43bf7a6362bd02e5d393ac1d39e1f17b 293367.pdf 4784a5ed76834f4fe36c167e75d2ac6aa0da9dec 293367.pdf 22969e436c9de61bfcd3023e11cde6fdf8c74d24e84374485a6d88343bddf68a 293367.pdf Title: Trends in Targeted Therapy Usage in Inflammatory Bowel Disease: TRENDY Study of ENEIDA Subject: Markers that allow for the selection of tailored treatments for individual patients with inflammatory bowel diseases (IBD) are yet to be identified. Our aim was to describe trends in real-life treatment usage. For this purpose, patients from the ENEIDA registry who received their first targeted IBD treatment (biologics or tofacitinib) between 2015 and 2021 were included. A subsequent analysis with Machine Learning models was performed. The study included 10,009 patients [71% with Crohn’s disease (CD) and 29% with ulcerative colitis (UC)]. In CD, anti-TNF (predominantly adalimumab) were the main agents in the 1st line of treatment (LoT), although their use declined over time. In UC, anti-TNF (mainly infliximab) use was predominant in 1st LoT, remaining stable over time. Ustekinumab and vedolizumab were the most prescribed drugs in 2nd and 3rd LoT in CD and UC, respectively. Overall, the use of biosimilars increased over time. Machine Learning failed to identify a model capable of predicting treatment patterns. In conclusion, drug positioning is different in CD and UC. Anti-TNF were the most used drugs in IBD 1st LoT, being adalimumab predominant in CD and infliximab in UC. Ustekinumab and vedolizumab have gained importance in CD and UC, respectively. The approval of biosimilars had a significant impact on treatment. Keywords: biologics; biosimilars; targeted therapy; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; trends; positioning Author: Celia Gómez-Labrador, Elena Ricart, Marisa Iborra, Eva Iglesias, María Dolores Martín-Arranz, Luisa de Castro, Ruth De Francisco, Francisco Javier García-Alonso, Ana Sanahuja, Carla J. Gargallo-Puyuelo, Francisco Mesonero, María José Casanova, Míriam Mañosa, Montserrat Rivero, Marta Calvo, Mónica Sierra-Ausin, Carlos González-Muñoza, Xavier Calvet, Santiago García-López, Jordi Guardiola, Lara Arias García, Lucía Márquez-Mosquera, Ana Gutiérrez, Yamile Zabana, Mercè Navarro-Llavat, Rufo Lorente Poyatos, Marta Piqueras, Leyanira Torrealba, Fernando Bermejo, Ángel Ponferrada-Díaz, José L. Pérez-Calle, Manuel Barreiro-de Acosta, Coral Tejido, José Luis Cabriada, Ignacio Marín-Jiménez, Óscar Roncero, Yolanda Ber, Luis Fernández-Salazar, Blau Camps Aler, Alfredo J. Lucendo, Jordina Llaó, Luis Bujanda, Carmen Muñoz Villafranca, Eugeni Domènech, María Chaparro and Javier P. Gisbert Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed May 8 11:00:01 2024 CEST ModDate: Wed May 8 11:31:06 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2305622 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XJLJSW+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 VYGGST+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 AQPCJP+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 KMBWIZ+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 XNWNGU+VnURWPalladioL Type 1 Custom yes yes no 28 0 IAFAOG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 74 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 84 0 HEBPPG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 98 0 HEBPPH+PalatinoLinotype CID TrueType Identity-H yes yes yes 101 0 HEBPPI+PalatinoLinotype TrueType WinAnsi yes yes no 107 0 HECAAJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 110 0 HECBAF+PalatinoLinotype TrueType MacRoman yes yes no 113 0 HECDEL+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 127 0 HEBPPG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 130 0 HEBPPH+PalatinoLinotype CID TrueType Identity-H yes yes yes 133 0 HEBPPI+PalatinoLinotype TrueType WinAnsi yes yes no 139 0 HECAAJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 142 0 FMFKGA+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 159 0 FMFHAL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 162 0 FMFHAM+PalatinoLinotype CID TrueType Identity-H yes yes yes 165 0 FMFHAN+PalatinoLinotype TrueType WinAnsi yes yes no 171 0 FMFHAP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 174 0 FMFHLN+PalatinoLinotype TrueType MacRoman yes yes no 177 0 FMFHAL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 191 0 FMFHAM+PalatinoLinotype CID TrueType Identity-H yes yes yes 194 0 FMFHAN+PalatinoLinotype TrueType WinAnsi yes yes no 200 0 FMFHAP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 203 0 FMFHLN+PalatinoLinotype TrueType MacRoman yes yes no 206 0 KGSZMU+VnURWPalladioL-Italic Type 1 Custom yes yes no 229 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-05 02:43:42 CEST RepresentationInformation: 293367.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-06-04 13:58:28 CEST Size: 2305622 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 415 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design and Population Destination: subsection.2.1 Item: Title: Data Collection Destination: subsection.2.2 Item: Title: Definitions Destination: subsection.2.3 Children: Item: Title: Targeted Therapies and Immunomodulatory Treatments Destination: subsubsection.2.3.1 Item: Title: Change of Line Destination: subsubsection.2.3.2 Item: Title: IASIST Score Destination: subsubsection.2.3.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Baseline Characteristics Destination: subsection.3.1 Item: Title: Crohn’s Disease Destination: subsection.3.2 Children: Item: Title: Patterns of Targeted Therapies by Line of Treatment Destination: subsubsection.3.2.1 Item: Title: Patterns of Therapy Changes in Different Lines of Treatment Destination: subsubsection.3.2.2 Item: Title: Ulcerative Colitis Destination: subsection.3.3 Children: Item: Title: Patterns of Targeted Therapies by Line of Treatment Destination: subsubsection.3.3.1 Item: Title: Patterns of Therapy Changes in Different Lines of Treatment Destination: subsubsection.3.3.2 Item: Title: Trends in Use of Biosimilars Destination: subsection.3.4 Item: Title: Factors Influencing Treatment Choice Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: section.A. Info: Title: Trends in Targeted Therapy Usage in Inflammatory Bowel Disease: TRENDY Study of ENEIDA Author: Celia Gómez-Labrador, Elena Ricart, Marisa Iborra, Eva Iglesias, María Dolores Martín-Arranz, Luisa de Castro, Ruth De Francisco, Francisco Javier García-Alonso, Ana Sanahuja, Carla J. Gargallo-Puyuelo, Francisco Mesonero, María José Casanova, Míriam Mañosa, Montserrat Rivero, Marta Calvo, Mónica Sierra-Ausin, Carlos González-Muñoza, Xavier Calvet, Santiago García-López, Jordi Guardiola, Lara Arias García, Lucía Márquez-Mosquera, Ana Gutiérrez, Yamile Zabana, Mercè Navarro-Llavat, Rufo Lorente Poyatos, Marta Piqueras, Leyanira Torrealba, Fernando Bermejo, Ángel Ponferrada-Díaz, José L. Pérez-Calle, Manuel Barreiro-de Acosta, Coral Tejido, José Luis Cabriada, Ignacio Marín-Jiménez, Óscar Roncero, Yolanda Ber, Luis Fernández-Salazar, Blau Camps Aler, Alfredo J. Lucendo, Jordina Llaó, Luis Bujanda, Carmen Muñoz Villafranca, Eugeni Domènech, María Chaparro and Javier P. Gisbert Subject: Markers that allow for the selection of tailored treatments for individual patients with inflammatory bowel diseases (IBD) are yet to be identified. Our aim was to describe trends in real-life treatment usage. For this purpose, patients from the ENEIDA registry who received their first targeted IBD treatment (biologics or tofacitinib) between 2015 and 2021 were included. A subsequent analysis with Machine Learning models was performed. The study included 10,009 patients [71% with Crohn’s disease (CD) and 29% with ulcerative colitis (UC)]. In CD, anti-TNF (predominantly adalimumab) were the main agents in the 1st line of treatment (LoT), although their use declined over time. In UC, anti-TNF (mainly infliximab) use was predominant in 1st LoT, remaining stable over time. Ustekinumab and vedolizumab were the most prescribed drugs in 2nd and 3rd LoT in CD and UC, respectively. Overall, the use of biosimilars increased over time. Machine Learning failed to identify a model capable of predicting treatment patterns. In conclusion, drug positioning is different in CD and UC. Anti-TNF were the most used drugs in IBD 1st LoT, being adalimumab predominant in CD and infliximab in UC. Ustekinumab and vedolizumab have gained importance in CD and UC, respectively. The approval of biosimilars had a significant impact on treatment. 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