f86ab87547a07f93640fb2522b4c9e90 299785.pdf 860e4dbda314403c056961c4272e54780ba46920 299785.pdf 17982bcc36247916d206babe01ee7a0286fd794833cc3d973ebca7888d4cfb58 299785.pdf Title: Physicochemical Compatibility of Ceftolozane-Tazobactam with Parenteral Nutrition Subject: Ceftolozane-tazobactam (CT) is used for the treatment of complicated infections and for multidrug-resistant strains of Pseudomonas aeruginosa and extended-spectrum beta-lactamase-producing enterobacteria. In certain cases, simultaneous administration of CT and parenteral nutrition (PN) may be required, but compatibility of Y-site co-administration is unknown. The aim of this study was to analyse the physicochemical compatibility of CT Y-site administered with PN. We evaluated a protocolized PN approach for critical patients in our center. We studied both bolus infusion (2 g ceftolozane/1 g tazobactam in 1 h) and continuous infusion (CI) (6 g ceftolozane/3 g tazobactam) strategies. Samples were visually observed against light, microscopically inspected, and pH was analysed using a pH meter. The mean lipid droplet diameter (MDD) was determined via dynamic light scattering. CT concentration was quantified using HPLC–HRMS. No alterations were observed through visual or microscopic inspection. Changes in pH were 0.2, and changes in osmolarity were less than 5%. MDD remained below 500 nm (284.5 2.1 for bolus CT and 286.8 7.5 for CI CT). CT concentrations at t = 0 h and t = 24 h remained within prespecified parameters in both infusion strategies. CT is physiochemically compatible with PN during simulated Y-site administration at the tested concentration and infusion rates. Keywords: ceftolozane-tazobactam; critical care; parenteral nutrition; PN; compatibility Author: Jan Thomas De Pourcq, Adria Riera, Laura Gras, Noe Garin, Maria Antònia Busquets, Joana Cardenete, Daniel Cardona and Pau Riera Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Jul 5 12:24:00 2024 CEST ModDate: Fri Jul 5 12:39:11 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1360337 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WLFTRW+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 CIQLLF+VnURWPalladioL Type 1 Custom yes yes yes 16 0 YMGGPV+URWPalladioL-Bold Type 1 Custom yes yes yes 21 0 BAKQBJ+URWPalladioL-Roma Type 1 Custom yes yes yes 27 0 PTXRZW+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 PQVFRT+CMSY10 Type 1 Builtin yes yes yes 37 0 VWRBXB+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 53 0 VVSYYB+EURM10 Type 1 Builtin yes yes yes 70 0 MPUDFL+PazoMath Type 1 Builtin yes yes yes 78 0 IPKCGN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 101 0 IPKGCP+ArialMT TrueType WinAnsi yes yes no 107 0 IPKCHO+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 110 0 IPKCNN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 116 0 IPKCNO+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 122 0 IPKCNP+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 125 0 IPKCOA+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 128 0 IPKCPA+PalatinoLinotype-Roman TrueType MacRoman yes yes no 131 0 IPKGBO+SymbolMT CID TrueType Identity-H yes yes yes 134 0 IPKCGN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 150 0 IPKGCP+ArialMT TrueType WinAnsi yes yes no 156 0 IPKCHO+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 159 0 IPKCNN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 165 0 IPKCNO+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 171 0 IPKCNP+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 174 0 IPKCOA+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 177 0 IPKCPA+PalatinoLinotype-Roman TrueType MacRoman yes yes no 180 0 IPKGBO+SymbolMT CID TrueType Identity-H yes yes yes 183 0 IPKCGN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 193 0 IPKGCP+ArialMT TrueType WinAnsi yes yes no 199 0 IPKHJJ+Calibri TrueType WinAnsi yes yes no 202 0 IPKCHO+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 205 0 IPKCNN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 211 0 IPKCNO+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 217 0 IPKCNP+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 220 0 IPKCOA+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 223 0 IPKCPA+PalatinoLinotype-Roman TrueType MacRoman yes yes no 226 0 IPKGBO+SymbolMT CID TrueType Identity-H yes yes yes 229 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-17 02:58:44 CET RepresentationInformation: 299785.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-13 12:22:49 CET Size: 1360337 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 454 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Results Destination: section.2 Children: Item: Title: Physical Stability Destination: subsection.2.1 Item: Title: Chemical Stability Destination: subsection.2.2 Item: Title: Discussion Destination: section.3 Item: Title: Materials and Methods Destination: section.4 Children: Item: Title: General Procedures Destination: subsection.4.1 Item: Title: Composition of PN Emulsions and CT Solutions Destination: subsection.4.2 Item: Title: Simulation of Y-Site Administration Destination: subsection.4.3 Item: Title: Sample Collection, Storage, and Analysis Destination: subsection.4.4 Item: Title: Stability Assessment Destination: subsection.4.5 Item: Title: Data Analysis and Statistics Destination: subsection.4.6 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Physicochemical Compatibility of Ceftolozane-Tazobactam with Parenteral Nutrition Author: Jan Thomas De Pourcq, Adria Riera, Laura Gras, Noe Garin, Maria Antònia Busquets, Joana Cardenete, Daniel Cardona and Pau Riera Subject: Ceftolozane-tazobactam (CT) is used for the treatment of complicated infections and for multidrug-resistant strains of Pseudomonas aeruginosa and extended-spectrum beta-lactamase-producing enterobacteria. In certain cases, simultaneous administration of CT and parenteral nutrition (PN) may be required, but compatibility of Y-site co-administration is unknown. The aim of this study was to analyse the physicochemical compatibility of CT Y-site administered with PN. We evaluated a protocolized PN approach for critical patients in our center. We studied both bolus infusion (2 g ceftolozane/1 g tazobactam in 1 h) and continuous infusion (CI) (6 g ceftolozane/3 g tazobactam) strategies. Samples were visually observed against light, microscopically inspected, and pH was analysed using a pH meter. The mean lipid droplet diameter (MDD) was determined via dynamic light scattering. CT concentration was quantified using HPLC HRMS. No alterations were observed through visual or microscopic inspection. Changes in pH were 0.2, and changes in osmolarity were less than 5%. MDD remained below 500 nm (284.5 2.1 for bolus CT and 286.8 7.5 for CI CT). CT concentrations at t = 0 h and t = 24 h remained within prespecified parameters in both infusion strategies. CT is physiochemically compatible with PN during simulated Y-site administration at the tested concentration and infusion rates. 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