788b830dae2d0380e67c634e863d176b dyae057.pdf aa3cad6c0dc9573135b0c5c481077c636658b163 dyae057.pdf fad0a680ebdb8c7fa0a428e0121defe600b65bcbef60fcdf779ceb700bceb257 dyae057.pdf Title: Changes in stillbirths and child and youth mortality in 2020 and 2021 during the COVID-19 pandemic Subject: Doi: 10.1093/ije/dyae057 International Journal of Epidemiology, 53, 3, 2024 Publication Date: 13/04/2024 Abstract Background The COVID-19 pandemic has been extensively studied for its impact on mortality, particularly in older age groups. However, the pandemic effects on stillbirths and mortality rates in neonates, infants, children and youth remain poorly understood. This study comprehensively analyses the pandemic influence on young mortality and stillbirths across 112 countries and territories in 2020 and 104 in 2021.Methods Using data from civil registers and vital statistics systems (CRVS) and the Health Management Information System (HMIS), we estimate expected mortality levels in a non-pandemic setting and relative mortality changes (p-scores) through generalized linear models. The analysis focuses on the distribution of country-specific mortality changes and the proportion of countries experiencing deficits, no changes and excess mortality in each age group.Results Results show that stillbirths and under-25 mortality were as expected in most countries during 2020 and 2021. However, among countries with changes, more experienced deficits than excess mortality, except for stillbirths, neonates and those aged 10–24 in 2021, where, despite the predominance of no changes, excess mortality prevailed. Notably, a fifth of examined countries saw increases in stillbirths and a quarter in young adult mortality (20–24) in 2021. Our findings are highly consistent between females and males and similar across income levels.Conclusion Despite global disruptions to essential services, stillbirths and youth mortality were as expected in most observed countries, challenging initial hypotheses. However, the study suggests the possibility of delayed adverse effects that require more time to manifest at the population level. Understanding the lasting impacts of the COVID-19 pandemic requires ongoing, long-term monitoring of health and deaths among children and youth, particularly in low- and lower-middle-income countries. Keywords: COVID-19 pandemic; infant mortality; youth mortality; stillbirths; excess mortality Author: Enrique Acosta Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4667/W Producer: PDFlib+PDI 9.0.7p3 (C++/Win32); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Sat Apr 13 13:24:11 2024 CEST ModDate: Thu May 16 11:40:12 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595 x 842 pts (A4) Page rot: 0 File size: 1217936 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OXUYZV+Verdana-Bold TrueType MacRoman yes yes no 817 0 XHQKDY+Verdana TrueType MacRoman yes yes no 819 0 BKARFL+Verdana-Italic TrueType MacRoman yes yes no 821 0 IAGPJV+SourceSansPro-Regular TrueType MacRoman yes yes no 823 0 UniversLTStd-Cn Type 1 Builtin yes no yes 159 0 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GVPMSL+Univers-Oblique Flags: Nonsymbolic, Italic FontBBox: -178, -273, 1145, 946 FontFile2: true XMP: uuid:ac4cf9fb-e764-0a4b-86ec-62d497a8236c uuid:6B9FB50C-48A5-395F-4C96-595558BB5E8E 2024-04-13T16:54:11+05:30 2024-05-16T11:40:12+02:00 Servigistics Arbortext Advanced Print Publisher 11.1.4667/W 2024-05-16T11:40:12+02:00 PDFlib+PDI 9.0.7p3 (C++/Win32); modified using iTextSharp 4.1.6 by 1T3XT COVID-19 pandemic; infant mortality; youth mortality; stillbirths; excess mortality application/pdf Changes in stillbirths and child and youth mortality in 2020 and 2021 during the COVID-19 pandemic Enrique Acosta Lucia Hug Helena Cruz-Castanheira David Sharrow José Henrique Monteiro da Silva Danzhen You Doi: 10.1093/ije/dyae057 International Journal of Epidemiology, 53, 3, 2024 Publication Date: 13/04/2024 Abstract Background The COVID-19 pandemic has been extensively studied for its impact on mortality, particularly in older age groups. However, the pandemic effects on stillbirths and mortality rates in neonates, infants, children and youth remain poorly understood. This study comprehensively analyses the pandemic influence on young mortality and stillbirths across 112 countries and territories in 2020 and 104 in 2021.Methods Using data from civil registers and vital statistics systems (CRVS) and the Health Management Information System (HMIS), we estimate expected mortality levels in a non-pandemic setting and relative mortality changes (p-scores) through generalized linear models. The analysis focuses on the distribution of country-specific mortality changes and the proportion of countries experiencing deficits, no changes and excess mortality in each age group.Results Results show that stillbirths and under-25 mortality were as expected in most countries during 2020 and 2021. However, among countries with changes, more experienced deficits than excess mortality, except for stillbirths, neonates and those aged 10–24 in 2021, where, despite the predominance of no changes, excess mortality prevailed. Notably, a fifth of examined countries saw increases in stillbirths and a quarter in young adult mortality (20–24) in 2021. Our findings are highly consistent between females and males and similar across income levels.Conclusion Despite global disruptions to essential services, stillbirths and youth mortality were as expected in most observed countries, challenging initial hypotheses. However, the study suggests the possibility of delayed adverse effects that require more time to manifest at the population level. Understanding the lasting impacts of the COVID-19 pandemic requires ongoing, long-term monitoring of health and deaths among children and youth, particularly in low- and lower-middle-income countries. © The Author(s) 2024. 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