0bb8d0bfd474edcbe9ab337276d2b5f6  299788.pdf
79ff1b5fcee6c0dcdd77befbdd0ed81d3f9ae699  299788.pdf
6d172635c0f6637046b3134bf30b494b411733ee5458adbdc6901fffb92737ab  299788.pdf

Title:           Spatial distribution of tumour immune infiltrate predicts outcomes of patients with high-risk soft tissue sarcomas after neoadjuvant chemotherapy
Subject:         eBioMedicine, 106 (2024) 105220. doi:10.1016/j.ebiom.2024.105220
Author:          Sandro Pasquali
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Mon Aug 12 03:16:05 2024 CEST
ModDate:         Mon Aug 12 03:20:14 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           12
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       2211070 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
BBGGJI+AdvOT20212610.B               Type 1C           WinAnsi          yes yes no     951  0
BBGGJJ+AdvOT20212610.B+fb            Type 1C           Custom           yes yes yes    956  0
BBGGJK+AdvOT2867105d.I               Type 1C           WinAnsi          yes yes no     958  0
BBGGJL+AdvstixtSym                   Type 1C           Custom           yes yes yes    962  0
BBGGKL+AdvOT3f9da5b7                 Type 1C           WinAnsi          yes yes no     968  0
BBGGKM+AdvOT3f9da5b7+20              Type 1C           WinAnsi          yes yes no     966  0
BBGGKN+AdvTT0d8bc80f.B               Type 1C           WinAnsi          yes yes no     976  0
BBGGKO+AdvTT0d8bc80f.B+fb            Type 1C           Custom           yes yes yes    971  0
BBGGLP+AdvTTae869a4c                 Type 1C           WinAnsi          yes yes no     974  0
BBGGMA+AdvTTac2dc932                 Type 1C           WinAnsi          yes yes no     980  0
BBGHCP+AdvTTae869a4c+fb              Type 1C           Custom           yes yes yes    625  0
BBGHDA+AdvTTae869a4c+20              Type 1C           WinAnsi          yes yes no     615  0
BBGHEB+AdvOT3f9da5b7+fb              Type 1C           Custom           yes yes yes    617  0
BBGHCO+AdvTT0d8bc80f.B+20            Type 1C           WinAnsi          yes yes no     618  0
BBGNJL+AdvTTb4077e6a                 Type 1C           WinAnsi          yes yes no     628  0
BBIAFJ+AdvOTb0c9bf5d+26              Type 1C           Custom           yes yes yes    647  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-12-18 02:50:01 CET
 RepresentationInformation: 299788.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-12-16 12:12:43 CET
  Size: 2211070
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-122
   Offset: 2175909
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 1061
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Spatial distribution of tumour immune infiltrate predicts outcomes of patients with high-risk soft tissue sarcomas after ne ...
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Methods
        Destination: flink2
        Children: 
         Item: 
          Title: Patients
          Destination: slink1
         Item: 
          Title: Spatial detection and quantification of immune cells
          Destination: slink2
         Item: 
          Title: Statistical analysis
          Destination: slink3
       Item: 
        Title: Results
        Destination: flink3
        Children: 
         Item: 
          Title: Distribution of immune cell infiltrate in STS after NAC
          Destination: slink4
         Item: 
          Title: Identification of prognostic sarcoma immune index scores (SIS) in spatially distinct TMA cores
          Destination: slink5
         Item: 
          Title: Association of the prognostic sarcoma immune index scores (SIS) with patient DFS and OS
          Destination: slink6
       Item: 
        Title: Discussion
        Destination: flink4
       Item: 
        Title: ContributorsStudy conception and design: Pasquali, Vallacchi, Collini, Gronchi.Acquisition, analysis, or interpretation of  ...
        Destination: blink1
       Item: 
        Title: Data sharing statementDeidentified participant data included in this manuscript will be made available to others upon reque ...
        Destination: blink2
       Item: 
        Title: Declaration of interests
        Destination: blink3
       Item: 
        Title: Acknowledgements
        Destination: blink4
       Item: 
        Title: Appendix A. Supplementary data
        Destination: flink5
       Item: 
        Title: References
        Destination: blink5
   Info: 
    Title: Spatial distribution of tumour immune infiltrate predicts outcomes of patients with high-risk soft tissue sarcomas after neoadjuvant chemotherapy
    Author: Sandro Pasquali
    Subject: eBioMedicine, 106 (2024) 105220. doi:10.1016/j.ebiom.2024.105220
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Mon Aug 12 03:46:05 CEST 2024
    ModDate: Mon Aug 12 03:50:14 CEST 2024
   ID: 0xedace7ce979cbccf74de5ded83039e9b, 0xec6a2c17637d494c840aec669b8c4367
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1778
      ImageHeight: 1358
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1776
      ImageHeight: 1572
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1777
      ImageHeight: 1727
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1218
      ImageHeight: 2253
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: BBGGJL+AdvstixtSym
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: BBGGJL+AdvstixtSym
       Flags: Symbolic
       FontBBox: -20, -1114, 1135, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BBGGKM+AdvOT3f9da5b7+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: BBGGKM+AdvOT3f9da5b7+20
       Flags: Nonsymbolic
       FontBBox: -156, -177, 916, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGHDA+AdvTTae869a4c+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: BBGHDA+AdvTTae869a4c+20
       Flags: Nonsymbolic
       FontBBox: -20, -239, 1197, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBIAFJ+AdvOTb0c9bf5d+26
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BBIAFJ+AdvOTb0c9bf5d+26
       Flags: Symbolic
       FontBBox: 59, -66, 810, 655
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BBGGKL+AdvOT3f9da5b7
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: BBGGKL+AdvOT3f9da5b7
       Flags: Nonsymbolic
       FontBBox: -52, -239, 791, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGHEB+AdvOT3f9da5b7+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: BBGHEB+AdvOT3f9da5b7+fb
       Flags: Symbolic
       FontBBox: 0, 0, 697, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BBGHCO+AdvTT0d8bc80f.B+20
      FontSubset: true
      FirstChar: 151
      LastChar: 151
      FontDescriptor: 
       FontName: BBGHCO+AdvTT0d8bc80f.B+20
       Flags: Nonsymbolic
       FontBBox: -20, -239, 1197, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGGKO+AdvTT0d8bc80f.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BBGGKO+AdvTT0d8bc80f.B+fb
       Flags: Symbolic
       FontBBox: 9, -10, 552, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BBGGLP+AdvTTae869a4c
      FontSubset: true
      FirstChar: 35
      LastChar: 233
      FontDescriptor: 
       FontName: BBGGLP+AdvTTae869a4c
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -250, 927, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGGKN+AdvTT0d8bc80f.B
      FontSubset: true
      FirstChar: 35
      LastChar: 215
      FontDescriptor: 
       FontName: BBGGKN+AdvTT0d8bc80f.B
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -250, 947, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGHCP+AdvTTae869a4c+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: BBGHCP+AdvTTae869a4c+fb
       Flags: Symbolic
       FontBBox: 19, -10, 552, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BBGGMA+AdvTTac2dc932
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: BBGGMA+AdvTTac2dc932
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -250, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGNJL+AdvTTb4077e6a
      FontSubset: true
      FirstChar: 46
      LastChar: 108
      FontDescriptor: 
       FontName: BBGNJL+AdvTTb4077e6a
       Flags: Nonsymbolic
       FontBBox: -104, -239, 822, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGGJI+AdvOT20212610.B
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: BBGGJI+AdvOT20212610.B
       Flags: Nonsymbolic
       FontBBox: -52, -239, 833, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBGGJJ+AdvOT20212610.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BBGGJJ+AdvOT20212610.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BBGGJK+AdvOT2867105d.I
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: BBGGJK+AdvOT2867105d.I
       Flags: Serif, Nonsymbolic
       FontBBox: -104, -239, 791, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.ebiom.2024.105220</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Spatial distribution of tumour immune infiltrate predicts outcomes of patients with high-risk soft tissue sarcomas after neoadjuvant chemotherapy</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Sandro Pasquali</rdf:li>
               <rdf:li>Viviana Vallacchi</rdf:li>
               <rdf:li>Luca Lalli</rdf:li>
               <rdf:li>Paola Collini</rdf:li>
               <rdf:li>Marta Barisella</rdf:li>
               <rdf:li>Cleofe Romagosa</rdf:li>
               <rdf:li>Silvia Bague</rdf:li>
               <rdf:li>Jean Michel Coindre</rdf:li>
               <rdf:li>Angelo Paolo Dei Tos</rdf:li>
               <rdf:li>Emanuela Palmerini</rdf:li>
               <rdf:li>Vittorio Quagliuolo</rdf:li>
               <rdf:li>Javier Martin-Broto</rdf:li>
               <rdf:li>Antonio Lopez-Pousa</rdf:li>
               <rdf:li>Giovanni Grignani</rdf:li>
               <rdf:li>Jean-Yves Blay</rdf:li>
               <rdf:li>Robert Diaz Beveridge</rdf:li>
               <rdf:li>Elena Casiraghi</rdf:li>
               <rdf:li>Silvia Brich</rdf:li>
               <rdf:li>Salvatore Lorenzo Renne</rdf:li>
               <rdf:li>Laura Bergamaschi</rdf:li>
               <rdf:li>Barbara Vergani</rdf:li>
               <rdf:li>Marta Sbaraglia</rdf:li>
               <rdf:li>Paolo Giovanni Casali</rdf:li>
               <rdf:li>Licia Rivoltini</rdf:li>
               <rdf:li>Silvia Stacchiotti</rdf:li>
               <rdf:li>Alessandro Gronchi</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Soft tissue sarcomas</rdf:li>
               <rdf:li>Tumour immune microenvironment</rdf:li>
               <rdf:li>Neoadjuvant chemotherapy</rdf:li>
               <rdf:li>Anthracycline</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">eBioMedicine, 106 (2024) 105220. doi:10.1016/j.ebiom.2024.105220</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Author(s)</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>eBioMedicine</prism:publicationName>
         <prism:copyright>© 2024 The Author(s). Published by Elsevier B.V.</prism:copyright>
         <prism:issn>2352-3964</prism:issn>
         <prism:volume>106</prism:volume>
         <prism:coverDisplayDate>August 2024</prism:coverDisplayDate>
         <prism:pageRange>105220</prism:pageRange>
         <prism:startingPage>105220</prism:startingPage>
         <prism:doi>10.1016/j.ebiom.2024.105220</prism:doi>
         <prism:url>https://doi.org/10.1016/j.ebiom.2024.105220</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.ebiom.2024.105220</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <TGji2od3-zgeRn92Gywf8nLNNz92Klt_.mt2GnwmPm9n_z.uLodiPo9eQmMmRm9yLmd2Tma/>
         <pdfx:doi>10.1016/j.ebiom.2024.105220</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2024-08-12T06:46:05+05:30</xap:CreateDate>
         <xap:ModifyDate>2024-08-12T06:50:14+05:30</xap:ModifyDate>
         <xap:MetadataDate>2024-08-12T06:50:14+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:tdm="http://www.w3.org/ns/tdmrep/">
         <tdm:reservation>1</tdm:reservation>
         <tdm:policy>https://www.elsevier.com/tdm/tdmrep-policy.json</tdm:policy>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:6d5e2768-4d2d-4948-a2dc-1145be2ffb99</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:c2a956b6-f6fe-42d1-8871-2820103b9493</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 87, 588, 87, 590
      Annotation: 
       Subtype: Link
       Rect: 88, 589, 91, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 92, 589, 96, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 97, 589, 101, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 153, 588, 153, 590
      Annotation: 
       Subtype: Link
       Rect: 155, 589, 158, 597
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 159, 589, 164, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 193, 588, 193, 590
      Annotation: 
       Subtype: Link
       Rect: 195, 589, 198, 597
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 199, 589, 206, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 244, 588, 244, 590
      Annotation: 
       Subtype: Link
       Rect: 246, 589, 249, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 296, 588, 296, 590
      Annotation: 
       Subtype: Link
       Rect: 297, 589, 301, 597
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 353, 588, 353, 590
      Annotation: 
       Subtype: Link
       Rect: 355, 589, 358, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 396, 588, 396, 590
      Annotation: 
       Subtype: Link
       Rect: 397, 589, 400, 597
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 460, 588, 460, 590
      Annotation: 
       Subtype: Link
       Rect: 462, 589, 465, 595
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 466, 589, 470, 597
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 100, 577, 100, 579
      Annotation: 
       Subtype: Link
       Rect: 101, 578, 103, 585
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 164, 577, 164, 579
      Annotation: 
       Subtype: Link
       Rect: 165, 578, 167, 585
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 224, 577, 224, 579
      Annotation: 
       Subtype: Link
       Rect: 226, 578, 229, 586
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 287, 577, 287, 579
      Annotation: 
       Subtype: Link
       Rect: 288, 578, 290, 586
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 354, 577, 354, 579
      Annotation: 
       Subtype: Link
       Rect: 356, 578, 361, 584
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 416, 577, 416, 579
      Annotation: 
       Subtype: Link
       Rect: 417, 578, 421, 584
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 465, 577, 465, 579
      Annotation: 
       Subtype: Link
       Rect: 466, 578, 470, 584
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 103, 566, 103, 568
      Annotation: 
       Subtype: Link
       Rect: 105, 567, 108, 573
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 155, 566, 155, 568
      Annotation: 
       Subtype: Link
       Rect: 157, 567, 160, 573
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 194, 566, 194, 568
      Annotation: 
       Subtype: Link
       Rect: 196, 567, 199, 573
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 273, 566, 273, 568
      Annotation: 
       Subtype: Link
       Rect: 275, 567, 277, 573
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 278, 567, 281, 573
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 339, 566, 339, 568
      Annotation: 
       Subtype: Link
       Rect: 341, 567, 344, 575
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 394, 566, 394, 568
      Annotation: 
       Subtype: Link
       Rect: 395, 567, 398, 574
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 448, 566, 448, 568
      Annotation: 
       Subtype: Link
       Rect: 449, 567, 451, 574
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 103, 555, 103, 557
      Annotation: 
       Subtype: Link
       Rect: 105, 556, 108, 562
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 149, 555, 149, 557
      Annotation: 
       Subtype: Link
       Rect: 151, 556, 154, 564
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 155, 556, 165, 562
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 217, 555, 217, 557
      Annotation: 
       Subtype: Link
       Rect: 218, 556, 222, 562
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 294, 555, 294, 557
      Annotation: 
       Subtype: Link
       Rect: 294, 556, 297, 562
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 298, 556, 312, 562
       Destination: 848
      Annotation: 
       Subtype: Link
       Rect: 100, 61, 208, 68
      Annotation: 
       Subtype: Link
       Rect: 250, 61, 337, 68
      Annotation: 
       Subtype: Link
       Rect: 367, 61, 466, 68
      Annotation: 
       Subtype: Link
       Rect: 70, 52, 188, 59
      Annotation: 
       Subtype: Link
       Rect: 487, 639, 515, 667
      Annotation: 
       Subtype: Link
       Rect: 487, 232, 540, 239
      Annotation: 
       Subtype: Link
       Rect: 487, 222, 543, 230
      Annotation: 
       Subtype: Link
       Rect: 487, 212, 509, 220
      Annotation: 
       Subtype: Link
       Rect: 39, 12, 96, 19
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 150, 505, 330, 514
      Annotation: 
       Subtype: Link
       Rect: 321, 181, 328, 188
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 258, 148, 260, 155
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 244, 137, 254, 144
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 180, 126, 185, 133
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 305, 126, 310, 133
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 213, 115, 225, 122
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 241, 93, 247, 100
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 248, 93, 253, 100
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 469, 203, 474, 210
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 475, 203, 489, 210
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 488, 203, 489, 212
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 426, 170, 431, 177
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 433, 170, 438, 177
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 438, 170, 438, 179
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 542, 159, 555, 166
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 410, 126, 415, 133
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 417, 126, 430, 133
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 430, 127, 430, 136
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 451, 115, 457, 122
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 457, 116, 457, 125
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 531, 82, 536, 89
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 538, 82, 543, 89
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 543, 83, 543, 92
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 432, 12, 489, 19
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 626, 174, 635
      Annotation: 
       Subtype: Link
       Rect: 169, 608, 174, 614
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 175, 608, 180, 614
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 180, 608, 180, 617
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 75, 542, 79, 549
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 81, 542, 85, 549
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 85, 542, 85, 551
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 39, 527, 128, 536
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 363, 516, 384, 525
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 39, 12, 96, 19
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 243, 608, 248, 614
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 218, 564, 223, 570
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 239, 509, 244, 516
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 536, 608, 541, 614
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 362, 575, 367, 581
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 544, 542, 549, 549
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 550, 542, 555, 549
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 499, 462, 555, 471
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 345, 451, 381, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 401, 451, 428, 460
       Destination: 50
      Annotation: 
       Subtype: Link
       Rect: 348, 374, 369, 383
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 432, 12, 489, 19
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 626, 167, 635
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 192, 626, 249, 635
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 39, 615, 78, 624
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 70, 582, 91, 591
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 212, 549, 238, 558
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 269, 615, 292, 624
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 269, 593, 290, 602
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 269, 527, 365, 536
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 39, 12, 96, 19
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 174, 615, 266, 624
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 227, 593, 325, 602
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 180, 571, 277, 580
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 271, 527, 328, 536
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 118, 516, 153, 525
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 221, 429, 318, 438
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 271, 385, 328, 394
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 118, 374, 156, 383
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 524, 626, 550, 635
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 397, 582, 420, 591
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 419, 494, 515, 503
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 446, 352, 553, 361
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 345, 341, 435, 350
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 514, 264, 537, 273
       Destination: 116
      Annotation: 
       Subtype: Link
       Rect: 345, 177, 442, 186
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 510, 71, 515, 77
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 516, 71, 521, 77
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 432, 12, 489, 19
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 103, 288, 110
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 289, 103, 294, 110
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 39, 12, 96, 19
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 432, 12, 489, 19
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 244, 553, 249, 559
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 66, 465, 71, 472
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 197, 443, 199, 450
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 201, 443, 206, 450
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 207, 443, 212, 450
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 102, 421, 107, 428
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 198, 388, 203, 395
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 63, 366, 68, 373
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 70, 366, 75, 373
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 70, 355, 75, 362
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 454, 509, 460, 516
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 444, 498, 457, 505
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 365, 476, 367, 483
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 369, 476, 374, 483
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 375, 476, 380, 483
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 434, 432, 439, 439
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 314, 377, 317, 384
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 318, 377, 320, 384
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 321, 377, 326, 384
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 327, 377, 332, 384
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 332, 378, 332, 387
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 392, 334, 397, 340
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 397, 334, 397, 343
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 324, 279, 329, 286
       Destination: 569
      Annotation: 
       Subtype: Link
       Rect: 329, 279, 329, 288
       Destination: 569
      Annotation: 
       Subtype: Link
       Rect: 324, 246, 329, 253
       Destination: 569
      Annotation: 
       Subtype: Link
       Rect: 329, 246, 329, 255
       Destination: 569
      Annotation: 
       Subtype: Link
       Rect: 39, 12, 96, 19
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 608, 164, 614
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 165, 608, 170, 614
       Destination: 249
      Annotation: 
       Subtype: Link
       Rect: 172, 608, 177, 614
       Destination: 569
      Annotation: 
       Subtype: Link
       Rect: 177, 608, 177, 617
       Destination: 569
      Annotation: 
       Subtype: Link
       Rect: 522, 396, 555, 403
      Annotation: 
       Subtype: Link
       Rect: 345, 387, 444, 394
      Annotation: 
       Subtype: Link
       Rect: 359, 353, 555, 360
      Annotation: 
       Subtype: Link
       Rect: 359, 345, 555, 352
      Annotation: 
       Subtype: Link
       Rect: 359, 338, 555, 344
      Annotation: 
       Subtype: Link
       Rect: 359, 330, 408, 336
      Annotation: 
       Subtype: Link
       Rect: 359, 322, 555, 329
      Annotation: 
       Subtype: Link
       Rect: 359, 314, 555, 321
      Annotation: 
       Subtype: Link
       Rect: 359, 306, 412, 313
      Annotation: 
       Subtype: Link
       Rect: 359, 298, 555, 305
      Annotation: 
       Subtype: Link
       Rect: 359, 290, 555, 297
      Annotation: 
       Subtype: Link
       Rect: 359, 282, 419, 289
      Annotation: 
       Subtype: Link
       Rect: 359, 274, 555, 281
      Annotation: 
       Subtype: Link
       Rect: 359, 266, 555, 273
      Annotation: 
       Subtype: Link
       Rect: 359, 258, 445, 265
      Annotation: 
       Subtype: Link
       Rect: 359, 250, 555, 257
      Annotation: 
       Subtype: Link
       Rect: 359, 242, 555, 249
      Annotation: 
       Subtype: Link
       Rect: 359, 234, 555, 241
      Annotation: 
       Subtype: Link
       Rect: 359, 226, 380, 233
      Annotation: 
       Subtype: Link
       Rect: 359, 218, 555, 225
      Annotation: 
       Subtype: Link
       Rect: 359, 210, 555, 217
      Annotation: 
       Subtype: Link
       Rect: 359, 202, 555, 209
      Annotation: 
       Subtype: Link
       Rect: 359, 194, 555, 201
      Annotation: 
       Subtype: Link
       Rect: 359, 186, 405, 193
      Annotation: 
       Subtype: Link
       Rect: 359, 178, 555, 185
      Annotation: 
       Subtype: Link
       Rect: 359, 170, 555, 177
      Annotation: 
       Subtype: Link
       Rect: 359, 162, 555, 169
      Annotation: 
       Subtype: Link
       Rect: 359, 154, 370, 161
      Annotation: 
       Subtype: Link
       Rect: 359, 146, 555, 153
      Annotation: 
       Subtype: Link
       Rect: 359, 138, 555, 145
      Annotation: 
       Subtype: Link
       Rect: 359, 130, 472, 137
      Annotation: 
       Subtype: Link
       Rect: 359, 122, 555, 129
      Annotation: 
       Subtype: Link
       Rect: 359, 114, 555, 121
      Annotation: 
       Subtype: Link
       Rect: 359, 106, 555, 113
      Annotation: 
       Subtype: Link
       Rect: 359, 98, 468, 105
      Annotation: 
       Subtype: Link
       Rect: 359, 90, 555, 97
      Annotation: 
       Subtype: Link
       Rect: 359, 82, 555, 89
      Annotation: 
       Subtype: Link
       Rect: 359, 74, 432, 81
      Annotation: 
       Subtype: Link
       Rect: 359, 67, 555, 73
      Annotation: 
       Subtype: Link
       Rect: 359, 59, 555, 65
      Annotation: 
       Subtype: Link
       Rect: 359, 51, 490, 58
      Annotation: 
       Subtype: Link
       Rect: 432, 12, 489, 19
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 53, 661, 249, 668
      Annotation: 
       Subtype: Link
       Rect: 53, 653, 249, 660
      Annotation: 
       Subtype: Link
       Rect: 53, 645, 124, 652
      Annotation: 
       Subtype: Link
       Rect: 53, 637, 249, 644
      Annotation: 
       Subtype: Link
       Rect: 53, 629, 197, 636
      Annotation: 
       Subtype: Link
       Rect: 53, 621, 249, 628
      Annotation: 
       Subtype: Link
       Rect: 53, 613, 249, 620
      Annotation: 
       Subtype: Link
       Rect: 53, 605, 77, 612
      Annotation: 
       Subtype: Link
       Rect: 53, 597, 249, 604
      Annotation: 
       Subtype: Link
       Rect: 53, 589, 150, 596
      Annotation: 
       Subtype: Link
       Rect: 53, 581, 249, 588
      Annotation: 
       Subtype: Link
       Rect: 53, 573, 249, 580
      Annotation: 
       Subtype: Link
       Rect: 53, 565, 249, 572
      Annotation: 
       Subtype: Link
       Rect: 53, 557, 247, 564
      Annotation: 
       Subtype: Link
       Rect: 53, 549, 249, 556
      Annotation: 
       Subtype: Link
       Rect: 53, 541, 249, 548
      Annotation: 
       Subtype: Link
       Rect: 53, 533, 249, 540
      Annotation: 
       Subtype: Link
       Rect: 53, 525, 249, 532
      Annotation: 
       Subtype: Link
       Rect: 53, 517, 184, 524
      Annotation: 
       Subtype: Link
       Rect: 53, 509, 249, 516
      Annotation: 
       Subtype: Link
       Rect: 53, 501, 249, 508
      Annotation: 
       Subtype: Link
       Rect: 53, 493, 249, 500
      Annotation: 
       Subtype: Link
       Rect: 53, 485, 110, 492
      Annotation: 
       Subtype: Link
       Rect: 53, 477, 249, 484
      Annotation: 
       Subtype: Link
       Rect: 53, 469, 249, 476
      Annotation: 
       Subtype: Link
       Rect: 53, 464, 201, 471
      Annotation: 
       Subtype: Link
       Rect: 205, 461, 249, 468
      Annotation: 
       Subtype: Link
       Rect: 53, 453, 109, 460
      Annotation: 
       Subtype: Link
       Rect: 53, 445, 249, 452
      Annotation: 
       Subtype: Link
       Rect: 53, 437, 249, 444
      Annotation: 
       Subtype: Link
       Rect: 53, 430, 249, 436
      Annotation: 
       Subtype: Link
       Rect: 53, 422, 249, 428
      Annotation: 
       Subtype: Link
       Rect: 53, 414, 100, 421
      Annotation: 
       Subtype: Link
       Rect: 53, 406, 249, 413
      Annotation: 
       Subtype: Link
       Rect: 53, 398, 249, 405
      Annotation: 
       Subtype: Link
       Rect: 53, 390, 249, 397
      Annotation: 
       Subtype: Link
       Rect: 53, 382, 91, 389
      Annotation: 
       Subtype: Link
       Rect: 53, 374, 249, 381
      Annotation: 
       Subtype: Link
       Rect: 53, 366, 249, 373
      Annotation: 
       Subtype: Link
       Rect: 53, 358, 163, 365
      Annotation: 
       Subtype: Link
       Rect: 53, 350, 249, 357
      Annotation: 
       Subtype: Link
       Rect: 53, 342, 249, 349
      Annotation: 
       Subtype: Link
       Rect: 53, 334, 133, 341
      Annotation: 
       Subtype: Link
       Rect: 53, 326, 249, 333
      Annotation: 
       Subtype: Link
       Rect: 53, 318, 249, 325
      Annotation: 
       Subtype: Link
       Rect: 53, 310, 249, 317
      Annotation: 
       Subtype: Link
       Rect: 53, 302, 102, 309
      Annotation: 
       Subtype: Link
       Rect: 53, 294, 249, 301
      Annotation: 
       Subtype: Link
       Rect: 53, 286, 249, 293
      Annotation: 
       Subtype: Link
       Rect: 53, 278, 105, 285
      Annotation: 
       Subtype: Link
       Rect: 53, 270, 249, 277
      Annotation: 
       Subtype: Link
       Rect: 53, 262, 249, 269
      Annotation: 
       Subtype: Link
       Rect: 53, 254, 249, 261
      Annotation: 
       Subtype: Link
       Rect: 53, 246, 136, 253
      Annotation: 
       Subtype: Link
       Rect: 53, 238, 249, 245
      Annotation: 
       Subtype: Link
       Rect: 53, 230, 249, 237
      Annotation: 
       Subtype: Link
       Rect: 53, 222, 105, 229
      Annotation: 
       Subtype: Link
       Rect: 53, 214, 249, 221
      Annotation: 
       Subtype: Link
       Rect: 53, 206, 249, 213
      Annotation: 
       Subtype: Link
       Rect: 53, 198, 182, 205
      Annotation: 
       Subtype: Link
       Rect: 53, 190, 249, 197
      Annotation: 
       Subtype: Link
       Rect: 53, 182, 249, 189
      Annotation: 
       Subtype: Link
       Rect: 53, 174, 212, 181
      Annotation: 
       Subtype: Link
       Rect: 53, 166, 249, 173
      Annotation: 
       Subtype: Link
       Rect: 53, 159, 245, 165
      Annotation: 
       Subtype: Link
       Rect: 53, 151, 249, 158
      Annotation: 
       Subtype: Link
       Rect: 53, 143, 249, 150
      Annotation: 
       Subtype: Link
       Rect: 53, 135, 151, 142
      Annotation: 
       Subtype: Link
       Rect: 53, 127, 249, 134
      Annotation: 
       Subtype: Link
       Rect: 53, 119, 249, 126
      Annotation: 
       Subtype: Link
       Rect: 53, 111, 247, 118
      Annotation: 
       Subtype: Link
       Rect: 53, 103, 249, 110
      Annotation: 
       Subtype: Link
       Rect: 53, 95, 249, 102
      Annotation: 
       Subtype: Link
       Rect: 53, 87, 249, 94
      Annotation: 
       Subtype: Link
       Rect: 53, 79, 129, 86
      Annotation: 
       Subtype: Link
       Rect: 53, 71, 249, 78
      Annotation: 
       Subtype: Link
       Rect: 53, 63, 249, 70
      Annotation: 
       Subtype: Link
       Rect: 53, 55, 249, 62
      Annotation: 
       Subtype: Link
       Rect: 53, 47, 161, 54
      Annotation: 
       Subtype: Link
       Rect: 280, 661, 476, 668
      Annotation: 
       Subtype: Link
       Rect: 280, 653, 476, 660
      Annotation: 
       Subtype: Link
       Rect: 280, 645, 474, 652
      Annotation: 
       Subtype: Link
       Rect: 280, 637, 476, 644
      Annotation: 
       Subtype: Link
       Rect: 280, 629, 476, 636
      Annotation: 
       Subtype: Link
       Rect: 280, 621, 373, 628
      Annotation: 
       Subtype: Link
       Rect: 280, 613, 476, 620
      Annotation: 
       Subtype: Link
       Rect: 280, 605, 476, 612
      Annotation: 
       Subtype: Link
       Rect: 280, 597, 476, 604
      Annotation: 
       Subtype: Link
       Rect: 280, 589, 349, 596
      Annotation: 
       Subtype: Link
       Rect: 280, 581, 476, 588
      Annotation: 
       Subtype: Link
       Rect: 280, 573, 474, 580
      Annotation: 
       Subtype: Link
       Rect: 280, 565, 476, 572
      Annotation: 
       Subtype: Link
       Rect: 280, 557, 476, 564
      Annotation: 
       Subtype: Link
       Rect: 280, 549, 476, 556
      Annotation: 
       Subtype: Link
       Rect: 280, 541, 389, 548
      Annotation: 
       Subtype: Link
       Rect: 280, 533, 476, 540
      Annotation: 
       Subtype: Link
       Rect: 280, 525, 476, 532
      Annotation: 
       Subtype: Link
       Rect: 280, 517, 476, 524
      Annotation: 
       Subtype: Link
       Rect: 280, 509, 294, 516
      Annotation: 
       Subtype: Link
       Rect: 280, 501, 476, 508
      Annotation: 
       Subtype: Link
       Rect: 280, 493, 476, 500
      Annotation: 
       Subtype: Link
       Rect: 280, 485, 476, 492
      Annotation: 
       Subtype: Link
       Rect: 280, 477, 393, 484
      Annotation: 
       Subtype: Link
       Rect: 280, 469, 476, 476
      Annotation: 
       Subtype: Link
       Rect: 280, 461, 476, 468
      Annotation: 
       Subtype: Link
       Rect: 280, 453, 450, 460
      Annotation: 
       Subtype: Link
       Rect: 280, 445, 476, 452
      Annotation: 
       Subtype: Link
       Rect: 280, 437, 476, 444
      Annotation: 
       Subtype: Link
       Rect: 280, 430, 476, 436
      Annotation: 
       Subtype: Link
       Rect: 280, 422, 476, 428
      Annotation: 
       Subtype: Link
       Rect: 280, 414, 476, 421
      Annotation: 
       Subtype: Link
       Rect: 280, 406, 323, 413
      Annotation: 
       Subtype: Link
       Rect: 280, 398, 476, 405
      Annotation: 
       Subtype: Link
       Rect: 280, 390, 476, 397
      Annotation: 
       Subtype: Link
       Rect: 280, 382, 476, 389
      Annotation: 
       Subtype: Link
       Rect: 280, 374, 376, 381
      Annotation: 
       Subtype: Link
       Rect: 280, 366, 476, 373
      Annotation: 
       Subtype: Link
       Rect: 280, 358, 398, 365
      Annotation: 
       Subtype: Link
       Rect: 280, 350, 476, 357
      Annotation: 
       Subtype: Link
       Rect: 280, 342, 476, 349
      Annotation: 
       Subtype: Link
       Rect: 280, 334, 476, 341
      Annotation: 
       Subtype: Link
       Rect: 280, 326, 304, 333
      Annotation: 
       Subtype: Link
       Rect: 280, 318, 476, 325
      Annotation: 
       Subtype: Link
       Rect: 280, 310, 476, 317
      Annotation: 
       Subtype: Link
       Rect: 280, 302, 466, 309
      Annotation: 
       Subtype: Link
       Rect: 280, 294, 476, 301
      Annotation: 
       Subtype: Link
       Rect: 280, 286, 476, 293
      Annotation: 
       Subtype: Link
       Rect: 280, 278, 476, 285
      Annotation: 
       Subtype: Link
       Rect: 280, 270, 476, 277
      Annotation: 
       Subtype: Link
       Rect: 280, 262, 345, 269
      Annotation: 
       Subtype: Link
       Rect: 280, 254, 476, 261
      Annotation: 
       Subtype: Link
       Rect: 280, 246, 476, 253
      Annotation: 
       Subtype: Link
       Rect: 280, 238, 476, 245
      Annotation: 
       Subtype: Link
       Rect: 280, 230, 336, 237
      Annotation: 
       Subtype: Link
       Rect: 280, 222, 476, 229
      Annotation: 
       Subtype: Link
       Rect: 280, 214, 476, 221
      Annotation: 
       Subtype: Link
       Rect: 280, 206, 476, 213
      Annotation: 
       Subtype: Link
       Rect: 280, 198, 388, 205
      Annotation: 
       Subtype: Link
       Rect: 280, 190, 476, 197
      Annotation: 
       Subtype: Link
       Rect: 280, 182, 476, 189
      Annotation: 
       Subtype: Link
       Rect: 280, 174, 398, 181
      Annotation: 
       Subtype: Link
       Rect: 280, 166, 476, 173
      Annotation: 
       Subtype: Link
       Rect: 280, 159, 476, 165
      Annotation: 
       Subtype: Link
       Rect: 280, 151, 377, 158
      Annotation: 
       Subtype: Link
       Rect: 280, 143, 476, 150
      Annotation: 
       Subtype: Link
       Rect: 280, 135, 476, 142
      Annotation: 
       Subtype: Link
       Rect: 280, 127, 403, 134
      Annotation: 
       Subtype: Link
       Rect: 280, 119, 476, 126
      Annotation: 
       Subtype: Link
       Rect: 280, 111, 476, 118
      Annotation: 
       Subtype: Link
       Rect: 280, 103, 476, 110
      Annotation: 
       Subtype: Link
       Rect: 280, 95, 322, 102
      Annotation: 
       Subtype: Link
       Rect: 280, 87, 476, 94
      Annotation: 
       Subtype: Link
       Rect: 280, 79, 476, 86
      Annotation: 
       Subtype: Link
       Rect: 280, 71, 476, 78
      Annotation: 
       Subtype: Link
       Rect: 280, 63, 371, 70
      Annotation: 
       Subtype: Link
       Rect: 280, 55, 476, 62
      Annotation: 
       Subtype: Link
       Rect: 280, 47, 472, 54
      Annotation: 
       Subtype: Link
       Rect: 39, 12, 96, 19
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 132, 661, 328, 668
      Annotation: 
       Subtype: Link
       Rect: 132, 653, 275, 660
      Annotation: 
       Subtype: Link
       Rect: 132, 645, 328, 652
      Annotation: 
       Subtype: Link
       Rect: 132, 637, 320, 644
      Annotation: 
       Subtype: Link
       Rect: 132, 629, 328, 636
      Annotation: 
       Subtype: Link
       Rect: 132, 621, 328, 628
      Annotation: 
       Subtype: Link
       Rect: 132, 613, 328, 620
      Annotation: 
       Subtype: Link
       Rect: 132, 605, 202, 612
      Annotation: 
       Subtype: Link
       Rect: 359, 661, 555, 668
      Annotation: 
       Subtype: Link
       Rect: 359, 653, 555, 660
      Annotation: 
       Subtype: Link
       Rect: 359, 645, 452, 652
      Annotation: 
       Subtype: Link
       Rect: 359, 637, 555, 644
      Annotation: 
       Subtype: Link
       Rect: 359, 629, 555, 636
      Annotation: 
       Subtype: Link
       Rect: 359, 621, 555, 628
      Annotation: 
       Subtype: Link
       Rect: 359, 613, 555, 620
      Annotation: 
       Subtype: Link
       Rect: 359, 605, 373, 612
      Annotation: 
       Subtype: Link
       Rect: 432, 12, 489, 19
  Checksum: 68308b56
   Type: CRC32
  Checksum: 0bb8d0bfd474edcbe9ab337276d2b5f6
   Type: MD5
  Checksum: 79ff1b5fcee6c0dcdd77befbdd0ed81d3f9ae699
   Type: SHA-1
  Checksum: 6d172635c0f6637046b3134bf30b494b411733ee5458adbdc6901fffb92737ab
   Type: SHA-256