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Title:           Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock‐in mouse model
Subject:         J of Inher Metab Disea 2024.47:494-508
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     Item: 
      Title: Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes i...
      Destination: atl_JIMD_12702_
      Children: 
       Item: 
        Title: 1  INTRODUCTION
        Destination: HeadingJIMD_12702jimd12702-sec-0001
       Item: 
        Title: 2  RESULTS
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        Children: 
         Item: 
          Title: 2.1  TH stabilization and BH4 assayed by differential scanning fluorimetry (DSF)
          Destination: HeadingJIMD_12702jimd12702-sec-0003
         Item: 
          Title: 2.2  Validation of BH4 in a THD human iPSC-based model
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         Item: 
          Title: 2.3  Effect of oral supplementation of BH4 to Th-Ki mice
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       Item: 
        Title: 3  DISCUSSION
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       Item: 
        Title: 4  MATERIALS AND METHODS
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         Item: 
          Title: 4.1  Antibodies
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         Item: 
          Title: 4.2  DSF assay of binding of BH4 and BH2 to TH
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         Item: 
          Title: 4.3  Description of the THD iPSC lines used in the study
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         Item: 
          Title: 4.4  iPSC differentiation to DA neurons
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          Title: 4.5  Treatment of dopaminergic neurons with BH4
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          Title: 4.6  Protein extraction and Western blotting
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          Title: 4.7  Intracellular dopamine ELISA
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          Title: 4.8  Immunocytochemistry
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          Title: 4.9  Mouse husbandry and genotyping
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          Title: 4.10  BH4 treatment
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          Title: 4.11  Motor function tests
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          Title: 4.12  Data analysis and statistics
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        Title: AUTHOR CONTRIBUTIONS
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       Item: 
        Title: ACKNOWLEDGMENTS
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       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
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       Item: 
        Title: ETHICS STATEMENT
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       Item: 
        Title: INFORMED CONSENT
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       Item: 
        Title: REFERENCES
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   Type: CRC32
  Checksum: 52f46f05375dfe55c7eb046267037c09
   Type: MD5
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   Type: SHA-256