87bf20939a2f79d558cc2e4f085bb029  pmc_9998313.pdf
06f17ffdb48e5a1e8ea6980700c0fe9291e2dea7  pmc_9998313.pdf
a89290ae2b20ccd8cc553c22842134b100b638702e7946194574dff6683fef0e  pmc_9998313.pdf

Title:          Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health
Subject:        Microchimica Acta, https://doi.org/10.1007/s00604-023-05692-4
Keywords:       γ-Cyclodextrin-MOFs (γ-CD-MOFs);Cannabidiol (CBD);DPPC liposomes (1,2-dipalmitoyl-sn-glycero-3-phosphocholine);Oral health;Synchrotron FTIR microspectroscopy
Author:          Jorge Rodríguez-Martínez
Creator:        Adobe InDesign 15.1 (Windows)
Producer:       Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Thu Mar  9 17:21:13 2023 CET
ModDate:        Thu Mar  9 18:06:39 2023 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          10
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      2021450 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes     33  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes     59  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    442  0
GAABNG+STIX-Regular                  Type 1C           Custom           yes yes yes     35  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     37  0
EOMRWU+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    443  0
STIX-Italic                          Type 1C           Custom           yes no  yes     34  0
IMEQQD+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    485  0
Springnew-Regular                    Type 1C           WinAnsi          yes no  yes    489  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes     36  0
Springnew-Regular2                   Type 1C           WinAnsi          yes no  yes    381  0
HMDDWE+STIXMath-Regular              Type 1C           Custom           yes yes no      60  0
HMDDWE+STIXGeneral-Regular           Type 1C           Custom           yes yes no      61  0
HMDDWE+STIXMathScript-Regular        Type 1C           Custom           yes yes yes     62  0
Springnew-Regular3                   Type 1C           WinAnsi          yes no  yes    387  0
UVCYPW+STIX-Bold                     Type 1C           WinAnsi          yes yes yes     97  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-02-02 02:31:57 CET
 RepresentationInformation: pmc_9998313.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-16 02:17:23 CET
  Size: 2021450
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 532
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Reagents
         Item: 
          Title: Drug delivery system synthesis
         Item: 
          Title: Characterization techniques
         Item: 
          Title: Drug release and quantification
         Item: 
          Title: Tooth sample preparation
         Item: 
          Title: Synchrotron radiation-based FTIR microspectroscopy (SR-µFTIR) measurements
         Item: 
          Title: Principal component analysis (PCA)
       Item: 
        Title: Results and discussion
        Children: 
         Item: 
          Title: Drug delivery systems characterization and olivetol quantification
         Item: 
          Title: Peaks assignment of enamel and dentin
         Item: 
          Title: Study of the treatments’ effect over the enamel
         Item: 
          Title: Study of the treatments’ effect over the dentin
       Item: 
        Title: Conclusions
       Item: 
        Title: Anchor 18
       Item: 
        Title: Acknowledgements 
       Item: 
        Title: References
   Info: 
    Title: Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health
    Author:  Jorge Rodríguez-Martínez
    Subject: Microchimica Acta, https://doi.org/10.1007/s00604-023-05692-4
    Keywords: γ-Cyclodextrin-MOFs (γ-CD-MOFs);Cannabidiol (CBD);DPPC liposomes (1,2-dipalmitoyl-sn-glycero-3-phosphocholine);Oral health;Synchrotron FTIR microspectroscopy
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Mar 09 17:21:13 CET 2023
    ModDate: Thu Mar 09 18:06:39 CET 2023
   ID: 0x53bbda7354b1caab9aed2f0016202006, 0x8f7ce116a34e874817170ee21c0e67f1
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 1077
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 1158
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 969
      ImageHeight: 1328
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2032
      ImageHeight: 1570
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2032
      ImageHeight: 1062
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: UVCYPW+STIX-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: UVCYPW+STIX-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GAABNG+STIX-Regular
      FontSubset: true
      FirstChar: 22
      LastChar: 250
      FontDescriptor: 
       FontName: GAABNG+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOMRWU+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EOMRWU+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HMDDWE+STIXMath-Regular
      FontSubset: true
      FirstChar: 28
      LastChar: 32
      FontDescriptor: 
       FontName: HMDDWE+STIXMath-Regular
       Flags: Symbolic
       FontBBox: 0, -177, 637, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: HMDDWE+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 5
      LastChar: 32
      FontDescriptor: 
       FontName: HMDDWE+STIXGeneral-Regular
       Flags: Symbolic
       FontBBox: 0, -218, 775, 706
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: HMDDWE+STIXMathScript-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: HMDDWE+STIXMathScript-Regular
       Flags: Symbolic
       FontBBox: 0, 0, 203, 313
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2023-03-09T16:21:13</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2023-03-09T18:06:39+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2023-03-09T18:06:39+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>γ-Cyclodextrin-MOFs (γ-CD-MOFs);Cannabidiol (CBD);DPPC liposomes (1,2-dipalmitoyl-sn-glycero-3-phosphocholine);Oral health;Synchrotron FTIR microspectroscopy</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s00604-023-05692-4</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer Vienna</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Microchimica Acta, https://doi.org/10.1007/s00604-023-05692-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>γ-Cyclodextrin-MOFs (γ-CD-MOFs)</rdf:li>
               <rdf:li>Cannabidiol (CBD)</rdf:li>
               <rdf:li>DPPC liposomes (1</rdf:li>
               <rdf:li>2-dipalmitoyl-sn-glycero-3-phosphocholine)</rdf:li>
               <rdf:li>Oral health</rdf:li>
               <rdf:li>Synchrotron FTIR microspectroscopy</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Jorge Rodríguez-Martínez</rdf:li>
               <rdf:li> María-Jesús Sánchez-Martín</rdf:li>
               <rdf:li> Manuel Valiente</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s00604-023-05692-4</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s00604-023-05692-4</prism:url>
         <prism:doi>10.1007/s00604-023-05692-4</prism:doi>
         <prism:issn>1436-5073</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Microchimica Acta</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s00604-023-05692-4</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:9cc617d1-d7bb-4db0-8af5-4fff059899d4</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:4312cd5f-cda3-4190-9edb-512270f8bc57</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:9cc617d1-d7bb-4db0-8af5-4fff059899d4</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-03-09T16:27:21Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name> María-Jesús Sánchez-Martín</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1678-6055</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 296, 634, 308, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 123, 329, 128, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 117, 304, 122, 289
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 278, 266, 283, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 112, 241, 117, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 113, 216, 118, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 149, 204, 154, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 378, 304, 383, 289
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 403, 279, 408, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 473, 254, 478, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 483, 254, 493, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 449, 191, 460, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 483, 141, 493, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 723, 64, 708
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 203, 623, 213, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 119, 473, 129, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 196, 385, 206, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 206, 285, 216, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 245, 248, 255, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 147, 173, 157, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 499, 374, 509, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 309, 336, 319, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 309, 124, 320, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 515, 111, 520, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 343, 86, 348, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 238, 575, 243, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 450, 483, 455, 468
       Flags: Print
       AppearanceDictionary: true
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 506, 383, 517, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 528, 346, 538, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 371, 308, 376, 293
       Flags: Print
       AppearanceDictionary: true
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 368, 246, 378, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 468, 108, 473, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 228, 436, 233, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 172, 261, 183, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 236, 186, 241, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 272, 149, 283, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 188, 86, 198, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 203, 86, 213, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 481, 399, 486, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 442, 186, 452, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 480, 174, 485, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 467, 111, 478, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 204, 299, 215, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 254, 274, 264, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 478, 324, 483, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 399, 286, 404, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 528, 161, 538, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 405, 99, 415, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 262, 311, 267, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 206, 299, 211, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 273, 211, 283, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 528, 736, 538, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 401, 686, 412, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 497, 674, 502, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 327, 586, 332, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 413, 511, 418, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 433, 461, 443, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 488, 261, 493, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 377, 174, 387, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 437, 124, 442, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 140, 249, 145, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 154, 249, 164, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 457, 286, 462, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 334, 174, 344, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 528, 124, 538, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 93, 324, 98, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 273, 249, 283, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 309, 411, 319, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 414, 386, 424, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 358, 299, 368, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 510, 224, 520, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 136, 442, 287, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 137, 165, 287, 152
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 696, 544, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 686, 371, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 363, 656, 507, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 626, 544, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 616, 351, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 586, 449, 573
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 546, 544, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 536, 366, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 493, 506, 544, 493
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 496, 437, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 456, 544, 443
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 446, 405, 433
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 445, 406, 544, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 396, 537, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 366, 544, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 356, 384, 343
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 326, 544, 313
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 316, 412, 303
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 368, 286, 529, 273
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 246, 462, 233
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 216, 544, 203
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 206, 383, 193
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 368, 166, 529, 153
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 412, 126, 521, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 355, 86, 508, 73
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 264, 716, 289, 703
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 706, 188, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 189, 666, 289, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 656, 149, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 85, 626, 257, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 586, 289, 573
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 576, 175, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 121, 546, 258, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 80, 506, 221, 493
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 264, 476, 289, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 466, 191, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 250, 436, 289, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 426, 197, 413
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 396, 289, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 386, 166, 373
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 225, 356, 289, 343
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 346, 145, 333
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 203, 316, 289, 303
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 306, 106, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 113, 276, 261, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 246, 289, 233
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 236, 168, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 706, 544, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 696, 384, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 493, 666, 544, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 656, 434, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 458, 616, 544, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 606, 404, 593
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 379, 566, 527, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 536, 544, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 526, 460, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 423, 486, 544, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 476, 372, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 506, 456, 544, 443
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 446, 432, 433
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 493, 416, 544, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 406, 438, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 386, 544, 373
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 376, 489, 363
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 361, 336, 501, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 435, 306, 544, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 296, 340, 283
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 276, 544, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 266, 423, 253
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 8d78c7c5
   Type: CRC32
  Checksum: 87bf20939a2f79d558cc2e4f085bb029
   Type: MD5
  Checksum: 06f17ffdb48e5a1e8ea6980700c0fe9291e2dea7
   Type: SHA-1
  Checksum: a89290ae2b20ccd8cc553c22842134b100b638702e7946194574dff6683fef0e
   Type: SHA-256