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DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Severe communication delays are independent of seizure burden and persist despite contemporary treatments in SCN1A+ Dravet syndrome: Insights from the ENVISION natural history study Children: Item: Title: Abstract Item: Title: 1|INTRODUCTION Item: Title: 2|MATERIALS AND METHODS Children: Item: Title: 2.1|Study design and participants Item: Title: 2.2|Clinical assessments Item: Title: 2.3|Statistical methods Item: Title: 3|RESULTS Children: Item: Title: 3.1|Baseline characteristics Item: Title: 3.2|Seizure burden Item: Title: 3.3|ASM use Item: Title: 3.4|Language/communication outcomes Children: Item: Title: 3.4.1|BSID-­III at Baseline Item: Title: 3.4.2|BSID-­III longitudinal evolution in overall cohort Item: Title: 3.4.3|BSID-­III longitudinal evolution by age groups Item: Title: 3.4.4|VABS-­III at Baseline Item: Title: 3.4.5|VABS-­III longitudinal evolution in overall cohort Item: Title: 3.4.6|VABS-­III longitudinal evolution by age groups Item: Title: 3.5|Correlations and predictors Item: Title: 4|DISCUSSION Item: Title: 5|CONCLUSIONS Item: Title: AUTHOR CONTRIBUTIONS Item: Title: ACKNOWLEDGMENTS Item: Title: FUNDING INFORMATION Item: Title: CONFLICT OF INTEREST STATEMENT Item: Title: PATIENT CONSENT STATEMENT Item: Title: CLINICAL TRIAL REGISTRATION Item: Title: REFERENCES Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1822 ImageHeight: 2754 ColorSpace: RGB 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