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Title:           Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
Subject:         Nature Communications, doi:10.1038/s41467-024-48569-7
Keywords:        
Author:          Sook Wah Yee
Creator:         Springer
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     Item: 
      Title: Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Human SLC22A10’showed no expression on the plasma membrane and no transporter activity of prototypical anionic substrates of SLC22 family members
          Destination: B1
         Item: 
          Title: The long isoform of chimpanzee and gorilla SLC22A10 was expressed on the plasma membrane whereas the short isoform was’not
          Destination: B2
         Item: 
          Title: Chimpanzee and gorilla SLC22A10 expressing the long isoform transport estradiol glucuronide but not other anions that are canonical substrates of members in the SLC22A’family
          Destination: B3
         Item: 
          Title: The SLC22A10 protein in humans consists of 541 amino acids, resulting from a single nucleotide insertion that causes a frameshift in the last’exon
          Destination: B4
         Item: 
          Title: Mutagenesis of a single amino acid, at position 220 of the human SLC22A10 ortholog, to the respective amino acid in great apes rescues the function of human SLC22A10
          Destination: B5
         Item: 
          Title: Human-specific p.Leu220Pro predates the common ancestor of modern humans and Neanderthals
          Destination: B6
         Item: 
          Title: Human and chimpanzee SLC22A10 with Pro220 exhibit lower protein expression compared to orthologs with’Leu220
          Destination: B7
         Item: 
          Title: Human SLC22A10 with Pro220 is predicted to have poor stability compared to orthologs with’Leu220
          Destination: B8
         Item: 
          Title: Analyses of SLC22A10 isoforms in chimpanzee, bonobo, orangutan and’gibbon
          Destination: B9
         Item: 
          Title: Uptake of various steroid glucuronides by chimpanzee SLC22A10 reveals that 17β-glucuronides are preferred over 3α-glucuronide conjugates
          Destination: B10
         Item: 
          Title: Chimpanzee SLC22A10-mediated uptake is sodium independent, pH independent, and trans-stimulated by glutaric’acid
          Destination: B11
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Generation of SLC22A10 ortholog cDNA constructs
          Destination: B12
         Item: 
          Title: Site-directed mutagenesis
          Destination: B13
         Item: 
          Title: Cell culture
          Destination: B14
         Item: 
          Title: Generation of cells transiently or stably expressing’cDNAs
          Destination: B15
         Item: 
          Title: Fluorescence microscopy
          Destination: B16
         Item: 
          Title: Transporter uptake studies
          Destination: B17
         Item: 
          Title: Kinetic studies of estradiol glucuronide
          Destination: B18
         Item: 
          Title: Protein extraction and global proteomics of HEK293 cells expressing SLC22A10 orthologs
          Destination: B19
         Item: 
          Title: RNA isolation and quantitative RT-PCR
          Destination: B20
         Item: 
          Title: Cloning of SLC22A10 in pooled human’liver
          Destination: B21
         Item: 
          Title: Calculating ΔΔG with the PRISM’s rosettaddGpipelne v 0.2.421 using Rosetta’v 3.15
          Destination: B22
         Item: 
          Title: Flow cytometry analysis
          Destination: B23
         Item: 
          Title: Transporter uptake studies and LC-MS/MS analysis
          Destination: B24
         Item: 
          Title: Sequencing data processing and analyses of SLC22A10 in greater’apes
          Destination: B25
         Item: 
          Title: SLC22A10 variants in archaic hominins and ancient’humans
          Destination: B26
         Item: 
          Title: Statistical analysis
          Destination: B27
         Item: 
          Title: Reporting summary
          Destination: B28
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: Code availability
        Destination: M2
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: Additional information
        Destination: M3
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