beb2ee47e9d4385d7b719fcaa884b53d Global_biogeography_of_microbes_driving.pdf 1bd3a2b016fd4d5531593e5f3a253d6491a5a06b Global_biogeography_of_microbes_driving.pdf 4d5744aadf574324599bd80ecadec7cdfab83d3b97b16a30fad1f15baf769ac8 Global_biogeography_of_microbes_driving.pdf Title: Global biogeography of microbes driving ocean ecological status under climate change Subject: Nature Communications, doi:10.1038/s41467-024-49124-0 Keywords: Author: Zhenyan Zhang Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri May 31 17:07:43 2024 CEST ModDate: Fri May 31 18:26:12 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2838899 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CDFFAD+AdvOT0c200bf0 Type 1C WinAnsi yes yes no 409 0 CDFFDD+AdvOT511ca30e.B Type 1C WinAnsi yes yes no 95 0 CDFDPD+AdvOT13119950 Type 1C WinAnsi yes yes no 97 0 CDFDPE+AdvOT89719618 Type 1C WinAnsi yes yes no 98 0 CDFDPF+AdvOTa2fa4214.B Type 1C WinAnsi yes yes no 686 0 CDFEOB+AdvOTdd63dae3 Type 1C WinAnsi yes yes no 99 0 CDFEOC+AdvOTdd63dae3+fb Type 1C Custom yes yes yes 101 0 CDFEOD+AdvOTdd63dae3+20 Type 1C WinAnsi yes yes no 102 0 CDFFFE+AdvOT70e1938e Type 1C WinAnsi yes yes no 93 0 CDFFFF+AdvOT70e1938e+fb Type 1C Custom yes yes yes 94 0 CDFFFD+AdvOT3d287b35.B Type 1C WinAnsi yes yes no 96 0 CDFFFG+AdvOTcc1f6510.I Type 1C WinAnsi yes yes no 100 0 CDFKHJ+ArialMT Type 1C Custom yes yes yes 126 0 CDFKHK+Arial-ItalicMT Type 1C WinAnsi yes yes no 127 0 CDFGNO+Arial-BoldMT Type 1C WinAnsi yes yes no 128 0 CDFMHO+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 145 0 CDGBMP+AdvOT3d287b35.B+fb Type 1C Custom yes yes yes 225 0 CDHNJH+AdvMacMthSyN Type 1C Custom yes yes yes 337 0 CDHNJF+AdvOTdd63dae3+03 Type 1C Custom yes yes yes 338 0 CDHNJG+AdvOTdd63dae3+22 Type 1C Custom yes yes no 339 0 CDHNMH+AdvP4C4E46 Type 1C Custom yes yes yes 359 0 CDHNPH+AdvOT23e3f5cb.I Type 1C WinAnsi yes yes no 410 0 CDHNPI+AdvOT0c200bf0+20 Type 1C WinAnsi yes yes no 411 0 CDHNPJ+AdvOT0c200bf0+fb Type 1C Custom yes yes yes 412 0 CDHODI+AdvOT13119950+20 Type 1C WinAnsi yes yes no 432 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-05 02:43:49 CEST RepresentationInformation: Global_biogeography_of_microbes_driving.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-06-03 14:36:21 CEST Size: 2838899 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 787 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Global biogeography of microbes driving ocean ecological status under climate’change Destination: title_link Children: Item: Title: Results Destination: A1 Children: Item: Title: Temporal and spatial variation in the ocean microbial communities Destination: B1 Item: Title: Mapping the microbial profiles in the global’ocean Destination: B2 Item: Title: Definition of the ecological status of ocean microbial communities Destination: B3 Item: Title: Changes in ecological status in the future’ocean Destination: B4 Item: Title: Environmental drivers in the alteration of ecological’status Destination: B5 Item: Title: Discussion Destination: A2 Item: Title: Methods Destination: A3 Children: Item: Title: Overview of ocean metagenome samples Destination: B6 Item: Title: Sampling protocol Destination: B7 Item: Title: DNA extraction protocol Destination: B8 Item: Title: Annotation and calculation of the abundance of marker genes and’taxa Destination: B9 Item: Title: Links between microbial profiles and environmental factors Destination: B10 Item: Title: Prediction of each microbial index in the global’ocean Destination: B11 Item: Title: Determining the ecological status of the ocean samples Destination: B12 Item: Title: Construction of a machine learning classifier for ecological’status Destination: B13 Item: Title: Machine learning prediction Destination: B14 Item: Title: Determining the contributions of the environmental factors Destination: B15 Item: Title: Development of the ESpredictor Destination: B16 Item: Title: Statistical analysis and visualization Destination: B17 Item: Title: Reporting summary Destination: B18 Item: Title: Data availability Destination: M1 Item: Title: Code availability Destination: M2 Item: Title: References Destination: A4 Item: Title: Acknowledgements Destination: A5 Item: Title: Author contributions Destination: A6 Item: Title: Competing interests Destination: A7 Item: Title: Additional information Destination: M3 Info: Title: Global biogeography of microbes driving ocean ecological status under climate change Author: Zhenyan Zhang Subject: Nature Communications, doi:10.1038/s41467-024-49124-0 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri May 31 17:37:43 CEST 2024 ModDate: Fri May 31 18:26:12 CEST 2024 ID: 0x8897fb0e1b1bdb43fab5ae189ebfe8d6, 0x03db42143e24ee3fe6ede5b01b80080c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 46 ImageHeight: 40 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 446 ImageHeight: 886 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 617 ImageHeight: 1300 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1986 ImageHeight: 626 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1996 ImageHeight: 2010 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Fonts: Type1: Font: BaseFont: CDFGNO+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: CDFGNO+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFMHO+AdvOT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: CDFMHO+AdvOT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDHNJH+AdvMacMthSyN FontSubset: true FirstChar: 2 LastChar: 240 FontDescriptor: FontName: CDHNJH+AdvMacMthSyN Flags: Symbolic FontBBox: 0, -947, 1239, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDHNJF+AdvOTdd63dae3+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: CDHNJF+AdvOTdd63dae3+03 Flags: Symbolic FontBBox: -156, -197, 833, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDHNJG+AdvOTdd63dae3+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: CDHNJG+AdvOTdd63dae3+22 Flags: Nonsymbolic FontBBox: -62, -250, 1083, 885 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CDFFAD+AdvOT0c200bf0 FontSubset: true FirstChar: 38 LastChar: 246 FontDescriptor: FontName: CDFFAD+AdvOT0c200bf0 Flags: Nonsymbolic FontBBox: -10, -208, 906, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDHNPH+AdvOT23e3f5cb.I FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: CDHNPH+AdvOT23e3f5cb.I Flags: Nonsymbolic FontBBox: -62, -208, 947, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDHNPI+AdvOT0c200bf0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: CDHNPI+AdvOT0c200bf0+20 Flags: Nonsymbolic FontBBox: -229, -104, 1083, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDHNPJ+AdvOT0c200bf0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: CDHNPJ+AdvOT0c200bf0+fb Flags: Symbolic FontBBox: 19, 0, 604, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDFFFE+AdvOT70e1938e FontSubset: true FirstChar: 65 LastChar: 122 FontDescriptor: FontName: CDFFFE+AdvOT70e1938e Flags: Serif, Nonsymbolic FontBBox: -114, -218, 989, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFFFF+AdvOT70e1938e+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: CDFFFF+AdvOT70e1938e+fb Flags: Symbolic FontBBox: 9, 0, 854, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDFFDD+AdvOT511ca30e.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: CDFFDD+AdvOT511ca30e.B Flags: Nonsymbolic FontBBox: -41, -218, 979, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFFFD+AdvOT3d287b35.B FontSubset: true FirstChar: 45 LastChar: 124 FontDescriptor: FontName: CDFFFD+AdvOT3d287b35.B Flags: Serif, Nonsymbolic FontBBox: -125, -218, 1000, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFDPD+AdvOT13119950 FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: CDFDPD+AdvOT13119950 Flags: Nonsymbolic FontBBox: -31, -218, 947, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDGBMP+AdvOT3d287b35.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: CDGBMP+AdvOT3d287b35.B+fb Flags: Symbolic FontBBox: 0, 0, 875, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDFDPE+AdvOT89719618 FontSubset: true FirstChar: 35 LastChar: 124 FontDescriptor: FontName: CDFDPE+AdvOT89719618 Flags: Nonsymbolic FontBBox: -20, -218, 927, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFEOB+AdvOTdd63dae3 FontSubset: true FirstChar: 37 LastChar: 215 FontDescriptor: FontName: CDFEOB+AdvOTdd63dae3 Flags: Serif, Nonsymbolic FontBBox: -93, -218, 979, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFFFG+AdvOTcc1f6510.I FontSubset: true FirstChar: 45 LastChar: 120 FontDescriptor: FontName: CDFFFG+AdvOTcc1f6510.I Flags: Nonsymbolic FontBBox: -218, -218, 1020, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFEOC+AdvOTdd63dae3+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: CDFEOC+AdvOTdd63dae3+fb Flags: Symbolic FontBBox: 19, 0, 812, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDFEOD+AdvOTdd63dae3+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: CDFEOD+AdvOTdd63dae3+20 Flags: Nonsymbolic FontBBox: -197, -125, 1322, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDHNMH+AdvP4C4E46 FontSubset: true FirstChar: 2 LastChar: 80 FontDescriptor: FontName: CDHNMH+AdvP4C4E46 Flags: Symbolic FontBBox: 55, -1000, 999, 0 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDFDPF+AdvOTa2fa4214.B FontSubset: true FirstChar: 71 LastChar: 121 FontDescriptor: FontName: CDFDPF+AdvOTa2fa4214.B Flags: Serif, Nonsymbolic FontBBox: -125, -218, 989, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDHODI+AdvOT13119950+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: CDHODI+AdvOT13119950+20 Flags: Nonsymbolic FontBBox: -229, -104, 1156, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CDFKHJ+ArialMT FontSubset: true FirstChar: 2 LastChar: 176 FontDescriptor: FontName: CDFKHJ+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CDFKHK+Arial-ItalicMT FontSubset: true FirstChar: 32 LastChar: 115 FontDescriptor: FontName: CDFKHK+Arial-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-024-49124-0 Global biogeography of microbes driving ocean ecological status under climate change Zhenyan Zhang Qi Zhang Bingfeng Chen Yitian Yu Tingzhang Wang Nuohan Xu Xiaoji Fan Josep Penuelas Zhengwei Fu Ye Deng Yong-Guan Zhu Haifeng Qian Springer US Nature Communications, doi:10.1038/s41467-024-49124-0 10.1038/s41467-024-49124-0 http://dx.doi.org/10.1038/s41467-024-49124-0 journal Nature Communications © 2024, The Author(s) 2041-1723 10.1038/s41467-024-49124-0 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-024-49124-0 springer.com springerlink.com Springer 2024-05-31T18:26:12+02:00 2024-05-31T20:37:43+05:30 2024-05-31T18:26:12+02:00 True VoR uuid:626b4f60-6df1-4ed7-a101-8a31c9c36b9a uuid:d92f2324-2492-414f-bc6b-a7a697596f14 default 1 converted uuid:32d6a961-667b-4bd7-b541-aa5bc58ad35e converted to PDF/A-2b pdfToolbox 2024-05-31T20:38:41+05:30 2 B Zhenyan Zhang http://orcid.org/0000-0002-9122-2391 Josep Penuelas http://orcid.org/0000-0002-7215-0150 Ye Deng http://orcid.org/0000-0002-7584-0632 Yong-Guan Zhu http://orcid.org/0000-0003-3861-8482 Haifeng Qian http://orcid.org/0000-0003-0807-9991 http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the ORCID of an author. orcid URI Gives the name of an author. name Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 283, 552, 285, 561 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 283, 552, 285, 561 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 292, 550, 293, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 283, 550, 292, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 292, 550, 293, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 394, 539, 396, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 394, 539, 396, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 403, 538, 404, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 395, 538, 403, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 403, 538, 405, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 539, 521, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 539, 521, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 529, 538, 530, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 538, 529, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 529, 538, 530, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 284, 527, 285, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 284, 527, 285, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 293, 525, 294, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 284, 525, 293, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 293, 525, 294, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 527, 372, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 527, 372, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 380, 525, 381, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 525, 380, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 380, 525, 381, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 290, 191, 292, 196 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 65, 148, 67, 153 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 70, 148, 73, 153 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 486, 191, 488, 196 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 489, 191, 492, 196 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 350, 159, 353, 164 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: -2, 479, 50, 511 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 38, 486, 50, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 38, 490, 40, 500 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 38, 490, 40, 500 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 262, 48, 327, 55 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 242, 726, 245, 731 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 246, 726, 249, 731 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 164, 705, 167, 710 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 168, 705, 173, 710 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 168, 651, 172, 656 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 193, 630, 198, 635 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 199, 630, 203, 635 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 55, 598, 59, 603 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 60, 598, 65, 603 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 66, 598, 71, 603 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 151, 598, 156, 603 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 157, 598, 162, 603 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 84, 587, 89, 592 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 92, 587, 97, 592 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 107, 544, 111, 549 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 94, 480, 97, 485 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 98, 480, 103, 485 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 104, 480, 110, 485 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 56, 437, 61, 442 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 84, 433, 87, 441 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 61, 373, 64, 378 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 85, 127, 90, 132 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 241, 84, 246, 89 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 139, 69, 142, 77 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 485, 737, 490, 742 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 553, 726, 559, 731 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 334, 716, 339, 721 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 372, 716, 377, 721 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 472, 679, 475, 687 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 426, 626, 429, 634 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 527, 587, 532, 592 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 332, 523, 335, 528 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 336, 523, 341, 528 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 342, 523, 347, 528 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 454, 486, 458, 495 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 328, 416, 333, 421 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 328, 384, 330, 389 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 331, 384, 333, 389 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 334, 384, 337, 389 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 452, 298, 457, 303 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 459, 298, 463, 303 Flags: Print AppearanceDictionary: true Destination: 363 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 229, 191, 235, 196 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 219, 169, 222, 174 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 223, 169, 228, 174 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 229, 169, 235, 174 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 88, 95, 93, 99 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 94, 95, 99, 99 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 347, 176, 351, 184 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 358, 165, 362, 173 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 338, 127, 343, 132 Flags: Print AppearanceDictionary: true Destination: 363 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 170, 197, 175, 206 Flags: Print AppearanceDictionary: true Destination: 139 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 221, 534, 227, 539 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 68, 512, 72, 517 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 73, 512, 78, 517 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 79, 512, 84, 517 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 129, 459, 135, 464 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 151, 390, 155, 398 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 187, 347, 192, 355 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 80, 319, 84, 324 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 58, 294, 62, 302 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 184, 272, 188, 281 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 58, 251, 62, 259 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 107, 219, 112, 227 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 90, 90, 94, 98 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 57, 58, 62, 66 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 360, 726, 365, 731 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 447, 726, 452, 731 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 534, 726, 540, 731 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 399, 662, 403, 667 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 405, 662, 409, 667 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 340, 651, 344, 656 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 341, 561, 346, 570 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 398, 384, 402, 389 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 403, 384, 407, 389 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 405, 352, 409, 356 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 410, 352, 415, 356 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 477, 315, 481, 323 Flags: Print AppearanceDictionary: true Destination: 233 Annotation: Subtype: Link Rect: 522, 294, 527, 302 Flags: Print AppearanceDictionary: true Destination: 233 Annotation: Subtype: Link Rect: 343, 234, 348, 239 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 505, 202, 511, 207 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 348, 137, 353, 142 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 354, 137, 359, 142 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 360, 137, 366, 142 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 474, 95, 479, 99 Flags: Print AppearanceDictionary: true Destination: 363 Thumb: true Page: Label: 6 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 72, 437, 78, 442 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 79, 437, 84, 442 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 86, 437, 91, 442 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 93, 437, 98, 442 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 219, 394, 221, 399 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 223, 394, 225, 399 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 227, 394, 230, 399 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 275, 309, 281, 314 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 151, 287, 157, 292 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 137, 277, 143, 281 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 160, 112, 294, 120 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 101, 74, 109 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 394, 416, 399, 421 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 400, 416, 406, 421 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 448, 405, 454, 410 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 375, 362, 380, 367 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 553, 362, 559, 367 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 554, 309, 559, 314 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 536, 277, 542, 281 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 512, 52, 516, 57 Flags: Print AppearanceDictionary: true Destination: 363 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 209, 733, 213, 741 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 195, 619, 200, 624 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 115, 598, 120, 603 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 183, 555, 188, 560 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 120, 405, 126, 410 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 113, 394, 117, 399 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 290, 223, 292, 228 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 52, 180, 58, 185 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 154, 165, 291, 173 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 89, 148, 95, 153 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 117, 116, 122, 121 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 281, 105, 285, 110 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 222, 69, 294, 77 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 58, 158, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 161, 62, 166, 67 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 238, 52, 243, 57 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 485, 587, 490, 592 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 436, 576, 442, 581 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 328, 491, 333, 496 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 554, 405, 559, 410 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 332, 341, 335, 346 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 336, 341, 341, 346 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 342, 341, 347, 346 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 481, 287, 486, 292 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 336, 223, 341, 228 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 460, 169, 465, 174 Flags: Print AppearanceDictionary: true Destination: 413 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 127, 501, 132, 506 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 391, 619, 396, 624 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 422, 469, 427, 474 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 472, 394, 477, 399 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 410, 294, 414, 302 Flags: Print AppearanceDictionary: true Destination: 343 Annotation: Subtype: Link Rect: 342, 69, 556, 77 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 267, 722, 294, 730 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 711, 181, 720 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 508, 71, 516 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 191, 469, 197, 474 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 159, 454, 164, 463 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 42, 422, 285, 430 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 412, 49, 420 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 235, 330, 240, 335 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 160, 283, 294, 291 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 272, 74, 281 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 253, 262, 294, 270 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 251, 178, 259 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 238, 240, 294, 248 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 229, 162, 238 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 241, 187, 294, 195 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 176, 177, 184 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 177, 180, 182, 185 Flags: Print AppearanceDictionary: true Destination: 413 Annotation: Subtype: Link Rect: 160, 165, 294, 173 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 154, 74, 163 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 407, 101, 546, 109 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 90, 340, 98 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 85, 155, 232, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 630, 477, 635 Flags: Print AppearanceDictionary: true Destination: 363 Annotation: Subtype: Link Rect: 549, 604, 554, 612 Flags: Print AppearanceDictionary: true Destination: 221 Annotation: Subtype: Link Rect: 383, 572, 559, 580 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 561, 367, 569 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 208, 465, 216 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 101, 421, 109 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 189, 615, 294, 623 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 604, 98, 612 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 86fe52b4 Type: CRC32 Checksum: beb2ee47e9d4385d7b719fcaa884b53d Type: MD5 Checksum: 1bd3a2b016fd4d5531593e5f3a253d6491a5a06b Type: SHA-1 Checksum: 4d5744aadf574324599bd80ecadec7cdfab83d3b97b16a30fad1f15baf769ac8 Type: SHA-256