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object 'bm_CR45' cannot be found Offset: 2264460 MIMEtype: application/pdf PDFMetadata: Objects: 872 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Circulating tumor DNA reveals complex biological’features with clinical relevance in’metastatic breast cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Plasma tumor fraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Plasma versus tissue DNA-based signatures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: ctDNA-based data versus tissue RNA-based expression data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: ctDNA-based signatures versus tissue ER and HER2’status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: ctDNA-based signatures in metastatic HR+/HER2- disease treated with endocrine therapy and a CDK4/6 inhibitor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: RB-LOH in tumor tissue versus plasma in metastatic HR+/HER2- disease treated with endocrine therapy and a CDK4/6 inhibitor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: ctDNA RB-LOH signature versus ctDNA RB1 individual region in metastatic HR+/HER2- disease treated with endocrine therapy and a CDK4/6 inhibitor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Independent prognostic validation of the RB-LOH signature Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Capturing biological features before and after CDK4/6 inhibition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Identifying ctDNA-based tumor subtypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Prognosis of ctDNA-based tumor subtypes in patients with metastatic HR+/HER2- disease treated with endocrine therapy and a CDK4/6 inhibitor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: DNA-based tumor subtypes in tissue samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Study participants and samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: DNA-sequencing of plasma samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Analytical validation analysis of the methodological approach Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: DNA-sequencing of FFPE tumor samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: DNA-based signature estimation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Gene expression analysis of FFPE tumor samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: METABRIC and MSK breast cancer datasets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: A DNA-based 4’subtype predictor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: General statistical procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer Author: Aleix Prat Subject: Nature Communications, doi:10.1038/s41467-023-36801-9 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT 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BaseFont: COEOHL+AdvOT0c200bf0+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: COEOHL+AdvOT0c200bf0+20 Flags: Nonsymbolic FontBBox: -229, -104, 1083, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COEJFB+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 43 FontDescriptor: FontName: COEJFB+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COEOKL+AdvOT13119950+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: COEOKL+AdvOT13119950+20 Flags: Nonsymbolic FontBBox: -229, -104, 1156, 770 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-023-36801-9 Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer Aleix Prat Fara Brasó-Maristany Olga Martínez-Sáez Esther Sanfeliu Youli Xia Meritxell Bellet Patricia Galván Débora Martínez Tomás Pascual Mercedes Marín-Aguilera Anna Rodríguez Nuria Chic Barbara Adamo Laia Paré Maria Vidal Mireia Margelí Ester Ballana Marina Gómez-Rey Mafalda Oliveira Eudald Felip Judit Matito Rodrigo Sánchez-Bayona Anna Suñol Cristina Saura Eva Ciruelos Pablo Tolosa Montserrat Muñoz Blanca González-Farré Patricia Villagrasa Joel S. Parker Charles M. Perou Ana Vivancos Springer US Nature Communications, doi:10.1038/s41467-023-36801-9 Springer 2023-03-01T11:54:36+01:00 2023-03-01T13:52:33+05:30 2023-03-01T11:54:36+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:aeac3553-8ab6-4117-b103-4eff4c6254db uuid:722337f5-9d79-4854-9812-0a3c32ebb6ea default 1 converted uuid:93ff2191-d487-470f-9179-04cc0b898ebf converted to PDF/A-2b pdfToolbox 2023-03-01T13:53:46+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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