ccb55ed0b384f1529d73e49c72541761 pmc_9965354.pdf c163cadbe165d738249fb30cdf411003d6481db2 pmc_9965354.pdf 5bfe78bbf8693ada42030ebd4de19a7e612046b3f4cb621b617267cffe310fc5 pmc_9965354.pdf Title: Metastatic Multifocal Malignant Peripheral Nerve Sheath Tumour in the Cervicothoracic Spinal Cord of a Dog Initially Mimicking Meningomyelitis Subject: A nine year old cross-breed dog was presented with a two week history of ambulatory tetraparesis and proprioceptive ataxia affecting all four limbs. Meningomyelitis of Unknown Origin (MUO) was presumptively diagnosed based on the magnetic resonance imaging (MRI) findings and cerebrospinal fluid (CSF) analysis. The dog received a tapering dose of glucocorticoids and cyclosporine, showing significant improvement and the stabilization of the clinical signs for seven months. After this period, the dog showed an acute clinical deterioration and a follow-up MRI revealed new multiple lesions affecting different spinal nerve roots along the cervicothoracic spinal cord. Following euthanasia, a final diagnose of multiple malignant peripheral nerve sheath tumors (MPNSTs) was made based on the histopathological examination. MPNSTs can affect the cranial nerves, spinal nerves or the associated nerve roots at any location and can lead to secondary spinal cord compression. The aim of the present case report is to describe the clinical presentation and atypical MRI findings of a dog with histologically confirmed multiple MPNSTs. According to the reviewed literature, this is the first reported case of simultaneous MPNSTs in the cervicothoracic spinal cord of a dog. Keywords: meningomyelitis of unknown origin; neoplasia; cerebrospinal fluid; magnetic resonance; histopathology; metastasis; immunosuppression; peripheral nerve sheath tumor Author: Javier Espinosa, María Ortega, Martí Pumarola, Eduardo Fraga and Laura Martín Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Feb 23 09:07:48 2023 CET ModDate: Thu Feb 23 09:16:13 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2297509 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GFKJOY+VnURWPalladioL Type 1 Custom yes yes no 10 0 SOEHQF+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 AEYGUM+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 DHZWXJ+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 CTCXDQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 71 0 VMCYID+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 84 0 SCVGSJ+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 88 0 SPSLSJ+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 92 0 DVCMRV+CMSY10 Type 1 Builtin yes yes no 103 0 VMCYID+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 118 0 SCVGSJ+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 122 0 SPSLSJ+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 126 0 VMCYID+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 144 0 SCVGSJ+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 148 0 SPSLSJ+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 152 0 WABLSD+SFRM1000 Type 1 Custom yes yes no 167 0 BOLMEN+SFRM0900 Type 1 Custom yes yes no 187 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-11 02:34:03 CET RepresentationInformation: pmc_9965354.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-09 02:13:31 CET Size: 2297509 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 325 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Case Presentation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Info: Title: Metastatic Multifocal Malignant Peripheral Nerve Sheath Tumour in the Cervicothoracic Spinal Cord of a Dog Initially Mimicking Meningomyelitis Author: Javier Espinosa, María Ortega, Martí Pumarola, Eduardo Fraga and Laura Martín Subject: A nine year old cross-breed dog was presented with a two week history of ambulatory tetraparesis and proprioceptive ataxia affecting all four limbs. Meningomyelitis of Unknown Origin (MUO) was presumptively diagnosed based on the magnetic resonance imaging (MRI) findings and cerebrospinal fluid (CSF) analysis. The dog received a tapering dose of glucocorticoids and cyclosporine, showing significant improvement and the stabilization of the clinical signs for seven months. After this period, the dog showed an acute clinical deterioration and a follow-up MRI revealed new multiple lesions affecting different spinal nerve roots along the cervicothoracic spinal cord. Following euthanasia, a final diagnose of multiple malignant peripheral nerve sheath tumors (MPNSTs) was made based on the histopathological examination. MPNSTs can affect the cranial nerves, spinal nerves or the associated nerve roots at any location and can lead to secondary spinal cord compression. The aim of the present case report is to describe the clinical presentation and atypical MRI findings of a dog with histologically confirmed multiple MPNSTs. According to the reviewed literature, this is the first reported case of simultaneous MPNSTs in the cervicothoracic spinal cord of a dog. 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