c30bbf80572ca6e48452eebe069b2ea4 300118.pdf 0ca27973f5b984da20945fab747fe4843363da35 300118.pdf 5e295f3a0651ad820f995c2910ddcdb0075834f907a2e2b47447e7a71eff3f3e 300118.pdf Title: A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets Subject: Atopic dermatitis and psoriasis are prevalent inflammatory skin conditions that significantly impact the quality of life of patients, with diverse treatment options available. Despite advances in understanding their underlying mechanisms, recent research highlights the significance of interleukins IL-18 and IL-37, in Th1, Th2, and Th17 inflammatory responses, closely associated with the pathogenesis of psoriasis and atopic dermatitis. Hence, IL-18 and IL-37 could potentially become therapeutic targets. This narrative review synthesizes knowledge on these interleukins, their roles in atopic dermatitis and psoriasis, and emerging treatment strategies. Findings of a literature search up to 30 May 2024, underscore a research gap in IL-37-targeted therapies. Conversely, IL-18-focused treatments have demonstrated promise in adult-onset Still’s Disease, warranting further exploration for their potential efficacy in psoriasis and atopic dermatitis. Keywords: Psoriasis; atopic dermatitis; IL-18; IL-37 Author: Lluís Rusiñol and Lluís Puig Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Aug 2 08:02:25 2024 CEST ModDate: Fri Aug 2 09:03:29 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2120410 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 GFKJOY+VnURWPalladioL Type 1 Custom yes yes yes 16 0 AMIYNH+URWPalladioL-Bold Type 1 Custom yes yes yes 21 0 PKIEMQ+URWPalladioL-Roma Type 1 Custom yes yes yes 27 0 NTSSAY+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 ASHNOE+EURM10 Type 1 Builtin yes yes yes 37 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 JGINAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 86 0 JGINAI+PalatinoLinotype CID TrueType Identity-H yes yes yes 89 0 JGINAJ+PalatinoLinotype TrueType WinAnsi yes yes no 95 0 JGINAL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 98 0 JGINFK+PalatinoLinotype TrueType MacRoman yes yes no 101 0 JGINAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 115 0 JGINAI+PalatinoLinotype CID TrueType Identity-H yes yes yes 118 0 JGINAJ+PalatinoLinotype TrueType WinAnsi yes yes no 124 0 JGINAL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 127 0 JGINFK+PalatinoLinotype TrueType MacRoman yes yes no 130 0 JGINAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 150 0 JGINAI+PalatinoLinotype CID TrueType Identity-H yes yes yes 153 0 JGINAJ+PalatinoLinotype TrueType WinAnsi yes yes no 159 0 JGINAL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 162 0 JGINFK+PalatinoLinotype TrueType MacRoman yes yes no 165 0 JGINAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 190 0 JGINAJ+PalatinoLinotype TrueType WinAnsi yes yes no 193 0 JGINAL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 196 0 JGINFK+PalatinoLinotype TrueType MacRoman yes yes no 199 0 BBETNX+PazoMath Type 1 Builtin yes yes yes 216 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-18 02:49:55 CET RepresentationInformation: 300118.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-16 13:55:56 CET Size: 2120410 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 795 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Item: Title: Atopic Dermatitis and Psoriasis Pathogenesis Destination: section.3 Item: Title: Biology of IL-18 Destination: section.4 Children: Item: Title: Synthesis of IL-18 Destination: subsection.4.1 Item: Title: Signaling of IL-18 Destination: subsection.4.2 Item: Title: IL-18 in Keratinocytes Destination: subsection.4.3 Item: Title: IL-18 in Immune Cells Destination: subsection.4.4 Item: Title: Biology of IL-37 Destination: section.5 Children: Item: Title: Synthesis of IL-37 Destination: subsection.5.1 Item: Title: IL-37 Signaling Destination: subsection.5.2 Item: Title: IL-37 in the Skin Destination: subsection.5.3 Item: Title: IL-37 in Immune Cells Destination: subsection.5.4 Item: Title: IL-18 and IL-37 in Inflammatory Skin Diseases Destination: section.6 Children: Item: Title: IL-18 and IL-37 as Therapeutic Targets Destination: subsection.6.1 Item: Title: IL-18 as a Therapeutic Target Destination: subsection.6.2 Item: Title: Tadekinig Alfa Destination: subsection.6.3 Item: Title: CMK-389 Destination: subsection.6.4 Item: Title: AMP18P1RA/IL-18bp-Fc-IL-1ra Destination: subsection.6.5 Item: Title: IL-37 as a Therapeutic Target Destination: subsection.6.6 Item: Title: Conclusions Destination: section.7 Item: Title: Future Directions Destination: section.8 Item: Title: References Destination: section.9 Info: Title: A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets Author: Lluís Rusiñol and Lluís Puig Subject: Atopic dermatitis and psoriasis are prevalent inflammatory skin conditions that significantly impact the quality of life of patients, with diverse treatment options available. Despite advances in understanding their underlying mechanisms, recent research highlights the significance of interleukins IL-18 and IL-37, in Th1, Th2, and Th17 inflammatory responses, closely associated with the pathogenesis of psoriasis and atopic dermatitis. Hence, IL-18 and IL-37 could potentially become therapeutic targets. This narrative review synthesizes knowledge on these interleukins, their roles in atopic dermatitis and psoriasis, and emerging treatment strategies. Findings of a literature search up to 30 May 2024, underscore a research gap in IL-37-targeted therapies. Conversely, IL-18-focused treatments have demonstrated promise in adult-onset Still’s Disease, warranting further exploration for their potential efficacy in psoriasis and atopic dermatitis. 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