e9be0994640e23040c0206752e30b6c5  New_genetic_drivers_in_hemorrhagic.pdf
32adc36191c63c23491cfc08639ce338d6a7051c  New_genetic_drivers_in_hemorrhagic.pdf
43e8c04abf6cb35bce88eb3f568901b95f1a5647b168c6942e20ac752b3e976f  New_genetic_drivers_in_hemorrhagic.pdf

Title:          New genetic drivers in hemorrhagic hereditary telangiectasia
Subject:        European Journal of Internal Medicine, 119 (2024) 99-108. doi:10.1016/j.ejim.2023.08.024
Keywords:       Hereditary hemorrhagic telangiectasia,Rare diseases,Genetics,SMAD6,Hypoxia
Author:         Pau Cerdà
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Wed Dec 27 15:30:16 2023 CET
ModDate:        Wed Dec 27 16:53:33 2023 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          10
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      2817029 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
NNLAUQ+TeX_CM_Roman                  Type 1C           Builtin          yes yes yes    792  0
LSGIJF+CharisSIL                     CID TrueType      Identity-H       yes yes yes    796  0
DPKQBV+STIX-Regular                  Type 1C           Custom           yes yes yes    801  0
AAHASG+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    806  0
TWRDXZ+STIX-Italic                   Type 1C           Custom           yes yes yes    811  0
GBNAGF+Univers                       Type 1C           Builtin          yes yes yes    816  0
BOGKJL+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    820  0
YHFVOA+CharisSIL                     CID TrueType      Identity-H       yes yes yes    783  0
AVRJLH+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    338  0
HTSILD+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes    343  0
USXXBE+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    331  0
VVCCGG+TeX_CM_Maths_Italic           Type 1C           Builtin          yes yes yes    347  0
BVCPMO+STIXGeneral                   Type 1C           Custom           yes yes yes     35  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-03-01 02:35:12 CET
 RepresentationInformation: New_genetic_drivers_in_hemorrhagic.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-02-29 19:46:09 CET
  Size: 2817029
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 899
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: New genetic drivers in hemorrhagic hereditary telangiectasia
      Destination: mk:title
      Children: 
       Item: 
        Title: 1 Background
        Destination: mk:H1_1
       Item: 
        Title: 2 Material and methods
        Destination: mk:H1_2
        Children: 
         Item: 
          Title: 2.1 Study participants and clinical data
          Destination: mk:H2_1
         Item: 
          Title: 2.2 Reagents
          Destination: mk:H2_2
         Item: 
          Title: 2.3 DNA extraction
          Destination: mk:H2_3
         Item: 
          Title: 2.4 Exome sequencing and data analysis
          Destination: mk:H2_4
         Item: 
          Title: 2.5 Mutagenesis
          Destination: mk:H2_5
         Item: 
          Title: 2.6 Generation of SMAD6 knock-out hTERT-HDMECs by CRISPR/Cas9
          Destination: mk:H2_6
         Item: 
          Title: 2.7 Cell transfection
          Destination: mk:H2_7
         Item: 
          Title: 2.8 Western blot
          Destination: mk:H2_8
       Item: 
        Title: 3 Results
        Destination: mk:H1_3
        Children: 
         Item: 
          Title: 3.1 Patients’ selection and clinical characteristics
          Destination: mk:H2_9
         Item: 
          Title: 3.2 Identification of new variants in HHT-like families
          Destination: mk:H2_10
         Item: 
          Title: 3.3 SMAD6 is a candidate for HHT pathogenesis
          Destination: mk:H2_11
       Item: 
        Title: 4 Discussion
        Destination: mk:H1_4
       Item: 
        Title: Ethics approval and consent to participate
        Destination: mk:H1_5
       Item: 
        Title: Consent for publication
        Destination: mk:H1_6
       Item: 
        Title: Availability of data and materials
        Destination: mk:H1_7
       Item: 
        Title: Funding
        Destination: mk:H1_8
       Item: 
        Title: CRediT authorship contribution statement
        Destination: mk:H1_9
       Item: 
        Title: Declaration of Competing Interest
        Destination: mk:HH1_2
       Item: 
        Title: Acknowledgements
        Destination: mk:HH1_3
       Item: 
        Title: References
        Destination: mk:HH2_1
   Info: 
    Title: New genetic drivers in hemorrhagic hereditary telangiectasia
    Author: Pau Cerdà
    Subject: European Journal of Internal Medicine, 119 (2024) 99-108. doi:10.1016/j.ejim.2023.08.024
    Keywords: Hereditary hemorrhagic telangiectasia,Rare diseases,Genetics,SMAD6,Hypoxia
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Wed Dec 27 15:30:16 CET 2023
    ModDate: Wed Dec 27 16:53:33 CET 2023
   ID: 0x0e3549db09638f0fe2905b98ff4f55af, 0xba17ae471055617d329506d7ea5acc43
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: AVRJLH+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: BOGKJL+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: AAHASG+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: LSGIJF+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: GBNAGF+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: GBNAGF+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: DPKQBV+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 9
      FontDescriptor: 
       FontName: DPKQBV+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BVCPMO+STIXGeneral
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BVCPMO+STIXGeneral
       Flags: Nonsymbolic
       FontBBox: -178, -443, 2000, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HTSILD+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: HTSILD+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: NNLAUQ+TeX_CM_Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: NNLAUQ+TeX_CM_Roman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: TWRDXZ+STIX-Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: TWRDXZ+STIX-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VVCCGG+TeX_CM_Maths_Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: VVCCGG+TeX_CM_Maths_Italic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: AVRJLH+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: AVRJLH+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
     Font: 
      BaseFont: BOGKJL+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: BOGKJL+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: AAHASG+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: AAHASG+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
     Font: 
      BaseFont: LSGIJF+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: LSGIJF+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.ejim.2023.08.024</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier B.V.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">European Journal of Internal Medicine, 119 (2024) 99-108. doi:10.1016/j.ejim.2023.08.024</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Hereditary hemorrhagic telangiectasia</rdf:li>
               <rdf:li>Rare diseases</rdf:li>
               <rdf:li>Genetics</rdf:li>
               <rdf:li>SMAD6</rdf:li>
               <rdf:li>Hypoxia</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">New genetic drivers in hemorrhagic hereditary telangiectasia</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Pau Cerdà</rdf:li>
               <rdf:li>Sandra D. Castillo</rdf:li>
               <rdf:li>Cinthia Aguilera</rdf:li>
               <rdf:li>Adriana Iriarte</rdf:li>
               <rdf:li>José Luis Rocamora</rdf:li>
               <rdf:li>Ane M. Larrinaga</rdf:li>
               <rdf:li>Francesc Viñals</rdf:li>
               <rdf:li>Mariona Graupera</rdf:li>
               <rdf:li>Antoni Riera-Mestre</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>European Journal of Internal Medicine</prism:publicationName>
         <prism:copyright>© 2023 The Authors. Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.</prism:copyright>
         <prism:issn>0953-6205</prism:issn>
         <prism:volume>119</prism:volume>
         <prism:coverDisplayDate>1 January 2024</prism:coverDisplayDate>
         <prism:coverDate>2024-01-01</prism:coverDate>
         <prism:pageRange>99-108</prism:pageRange>
         <prism:startingPage>99</prism:startingPage>
         <prism:endingPage>108</prism:endingPage>
         <prism:doi>10.1016/j.ejim.2023.08.024</prism:doi>
         <prism:url>https://doi.org/10.1016/j.ejim.2023.08.024</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.ejim.2023.08.024</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.ejim.2023.08.024</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>27th December 2023</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2023-12-27T15:53:33</xmp:ModifyDate>
         <xmp:CreateDate>2023-12-27T14:30:16</xmp:CreateDate>
         <xmp:MetadataDate>2023-12-27T15:53:33</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>27th December 2023</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>Hereditary hemorrhagic telangiectasia,Rare diseases,Genetics,SMAD6,Hypoxia</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b6ed5266-03cb-4855-90c0-636283357f42</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 99
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 87, 593, 93, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 94, 593, 101, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 102, 593, 107, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 108, 588, 206, 599
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 206, 593, 212, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 213, 588, 303, 599
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 303, 593, 309, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 310, 593, 316, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 317, 588, 399, 599
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 399, 593, 405, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 405, 593, 412, 604
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 413, 588, 420, 599
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 132, 580, 139, 591
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 139, 576, 232, 586
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 232, 576, 318, 586
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 318, 580, 323, 591
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 324, 580, 330, 591
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 331, 576, 429, 586
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 429, 580, 436, 591
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 437, 580, 441, 591
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 442, 576, 448, 586
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 134, 567, 140, 578
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 141, 567, 147, 578
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 148, 567, 154, 578
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 155, 567, 161, 578
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 162, 570, 166, 575
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 162, 563, 166, 573
       Flags: Print
       Destination: 768
      Annotation: 
       Subtype: Link
       Rect: 110, 173, 122, 181
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 511, 236, 522, 244
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 422, 205, 433, 213
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 540, 173, 545, 181
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 547, 173, 552, 181
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 98, 114, 187, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 279, 667, 392, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 178, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 297, 749, 300, 757
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 203, 748, 390, 760
      Annotation: 
       Subtype: Link
       Rect: 499, 616, 528, 645
      Annotation: 
       Subtype: Link
       Rect: 99, 48, 265, 59
    Page: 
     Label: 100
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 237, 678, 242, 686
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 244, 678, 248, 686
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 161, 626, 172, 634
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 40, 594, 45, 602
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 47, 594, 56, 602
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 262, 563, 271, 571
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 274, 563, 283, 571
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 108, 542, 113, 550
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 115, 542, 119, 550
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 224, 458, 240, 466
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 243, 437, 272, 445
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 121, 81, 136, 89
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 363, 720, 368, 728
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 370, 720, 379, 728
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 462, 689, 466, 696
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 469, 689, 478, 696
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 397, 668, 402, 676
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 404, 668, 413, 676
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 306, 238, 322, 246
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 468, 175, 483, 183
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 375, 113, 390, 121
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 539, 102, 555, 110
       Flags: Print
       Destination: 166
    Page: 
     Label: 101
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 709, 232, 717
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 234, 709, 243, 717
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 231, 605, 240, 613
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 242, 605, 251, 613
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 114, 594, 130, 602
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 135, 584, 151, 592
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 37, 573, 53, 581
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 118, 573, 134, 581
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 407, 458, 434, 466
       Flags: Print
       Destination: 60
      Annotation: 
       Subtype: Link
       Rect: 392, 448, 412, 456
       Flags: Print
       Destination: 60
      Annotation: 
       Subtype: Link
       Rect: 471, 385, 491, 392
       Flags: Print
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 493, 322, 513, 330
       Flags: Print
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 327, 290, 353, 298
       Flags: Print
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 403, 207, 412, 215
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 415, 207, 424, 215
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 440, 144, 455, 152
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 424, 102, 433, 110
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 435, 102, 444, 110
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 359, 71, 368, 79
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 371, 71, 380, 79
       Flags: Print
       Destination: 166
    Page: 
     Label: 102
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 65, 86, 81, 94
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 169, 65, 184, 73
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 306, 96, 322, 104
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 459, 54, 474, 62
       Flags: Print
       Destination: 166
    Page: 
     Label: 103
     Sequence: 5
    Page: 
     Label: 104
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 140, 597, 156, 605
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 68, 534, 84, 542
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 57, 524, 73, 532
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 79, 492, 95, 500
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 235, 461, 251, 469
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 69, 429, 85, 437
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 117, 408, 132, 416
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 224, 335, 240, 343
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 270, 314, 286, 322
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 160, 175, 169, 183
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 171, 175, 180, 183
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 138, 165, 158, 173
       Flags: Print
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 230, 144, 246, 152
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 256, 81, 265, 89
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 267, 81, 276, 89
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 137, 50, 157, 58
       Flags: Print
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 527, 586, 546, 594
       Flags: Print
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 520, 461, 529, 469
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 531, 461, 540, 469
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 543, 461, 552, 469
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 403, 440, 412, 448
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 415, 440, 424, 448
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 438, 408, 462, 416
       Flags: Print
       Destination: 127
      Annotation: 
       Subtype: Link
       Rect: 364, 283, 373, 291
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 375, 283, 384, 291
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 421, 252, 437, 260
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 524, 168, 540, 176
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 436, 157, 452, 165
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 380, 126, 396, 134
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 415, 74, 431, 82
       Flags: Print
       Destination: 309
    Page: 
     Label: 105
     Sequence: 7
    Page: 
     Label: 106
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 37, 730, 53, 738
       Flags: Print
       Destination: 309
      Annotation: 
       Subtype: Link
       Rect: 77, 636, 92, 644
       Flags: Print
       Destination: 309
      Annotation: 
       Subtype: Link
       Rect: 119, 563, 128, 571
       Flags: Print
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 130, 563, 139, 571
       Flags: Print
       Destination: 309
      Annotation: 
       Subtype: Link
       Rect: 141, 563, 150, 571
       Flags: Print
       Destination: 309
      Annotation: 
       Subtype: Link
       Rect: 457, 297, 554, 304
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 289, 379, 296
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 430, 265, 534, 272
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 257, 358, 264
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 444, 241, 553, 248
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 233, 551, 240
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 226, 545, 232
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 218, 362, 224
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 410, 194, 511, 200
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 370, 170, 493, 176
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 483, 146, 555, 152
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 138, 378, 144
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 437, 122, 509, 128
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 114, 374, 120
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 448, 90, 554, 96
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 82, 358, 88
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 472, 58, 547, 65
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 50, 372, 57
       Flags: Print
    Page: 
     Label: 107
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 134, 716, 242, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 213, 692, 285, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 684, 108, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 253, 668, 286, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 660, 153, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 169, 636, 241, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 628, 119, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 175, 604, 284, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 228, 588, 273, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 580, 134, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 229, 565, 274, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 557, 111, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 245, 533, 278, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 525, 159, 531
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 178, 509, 254, 515
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 501, 110, 507
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 188, 477, 260, 483
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 469, 89, 475
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 151, 445, 260, 451
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 437, 83, 443
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 413, 162, 419
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 145, 381, 253, 388
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 185, 365, 257, 372
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 357, 117, 364
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 264, 341, 286, 348
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 333, 154, 340
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 261, 317, 283, 324
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 309, 156, 316
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 161, 294, 250, 300
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 166, 278, 278, 284
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 169, 246, 284, 252
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 121, 230, 226, 236
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 188, 214, 272, 220
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 206, 81, 212
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 183, 182, 255, 188
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 174, 108, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 150, 184, 156
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 236, 134, 282, 140
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 126, 151, 133
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 241, 110, 286, 117
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 102, 139, 109
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 94, 286, 101
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 86, 284, 93
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 78, 201, 85
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 469, 732, 544, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 724, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 443, 708, 519, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 700, 390, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 492, 684, 538, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 676, 370, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 466, 652, 555, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 644, 348, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 372, 620, 501, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 344, 596, 452, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 588, 538, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 580, 540, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 572, 496, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 532, 549, 554, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 541, 399, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 516, 525, 549, 531
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 517, 398, 523
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 437, 501, 549, 507
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 392, 477, 496, 483
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 465, 453, 537, 459
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 445, 373, 451
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 413, 437, 419
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 457, 389, 547, 396
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 381, 370, 388
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 496, 365, 541, 372
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 357, 408, 364
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 376, 333, 498, 340
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 309, 457, 316
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 476, 286, 547, 292
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 278, 359, 284
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 408, 254, 514, 260
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 358, 230, 464, 236
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 206, 446, 212
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 351, 182, 454, 188
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 496, 166, 542, 172
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 158, 407, 164
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 519, 142, 552, 148
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 134, 397, 140
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 490, 110, 536, 117
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 102, 403, 109
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 446, 78, 518, 85
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 70, 402, 77
       Flags: Print
    Page: 
     Label: 108
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 262, 724, 284, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 716, 162, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 235, 692, 286, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 684, 84, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 443, 724, 551, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 716, 346, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 429, 700, 527, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 531, 676, 553, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 668, 406, 674
       Flags: Print
  Checksum: c47221a2
   Type: CRC32
  Checksum: e9be0994640e23040c0206752e30b6c5
   Type: MD5
  Checksum: 32adc36191c63c23491cfc08639ce338d6a7051c
   Type: SHA-1
  Checksum: 43e8c04abf6cb35bce88eb3f568901b95f1a5647b168c6942e20ac752b3e976f
   Type: SHA-256