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LastModified: 2024-12-16 11:58:39 CET Size: 2150071 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 576 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study Destination: bmark_1703463020 Children: Item: Title: Introduction Destination: s1 Item: Title: Patients and methods Destination: s2 Children: Item: Title: Patients Destination: s2_1 Item: Title: RNA extraction and quantification Destination: s2_2 Item: Title: Library preparation and small RNA-sequencing of the discovery group Destination: s2_3 Item: Title: Differential expression analysis of the discovery group Destination: s2_4 Item: Title: Prediction of miRNA targets and over-representation analysis of the discovery group Destination: s2_5 Item: Title: Validation by Real-time qPCR of miRNA signatures from plasma in a validation group Destination: s2_6 Item: Title: Validation of miRNAs as biomarkers Destination: s2_7 Item: Title: Results Destination: s3 Children: Item: Title: Clinical characteristics of Cushing’s syndrome patients and controls Destination: s3_1 Item: Title: Identification of differentially expressed miRNAs by small RNA-sequencing Destination: s3_2 Item: Title: Enrichment analysis of miRNA targets and pathways in the context of Cushing’s syndrome Destination: s3_3 Item: Title: Validation of the differentially expressed miRNAs by RT-qPCR Destination: s3_4 Item: Title: Phenotypic characterization of Cushing’s syndrome patients with and without sarcopenia according to miRNA expression Destination: s3_5 Item: Title: miR-28-5p as a phenotypic biomarker of sarcopenia in Cushing’s syndrome Destination: s3_6 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Keywords: microRNA, miR-28-5p, myomiRs, sarcopenia, myopathy, Cushing syndrome ID: 0x80a9793f7455488ffda184a316429aca, 0xc399782a9710684fb66fc1c7c73512df Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1299 ImageHeight: 1310 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1559 ImageHeight: 1039 BitsPerSample: 8 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Pallardo José-Luis García-Giménez Anna Aulinas Luciana Martel-Duguech Susan M. Webb Elena Valassi Seco-Cervera M, Ibáñez-Cabellos JS, Pallardo FV, García-Giménez J-L, Aulinas A, Martel-Duguech L, Webb SM and Valassi E (2024) Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study. Front. Endocrinol. 15:1410080 Copyright © 2024 Seco-Cervera, Ibáñez-Cabellos, Pallardo, García-Giménez, Aulinas, Martel-Duguech, Webb and Valassi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. microRNA miR-28-5p myomiRs sarcopenia myopathy Cushing syndrome Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study microRNA, miR-28-5p, myomiRs, sarcopenia, myopathy, Cushing syndrome True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 460, 706 Annotation: Subtype: Link Rect: 221, 660, 474, 681 Annotation: Subtype: Link Rect: 221, 635, 457, 656 Annotation: Subtype: Link Rect: 221, 610, 452, 631 Annotation: Subtype: Link Rect: 221, 585, 440, 606 Annotation: Subtype: Link Rect: 221, 560, 323, 581 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 519, 127, 526 Annotation: Subtype: Link Rect: 60, 499, 138, 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