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Title:           Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
Subject:         DOI: 10.1093/cvr/cvae061; Cardiovascular Research, 120, 7, 2024-03-25.; Abstract:  Aims: Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 on bile acid (BA), lipid profile, and lipoprotein function. Methods and results: Healthy overweight individuals were included in this study. The probiotic intake was associated with a progressive decrease of conjugated BAs in serum, due to the reduction of tauro- and glyco-conjugated forms. Plasma levels of fibroblast growth factor-19 were significantly reduced and correlated with BA changes. The probiotic induced significant changes in serum lipids, with reduction in non-HDL cholesterol (non-HDLc) and LDL cholesterol (L
Keywords:        Small LDL; LDL oxidative capacity; ApoB; Microbiota; Bile acid deconjugation
Author:          Teresa Padro
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      Title: Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans
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        Title: 1. Introduction
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          Title: 2.4 Anthropometric data, blood pressure, serum lipid profile, and other biochemical measurements
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          Title: 2.5 Analysis of BA profile in serum and faeces
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          Title: 2.6 Metabolic profile of lipoproteins, glycoproteins, lipids, and low molecular weight metabolites by 1H-nuclear magnetic resonance
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          Title: 2.10 Microbiota analysis
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          Title: 2.11 Characterization of BSH activity of AB-LIFE strains
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          Title: 2.12 Statistical analysis
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          Title: 3.1 Clinical and biochemical characteristics at baseline and after probiotic intervention
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          Title: 3.2 Effects of the probiotic intervention on BAs
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          Title: 3.3 Effects of the probiotic intervention on FGF-19 plasma levels
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   Type: CRC32
  Checksum: 66df5eeb5b9e3ef6120dabca997b57b6
   Type: MD5
  Checksum: cf6f98e4f4429c3d2e46b66538f05b7acdae122c
   Type: SHA-1
  Checksum: b25335e9b1f331568fca9dadc8f2a08709634c99c14eea24644111794ea125ff
   Type: SHA-256