fc90c59b8ee0889af4ac6f60f093e6ab ProNeu_a2024v234p102572iENG.pdf 3f34eab99ef5541cead716b98116cb9c233dec33 ProNeu_a2024v234p102572iENG.pdf 0251f4b6d287747d5c439e544c65fe4360523c89856552c59d169d373064c9f0 ProNeu_a2024v234p102572iENG.pdf Title: Caenorhabditis elegans RAC1/ced-10 mutants as a new animal model to study very early stages of Parkinson’s disease Subject: Progress in Neurobiology, 234 (2024) 102572. doi:10.1016/j.pneurobio.2024.102572 Keywords: Early-Parkinson’s disease,Early diagnosis RAC1/ced-10 nematodes,Lipid metabolism,GABAergic impairment Author: A. Muñoz-Juan Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Apr 23 15:29:04 2024 CEST ModDate: Tue Apr 23 17:11:20 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 8200582 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SGRLIG+CharisSIL-Italic CID TrueType Identity-H yes yes yes 942 0 KWIBZD+CharisSIL-Bold CID TrueType Identity-H yes yes yes 947 0 VXCJFZ+Univers Type 1C Builtin yes yes yes 952 0 BRWWWZ+TeX_CM_Roman Type 1C Builtin yes yes yes 956 0 ACXMOE+CharisSIL CID TrueType Identity-H yes yes yes 960 0 BREDNN+STIX-Regular Type 1C Custom yes yes yes 965 0 DOIVWM+CharisSIL CID TrueType Identity-H yes yes yes 933 0 ZQGGRO+STIX-Italic Type 1C Custom yes yes yes 407 0 CTKRFM+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 412 0 PORKQE+CharisSIL-Italic CID TrueType Identity-H yes yes yes 400 0 LKDAAQ+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 417 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 424 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-25 02:43:09 CEST RepresentationInformation: ProNeu_a2024v234p102572iENG.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 10:03:15 CEST Size: 8200582 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'sec0125' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0125' cannot be found ID: PDF-HUL-122 Offset: 8146362 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1041 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Caenorhabditis elegans RAC1/ced-10 mutants as a new animal model to study very early stages of Parkinson’s disease Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 C elegans strains Destination: mk:H2_1 Item: Title: 2.2 Worm culture and maintenance Destination: mk:H2_2 Item: Title: 2.3 Blinding of experiments and replicates Destination: mk:H2_3 Item: Title: 2.4 Visualization of engulfment defects Destination: mk:H2_4 Item: Title: 2.5 Aggregate quantification Destination: mk:H2_5 Item: Title: 2.6 Thrashing assay Destination: mk:H2_6 Item: Title: 2.7 Quantification of GABAergic-associated abnormalities Destination: mk:H2_7 Item: Title: 2.8 Synchrotron radiation µfourier-transform infrared spectroscopy (SR-µFTIR) Destination: mk:H2_8 Item: Title: 2.9 Oil red O staining Destination: mk:H2_9 Item: Title: 2.10 Microscopy and imaging Destination: mk:H2_10 Item: Title: 2.11 Lipidomic profiling Destination: mk:H2_11 Item: Title: 2.12 Multivariate data analysis Destination: mk:H2_12 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 RAC1/ced-10 mutants exhibit decreased accumulation of Asyn before reaching adulthood in C. elegans. Destination: mk:H2_13 Item: Title: 3.2 RAC1/ced-10 mutant worms display both altered defecation program and impaired GABAergic morphology before reaching the ... Destination: mk:H2_14 Item: Title: 3.3 Increased lipid unsaturation and peroxidation characterize young RAC1/ced-10 worms Destination: mk:H2_15 Item: Title: 3.4 RAC1/ced-10 mutant animals display lipidomic abnormalities before adulthood Destination: mk:H2_16 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: 5 Conclusions Destination: mk:H1_5 Item: Title: CRediT authorship contribution statement Destination: mk:H1_6 Item: Title: Funding sources Destination: mk:H1_7 Item: Title: Declaration of Competing Interest Destination: mk:HH1_3 Item: Title: Data availability Destination: datalink4 Item: Title: Acknowledgements Destination: mk:HH1_5 Item: Title: Appendix A Supporting information Destination: mk:H1_8 Item: Title: References Destination: mk:HH2_1 Info: Title: Caenorhabditis elegans RAC1/ced-10 mutants as a new animal model to study very early stages of Parkinson’s disease Author: A. Muñoz-Juan Subject: Progress in Neurobiology, 234 (2024) 102572. doi:10.1016/j.pneurobio.2024.102572 Keywords: Early-Parkinson’s disease,Early diagnosis RAC1/ced-10 nematodes,Lipid metabolism,GABAergic impairment Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Apr 23 15:29:04 CEST 2024 ModDate: Tue Apr 23 17:11:20 CEST 2024 ID: 0xda85e6d9a84ebf0b84aefc88eb78a94d, 0x93f5f9176fbb51a9311c844404910963 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: ACXMOE+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: LKDAAQ+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: KWIBZD+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: SGRLIG+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BREDNN+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: BREDNN+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZQGGRO+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: ZQGGRO+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VXCJFZ+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: VXCJFZ+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: BRWWWZ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: BRWWWZ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: CTKRFM+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: CTKRFM+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: SGRLIG+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SGRLIG+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: ACXMOE+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ACXMOE+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: LKDAAQ+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LKDAAQ+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: KWIBZD+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KWIBZD+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 110, 571, 204, 582 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 204, 571, 253, 582 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 253, 571, 302, 582 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 302, 571, 379, 582 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 379, 576, 385, 587 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 386, 571, 459, 582 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 459, 576, 465, 587 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 465, 571, 471, 582 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 82, 558, 142, 569 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 142, 563, 148, 574 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 149, 558, 225, 569 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 225, 563, 231, 574 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 231, 558, 282, 569 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 282, 563, 289, 574 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 289, 563, 296, 574 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 296, 563, 303, 574 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 304, 566, 308, 571 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 304, 563, 310, 574 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 311, 558, 315, 569 Flags: Print Destination: 918 Annotation: Subtype: Link Rect: 161, 170, 234, 178 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 524, 191, 557, 199 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 180, 353, 188 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 103, 114, 171, 121 Flags: Print Annotation: Subtype: Link Rect: 175, 114, 250, 121 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 268, 667, 403, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 199, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 225, 748, 369, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 406, 57, 552, 69 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 251, 709, 288, 717 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 37, 699, 78, 707 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 160, 668, 227, 676 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 164, 657, 238, 665 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 168, 626, 249, 634 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 184, 615, 255, 623 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 256, 605, 288, 613 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 594, 55, 602 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 118, 511, 199, 519 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 40, 479, 110, 487 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 97, 448, 235, 456 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 62, 396, 118, 404 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 97, 375, 159, 383 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 40, 291, 110, 299 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 259, 270, 288, 278 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 260, 76, 268 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 119, 239, 183, 247 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 258, 81, 288, 89 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 37, 71, 55, 79 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 66, 60, 148, 68 Flags: Print Destination: null Annotation: Subtype: Link Rect: 397, 647, 454, 655 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 480, 647, 505, 655 Flags: Print Destination: null Annotation: Subtype: Link Rect: 354, 594, 411, 602 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 553, 330, 561 Flags: Print Destination: null Annotation: Subtype: Link Rect: 347, 458, 408, 466 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 509, 322, 557, 330 Flags: Print Annotation: Subtype: Link Rect: 306, 312, 342, 320 Flags: Print Annotation: Subtype: Link Rect: 309, 113, 378, 121 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 349, 60, 416, 68 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 430, 60, 520, 68 Flags: Print Destination: 287 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 241, 552, 288, 560 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 37, 542, 55, 550 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 146, 343, 210, 351 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 448, 730, 518, 738 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 523, 699, 557, 707 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 306, 689, 375, 696 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 451, 636, 545, 644 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 362, 238, 472, 246 Flags: Print Annotation: Subtype: Link Rect: 385, 207, 484, 215 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 536, 196, 557, 204 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 186, 348, 194 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 345, 154, 446, 162 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 437, 102, 536, 110 Flags: Print Destination: 287 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 207, 584, 288, 592 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 573, 55, 581 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 156, 398, 217, 406 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 171, 304, 232, 312 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 403, 657, 460, 665 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 447, 573, 467, 581 Flags: Print Destination: 58 Annotation: Subtype: Link Rect: 464, 479, 530, 487 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 469, 333, 477 Flags: Print Destination: null Annotation: Subtype: Link Rect: 410, 448, 485, 456 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 495, 448, 557, 456 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 437, 324, 445 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 340, 406, 411, 414 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 322, 333, 343, 341 Flags: Print Destination: 79 Page: Label: 5 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 203, 725, 223, 733 Flags: Print Destination: 79 Annotation: Subtype: Link Rect: 468, 720, 529, 728 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 186, 155, 246, 162 Flags: Print Destination: 240 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 40, 242, 62, 250 Flags: Print Destination: 79 Annotation: Subtype: Link Rect: 49, 133, 104, 141 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 249, 123, 288, 131 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 37, 113, 111, 121 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 264, 92, 288, 100 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 37, 81, 122, 89 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 86, 60, 193, 68 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 268, 60, 288, 68 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 40, 50, 60, 58 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 377, 232, 398, 240 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 309, 211, 329, 219 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 334, 201, 440, 209 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 445, 180, 552, 188 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 533, 107, 557, 114 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 306, 96, 393, 104 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 441, 86, 516, 94 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 309, 65, 385, 73 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 390, 65, 493, 73 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 439, 54, 540, 62 Flags: Print Destination: 287 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 197, 699, 266, 707 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 431, 730, 497, 738 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 423, 699, 445, 707 Flags: Print Destination: null Annotation: Subtype: Link Rect: 535, 689, 557, 696 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 306, 678, 345, 686 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 425, 668, 445, 676 Flags: Print Destination: 86 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 90, 720, 109, 728 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 83, 709, 157, 717 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 123, 668, 143, 676 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 359, 689, 413, 696 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 401, 668, 459, 676 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 626, 325, 634 Flags: Print Destination: 123 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 37, 689, 57, 696 Flags: Print Destination: 123 Annotation: Subtype: Link Rect: 139, 657, 233, 665 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 147, 605, 167, 613 Flags: Print Destination: 123 Annotation: Subtype: Link Rect: 126, 584, 146, 592 Flags: Print Destination: 123 Annotation: Subtype: Link Rect: 228, 469, 248, 477 Flags: Print Destination: 123 Annotation: Subtype: Link Rect: 158, 437, 178, 445 Flags: Print Destination: 123 Annotation: Subtype: Link Rect: 84, 417, 104, 425 Flags: Print Destination: 123 Annotation: Subtype: Link Rect: 154, 351, 221, 359 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 157, 309, 231, 317 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 40, 288, 63, 296 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 87, 288, 91, 296 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 255, 267, 288, 275 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 257, 55, 265 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 454, 709, 557, 717 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 699, 350, 707 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 386, 678, 406, 686 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 406, 668, 426, 676 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 438, 647, 463, 655 Flags: Print Destination: null Annotation: Subtype: Link Rect: 542, 615, 557, 623 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 605, 346, 613 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 400, 542, 420, 550 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 464, 532, 485, 540 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 517, 511, 537, 519 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 507, 479, 536, 487 Flags: Print Destination: null Annotation: Subtype: Link Rect: 374, 448, 404, 456 Flags: Print Destination: null Annotation: Subtype: Link Rect: 471, 417, 490, 425 Flags: Print Destination: 185 Annotation: Subtype: Link Rect: 445, 396, 466, 404 Flags: Print Destination: 185 Annotation: Subtype: Link Rect: 415, 364, 436, 372 Flags: Print Destination: 185 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 444, 135, 499, 143 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 465, 103, 538, 111 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 503, 61, 557, 69 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 306, 51, 324, 59 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 347, 51, 406, 59 Flags: Print Destination: 240 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 182, 730, 250, 738 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 40, 709, 101, 717 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 239, 657, 288, 665 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 647, 55, 655 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 79, 647, 137, 655 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 104, 573, 288, 581 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 563, 78, 571 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 246, 521, 270, 529 Flags: Print Destination: null Annotation: Subtype: Link Rect: 250, 511, 288, 519 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 500, 55, 508 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 228, 427, 283, 435 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 210, 375, 283, 383 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 190, 354, 240, 362 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 256, 343, 288, 351 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 37, 333, 77, 341 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 71, 312, 138, 320 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 79, 291, 138, 299 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 203, 260, 288, 268 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 37, 249, 129, 257 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 107, 207, 185, 215 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 96, 176, 173, 184 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 155, 113, 219, 121 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 234, 50, 288, 58 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 730, 324, 738 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 386, 720, 452, 728 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 537, 678, 557, 686 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 306, 668, 348, 676 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 341, 605, 400, 613 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 458, 584, 530, 592 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 309, 521, 381, 529 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 361, 396, 413, 404 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 430, 364, 516, 372 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 476, 312, 529, 320 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 390, 197, 472, 205 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 416, 134, 501, 142 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 366, 82, 438, 90 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 372, 50, 457, 58 Flags: Print Destination: 287 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 40, 647, 108, 655 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 162, 615, 233, 623 Flags: Print Destination: 287 Annotation: Subtype: Link Rect: 236, 563, 288, 571 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 37, 553, 55, 561 Flags: Print Destination: 240 Annotation: Subtype: Link Rect: 517, 605, 557, 613 Flags: Print Annotation: Subtype: Link Rect: 306, 594, 372, 602 Flags: Print Annotation: Subtype: Link Rect: 325, 532, 356, 540 Flags: Print Destination: 58 Annotation: Subtype: Link Rect: 428, 532, 451, 540 Flags: Print Destination: null Annotation: Subtype: Link Rect: 368, 427, 504, 435 Flags: Print Annotation: Subtype: Link Rect: 495, 380, 541, 387 Flags: Print Annotation: Subtype: Link Rect: 318, 372, 434, 379 Flags: Print Annotation: Subtype: Link Rect: 354, 348, 469, 355 Flags: Print Annotation: Subtype: Link Rect: 409, 324, 514, 331 Flags: Print Annotation: Subtype: Link Rect: 385, 300, 510, 307 Flags: Print Annotation: Subtype: Link Rect: 347, 277, 463, 283 Flags: Print Annotation: Subtype: Link Rect: 318, 245, 421, 251 Flags: Print Annotation: Subtype: Link Rect: 459, 229, 535, 235 Flags: Print Annotation: Subtype: Link Rect: 318, 221, 363, 227 Flags: Print Annotation: Subtype: Link Rect: 318, 205, 437, 211 Flags: Print Annotation: Subtype: Link Rect: 349, 181, 483, 187 Flags: Print Annotation: Subtype: Link Rect: 522, 165, 555, 171 Flags: Print Annotation: Subtype: Link Rect: 318, 157, 397, 163 Flags: Print Annotation: Subtype: Link Rect: 461, 141, 555, 147 Flags: Print Annotation: Subtype: Link Rect: 318, 133, 356, 139 Flags: Print Annotation: Subtype: Link Rect: 480, 109, 555, 116 Flags: Print Annotation: Subtype: Link Rect: 318, 101, 386, 108 Flags: Print Annotation: Subtype: Link Rect: 378, 77, 499, 84 Flags: Print Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 207, 732, 283, 738 Flags: Print Annotation: Subtype: Link Rect: 49, 724, 128, 730 Flags: Print Annotation: Subtype: Link Rect: 189, 708, 265, 714 Flags: Print Annotation: Subtype: Link Rect: 49, 700, 129, 706 Flags: Print Annotation: Subtype: Link Rect: 241, 684, 286, 690 Flags: Print Annotation: Subtype: Link Rect: 49, 676, 126, 682 Flags: Print Annotation: Subtype: Link Rect: 184, 660, 278, 666 Flags: Print Annotation: Subtype: Link Rect: 49, 652, 82, 658 Flags: Print Annotation: Subtype: Link Rect: 159, 628, 277, 635 Flags: Print Annotation: Subtype: Link Rect: 49, 620, 73, 627 Flags: Print Annotation: Subtype: Link Rect: 73, 596, 178, 603 Flags: Print Annotation: Subtype: Link Rect: 247, 580, 280, 587 Flags: Print Annotation: Subtype: Link Rect: 49, 572, 147, 579 Flags: Print Annotation: Subtype: Link Rect: 100, 557, 203, 563 Flags: Print Annotation: Subtype: Link Rect: 112, 541, 214, 547 Flags: Print Annotation: Subtype: Link Rect: 174, 525, 280, 531 Flags: Print Annotation: Subtype: Link Rect: 49, 517, 74, 523 Flags: Print Annotation: Subtype: Link Rect: 191, 493, 263, 499 Flags: Print Annotation: Subtype: Link Rect: 49, 485, 100, 491 Flags: Print Annotation: Subtype: Link Rect: 176, 469, 248, 475 Flags: Print Annotation: Subtype: Link Rect: 49, 461, 142, 467 Flags: Print Annotation: Subtype: Link Rect: 99, 437, 202, 443 Flags: Print Annotation: Subtype: Link Rect: 119, 413, 241, 419 Flags: Print Annotation: Subtype: Link Rect: 180, 397, 252, 403 Flags: Print Annotation: Subtype: Link Rect: 49, 389, 100, 396 Flags: Print Annotation: Subtype: Link Rect: 241, 373, 286, 380 Flags: Print Annotation: Subtype: Link Rect: 49, 365, 129, 372 Flags: Print Annotation: Subtype: Link Rect: 128, 341, 256, 348 Flags: Print Annotation: Subtype: Link Rect: 49, 317, 157, 324 Flags: Print Annotation: Subtype: Link Rect: 109, 294, 220, 300 Flags: Print Annotation: Subtype: Link Rect: 263, 278, 285, 284 Flags: Print Annotation: Subtype: Link Rect: 49, 270, 158, 276 Flags: Print Annotation: Subtype: Link Rect: 85, 238, 215, 244 Flags: Print Annotation: Subtype: Link Rect: 361, 716, 483, 722 Flags: Print Annotation: Subtype: Link Rect: 454, 700, 526, 706 Flags: Print Annotation: Subtype: Link Rect: 318, 692, 385, 698 Flags: Print Annotation: Subtype: Link Rect: 409, 676, 535, 682 Flags: Print Annotation: Subtype: Link Rect: 435, 652, 542, 658 Flags: Print Annotation: Subtype: Link Rect: 318, 644, 340, 651 Flags: Print Annotation: Subtype: Link Rect: 482, 628, 554, 635 Flags: Print Annotation: Subtype: Link Rect: 318, 620, 346, 627 Flags: Print Annotation: Subtype: Link Rect: 463, 596, 550, 603 Flags: Print Annotation: Subtype: Link Rect: 318, 588, 342, 595 Flags: Print Annotation: Subtype: Link Rect: 495, 565, 540, 571 Flags: Print Annotation: Subtype: Link Rect: 318, 557, 395, 563 Flags: Print Annotation: Subtype: Link Rect: 418, 533, 537, 539 Flags: Print Annotation: Subtype: Link Rect: 318, 509, 421, 515 Flags: Print Annotation: Subtype: Link Rect: 347, 485, 473, 491 Flags: Print Annotation: Subtype: Link Rect: 413, 469, 527, 475 Flags: Print Annotation: Subtype: Link Rect: 345, 445, 460, 451 Flags: Print Annotation: Subtype: Link Rect: 462, 429, 534, 435 Flags: Print Annotation: Subtype: Link Rect: 318, 421, 353, 427 Flags: Print Annotation: Subtype: Link Rect: 318, 397, 454, 403 Flags: Print Annotation: Subtype: Link Rect: 478, 389, 550, 396 Flags: Print Annotation: Subtype: Link Rect: 318, 381, 372, 388 Flags: Print Annotation: Subtype: Link Rect: 455, 357, 548, 364 Flags: Print Annotation: Subtype: Link Rect: 318, 349, 359, 356 Flags: Print Annotation: Subtype: Link Rect: 441, 333, 513, 340 Flags: Print Annotation: Subtype: Link Rect: 318, 325, 369, 332 Flags: Print Annotation: Subtype: Link Rect: 505, 301, 550, 308 Flags: Print Annotation: Subtype: Link Rect: 318, 294, 372, 300 Flags: Print Annotation: Subtype: Link Rect: 360, 270, 490, 276 Flags: Print Annotation: Subtype: Link Rect: 413, 254, 544, 260 Flags: Print Checksum: 0700e56e Type: CRC32 Checksum: fc90c59b8ee0889af4ac6f60f093e6ab Type: MD5 Checksum: 3f34eab99ef5541cead716b98116cb9c233dec33 Type: SHA-1 Checksum: 0251f4b6d287747d5c439e544c65fe4360523c89856552c59d169d373064c9f0 Type: SHA-256