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MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Early pseudoprogression and progression lesions in glioblastoma patients are both metabolically heterogeneous Destination: atl_NBM_5095_ Children: Item: Title: 1 INTRODUCTION Destination: HeadingNBM_5095nbm5095-sec-0001 Item: Title: 2 MATERIALS AND METHODS Destination: HeadingNBM_5095nbm5095-sec-0002 Children: Item: Title: 2.1 Study design and sample size calculation for machine learning (MLe) Destination: HeadingNBM_5095nbm5095-sec-0003 Item: Title: 2.2 Ethics statement Destination: HeadingNBM_5095nbm5095-sec-0004 Item: Title: 2.3 Inclusion criteria Destination: HeadingNBM_5095nbm5095-sec-0005 Item: Title: 2.4 Acquisition protocol Destination: HeadingNBM_5095nbm5095-sec-0006 Item: Title: 2.5 MRS data processing Destination: HeadingNBM_5095nbm5095-sec-0007 Item: Title: 2.6 MRS data analysis Destination: HeadingNBM_5095nbm5095-sec-0008 Children: Item: Title: 2.6.1 Data analysis design Destination: HeadingNBM_5095nbm5095-sec-0009 Item: Title: 2.6.2 cNMF Destination: HeadingNBM_5095nbm5095-sec-0010 Item: Title: 2.6.3 Visualization: winning source maps Destination: HeadingNBM_5095nbm5095-sec-0011 Item: Title: 2.6.4 Statistics Destination: HeadingNBM_5095nbm5095-sec-0012 Item: Title: 2.6.5 MLe-based classification Destination: HeadingNBM_5095nbm5095-sec-0013 Item: Title: 3 RESULTS Destination: HeadingNBM_5095nbm5095-sec-0014 Children: Item: Title: 3.1 Number of patients and voxels Destination: HeadingNBM_5095nbm5095-sec-0015 Item: Title: 3.2 Source extraction from SCER spectra Destination: HeadingNBM_5095nbm5095-sec-0016 Item: Title: 3.3 Statistics Destination: HeadingNBM_5095nbm5095-sec-0017 Item: Title: 3.4 Visualization Destination: HeadingNBM_5095nbm5095-sec-0018 Item: Title: 3.5 MLe classification analysis Destination: HeadingNBM_5095nbm5095-sec-0019 Item: Title: 4 DISCUSSION Destination: HeadingNBM_5095nbm5095-sec-0020 Item: Title: AUTHOR CONTRIBUTIONS Destination: HeadingNBM_5095nbm5095-sec-0021 Item: Title: ACKNOWLEDGMENTS Destination: HeadingNBM_5095nbm5095-sec-0022 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: HeadingNBM_5095nbm5095-sec-0023 Item: Title: REFERENCES Destination: HeadingNBM_5095nbm5095-bibl-00011 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 241 ImageHeight: 83 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG 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