107ec4006fc547dad1b682831854d15c 298691.pdf 816a9f9cca26141e06a20879fba956e0863ace85 298691.pdf 9a0e84d09a736216354bfd93f889a205acfef1a44cfc83d45394cb470bfe918a 298691.pdf Title: The role of basal insulins in the treatment of people with type 2 diabetes and chronic kidney disease: A narrative review Subject: Diabetes Obesity Metabolism 2024.26:1157-1170 Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 11.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Thu Feb 22 07:42:12 2024 CET ModDate: Tue Jul 23 13:02:39 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1047722 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EOLABI+AdvTT6071803a.B Type 1C WinAnsi yes yes no 55 0 EOLAMF+AdvTTa9c1b374 Type 1C WinAnsi yes yes no 56 0 EOLAMG+AdvP4C4E59 Type 1C Custom yes yes yes 100 0 EOLFBM+AdvTTeb5f0e55.I Type 1C WinAnsi yes yes no 187 0 EOLFBN+AdvTTa9c1b374+20 Type 1C Custom yes yes yes 57 0 EOLFEN+AdvTTa9c1b374+22 Type 1C Custom yes yes yes 58 0 Times-Roman Type 1 WinAnsi no no no 5 0 EOLFNL+Arial-BoldMT Type 1C Custom yes yes no 97 0 EOLFNM+ArialMT Type 1C Custom yes yes yes 98 0 EOLFOM+AdvTTfac587ca.B Type 1C WinAnsi yes yes no 99 0 EOLHBG+AdvP4C4E74 Type 1C Custom yes yes no 129 0 Arial-BoldItalicMT Type 1C WinAnsi yes no no 244 0 EOLLKM+AdvTT6071803a.B+20 Type 1C WinAnsi yes yes no 245 0 EOLLLN+AdvOT8b40f9c2.B Type 1C WinAnsi yes yes no 246 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-08-10 02:38:28 CEST RepresentationInformation: 298691.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-08-07 15:46:59 CEST Size: 1047722 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: The role of basal insulins in the treatment of people with type 2 diabetes and chronic kidney disease: A narrative review Destination: atl_DOM_15425_ Children: Item: Title: 1 INTRODUCTION Destination: HeadingDOM_15425dom15425-sec-0001 Item: Title: 2 CHRONIC KIDNEY DISEASE IN TYPE 2 DIABETES: THE BURDEN REMAINS Destination: HeadingDOM_15425dom15425-sec-0002 Item: Title: 3 IMPACT OF CHRONIC KIDNEY DISEASE ON THE RISK OF HYPOGLYCAEMIA Destination: HeadingDOM_15425dom15425-sec-0003 Item: Title: 4 INSULIN USE IN MANAGEMENT OF TYPE 2 DIABETES IN PEOPLE WITH CHRONIC KIDNEY DISEASE Destination: HeadingDOM_15425dom15425-sec-0004 Children: Item: Title: 4.1 Glycaemic assessment in chronic kidney disease Destination: HeadingDOM_15425dom15425-sec-0005 Item: Title: 5 RATIONALE FOR INSULIN THERAPY IN TYPE 2 DIABETES WITH CHRONIC KIDNEY DISEASE Destination: HeadingDOM_15425dom15425-sec-0006 Item: Title: 6 IMPACT OF CHRONIC KIDNEY DISEASE ON INSULIN REQUIREMENTS Destination: HeadingDOM_15425dom15425-sec-0007 Item: Title: 7 BASAL INSULIN THERAPY IN KIDNEY FUNCTION IMPAIRMENT Destination: HeadingDOM_15425dom15425-sec-0008 Children: Item: Title: 7.1 Pharmacokinetic and pharmacodynamic studies Destination: HeadingDOM_15425dom15425-sec-0009 Item: Title: 7.2 Randomized controlled trials data and subanalyses Destination: HeadingDOM_15425dom15425-sec-0010 Item: Title: 7.3 Head-to-head trials of glargine 300U/ml and insulin degludec Destination: HeadingDOM_15425dom15425-sec-0011 Item: Title: 7.4 Real-world evidence Destination: HeadingDOM_15425dom15425-sec-0012 Item: Title: 8 PRACTICAL CONSIDERATIONS FOR INSULIN IN CHRONIC KIDNEY DISEASE AND TYPE 2 DIABETES Destination: HeadingDOM_15425dom15425-sec-0013 Item: Title: 9 CONCLUSION Destination: HeadingDOM_15425dom15425-sec-0014 Item: Title: AUTHOR CONTRIBUTIONS Destination: HeadingDOM_15425dom15425-sec-0015 Item: Title: ACKNOWLEDGMENTS Destination: HeadingDOM_15425dom15425-sec-0016 Item: Title: FUNDING INFORMATION Destination: HeadingDOM_15425dom15425-sec-0017 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: HeadingDOM_15425dom15425-sec-0018 Children: Item: Title: PEER REVIEW Destination: HeadingDOM_15425dom15425-sec-0021 Item: Title: DATA AVAILABILITY STATEMENT Destination: HeadingDOM_15425dom15425-sec-0020 Item: Title: REFERENCES Destination: HeadingDOM_15425dom15425-bibl-00011 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: EOLFNL+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 224 FontDescriptor: FontName: EOLFNL+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true EncodingDictionary: BaseEncoding: MacRomanEncoding Differences: true Font: BaseFont: EOLHBG+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EOLHBG+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: EOLFNM+ArialMT FontSubset: true FirstChar: 2 LastChar: 138 FontDescriptor: FontName: EOLFNM+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOLFOM+AdvTTfac587ca.B FontSubset: true FirstChar: 49 LastChar: 85 FontDescriptor: FontName: EOLFOM+AdvTTfac587ca.B Flags: Nonsymbolic FontBBox: -72, -177, 1062, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOLAMG+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 61 FontDescriptor: FontName: EOLAMG+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Arial-BoldItalicMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldItalicMT Flags: Nonsymbolic, Italic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOLLKM+AdvTT6071803a.B+20 FontSubset: true FirstChar: 134 LastChar: 135 FontDescriptor: FontName: EOLLKM+AdvTT6071803a.B+20 Flags: Nonsymbolic FontBBox: -250, -229, 1218, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOLLLN+AdvOT8b40f9c2.B FontSubset: true FirstChar: 167 LastChar: 167 FontDescriptor: FontName: EOLLLN+AdvOT8b40f9c2.B Flags: Nonsymbolic FontBBox: -62, -208, 979, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOLABI+AdvTT6071803a.B FontSubset: true FirstChar: 44 LastChar: 237 FontDescriptor: FontName: EOLABI+AdvTT6071803a.B Flags: Nonsymbolic FontBBox: -52, -177, 1041, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOLAMF+AdvTTa9c1b374 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: EOLAMF+AdvTTa9c1b374 Flags: Nonsymbolic FontBBox: -41, -177, 1010, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOLFBN+AdvTTa9c1b374+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: EOLFBN+AdvTTa9c1b374+20 Flags: Symbolic FontBBox: -239, -218, 1166, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOLFEN+AdvTTa9c1b374+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EOLFEN+AdvTTa9c1b374+22 Flags: Symbolic FontBBox: 0, -166, 677, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOLFBM+AdvTTeb5f0e55.I FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: EOLFBM+AdvTTeb5f0e55.I Flags: Nonsymbolic FontBBox: -83, -177, 989, 927 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdfdoi:10.1111/dom.15425 10.1111/dom.15425https://doi.org/10.1111/dom.15425 2024-01-15truedom-pubs.onlinelibrary.wiley.com10.1111/dom.15425 dom-pubs.onlinelibrary.wiley.comtrue10.1111/dom.154252024-01-15 VoR Pages: Page: Label: 1157 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 132, 592, 133, 604 Destination: 332 Annotation: Subtype: Link Rect: 132, 597, 145, 610 Destination: 332 Annotation: Subtype: Link Rect: 148, 596, 156, 604 Annotation: Subtype: Link Rect: 297, 592, 298, 604 Destination: 332 Annotation: Subtype: Link Rect: 297, 597, 304, 610 Destination: 332 Annotation: Subtype: Link Rect: 434, 592, 435, 604 Destination: 332 Annotation: Subtype: Link Rect: 434, 597, 455, 610 Destination: 332 Annotation: Subtype: Link Rect: 147, 574, 148, 586 Destination: 332 Annotation: Subtype: Link Rect: 147, 579, 153, 591 Destination: 332 Annotation: Subtype: Link Rect: 285, 574, 286, 586 Destination: 332 Annotation: Subtype: Link Rect: 285, 579, 311, 591 Destination: 332 Annotation: Subtype: Link Rect: 313, 578, 322, 586 Annotation: Subtype: Link Rect: 65, 184, 134, 191 Annotation: Subtype: Link Rect: 205, 62, 350, 69 Annotation: Subtype: Link Rect: 409, 22, 518, 29 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Thumb: true Page: Label: 1158 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 257, 685, 261, 693 Destination: 274 Annotation: Subtype: Link Rect: 284, 659, 288, 667 Destination: 274 Annotation: Subtype: Link Rect: 89, 581, 99, 589 Destination: 274 Annotation: Subtype: Link Rect: 82, 360, 85, 368 Destination: 274 Annotation: Subtype: Link Rect: 199, 347, 203, 355 Destination: 274 Annotation: Subtype: Link Rect: 258, 269, 261, 277 Destination: 274 Annotation: Subtype: Link Rect: 187, 243, 190, 251 Destination: 274 Annotation: Subtype: Link Rect: 65, 204, 69, 212 Destination: 274 Annotation: Subtype: Link Rect: 222, 165, 226, 173 Destination: 274 Annotation: Subtype: Link Rect: 143, 113, 147, 121 Destination: 274 Annotation: Subtype: Link Rect: 284, 87, 288, 95 Destination: 274 Annotation: Subtype: Link Rect: 383, 724, 387, 732 Destination: 274 Annotation: Subtype: Link Rect: 523, 711, 526, 719 Destination: 274 Annotation: Subtype: Link Rect: 492, 685, 496, 693 Destination: 274 Annotation: Subtype: Link Rect: 460, 659, 463, 667 Destination: 274 Annotation: Subtype: Link Rect: 529, 594, 533, 602 Destination: 274 Annotation: Subtype: Link Rect: 510, 555, 532, 563 Destination: 274 Annotation: Subtype: Link Rect: 525, 503, 540, 511 Destination: 274 Annotation: Subtype: Link Rect: 422, 399, 437, 407 Destination: 274 Annotation: Subtype: Link Rect: 542, 386, 549, 394 Destination: 274 Annotation: Subtype: Link Rect: 481, 347, 505, 355 Destination: 274 Annotation: Subtype: Link Rect: 464, 282, 488, 290 Destination: 274 Annotation: Subtype: Link Rect: 383, 217, 390, 225 Destination: 297 Annotation: Subtype: Link Rect: 401, 188, 406, 196 Destination: 93 Annotation: Subtype: Link Rect: 350, 165, 374, 173 Destination: 274 Annotation: Subtype: Link Rect: 493, 126, 516, 134 Destination: 274 Annotation: Subtype: Link Rect: 406, 87, 413, 95 Destination: 297 Annotation: Subtype: Link Rect: 424, 61, 431, 69 Destination: 274 Thumb: true Page: Label: 1159 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 174, 503, 180, 511 Destination: 297 Annotation: Subtype: Link Rect: 137, 451, 144, 459 Destination: 297 Annotation: Subtype: Link Rect: 230, 438, 237, 446 Destination: 297 Annotation: Subtype: Link Rect: 123, 256, 127, 264 Destination: 274 Annotation: Subtype: Link Rect: 170, 217, 174, 225 Destination: 274 Annotation: Subtype: Link Rect: 247, 113, 250, 121 Destination: 274 Annotation: Subtype: Link Rect: 112, 87, 119, 95 Destination: 297 Annotation: Subtype: Link Rect: 462, 503, 466, 511 Destination: 274 Annotation: Subtype: Link Rect: 538, 373, 549, 381 Destination: 274 Annotation: Subtype: Link Rect: 453, 308, 469, 316 Destination: 274 Annotation: Subtype: Link Rect: 325, 269, 332, 277 Destination: 297 Annotation: Subtype: Link Rect: 322, 243, 329, 251 Destination: 297 Annotation: Subtype: Link Rect: 429, 230, 444, 238 Destination: 297 Annotation: Subtype: Link Rect: 505, 191, 512, 199 Destination: 297 Annotation: Subtype: Link Rect: 470, 139, 477, 147 Destination: 297 Annotation: Subtype: Link Rect: 489, 87, 504, 95 Destination: 274 Thumb: true Page: Label: 1160 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 121, 711, 128, 719 Destination: 297 Annotation: Subtype: Link Rect: 91, 646, 99, 654 Destination: 274 Annotation: Subtype: Link Rect: 141, 607, 148, 615 Destination: 297 Annotation: Subtype: Link Rect: 86, 555, 89, 563 Destination: 274 Annotation: Subtype: Link Rect: 137, 464, 152, 472 Destination: 297 Annotation: Subtype: Link Rect: 65, 425, 88, 433 Destination: 274 Annotation: Subtype: Link Rect: 115, 412, 122, 420 Destination: 297 Annotation: Subtype: Link Rect: 271, 373, 288, 381 Destination: 297 Annotation: Subtype: Link Rect: 98, 334, 113, 342 Destination: 297 Annotation: Subtype: Link Rect: 228, 295, 235, 303 Destination: 297 Annotation: Subtype: Link Rect: 83, 256, 90, 264 Destination: 297 Annotation: Subtype: Link Rect: 96, 204, 103, 212 Destination: 297 Annotation: Subtype: Link Rect: 128, 165, 135, 173 Destination: 297 Annotation: Subtype: Link Rect: 187, 139, 194, 147 Destination: 297 Annotation: Subtype: Link Rect: 281, 126, 288, 134 Destination: 297 Annotation: Subtype: Link Rect: 252, 100, 259, 108 Destination: 274 Annotation: Subtype: Link Rect: 101, 61, 108, 69 Destination: 274 Annotation: Subtype: Link Rect: 452, 594, 459, 602 Destination: 297 Annotation: Subtype: Link Rect: 396, 568, 403, 576 Destination: 297 Annotation: Subtype: Link Rect: 450, 552, 455, 560 Destination: 163 Annotation: Subtype: Link Rect: 462, 503, 477, 511 Destination: 297 Annotation: Subtype: Link Rect: 360, 477, 366, 485 Destination: 297 Annotation: Subtype: Link Rect: 390, 435, 394, 443 Destination: 184 Annotation: Subtype: Link Rect: 379, 422, 383, 430 Destination: 241 Annotation: Subtype: Link Rect: 388, 269, 395, 277 Destination: 297 Annotation: Subtype: Link Rect: 534, 165, 541, 173 Destination: 297 Annotation: Subtype: Link Rect: 322, 87, 329, 95 Destination: 297 Annotation: Subtype: Link Rect: 375, 48, 381, 56 Destination: 297 Thumb: true Page: Label: 1161 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 81, 243, 87, 251 Destination: 297 Annotation: Subtype: Link Rect: 155, 191, 162, 199 Destination: 297 Annotation: Subtype: Link Rect: 156, 74, 163, 82 Destination: 297 Annotation: Subtype: Link Rect: 389, 282, 395, 290 Destination: 305 Annotation: Subtype: Link Rect: 497, 243, 504, 251 Destination: 305 Annotation: Subtype: Link Rect: 464, 204, 471, 212 Destination: 305 Annotation: Subtype: Link Rect: 475, 165, 482, 173 Destination: 305 Annotation: Subtype: Link Rect: 370, 87, 377, 95 Destination: 305 Annotation: Subtype: Link Rect: 81, 672, 102, 680 Destination: 297 Annotation: Subtype: Link Rect: 134, 637, 151, 645 Destination: 297 Annotation: Subtype: Link Rect: 134, 560, 141, 568 Destination: 297 Annotation: Subtype: Link Rect: 100, 536, 115, 543 Destination: 297 Annotation: Subtype: Link Rect: 105, 448, 126, 456 Destination: 297 Thumb: true Page: Label: 1162 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 84, 669, 91, 676 Destination: 297 Annotation: Subtype: Link Rect: 101, 536, 107, 543 Destination: 297 Annotation: Subtype: Link Rect: 99, 438, 106, 445 Destination: 297 Annotation: Subtype: Link Rect: 77, 172, 91, 179 Destination: 297 Thumb: true Page: Label: 1163 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 97, 469, 104, 477 Destination: 297 Annotation: Subtype: Link Rect: 77, 459, 83, 466 Destination: 297 Annotation: Subtype: Link Rect: 92, 203, 98, 211 Destination: 297 Thumb: true Page: Label: 1164 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 77, 571, 83, 578 Destination: 297 Annotation: Subtype: Link Rect: 96, 389, 103, 396 Destination: 305 Annotation: Subtype: Link Rect: 100, 81, 106, 88 Destination: 305 Thumb: true Page: Label: 1165 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 92, 511, 98, 519 Destination: 305 Annotation: Subtype: Link Rect: 77, 361, 83, 368 Destination: 305 Annotation: Subtype: Link Rect: 91, 210, 98, 218 Destination: 305 Annotation: Subtype: Link Rect: 92, 133, 99, 141 Destination: 305 Thumb: true Page: Label: 1166 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 77, 364, 83, 372 Destination: 305 Annotation: Subtype: Link Rect: 102, 245, 108, 253 Destination: 305 Thumb: true Page: Label: 1167 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 238, 412, 245, 420 Destination: 305 Annotation: Subtype: Link Rect: 170, 373, 177, 381 Destination: 305 Annotation: Subtype: Link Rect: 114, 334, 121, 342 Destination: 305 Annotation: Subtype: Link Rect: 281, 295, 288, 303 Destination: 305 Annotation: Subtype: Link Rect: 186, 217, 193, 225 Destination: 305 Annotation: Subtype: Link Rect: 281, 126, 288, 134 Destination: 297 Annotation: Subtype: Link Rect: 511, 399, 526, 407 Destination: 297 Annotation: Subtype: Link Rect: 353, 360, 368, 368 Destination: 297 Annotation: Subtype: Link Rect: 424, 334, 431, 342 Destination: 305 Annotation: Subtype: Link Rect: 515, 308, 522, 316 Destination: 297 Annotation: Subtype: Link Rect: 490, 217, 497, 225 Destination: 297 Thumb: true Page: Label: 1168 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 240, 71, 288, 79 Annotation: Subtype: Link Rect: 45, 58, 272, 66 Annotation: Subtype: Link Rect: 45, 45, 68, 53 Annotation: Subtype: Link Rect: 347, 658, 356, 666 Annotation: Subtype: Link Rect: 358, 656, 501, 664 Annotation: Subtype: Link Rect: 358, 645, 367, 653 Annotation: Subtype: Link Rect: 369, 643, 512, 651 Thumb: true Page: Label: 1169 Sequence: 13 Thumb: true Page: Label: 1170 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 375, 481, 448, 489 Thumb: true Checksum: 75196967 Type: CRC32 Checksum: 107ec4006fc547dad1b682831854d15c Type: MD5 Checksum: 816a9f9cca26141e06a20879fba956e0863ace85 Type: SHA-1 Checksum: 9a0e84d09a736216354bfd93f889a205acfef1a44cfc83d45394cb470bfe918a Type: SHA-256