ba464b18c0fbf55758d994c433ec28c3 1-s2.0-S0048969724007307-main.pdf 60192bce54275b92c392327974981f20a8015c41 1-s2.0-S0048969724007307-main.pdf 5c52081ad8184f74602d4c7324831e613907e3f9ecaf6d98e9c8681bca6f6576 1-s2.0-S0048969724007307-main.pdf Title: Are bioplastics safe? Hazardous effects of polylactic acid (PLA) nanoplastics in Drosophila Subject: Science of the Total Environment, 919 (2024) 170592. doi:10.1016/j.scitotenv.2024.170592 Keywords: Polylactic acid,Nanoplastics,Internalization pathway,Oxidative stress,Inflammation,Genotoxicity,Microbiota,Drosophila melanogaster Author: Mohamed Alaraby Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Feb 22 08:20:42 2024 CET ModDate: Thu Feb 22 08:26:21 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2981682 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AMOYZH+CharisSIL CID TrueType Identity-H yes yes yes 1088 0 ISKIIM+STIX-Regular Type 1C Custom yes yes yes 1093 0 GBNAGF+Univers Type 1C Builtin yes yes yes 1098 0 KFMWCA+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1102 0 IRFOQO+TeX_CM_Roman Type 1C Builtin yes yes yes 1107 0 YGPXYW+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 1111 0 VBPTOZ+CharisSIL CID TrueType Identity-H yes yes yes 1079 0 CNADXM+CharisSIL-Bold CID TrueType Identity-H yes yes yes 506 0 ZEYNAX+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 511 0 HSLZNL+CharisSIL-Italic CID TrueType Identity-H yes yes yes 499 0 FZQJDT+STIXGeneral Type 1C Custom yes yes yes 40 0 EFEAEJ+Arial-BoldMT Type 1C WinAnsi yes yes no 56 0 EFEAII+Calibri-Bold Type 1C WinAnsi yes yes no 59 0 YWFNCZ+STIX-Italic Type 1C Custom yes yes yes 93 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 520 0 EFFHEL+ArialMT Type 1C WinAnsi yes yes no 84 0 EFFHHL+ArialRoundedMTBold Type 1C WinAnsi yes yes no 87 0 EFIHEF+ArialMT Type 1C WinAnsi yes yes no 170 0 EFLCMJ+Arial-BoldMT Type 1C WinAnsi yes yes no 192 0 EFLCMK+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 195 0 EFLCNL+ArialMT Type 1C WinAnsi yes yes no 198 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-25 02:43:01 CEST RepresentationInformation: 1-s2.0-S0048969724007307-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-22 01:43:24 CEST Size: 2981682 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1170 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Are bioplastics safe? Hazardous effects of polylactic acid (PLA) nanoplastics in Drosophila Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Material and methods Destination: mk:H1_2 Children: Item: Title: 2.1 PLA-MNPLs obtention Destination: mk:H2_1 Item: Title: 2.2 PLA-NPLs physicochemical characterization Destination: mk:H2_2 Item: Title: 2.3 Drosophila melanogaster (in vivo study) Destination: mk:H2_3 Children: Item: Title: 2.3.1 Toxicity studies Destination: mk:H3_4 Item: Title: 2.3.2 PLA-NPLs internalization following ingestion Destination: mk:H3_5 Item: Title: 2.3.3 Molecular response (Real-Time PCR) Destination: mk:H3_6 Item: Title: 2.3.4 Oxidative stress induction Destination: mk:H3_7 Item: Title: 2.3.5 Genotoxic damage induction Destination: mk:H3_8 Item: Title: 2.4 Statistical analysis Destination: mk:H2_9 Item: Title: 3 Results and discussion Destination: mk:H1_3 Children: Item: Title: 3.1 PLA-NPLs characterization Destination: mk:H2_10 Item: Title: 3.2 Toxicity of PLA-NPLs Destination: mk:H2_11 Item: Title: 3.3 Digestion and internalization Destination: mk:H2_12 Item: Title: 3.4 The potential impacts of PLA-NPL exposure Destination: mk:H2_13 Item: Title: 3.5 Oxidative stress and genotoxicity Destination: mk:H2_14 Item: Title: 4 Conclusions Destination: mk:H1_4 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Declaration of competing interest Destination: mk:HH1_3 Item: Title: Data availability Destination: datalink4 Item: Title: Acknowledgment Destination: mk:HH1_5 Item: Title: Appendix A Supplementary data Destination: mk:H1_6 Item: Title: References Destination: mk:HH2_1 Info: Title: Are bioplastics safe? Hazardous effects of polylactic acid (PLA) nanoplastics in Drosophila Author: Mohamed Alaraby Subject: Science of the Total Environment, 919 (2024) 170592. doi:10.1016/j.scitotenv.2024.170592 Keywords: Polylactic acid,Nanoplastics,Internalization pathway,Oxidative stress,Inflammation,Genotoxicity,Microbiota,Drosophila melanogaster Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Feb 22 08:20:42 CET 2024 ModDate: Thu Feb 22 08:26:21 CET 2024 ID: 0x28c1dd60868fdb19c6c1d208f67db8a4, 0x7d087d5b331850b3f182a507a5f08529 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: AMOYZH+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: CNADXM+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: KFMWCA+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: ZEYNAX+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: IRFOQO+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: IRFOQO+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: ISKIIM+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 8 FontDescriptor: FontName: ISKIIM+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YGPXYW+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: YGPXYW+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: FZQJDT+STIXGeneral FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FZQJDT+STIXGeneral Flags: Nonsymbolic FontBBox: -178, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: GBNAGF+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: GBNAGF+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: YWFNCZ+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: YWFNCZ+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: KFMWCA+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KFMWCA+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: ZEYNAX+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ZEYNAX+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: AMOYZH+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AMOYZH+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: CNADXM+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CNADXM+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true XMP: http://creativecommons.org/licenses/by/4.0/ elsevier.com sciencedirect.com true 10.1016/j.scitotenv.2024.170592 2010-04-23 application/pdf 10.1016/j.scitotenv.2024.170592 Elsevier B.V. Science of the Total Environment, 919 (2024) 170592. doi:10.1016/j.scitotenv.2024.170592 Polylactic acid Nanoplastics Internalization pathway Oxidative stress Inflammation Genotoxicity Microbiota Drosophila melanogaster Are bioplastics safe? Hazardous effects of polylactic acid (PLA) nanoplastics in Drosophila Mohamed Alaraby Doaa Abass Marinella Farre Alba Hernández Ricard Marcos VoR 22nd February 2024 Acrobat Distiller 8.1.0 (Windows) Polylactic acid,Nanoplastics,Internalization pathway,Oxidative stress,Inflammation,Genotoxicity,Microbiota,Drosophila melanogaster 22nd February 2024 sciencedirect.com elsevier.com true 2010-04-23 10.1016/j.scitotenv.2024.170592 noindex journal © 2024 The Authors. Published by Elsevier B.V. 2024-04-01 1 April 2024 10.1016/j.scitotenv.2024.170592 0048-9697 170592 Science of the Total Environment 170592 https://doi.org/10.1016/j.scitotenv.2024.170592 919 2024-02-22T07:20:42 Elsevier 2024-02-22T07:26:21 2024-02-22T07:26:21 uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 True Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 126, 576, 132, 587 Flags: Print Destination: 1059 Annotation: Subtype: Link Rect: 133, 576, 139, 587 Flags: Print Destination: 1059 Annotation: Subtype: Link Rect: 140, 579, 144, 584 Flags: Print Destination: 1059 Annotation: Subtype: Link Rect: 140, 571, 206, 582 Flags: Print Destination: 1059 Annotation: Subtype: Link Rect: 206, 576, 212, 587 Flags: Print Destination: 1059 Annotation: Subtype: Link Rect: 213, 571, 299, 582 Flags: Print Destination: 1059 Annotation: Subtype: Link Rect: 299, 571, 386, 582 Flags: Print Destination: 1059 Annotation: Subtype: Link Rect: 386, 576, 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