f829d8c320d34a78a84f9c3b89d0e6cf nantod_a2024_v56_p102254.pdf bc05f274661787a617190705879beaf6dfe3f29a nantod_a2024_v56_p102254.pdf 5a21c1b595523225a212dde95de8cd203d047040a32c2906973876437997c947 nantod_a2024_v56_p102254.pdf Title: Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures Subject: Nano Today, 56 (2024) 102254. doi:10.1016/j.nantod.2024.102254 Keywords: Lung organoid,Carbon nanomaterial (GO and MWCNT),Pulmonary exposure,Lung fibrosis,Alternative toxicology model,Nanotoxicity Author: Rahaf Issa Creator: Elsevier Producer: iLovePDF CreationDate: Mon Jun 10 23:45:44 2024 CEST ModDate: Thu Oct 24 12:15:01 2024 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 899362 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BKSLIU+CharisSIL CID TrueType Identity-H yes yes yes 34 0 AEPIHR+CharisSIL-Italic CID TrueType Identity-H yes yes yes 39 0 AAAAAH+TimesNewRomanPS-ItalicMT CID TrueType Identity-H yes yes yes 44 0 ERNRUV+TeX_CM_Roman Type 1C Builtin yes yes yes 49 0 AADSYP+CharisSIL-Bold CID TrueType Identity-H yes yes yes 53 0 TILRTQ+STIX-Regular Type 1C Custom yes yes yes 58 0 AAAAAH+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 63 0 SUGRRU+Univers Type 1C Builtin yes yes yes 69 0 AVJGQI+CharisSIL CID TrueType Identity-H yes yes yes 17 0 AFDEQK+STIX-Bold Type 1C Custom yes yes yes 122 0 DJSAXP+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 127 0 VVCCGG+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 131 0 AAEAOJ+CharisSIL-Italic CID TrueType Identity-H yes yes yes 114 0 AAAAAD+CharisSIL-BoldItalic CID TrueType Identity-H yes yes yes 181 0 VBCDLR+STIXTwoMath Type 1C Custom yes yes yes 264 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-14 02:47:25 CET RepresentationInformation: nantod_a2024_v56_p102254.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-25 07:07:40 CEST Size: 899362 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 11 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures Destination: mk:title Children: Item: Title: Introduction Destination: mk:H1_1 Item: Title: Materials and methods Destination: mk:H1_2 Children: Item: Title: hESC maintenance Destination: mk:H2_1 Item: Title: Human lung organoid culture Destination: mk:H2_2 Item: Title: Material preparation Destination: mk:H2_3 Item: Title: Microinjection of NMs Destination: mk:H2_4 Item: Title: Quantification of cell number per organoid Destination: mk:H2_5 Item: Title: Histology Destination: mk:H2_6 Item: Title: Immunofluorescence Destination: mk:H2_7 Item: Title: Quantification of immunofluorescence Destination: mk:H2_8 Item: Title: Flow cytometry Destination: mk:H2_9 Item: Title: Annexin V/propidium iodide staining Destination: mk:H2_10 Item: Title: Live imaging Destination: mk:H2_11 Item: Title: Transmission electron microscopy Destination: mk:H2_12 Item: Title: Statistical analysis Destination: mk:H2_13 Item: Title: Results Destination: mk:H1_3 Children: Item: Title: HLOs development and characterization Destination: mk:H2_14 Item: Title: Lung organoid exposure model Destination: mk:H2_15 Item: Title: s/lGO and MWCNT exposure does not permanently impact organoid viability Destination: mk:H2_16 Item: Title: MWCNT but not GO cause remodelling of the organoid epithelium Destination: mk:H2_17 Item: Title: GO sheets interact less than MWCNT with alveolar cells Destination: mk:H2_18 Item: Title: MWCNT induce pulmonary fibrosis in the organoid after 7d exposure Destination: mk:H2_19 Item: Title: Discussion Destination: mk:H1_4 Item: Title: Conclusions Destination: mk:H1_5 Item: Title: Author statement Destination: mk:H1_6 Item: Title: CRediT authorship contribution statement Destination: mk:H1_7 Item: Title: Declaration of competing interest Destination: mk:HH1_2 Item: Title: Data availability Destination: datalink3 Item: Title: Acknowledgments Destination: mk:HH1_4 Item: Title: Authors contributions Destination: mk:H1_8 Item: Title: Appendix A Supporting information Destination: mk:H1_9 Item: Title: References Destination: mk:HH2_1 Filters: FilterPipeline: FlateDecode FilterPipeline: FlateDecode DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 124 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode DCTDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 118 ImageHeight: 149 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode DCTDecode Fonts: Type0: Font: BaseFont: BKSLIU+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: AADSYP+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAAAD+CharisSIL-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: AEPIHR+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAAAH+TimesNewRomanPS-ItalicMT Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAAAH+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: ERNRUV+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: ERNRUV+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: SUGRRU+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: SUGRRU+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VBCDLR+STIXTwoMath FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: VBCDLR+STIXTwoMath Flags: Nonsymbolic FontBBox: -994, -1641, 3072, 2627 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TILRTQ+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: TILRTQ+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AFDEQK+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: AFDEQK+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DJSAXP+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: DJSAXP+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: AAAAAH+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAAAH+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: BKSLIU+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: BKSLIU+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: AADSYP+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AADSYP+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: AAAAAD+CharisSIL-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAAAD+CharisSIL-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -741, -533, 1795, 1320 FontFile2: true Font: BaseFont: AEPIHR+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AEPIHR+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: AAAAAH+TimesNewRomanPS-ItalicMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAAAH+TimesNewRomanPS-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -498, -307, 1120, 1023 FontFile2: true Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 87, 576, 93, 587 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 94, 571, 166, 582 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 166, 571, 260, 582 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 260, 576, 266, 587 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 267, 576, 273, 587 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 274, 571, 353, 582 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 353, 576, 359, 587 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 360, 576, 366, 587 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 367, 579, 371, 584 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 367, 571, 371, 582 Flags: Print Destination: 4 Annotation: Subtype: Link Rect: 179, 312, 197, 320 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 157, 301, 177, 309 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 166, 270, 177, 278 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 387, 343, 398, 351 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 382, 322, 393, 330 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 405, 301, 416, 309 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 326, 270, 350, 278 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 346, 249, 362, 257 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 451, 197, 467, 205 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 306, 186, 333, 194 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 543, 176, 557, 184 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 98, 104, 203, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 267, 667, 404, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 189, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 247, 748, 346, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 406, 57, 552, 69 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 37, 730, 49, 738 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 131, 709, 182, 717 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 186, 689, 202, 696 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 207, 678, 223, 686 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 71, 668, 87, 676 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 62, 647, 89, 655 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 196, 636, 212, 644 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 108, 553, 143, 561 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 175, 532, 191, 540 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 183, 511, 199, 519 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 109, 500, 125, 508 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 104, 490, 120, 498 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 245, 490, 261, 498 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 119, 469, 135, 477 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 98, 406, 138, 414 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 130, 385, 159, 393 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 105, 354, 120, 362 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 200, 343, 227, 351 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 229, 312, 247, 320 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 96, 218, 112, 226 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 191, 155, 220, 163 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 327, 605, 354, 612 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 445, 217, 456, 225 Flags: Print Destination: 14 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 203, 689, 218, 696 Flags: Print Destination: 15 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 402, 477, 422, 485 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 433, 477, 460, 485 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 362, 466, 384, 474 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 131, 127, 145, 134 Flags: Print Destination: 15 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 228, 730, 248, 738 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 126, 709, 146, 717 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 225, 689, 245, 696 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 171, 647, 191, 655 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 234, 636, 255, 644 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 209, 626, 230, 634 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 225, 563, 245, 571 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 526, 597, 546, 605 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 526, 566, 546, 574 Flags: Print Destination: 8 Annotation: Subtype: Link Rect: 385, 493, 406, 501 Flags: Print Destination: 8 Annotation: Subtype: Link Rect: 366, 462, 386, 469 Flags: Print Destination: 8 Annotation: Subtype: Link Rect: 309, 430, 330, 438 Flags: Print Destination: 8 Annotation: Subtype: Link Rect: 231, 79, 242, 86 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 541, 79, 555, 86 Flags: Print Destination: 15 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 151, 699, 171, 707 Flags: Print Destination: 8 Annotation: Subtype: Link Rect: 260, 678, 271, 686 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 272, 668, 288, 676 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 40, 657, 60, 665 Flags: Print Destination: 8 Annotation: Subtype: Link Rect: 214, 636, 225, 644 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 164, 594, 180, 602 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 37, 427, 57, 435 Flags: Print Destination: 8 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 240, 699, 256, 707 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 181, 678, 204, 686 Flags: Print Destination: 9 Annotation: Subtype: Link Rect: 184, 647, 203, 655 Flags: Print Destination: 9 Annotation: Subtype: Link Rect: 198, 626, 219, 634 Flags: Print Destination: 9 Annotation: Subtype: Link Rect: 256, 512, 274, 520 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 389, 720, 422, 728 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 375, 678, 395, 686 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 511, 636, 534, 644 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 379, 615, 400, 623 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 408, 615, 412, 623 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 423, 615, 427, 623 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 354, 594, 375, 602 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 398, 584, 419, 592 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 430, 584, 434, 592 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 423, 553, 443, 561 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 452, 553, 456, 561 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 466, 553, 470, 561 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 375, 532, 396, 540 Flags: Print Destination: 11 Annotation: Subtype: Link Rect: 359, 490, 379, 498 Flags: Print Destination: 11 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 162, 226, 184, 234 Flags: Print Destination: 11 Annotation: Subtype: Link Rect: 139, 113, 166, 121 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 169, 102, 189, 110 Flags: Print Destination: 9 Annotation: Subtype: Link Rect: 258, 92, 277, 100 Flags: Print Destination: 11 Annotation: Subtype: Link Rect: 230, 81, 250, 89 Flags: Print Destination: 11 Annotation: Subtype: Link Rect: 72, 60, 93, 68 Flags: Print Destination: 11 Annotation: Subtype: Link Rect: 418, 226, 434, 234 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 464, 205, 485, 213 Flags: Print Destination: 12 Annotation: Subtype: Link Rect: 493, 142, 514, 150 Flags: Print Destination: 12 Annotation: Subtype: Link Rect: 425, 121, 445, 129 Flags: Print Destination: 12 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 198, 296, 210, 304 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 182, 254, 231, 262 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 236, 243, 274, 251 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 228, 170, 255, 178 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 260, 170, 280, 178 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 40, 139, 60, 147 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 128, 118, 144, 126 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 209, 107, 236, 115 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 140, 76, 156, 84 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 119, 55, 146, 63 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 345, 275, 365, 283 Flags: Print Destination: 8 Annotation: Subtype: Link Rect: 496, 212, 512, 220 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 306, 118, 342, 126 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 396, 118, 442, 126 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 386, 97, 402, 105 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 486, 86, 536, 94 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 520, 55, 536, 63 Flags: Print Destination: 14 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 98, 699, 114, 707 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 203, 668, 223, 676 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 76, 647, 106, 655 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 270, 636, 286, 644 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 81, 615, 100, 623 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 110, 615, 114, 623 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 150, 584, 166, 592 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 37, 553, 48, 561 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 264, 511, 286, 519 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 257, 500, 273, 508 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 225, 458, 246, 466 Flags: Print Destination: 9 Annotation: Subtype: Link Rect: 253, 448, 268, 456 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 109, 406, 131, 414 Flags: Print Destination: 9 Annotation: Subtype: Link Rect: 220, 396, 258, 404 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 152, 375, 168, 383 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 40, 343, 60, 351 Flags: Print Destination: 11 Annotation: Subtype: Link Rect: 160, 333, 187, 341 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 85, 291, 105, 299 Flags: Print Destination: 12 Annotation: Subtype: Link Rect: 118, 270, 167, 278 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 208, 239, 235, 247 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 113, 218, 132, 226 Flags: Print Destination: 11 Annotation: Subtype: Link Rect: 131, 197, 147, 205 Flags: Print Destination: 15 Annotation: Subtype: Link Rect: 164, 124, 184, 132 Flags: Print Destination: 9 Annotation: Subtype: Link Rect: 152, 103, 172, 111 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 181, 103, 185, 111 Flags: Print Destination: 10 Annotation: Subtype: Link Rect: 195, 103, 199, 111 Flags: Print Destination: 10 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 368, 668, 493, 676 Flags: Print Annotation: Subtype: Link Rect: 322, 629, 554, 635 Flags: Print Annotation: Subtype: Link Rect: 322, 621, 533, 627 Flags: Print Annotation: Subtype: Link Rect: 322, 613, 354, 619 Flags: Print Annotation: Subtype: Link Rect: 322, 605, 541, 611 Flags: Print Annotation: Subtype: Link Rect: 322, 597, 555, 603 Flags: Print Annotation: Subtype: Link Rect: 322, 589, 397, 595 Flags: Print Annotation: Subtype: Link Rect: 322, 581, 549, 587 Flags: Print Annotation: Subtype: Link Rect: 322, 573, 551, 579 Flags: Print Annotation: Subtype: Link Rect: 322, 565, 365, 571 Flags: Print Annotation: Subtype: Link Rect: 322, 557, 548, 563 Flags: Print Annotation: Subtype: Link Rect: 322, 549, 541, 555 Flags: Print Annotation: Subtype: Link Rect: 322, 541, 555, 547 Flags: Print Annotation: Subtype: Link Rect: 322, 533, 555, 539 Flags: Print Annotation: Subtype: Link Rect: 322, 525, 330, 532 Flags: Print Annotation: Subtype: Link Rect: 322, 517, 555, 524 Flags: Print Annotation: Subtype: Link Rect: 322, 509, 475, 516 Flags: Print Annotation: Subtype: Link Rect: 322, 501, 553, 508 Flags: Print Annotation: Subtype: Link Rect: 322, 493, 553, 500 Flags: Print Annotation: Subtype: Link Rect: 322, 485, 555, 492 Flags: Print Annotation: Subtype: Link Rect: 322, 477, 473, 484 Flags: Print Annotation: Subtype: Link Rect: 322, 469, 550, 476 Flags: Print Annotation: Subtype: Link Rect: 322, 461, 506, 468 Flags: Print Annotation: Subtype: Link Rect: 323, 453, 545, 460 Flags: Print Annotation: Subtype: Link Rect: 323, 445, 555, 452 Flags: Print Annotation: Subtype: Link Rect: 323, 437, 342, 444 Flags: Print Annotation: Subtype: Link Rect: 323, 429, 531, 436 Flags: Print Annotation: Subtype: Link Rect: 323, 422, 541, 428 Flags: Print Annotation: Subtype: Link Rect: 323, 414, 513, 420 Flags: Print Annotation: Subtype: Link Rect: 323, 406, 535, 412 Flags: Print Annotation: Subtype: Link Rect: 323, 398, 418, 404 Flags: Print Annotation: Subtype: Link Rect: 323, 390, 550, 396 Flags: Print Annotation: Subtype: Link Rect: 323, 382, 394, 388 Flags: Print Annotation: Subtype: Link Rect: 323, 374, 547, 380 Flags: Print Annotation: Subtype: Link Rect: 323, 366, 523, 372 Flags: Print Annotation: Subtype: Link Rect: 323, 358, 555, 364 Flags: Print Annotation: Subtype: Link Rect: 323, 350, 537, 356 Flags: Print Annotation: Subtype: Link Rect: 323, 342, 555, 348 Flags: Print Annotation: Subtype: Link Rect: 323, 334, 555, 340 Flags: Print Annotation: Subtype: Link Rect: 323, 326, 396, 332 Flags: Print Annotation: Subtype: Link Rect: 323, 318, 555, 324 Flags: Print Annotation: Subtype: Link Rect: 323, 310, 437, 316 Flags: Print Annotation: Subtype: Link Rect: 323, 302, 543, 308 Flags: Print Annotation: Subtype: Link Rect: 323, 294, 555, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 399, 292 Flags: Print Annotation: Subtype: Link Rect: 323, 278, 555, 284 Flags: Print Annotation: Subtype: Link Rect: 323, 270, 508, 276 Flags: Print Annotation: Subtype: Link Rect: 323, 262, 555, 268 Flags: Print Annotation: Subtype: Link Rect: 323, 254, 542, 261 Flags: Print Annotation: Subtype: Link Rect: 323, 246, 543, 253 Flags: Print Annotation: Subtype: Link Rect: 323, 238, 435, 245 Flags: Print Annotation: Subtype: Link Rect: 323, 230, 555, 237 Flags: Print Annotation: Subtype: Link Rect: 323, 222, 470, 229 Flags: Print Annotation: Subtype: Link Rect: 323, 214, 545, 221 Flags: Print Annotation: Subtype: Link Rect: 323, 206, 464, 213 Flags: Print Annotation: Subtype: Link Rect: 323, 198, 543, 205 Flags: Print Annotation: Subtype: Link Rect: 323, 190, 544, 197 Flags: Print Annotation: Subtype: Link Rect: 323, 182, 542, 189 Flags: Print Annotation: Subtype: Link Rect: 323, 174, 351, 181 Flags: Print Annotation: Subtype: Link Rect: 323, 166, 540, 173 Flags: Print Annotation: Subtype: Link Rect: 323, 158, 484, 165 Flags: Print Annotation: Subtype: Link Rect: 323, 151, 542, 157 Flags: Print Annotation: Subtype: Link Rect: 323, 143, 466, 149 Flags: Print Annotation: Subtype: Link Rect: 323, 135, 540, 141 Flags: Print Annotation: Subtype: Link Rect: 323, 127, 482, 133 Flags: Print Annotation: Subtype: Link Rect: 323, 119, 555, 125 Flags: Print Annotation: Subtype: Link Rect: 323, 111, 548, 117 Flags: Print Annotation: Subtype: Link Rect: 323, 103, 548, 109 Flags: Print Annotation: Subtype: Link Rect: 323, 95, 555, 101 Flags: Print Annotation: Subtype: Link Rect: 323, 87, 525, 93 Flags: Print Annotation: Subtype: Link Rect: 323, 79, 555, 85 Flags: Print Annotation: Subtype: Link Rect: 323, 71, 555, 77 Flags: Print Annotation: Subtype: Link Rect: 323, 63, 351, 69 Flags: Print Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 54, 732, 284, 738 Flags: Print Annotation: Subtype: Link Rect: 54, 724, 275, 730 Flags: Print Annotation: Subtype: Link Rect: 54, 716, 107, 722 Flags: Print Annotation: Subtype: Link Rect: 54, 708, 284, 714 Flags: Print Annotation: Subtype: Link Rect: 54, 700, 161, 706 Flags: Print Annotation: Subtype: Link Rect: 54, 692, 279, 698 Flags: Print Annotation: Subtype: Link Rect: 54, 684, 188, 690 Flags: Print Annotation: Subtype: Link Rect: 54, 676, 284, 682 Flags: Print Annotation: Subtype: Link Rect: 54, 668, 237, 674 Flags: Print Annotation: Subtype: Link Rect: 54, 660, 274, 666 Flags: Print Annotation: Subtype: Link Rect: 54, 652, 286, 658 Flags: Print Annotation: Subtype: Link Rect: 54, 644, 214, 651 Flags: Print Annotation: Subtype: Link Rect: 54, 636, 286, 643 Flags: Print Annotation: Subtype: Link Rect: 54, 628, 267, 635 Flags: Print Annotation: Subtype: Link Rect: 54, 620, 226, 627 Flags: Print Annotation: Subtype: Link Rect: 54, 612, 282, 619 Flags: Print Annotation: Subtype: Link Rect: 54, 604, 270, 611 Flags: Print Annotation: Subtype: Link Rect: 54, 596, 259, 603 Flags: Print Annotation: Subtype: Link Rect: 54, 588, 279, 595 Flags: Print Annotation: Subtype: Link Rect: 54, 580, 151, 587 Flags: Print Annotation: Subtype: Link Rect: 54, 572, 260, 579 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 286, 571 Flags: Print Annotation: Subtype: Link Rect: 54, 557, 206, 563 Flags: Print Annotation: Subtype: Link Rect: 54, 549, 281, 555 Flags: Print Annotation: Subtype: Link Rect: 54, 541, 267, 547 Flags: Print Annotation: Subtype: Link Rect: 54, 533, 225, 539 Flags: Print Annotation: Subtype: Link Rect: 323, 732, 529, 738 Flags: Print Annotation: Subtype: Link Rect: 323, 724, 555, 730 Flags: Print Annotation: Subtype: Link Rect: 323, 716, 489, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 708, 543, 714 Flags: Print Annotation: Subtype: Link Rect: 323, 700, 555, 706 Flags: Print Annotation: Subtype: Link Rect: 323, 692, 347, 698 Flags: Print Annotation: Subtype: Link Rect: 323, 684, 546, 690 Flags: Print Annotation: Subtype: Link Rect: 323, 676, 555, 682 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 400, 674 Flags: Print Annotation: Subtype: Link Rect: 323, 660, 552, 666 Flags: Print Annotation: Subtype: Link Rect: 323, 652, 376, 658 Flags: Print Annotation: Subtype: Link Rect: 323, 644, 541, 651 Flags: Print Annotation: Subtype: Link Rect: 323, 636, 544, 643 Flags: Print Annotation: Subtype: Link Rect: 323, 628, 555, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 533, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 543, 619 Flags: Print Annotation: Subtype: Link Rect: 323, 604, 429, 611 Flags: Print Annotation: Subtype: Link Rect: 323, 596, 553, 603 Flags: Print Annotation: Subtype: Link Rect: 323, 588, 487, 595 Flags: Print Annotation: Subtype: Link Rect: 323, 580, 546, 587 Flags: Print Annotation: Subtype: Link Rect: 323, 572, 543, 579 Flags: Print Annotation: Subtype: Link Rect: 323, 565, 533, 571 Flags: Print Annotation: Subtype: Link Rect: 323, 557, 555, 563 Flags: Print Annotation: Subtype: Link Rect: 323, 549, 376, 555 Flags: Print Annotation: Subtype: Link Rect: 323, 541, 552, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 533, 487, 539 Flags: Print Checksum: 6a30903e Type: CRC32 Checksum: f829d8c320d34a78a84f9c3b89d0e6cf Type: MD5 Checksum: bc05f274661787a617190705879beaf6dfe3f29a Type: SHA-1 Checksum: 5a21c1b595523225a212dde95de8cd203d047040a32c2906973876437997c947 Type: SHA-256