6e5c6346182bfa547c9fe6482fbfd9cc pmc_9999729.pdf dae60fdc2dfbc4804bb50d4b50131df2c4e9ee57 pmc_9999729.pdf 7b50b2666b21a93d1dd139ccea30d1a04dbeaf9cc832cbb8db57d4bb0b71a54f pmc_9999729.pdf Title: APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke Subject: In the reperfusion era, a new paradigm of treating patients with endovascular treatment (EVT) and neuroprotective drugs is emerging as a promising therapeutic option for patients with acute ischemic stroke (AIS). Keywords: clinical trial, stroke, aptamer, inflammation, neuroprotection, ApTOLL, TLR4 Author: Macarena Hernández-Jiménez Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Feb 24 06:06:51 2023 CET ModDate: Fri Feb 24 08:28:05 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 969504 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YZFLEC+MuseoSans-700 Type 1C Custom yes yes yes 40 0 JHJDEJ+MuseoSans-300 Type 1C Custom yes yes yes 43 0 QHJMAR+MuseoSans-300Italic Type 1C WinAnsi yes yes no 58 0 VHZGVI+MinionPro-Regular Type 1C Custom yes yes no 61 0 PLGADC+MuseoSans-500 Type 1C Custom yes yes yes 68 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 71 0 AXEIWK+MTSY Type 1C Custom yes yes yes 100 0 OMGCPV+MinionPro-It Type 1C WinAnsi yes yes no 104 0 LSNCSL+MinionPro-Bold Type 1C Custom yes yes no 116 0 TBWXXV+MTGU Type 1C Custom yes yes no 136 0 GJOHUO+MTSYB Type 1C Custom yes yes no 145 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-08 02:27:14 CEST RepresentationInformation: pmc_9999729.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-30 02:14:57 CEST Size: 969504 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 241 FreeObjects: 17 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischem椀挀 猀琀爀漀欀攩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀㄀⸀ 䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㌲‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸲㠯䅣瑩潮⽇潔漯偲敶″ㄠ〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: 2. Methods and analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: 2.1. Overall design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2.2. Objectives and endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 2.3. Inclusion and exclusion criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 2.3.1. Inclusion criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: 2.3.1.1. Specific neuroimaging inclusion criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.3.2. Exclusion criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: 2.3.2.1. Specific neuroimaging exclusion criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.4. Enrollment and randomization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 2.4.1. Treatment blinding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.4.2. Enrollment and randomization Phase Ib Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.4.3. Transition from Phase Ib to Phase IIa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.4.4. Enrollment and randomization in Phase IIa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.5. Study treatments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: 2.5.1. Study treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.5.2. Medications/treatment permitted and not permitted before and during the clinical study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.6. Study assessments and procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.7. Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 3. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Conflict of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Publisher's note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke Author: Macarena Hernández-Jiménez Subject: In the reperfusion era, a new paradigm of treating patients with endovascular treatment (EVT) and neuroprotective drugs is emerging as a promising therapeutic option for patients with acute ischemic stroke (AIS). 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Macarena Hernández-Jiménez Francisco Abad-Santos Ian Cotgreave Jaime Gallego Bernd Jilma Alan Flores Tudor G. Jovin José Vivancos Carlos A. Molina Joan Montaner Joaquı́n Casariego Mads Dalsgaard Marı́a Hernández-Pérez David S. 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