88c941f102887a6ed793556a6b55b925 300119.pdf eba73c685cacf861029de729c5dbca53977f7209 300119.pdf 9f2a9494297ca4406ce8ab2029aa5117b4ec86e30a1b9db6a64ec131909206f6 300119.pdf Title: Outcomes of Bariatric Surgery in Patients with Schizophrenia Subject: Background: Outcomes of bariatric surgery (BS) in patients with schizophrenia are poorly understood. We aimed to analyze the effects of BS in patients with schizophrenia (SZ) or schizoaffective disorder (SZA). Methods: This was a multicenter, retrospective case-control study in patients with SZ or SZA who had undergone BS in seven public referral hospitals in Spain. Controls without psychiatric comorbidity were selected in a 1:4 ratio. Detailed clinical and biochemical data were collected preoperatively and at 12, 24, 36, 48, and 60 months after BS. Results: Twenty patients with SZ (n = 15; 75%) or SZA (n = 5; 25%) and 80 matched controls were studied. There were no differences between patients and controls concerning the evolution of the percentage of total weight loss. The remission rate of the main comorbidities was similar between groups except for hypertension, which was lower in patients with a psychotic disorder from year 3. There were no mortalities within 30 days of surgery in either group. The psychiatric medication burden did not change during follow-up. Conclusions: BS is safe and effective in carefully selected patients with SZ. The course of the psychiatric disease does not seem to be worsened by the procedure. Keywords: obesity; obesity surgery; schizophrenia; severe mental illness; weight loss Author: Inka Miñambres, Miguel Ángel Rubio-Herrera, Joana Nicolau, Camila Milad, Maria José Morales, Marta Bueno, Alfonso Calañas, Mar Carceller-Sindreu and Ana de Hollanda Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Jul 31 10:42:13 2024 CEST ModDate: Wed Jul 31 10:44:48 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 649724 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AIPYBR+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 GJXFXV+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 AOTLZR+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 RZMTVT+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 UZLFPZ+VnURWPalladioL Type 1 Custom yes yes yes 32 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 JYUNWZ+CMSY10 Type 1 Builtin yes yes yes 65 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes yes 73 0 EGHBHN+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 116 0 EGHBHO+PalatinoLinotype CID TrueType Identity-H yes yes yes 119 0 EGHBIO+PalatinoLinotype TrueType WinAnsi yes yes no 125 0 EGHBJA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 128 0 IAEDDG+PalatinoLinotype TrueType WinAnsi yes yes no 163 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-18 02:49:52 CET RepresentationInformation: 300119.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-16 14:15:27 CET Size: 649724 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 338 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Main Outcomes and Measures Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Characteristics of Participants Destination: subsection.3.1 Item: Title: Weight and Comorbidities Evolution Destination: subsection.3.2 Item: Title: Surgical Complications Destination: subsection.3.3 Item: Title: Other Follow-Up Data Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Outcomes of Bariatric Surgery in Patients with Schizophrenia Author: Inka Miñambres, Miguel Ángel Rubio-Herrera, Joana Nicolau, Camila Milad, Maria José Morales, Marta Bueno, Alfonso Calañas, Mar Carceller-Sindreu and Ana de Hollanda Subject: Background: Outcomes of bariatric surgery (BS) in patients with schizophrenia are poorly understood. We aimed to analyze the effects of BS in patients with schizophrenia (SZ) or schizoaffective disorder (SZA). Methods: This was a multicenter, retrospective case-control study in patients with SZ or SZA who had undergone BS in seven public referral hospitals in Spain. Controls without psychiatric comorbidity were selected in a 1:4 ratio. Detailed clinical and biochemical data were collected preoperatively and at 12, 24, 36, 48, and 60 months after BS. Results: Twenty patients with SZ (n = 15; 75%) or SZA (n = 5; 25%) and 80 matched controls were studied. There were no differences between patients and controls concerning the evolution of the percentage of total weight loss. The remission rate of the main comorbidities was similar between groups except for hypertension, which was lower in patients with a psychotic disorder from year 3. There were no mortalities within 30 days of surgery in either group. The psychiatric medication burden did not change during follow-up. Conclusions: BS is safe and effective in carefully selected patients with SZ. The course of the psychiatric disease does not seem to be worsened by the procedure. Keywords: obesity; obesity surgery; schizophrenia; severe mental illness; weight loss Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Jul 31 10:42:13 CEST 2024 ModDate: Wed Jul 31 10:44:48 CEST 2024 ID: 0xeab0c9f35c3eba3526785e19dac2f0e0, 0xeab0c9f35c3eba3526785e19dac2f0e0 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: GJXFXV+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 241 FontDescriptor: FontName: GJXFXV+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: UZLFPZ+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 226 FontDescriptor: FontName: UZLFPZ+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JYUNWZ+CMSY10 FontSubset: true FirstChar: 0 LastChar: 6 FontDescriptor: FontName: JYUNWZ+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true ToUnicode: true Font: BaseFont: AOTLZR+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: AOTLZR+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: QLBIEB+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: QLBIEB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AIPYBR+VnURWPalladioL-Bold FontSubset: true FirstChar: 129 LastChar: 178 FontDescriptor: FontName: AIPYBR+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: RZMTVT+URWPalladioL-Ital FontSubset: true FirstChar: 45 LastChar: 122 FontDescriptor: FontName: RZMTVT+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 54, 281, 152, 290 Annotation: Subtype: Link Rect: 34, 271, 72, 278 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 125, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 149, 87 Annotation: Subtype: Link Rect: 34, 757, 169, 793 Annotation: Subtype: Link Rect: 515, 757, 560, 793 Annotation: Subtype: Link Rect: 284, 679, 295, 693 Annotation: Subtype: Link Rect: 367, 679, 378, 693 Annotation: Subtype: Link Rect: 450, 679, 461, 693 Annotation: Subtype: Link Rect: 110, 668, 121, 680 Annotation: Subtype: Link Rect: 348, 668, 359, 680 Annotation: Subtype: Link Rect: 474, 668, 485, 680 Annotation: Subtype: Link Rect: 539, 105, 546, 114 ActionDest: 174 Annotation: Subtype: Link Rect: 549, 105, 556, 114 ActionDest: 174 Annotation: Subtype: Link Rect: 464, 68, 471, 76 ActionDest: 174 Annotation: Subtype: Link Rect: 474, 67, 481, 76 ActionDest: 174 Annotation: Subtype: Link Rect: 120, 17, 254, 28 Annotation: Subtype: Link Rect: 404, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 414, 87, 433 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 440, 744, 446, 752 ActionDest: 174 Annotation: Subtype: Link Rect: 534, 706, 541, 715 ActionDest: 174 Annotation: Subtype: Link Rect: 544, 706, 556, 715 ActionDest: 174 Annotation: Subtype: Link Rect: 187, 668, 194, 677 ActionDest: 174 Annotation: Subtype: Link Rect: 197, 668, 209, 677 ActionDest: 174 Annotation: Subtype: Link Rect: 502, 656, 514, 665 ActionDest: 174 Annotation: Subtype: Link Rect: 517, 656, 529, 665 ActionDest: 174 Annotation: Subtype: Link Rect: 185, 618, 197, 627 ActionDest: 174 Annotation: Subtype: Link Rect: 200, 618, 212, 627 ActionDest: 174 Annotation: Subtype: Link Rect: 204, 568, 216, 577 ActionDest: 174 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 253, 718, 265, 727 ActionDest: 177 Annotation: Subtype: Link Rect: 466, 300, 473, 312 ActionDest: 70 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 423, 608, 430, 620 ActionDest: 146 Annotation: Subtype: Link Rect: 336, 558, 343, 570 ActionDest: 78 Page: Sequence: 5 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 196, 511, 203, 524 ActionDest: 149 Annotation: Subtype: Link Rect: 321, 270, 332, 278 ActionDest: 177 Annotation: Subtype: Link Rect: 271, 134, 283, 142 ActionDest: 177 Annotation: Subtype: Link Rect: 286, 133, 298, 142 ActionDest: 177 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 187, 743, 199, 752 ActionDest: 177 Annotation: Subtype: Link Rect: 199, 744, 211, 752 ActionDest: 177 Annotation: Subtype: Link Rect: 376, 743, 388, 752 ActionDest: 177 Annotation: Subtype: Link Rect: 269, 718, 281, 727 ActionDest: 177 Annotation: Subtype: Link Rect: 427, 693, 439, 702 ActionDest: 177 Annotation: Subtype: Link Rect: 440, 693, 452, 702 ActionDest: 177 Annotation: Subtype: Link Rect: 345, 643, 357, 652 ActionDest: 177 Annotation: Subtype: Link Rect: 470, 618, 482, 627 ActionDest: 177 Annotation: Subtype: Link Rect: 220, 580, 232, 589 ActionDest: 177 Annotation: Subtype: Link Rect: 233, 580, 244, 589 ActionDest: 177 Annotation: Subtype: Link Rect: 367, 492, 379, 501 ActionDest: 177 Annotation: Subtype: Link Rect: 380, 492, 392, 501 ActionDest: 177 Annotation: Subtype: Link Rect: 205, 392, 217, 401 ActionDest: 177 Annotation: Subtype: Link Rect: 217, 317, 229, 326 ActionDest: 177 Annotation: Subtype: Link Rect: 325, 291, 337, 301 ActionDest: 177 Annotation: Subtype: Link Rect: 525, 279, 537, 288 ActionDest: 177 Annotation: Subtype: Link Rect: 498, 153, 510, 162 ActionDest: 177 Annotation: Subtype: Link Rect: 428, 103, 440, 112 ActionDest: 177 Annotation: Subtype: Link Rect: 440, 103, 452, 112 ActionDest: 177 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 456, 743, 463, 752 ActionDest: 174 Annotation: Subtype: Link Rect: 466, 743, 478, 752 ActionDest: 174 Annotation: Subtype: Link Rect: 193, 706, 205, 715 ActionDest: 177 Annotation: Subtype: Link Rect: 410, 693, 422, 702 ActionDest: 177 Annotation: Subtype: Link Rect: 255, 630, 267, 639 ActionDest: 177 Annotation: Subtype: Link Rect: 517, 568, 528, 577 ActionDest: 177 Annotation: Subtype: Link Rect: 529, 568, 541, 577 ActionDest: 177 Annotation: Subtype: Link Rect: 544, 568, 556, 577 ActionDest: 177 Annotation: Subtype: Link Rect: 331, 492, 342, 501 ActionDest: 174 Annotation: Subtype: Link Rect: 214, 430, 226, 439 ActionDest: 180 Annotation: Subtype: Link Rect: 227, 430, 239, 439 ActionDest: 180 Annotation: Subtype: Link Rect: 206, 342, 218, 351 ActionDest: 180 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 462, 534, 500, 545 Annotation: Subtype: Link Rect: 520, 522, 557, 533 Annotation: Subtype: Link Rect: 519, 499, 557, 510 Annotation: Subtype: Link Rect: 59, 488, 95, 499 Annotation: Subtype: Link Rect: 429, 465, 466, 476 Annotation: Subtype: Link Rect: 336, 442, 373, 453 Annotation: Subtype: Link Rect: 380, 442, 416, 453 Annotation: Subtype: Link Rect: 505, 419, 543, 430 Annotation: Subtype: Link Rect: 253, 384, 291, 395 Annotation: Subtype: Link Rect: 297, 384, 333, 395 Annotation: Subtype: Link Rect: 160, 362, 197, 372 Annotation: Subtype: Link Rect: 203, 362, 239, 372 Annotation: Subtype: Link Rect: 448, 338, 485, 349 Annotation: Subtype: Link Rect: 303, 315, 341, 326 Annotation: Subtype: Link Rect: 232, 281, 269, 291 Annotation: Subtype: Link Rect: 276, 281, 312, 291 Annotation: Subtype: Link Rect: 384, 246, 422, 257 Annotation: Subtype: Link Rect: 428, 246, 464, 257 Annotation: Subtype: Link Rect: 520, 235, 557, 245 Annotation: Subtype: Link Rect: 59, 224, 95, 234 Annotation: Subtype: Link Rect: 382, 200, 418, 211 Annotation: Subtype: Link Rect: 395, 177, 433, 188 Annotation: Subtype: Link Rect: 439, 177, 475, 188 Annotation: Subtype: Link Rect: 453, 154, 490, 165 Annotation: Subtype: Link Rect: 113, 132, 150, 142 Annotation: Subtype: Link Rect: 156, 132, 192, 142 Annotation: Subtype: Link Rect: 470, 108, 508, 119 Annotation: Subtype: Link Rect: 370, 85, 407, 96 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 59, 719, 96, 729 Annotation: Subtype: Link Rect: 473, 695, 511, 706 Annotation: Subtype: Link Rect: 104, 661, 141, 671 Annotation: Subtype: Link Rect: 147, 661, 183, 671 Annotation: Subtype: Link Rect: 131, 627, 168, 637 Annotation: Subtype: Link Rect: 175, 627, 211, 637 Annotation: Subtype: Link Rect: 182, 604, 219, 614 Annotation: Subtype: Link Rect: 225, 604, 261, 614 Annotation: Subtype: Link Rect: 104, 569, 141, 579 Annotation: Subtype: Link Rect: 147, 569, 183, 579 Annotation: Subtype: Link Rect: 409, 545, 447, 556 Annotation: Subtype: Link Rect: 305, 511, 342, 522 Annotation: Subtype: Link Rect: 82, 489, 119, 499 Annotation: Subtype: Link Rect: 125, 489, 161, 499 Annotation: Subtype: Link Rect: 185, 453, 223, 464 Annotation: Subtype: Link Rect: 154, 430, 192, 441 Annotation: Subtype: Link Rect: 280, 407, 317, 418 Annotation: Subtype: Link Rect: 324, 407, 360, 418 Annotation: Subtype: Link Rect: 154, 373, 191, 384 Annotation: Subtype: Link Rect: 197, 373, 233, 384 Annotation: Subtype: Link Rect: 131, 351, 168, 361 Annotation: Subtype: Link Rect: 175, 351, 211, 361 Annotation: Subtype: Link Rect: 118, 316, 155, 326 Annotation: Subtype: Link Rect: 161, 316, 197, 326 Annotation: Subtype: Link Rect: 95, 282, 133, 292 Annotation: Subtype: Link Rect: 139, 282, 175, 292 Annotation: Subtype: Link Rect: 477, 269, 515, 280 Annotation: Subtype: Link Rect: 521, 269, 557, 280 Annotation: Subtype: Link Rect: 59, 247, 95, 257 Annotation: Subtype: Link Rect: 95, 213, 132, 223 Annotation: Subtype: Link Rect: 369, 189, 406, 200 Annotation: Subtype: Link Rect: 150, 166, 188, 177 Annotation: Subtype: Link Rect: 194, 166, 230, 177 Annotation: Subtype: Link Rect: 436, 131, 474, 142 Annotation: Subtype: Link Rect: 480, 131, 516, 142 Annotation: Subtype: Link Rect: 310, 109, 348, 119 Annotation: Subtype: Link Rect: 354, 109, 390, 119 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 394, 695, 430, 706 Annotation: Subtype: Link Rect: 117, 650, 155, 660 Checksum: 64269726 Type: CRC32 Checksum: 88c941f102887a6ed793556a6b55b925 Type: MD5 Checksum: eba73c685cacf861029de729c5dbca53977f7209 Type: SHA-1 Checksum: 9f2a9494297ca4406ce8ab2029aa5117b4ec86e30a1b9db6a64ec131909206f6 Type: SHA-256