0887d05ae4d226fb11f1cd0b6411764a pmc_9964600.pdf 40cb9db8c86aa24d55b8c330f30073b062994507 pmc_9964600.pdf 31bc1395e5e8c3b4bf1180c6afcf61257565d24b16568905002a1dbc76934f10 pmc_9964600.pdf Title: Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study Subject: There is no published evidence on the possible differences in multimorbidity, inappropriate prescribing, and adverse outcomes of care, simultaneously, from a sex perspective in older patients. We aimed to identify those possible differences in patients hospitalized because of a chronic disease exacerbation. A multicenter, prospective cohort study of 740 older hospitalized patients (65 years) was designed, registering sociodemographic variables, frailty, Barthel index, chronic conditions (CCs), geriatric syndromes (GSs), polypharmacy, potentially inappropriate prescribing (PIP) according to STOPP/START criteria, and adverse drug reactions (ADRs). Outcomes were length of stay (LOS), discharge to nursing home, in-hospital mortality, cause of mortality, and existence of any ADR and its worst consequence. Bivariate analyses between sex and all variables were performed, and a network graph was created for each sex using CC and GS. A total of 740 patients were included (53.2% females, 53.5% 85 years old). Women presented higher prevalence of frailty, and more were living in a nursing home or alone, and had a higher percentage of PIP related to anxiolytics or pain management drugs. Moreover, they presented significant pairwise associations between CC, such as asthma, vertigo, thyroid diseases, osteoarticular diseases, and sleep disorders, and with GS, such as chronic pain, constipation, and anxiety/depression. No significant differences in immediate adverse outcomes of care were observed between men and women in the exacerbation episode. Keywords: sex perspective; multimorbidity; network analysis; potentially inappropriate medication; adverse drug reaction; in-hospital mortality; outcomes of care Author: Marisa Baré, Marina Lleal, Daniel Sevilla-Sánchez, Sara Ortonobes, Susana Herranz, Olivia Ferrandez, Celia Corral-Vázquez, Núria Molist, Gloria Julia Nazco, Candelaria Martín-González, Miguel Ángel Márquez and on behalf of the MoPIM Study Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Feb 18 09:34:15 2023 CET ModDate: Sat Feb 18 09:38:08 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1244052 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QDTEUF+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 TUGGLO+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 XJMTFK+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 PDTLUH+CMSY10 Type 1 Builtin yes yes no 23 0 SWQFHZ+VnURWPalladioL Type 1 Custom yes yes no 27 0 FJDQIS+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 84 0 MFLDOF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 101 0 MFLDOH+PalatinoLinotype TrueType WinAnsi yes yes no 104 0 MFLDPJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 107 0 MFLDOF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 121 0 MFLDOH+PalatinoLinotype TrueType WinAnsi yes yes no 124 0 MFLDPJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 127 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-14 02:37:29 CEST RepresentationInformation: pmc_9964600.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-02 02:16:56 CET Size: 1244052 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 323 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Design and Setting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Data Acquisition and Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Sampling and Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Main Important Results and Novelty Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Comparing with Other Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Clinical Interpretation of Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Possible Clinical Implications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Strengths and Limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study Author: Marisa Baré, Marina Lleal, Daniel Sevilla-Sánchez, Sara Ortonobes, Susana Herranz, Olivia Ferrandez, Celia Corral-Vázquez, Núria Molist, Gloria Julia Nazco, Candelaria Martín-González, Miguel Ángel Márquez and on behalf of the MoPIM Study Group Subject: There is no published evidence on the possible differences in multimorbidity, inappropriate prescribing, and adverse outcomes of care, simultaneously, from a sex perspective in older patients. We aimed to identify those possible differences in patients hospitalized because of a chronic disease exacerbation. A multicenter, prospective cohort study of 740 older hospitalized patients (65 years) was designed, registering sociodemographic variables, frailty, Barthel index, chronic conditions (CCs), geriatric syndromes (GSs), polypharmacy, potentially inappropriate prescribing (PIP) according to STOPP/START criteria, and adverse drug reactions (ADRs). Outcomes were length of stay (LOS), discharge to nursing home, in-hospital mortality, cause of mortality, and existence of any ADR and its worst consequence. Bivariate analyses between sex and all variables were performed, and a network graph was created for each sex using CC and GS. A total of 740 patients were included (53.2% females, 53.5% 85 years old). Women presented higher prevalence of frailty, and more were living in a nursing home or alone, and had a higher percentage of PIP related to anxiolytics or pain management drugs. Moreover, they presented significant pairwise associations between CC, such as asthma, vertigo, thyroid diseases, osteoarticular diseases, and sleep disorders, and with GS, such as chronic pain, constipation, and anxiety/depression. No significant differences in immediate adverse outcomes of care were observed between men and women in the exacerbation episode. 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