 0.17–0.87]), satisfaction with social roles (OR = 0.86 [CI, 0.79–0.94]), better cognitive function (OR = 0.92 [CI, 0.89–0.95]), and sexualized drug use once in a lifetime (OR = 0.52 [CI, 0.29–0.93]). This study showed a high prevalence of depressive symptoms in PLWH, especially among women and transgender people. The association between psychosocial variables and depressive symptoms highlights the multidimensionality of the problem and identifies areas for intervention. This study found that the management of mental health issues is an area that needs to be improved and tailored to specific groups, with the aim of enhancing the well-being of PLWH. Keywords: depressive symptoms; health-related quality of life; HIV/AIDS; gender; transgender Author: Ivet Bayes-Marin, Laia Egea-Cortés, Jorge Palacio-Vieira, Andreu Bruguera, Jocelyn Mesías-Gazmuri, Josep M. Llibre, Emma Fernández, Arkaitz Imaz, Carlos G. Forero, Cristina Agustí, Laia Arbones-Fernández, José M. Miró, Jordi Casabona and Juliana Reyes-Ureña Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Feb 19 10:26:41 2023 CET ModDate: Sun Feb 19 10:32:34 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 447323 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MMZYIV+VnURWPalladioL Type 1 Custom yes yes no 10 0 XCHJEA+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 LTJRPS+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 NWTEHU+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 CNXSVA+CMSY10 Type 1 Builtin yes yes no 74 0 ZIPEAN+EURM10 Type 1 Builtin yes yes no 78 0 WHTXFA+URWPalladioL-BoldItal Type 1 Custom yes yes no 91 0 NJWNDJ+VnURWPalladioL-Italic Type 1 Custom yes yes no 126 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-08 02:35:59 CEST RepresentationInformation: pmc_9964424.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-02 02:16:58 CET Size: 447323 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 369 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Sample Recruitment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Predictors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: General Characteristics of the Study Population by Prevalence of Depressive Symptoms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: General Characteristics of the Study Population by Gender and Prevalence of Depressive Symptoms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Factors Associated with the Prevalence of Depressive Symptoms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Determinants of Depressive Symptoms in People Living with HIV: Findings from a Population-Based Study with a Gender Perspective Author: Ivet Bayes-Marin, Laia Egea-Cortés, Jorge Palacio-Vieira, Andreu Bruguera, Jocelyn Mesías-Gazmuri, Josep M. Llibre, Emma Fernández, Arkaitz Imaz, Carlos G. Forero, Cristina Agustí, Laia Arbones-Fernández, José M. Miró, Jordi Casabona and Juliana Reyes-Ureña Subject: Depressive symptoms are common among people living with HIV (PLWH). The aim of this study was to identify the determinants of depressive symptoms in PLWH in Spain. A total of 1060 PLWH participated in this cross-sectional study and completed the Patient Health Questionnaire-9. The odds ratios for the presence of depressive symptoms were analyzed in a multivariable logistic regression model, including sociodemographic data, comorbidities, health-related behaviors, and social-environment-related variables. We found an overall prevalence of depressive symptoms of 21.42%; by subgroup, namely men, women, and transgender persons, prevalence was 18.13%, 32.81%, and 37.14%, respectively. Moreover, social isolation (OR = 1.05 [CI, 1.02 1.08]) and poor physical and mental quality of life (OR = 1.06 [CI, 1.02 1.09] and OR = 1.13 [CI, 1.09 1.17], respectively) were associated with depressive symptoms. As protective factors, we identified serodisclosure to more people (vs. none; OR = 0.39 [CI, 0.17 0.87]), satisfaction with social roles (OR = 0.86 [CI, 0.79 0.94]), better cognitive function (OR = 0.92 [CI, 0.89 0.95]), and sexualized drug use once in a lifetime (OR = 0.52 [CI, 0.29 0.93]). This study showed a high prevalence of depressive symptoms in PLWH, especially among women and transgender people. The association between psychosocial variables and depressive symptoms highlights the multidimensionality of the problem and identifies areas for intervention. This study found that the management of mental health issues is an area that needs to be improved and tailored to specific groups, with the aim of enhancing the well-being of PLWH. 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