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Title:          Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
Subject:        EMBO Mol Med 2024.16:64-92
Keywords:       Chromosomal Instability; Aneuploidy; Childhood B-cell Acute Lymphoblastic Leukemia; Disease Models
Author:         Oscar Molina
Creator:        Springer
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     Item: 
      Title: Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
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       Item: 
        Title: Introduction
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: Chr-CNH is consistently higher in aneuploid subtypes of childhood B-ALL
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         Item: 
          Title: Patient-derived xenograft (PDX) models recapitulate the clinical outcome of cB-ALL in patients with variable ploidy’levels
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         Item: 
          Title: Aneuploid cB-ALL subtypes are characterized by’higher’rates of mitotic defects and chromosome’mis-segregation
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         Item: 
          Title: CIN is associated with moderate levels of intraclonal chr-„CNH in aneuploid cB-ALL
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         Item: 
          Title: CIN influences cB-ALL progression in PDX’models
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         Item: 
          Title: Mathematical modeling confirms a relationship between CIN and disease progression
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         Item: 
          Title: Adaption of the mitotic spindle machinery to’regulate’chromosome segregation is associated with’CIN in cB-ALL
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       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
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        Children: 
         Item: 
          Title: Pediatric B-ALL leukemic samples
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         Item: 
          Title: Low-pass single-cell’WGSeq
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         Item: 
          Title: PDX generation and follow-up
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         Item: 
          Title: Immunofluorescence and microscopy analyses
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         Item: 
          Title: Multicolor fluorescence in’situ hybridization on metaphase chromosomes
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         Item: 
          Title: In silico modeling of chromosome instability
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          Children: 
           Item: 
            Title: Fitness per chromosome determination
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           Item: 
            Title: Agent-based model for in silico analyses of chromosomal instability
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         Item: 
          Title: Mass spectrometry and proteomic analyses
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         Item: 
          Title: RNA-sequencing
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         Item: 
          Title: Statistical analyses
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       Item: 
        Title: Data availability
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        Title: References
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       Item: 
        Title: The paper explained
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          Title: Acknowledgements
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          Title: Author contributions
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         Item: 
          Title: Disclosure and competing interests statement
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       Item: 
        Title: ACKNOWLEDGMENTS
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               <rdf:li xml:lang="x-default">Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression</rdf:li>
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         <dc:creator>
            <rdf:Seq>
               <rdf:li>Oscar Molina</rdf:li>
               <rdf:li>Carmen Ortega-Sabater</rdf:li>
               <rdf:li>Namitha Thampi</rdf:li>
               <rdf:li>Narcís Fernández-Fuentes</rdf:li>
               <rdf:li>Mercedes Guerrero-Murillo</rdf:li>
               <rdf:li>Alba Martínez-Moreno</rdf:li>
               <rdf:li>Meritxell Vinyoles</rdf:li>
               <rdf:li>Talía Velasco-Hernández</rdf:li>
               <rdf:li>Clara Bueno</rdf:li>
               <rdf:li>Juan L Trincado</rdf:li>
               <rdf:li>Isabel Granada</rdf:li>
               <rdf:li>Diana Campos</rdf:li>
               <rdf:li>Carles Giménez</rdf:li>
               <rdf:li>Judith M Boer</rdf:li>
               <rdf:li>Monique L Boer</rdf:li>
               <rdf:li>Gabriel F Calvo</rdf:li>
               <rdf:li>Mireia Camós</rdf:li>
               <rdf:li>Jose-Luis Fuster</rdf:li>
               <rdf:li>Pablo Velasco</rdf:li>
               <rdf:li>Paola Ballerini</rdf:li>
               <rdf:li>Franco Locatelli</rdf:li>
               <rdf:li>Charles G Mullighan</rdf:li>
               <rdf:li>Diana C J Spierings</rdf:li>
               <rdf:li>Floris Foijer</rdf:li>
               <rdf:li>Víctor M Pérez-García</rdf:li>
               <rdf:li>Pablo Menéndez</rdf:li>
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               <rdf:li>Chromosomal Instability; Aneuploidy; Childhood B-cell Acute Lymphoblastic Leukemia; Disease Models</rdf:li>
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   Type: CRC32
  Checksum: b4150cb6d1705754b7bd400f57df8cc5
   Type: MD5
  Checksum: 61c662ba91a52196d742c3800c458225bfe1dfd0
   Type: SHA-1
  Checksum: 8a4b0a67cb42e5e3065ae1cf6cd8d38a526504406e70e3d16fad7ff9b3c40962
   Type: SHA-256