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Title:           Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification
Subject:         Translational Research, 264 (2024) 1-14. doi:10.1016/j.trsl.2023.09.004
Keywords:        "Cardiovascular calcification"; "osteogenic differentiation"; "atherosclerosis"; "NOR-1"
Author:          Carme Ballester-Servera
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      Title: Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification
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       Item: 
        Title: INTRODUCTION
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       Item: 
        Title: MATERIALS AND METHODS
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         Item: 
          Title: Human samples
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         Item: 
          Title: VSMC and VICs isolation and culture under osteogenic conditions
          Destination: Head5
         Item: 
          Title: Calcium assessment in cell culture
          Destination: Head6
         Item: 
          Title: Western blotting
          Destination: Head7
         Item: 
          Title: Gene silencing and overexpression in VICs
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         Item: 
          Title: Generation of human IL-6 promoter constructs, and transient transfections and luciferase assays
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         Item: 
          Title: Animal handling
          Destination: Head10
         Item: 
          Title: Ex vivo vascular calcification
          Destination: Head11
         Item: 
          Title: Plasma analysis
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         Item: 
          Title: Oil Red O staining of en face aortas
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         Item: 
          Title: Analysis of macroscopic calcification by near-infrared fluorescence imaging
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         Item: 
          Title: Histology and immunohistochemistry
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          Title: Statistical analysis
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       Item: 
        Title: RESULTS
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         Item: 
          Title: NOR-1 expression is enhanced in calcified human aortic valves
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         Item: 
          Title: NOR-1 is upregulated in calcifying VICs incubated under osteogenic conditions
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         Item: 
          Title: NOR-1 negatively regulates the expression of osteogenic genes in VICs protecting against calcification induced by high-phosphate medium
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         Item: 
          Title: NOR-1 is detected in calcified human atherosclerotic arteries and is upregulated under osteogenic conditions that promotes hVSMC calcification
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         Item: 
          Title: Transgenic overexpression of NOR-1 reduced mVSMC calcification both in vitro and ex vivo
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         Item: 
          Title: Transgenic overexpression of NOR-1 in mVSMC reduced both atherosclerosis and the calcification of the intima of atherosclerotic lesions
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        Title: DISCUSSION
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        Title: Acknowledgments
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       Item: 
        Title: Supplementary materials
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       Item: 
        Title: References
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    Title: Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification
    Author: Carme Ballester-Servera
    Subject: Translational Research, 264 (2024) 1-14. doi:10.1016/j.trsl.2023.09.004
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  Checksum: f9d2a3d5
   Type: CRC32
  Checksum: c93c0724cbbdb0152ccd9aae0765f7b2
   Type: MD5
  Checksum: 4ce3d1418d73f31615ea13b0b9fab1f381cfc918
   Type: SHA-1
  Checksum: 862eb173c40e899be09e7459f86be9f2d8a8801abb86a6efb35ce10d1c22d632
   Type: SHA-256