e2f4730c93ebb48bffad088d12a66c9a  300120.pdf
16e79374612f433ad5802320e6e3f687f89b4de3  300120.pdf
ecb27b0d61d95560b910b1c2da34e4434a09ed1d51e34014bee28a8c2882ab10  300120.pdf

Title:           Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility
Subject:         Nature Communications, doi:10.1038/s41467-024-50930-9
Keywords:        
Author:          Birgit Stallmeyer
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Fri Aug  2 15:54:28 2024 CEST
ModDate:         Mon Aug  5 16:05:34 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           18
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       4881394 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
GIMACG+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no     117  0
GILPNF+AdvOTcc1f6510.I               Type 1C           WinAnsi          yes yes no      83  0
GIMACH+AdvOT0c200bf0+fb              Type 1C           Custom           yes yes yes    486  0
GILPOG+AdvOTdd63dae3+fb              Type 1C           Custom           yes yes yes     84  0
GILPOH+AdvOTdd63dae3+20              Type 1C           Custom           yes yes yes     85  0
GILKFB+AdvOT13119950                 Type 1C           WinAnsi          yes yes no      86  0
GILKFC+AdvOT89719618                 Type 1C           WinAnsi          yes yes no      88  0
GILKGC+AdvOTa2fa4214.B               Type 1C           WinAnsi          yes yes no     911  0
GILNGB+AdvOT13119950+01              Type 1C           Custom           yes yes yes    912  0
GIMAIG+AdvOT511ca30e.B               Type 1C           WinAnsi          yes yes no      91  0
GILONJ+AdvOT13119950+20              Type 1C           WinAnsi          yes yes no     515  0
GILPME+AdvOTdd63dae3                 Type 1C           WinAnsi          yes yes no      93  0
GIMANI+AdvOTdd63dae3+03              Type 1C           Custom           yes yes yes     87  0
GIMAKH+AdvOT70e1938e                 Type 1C           WinAnsi          yes yes no      89  0
GIMAKI+AdvOTdd63dae3+22              Type 1C           Custom           yes yes yes     90  0
GIMAKG+AdvOT3d287b35.B               Type 1C           WinAnsi          yes yes no      92  0
GINEAE+AdvOT23e3f5cb.I               Type 1C           WinAnsi          yes yes no     118  0
GINEAF+AdvMacMthSyN                  Type 1C           Custom           yes yes no     119  0
GINEAD+AdvOT13119950+fb              Type 1C           Custom           yes yes yes    120  0
GIOJPB+AdvOT8608a8d1                 Type 1C           WinAnsi          yes yes no     185  0
GIOJOA+AdvOT3d287b35.B+fb            Type 1C           Custom           yes yes yes    186  0
GJCBOK+AdvOT70e1938e+fb              Type 1C           Custom           yes yes yes    275  0
GJEHPB+AdvOTdd63dae3+01              Type 1C           MacRoman         yes yes no     353  0
GJEIEA+AdvOTdd63dae3+21              Type 1C           WinAnsi          yes yes no     400  0
GJEIHA+AdvOT401859e4.I               Type 1C           WinAnsi          yes yes no     423  0
GJEINP+AdvOT0c200bf0+20              Type 1C           WinAnsi          yes yes no     487  0
GJEJCO+AdvOT0c200bf0+01              Type 1C           Custom           yes yes yes    498  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-01-31 04:18:30 CET
 RepresentationInformation: 300120.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-01-30 12:53:25 CET
  Size: 4881394
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1071
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Genes of the piRNA pathway are frequently mutated in infertile men
          Destination: B1
         Item: 
          Title: Variants in genes encoding components of the piRISC complex
          Destination: B2
         Item: 
          Title: Variants in genes involved in piRNA metabolic processes
          Destination: B3
         Item: 
          Title: Variants in the scaffold proteins encoded by the TDRD gene family
          Destination: B4
         Item: 
          Title: Impact of identified variants on expression of piRNA pathway components
          Destination: B5
         Item: 
          Title: Impact of identified variants on piRNA processing and transposon silencing
          Destination: B6
         Item: 
          Title: Comparison of piRNA factor gene-related testicular phenotypes between mice and men
          Destination: B7
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Ethical approval
          Destination: B8
         Item: 
          Title: Study cohorts
          Destination: B9
         Item: 
          Title: Exome and genome sequencing
          Destination: B10
         Item: 
          Title: Variant calling
          Destination: B11
         Item: 
          Title: Gene Ontology analysis
          Destination: B12
         Item: 
          Title: Screening of exome data for biallelic high-impact variants
          Destination: B13
         Item: 
          Title: Further genetic analysis
          Destination: B14
         Item: 
          Title: NGS library preparation and long read sequencing using the MinION system
          Destination: B15
         Item: 
          Title: Minigene assay
          Destination: B16
         Item: 
          Title: Characterization of translation initiation in PLD6 c.1A>T
          Destination: B17
         Item: 
          Title: AlphaFold2 protein structure
          Destination: B18
         Item: 
          Title: Histology and Immunohistochemical staining
          Destination: B19
         Item: 
          Title: RNA extraction and small RNA sequencing
          Destination: B20
         Item: 
          Title: Statistics and reproducibility
          Destination: B21
         Item: 
          Title: Reporting summary
          Destination: B22
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Funding
        Destination: A7
       Item: 
        Title: Competing interests
        Destination: A8
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility
    Author: Birgit Stallmeyer
    Subject: Nature Communications, doi:10.1038/s41467-024-50930-9
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Fri Aug 02 16:24:28 CEST 2024
    ModDate: Mon Aug 05 16:05:34 CEST 2024
   ID: 0x1a17c81e84150bafce7aa5425f37c539, 0x7c832e831c2d7e3bdd4d90b949a3f459
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1639
      ImageHeight: 2500
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 2493
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 2196
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1986
      ImageHeight: 2500
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1850
      ImageHeight: 2500
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 1437
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
   Fonts: 
    Type1: 
     Font: 
      BaseFont: GILONJ+AdvOT13119950+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: GILONJ+AdvOT13119950+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1156, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GILKGC+AdvOTa2fa4214.B
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: GILKGC+AdvOTa2fa4214.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GILNGB+AdvOT13119950+01
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GILNGB+AdvOT13119950+01
       Flags: Symbolic
       FontBBox: -31, -218, 947, 1125
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GJEIEA+AdvOTdd63dae3+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: GJEIEA+AdvOTdd63dae3+21
       Flags: Nonsymbolic
       FontBBox: -31, -145, 1125, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GILPNF+AdvOTcc1f6510.I
      FontSubset: true
      FirstChar: 44
      LastChar: 119
      FontDescriptor: 
       FontName: GILPNF+AdvOTcc1f6510.I
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1020, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GJCBOK+AdvOT70e1938e+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GJCBOK+AdvOT70e1938e+fb
       Flags: Symbolic
       FontBBox: 9, 0, 854, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GILPOG+AdvOTdd63dae3+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: GILPOG+AdvOTdd63dae3+fb
       Flags: Symbolic
       FontBBox: 19, 0, 812, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GILPOH+AdvOTdd63dae3+20
      FontSubset: true
      FirstChar: 2
      LastChar: 151
      FontDescriptor: 
       FontName: GILPOH+AdvOTdd63dae3+20
       Flags: Symbolic
       FontBBox: -197, -125, 1322, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GILKFB+AdvOT13119950
      FontSubset: true
      FirstChar: 38
      LastChar: 252
      FontDescriptor: 
       FontName: GILKFB+AdvOT13119950
       Flags: Nonsymbolic
       FontBBox: -31, -218, 947, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GIMANI+AdvOTdd63dae3+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: GIMANI+AdvOTdd63dae3+03
       Flags: Symbolic
       FontBBox: -156, -197, 833, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GILKFC+AdvOT89719618
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: GILKFC+AdvOT89719618
       Flags: Nonsymbolic
       FontBBox: -20, -218, 927, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GIMAKH+AdvOT70e1938e
      FontSubset: true
      FirstChar: 45
      LastChar: 122
      FontDescriptor: 
       FontName: GIMAKH+AdvOT70e1938e
       Flags: Serif, Nonsymbolic
       FontBBox: -114, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GIMAKI+AdvOTdd63dae3+22
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: GIMAKI+AdvOTdd63dae3+22
       Flags: Symbolic
       FontBBox: -62, -250, 1083, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GIMAIG+AdvOT511ca30e.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: GIMAIG+AdvOT511ca30e.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 979, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GIMAKG+AdvOT3d287b35.B
      FontSubset: true
      FirstChar: 40
      LastChar: 124
      FontDescriptor: 
       FontName: GIMAKG+AdvOT3d287b35.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 1000, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GILPME+AdvOTdd63dae3
      FontSubset: true
      FirstChar: 35
      LastChar: 252
      FontDescriptor: 
       FontName: GILPME+AdvOTdd63dae3
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -218, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GJEHPB+AdvOTdd63dae3+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: GJEHPB+AdvOTdd63dae3+01
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -208, 906, 958
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: GIMACH+AdvOT0c200bf0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GIMACH+AdvOT0c200bf0+fb
       Flags: Symbolic
       FontBBox: 19, 0, 604, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GJEIHA+AdvOT401859e4.I
      FontSubset: true
      FirstChar: 54
      LastChar: 80
      FontDescriptor: 
       FontName: GJEIHA+AdvOT401859e4.I
       Flags: Nonsymbolic
       FontBBox: -229, -218, 1072, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GJEINP+AdvOT0c200bf0+20
      FontSubset: true
      FirstChar: 134
      LastChar: 150
      FontDescriptor: 
       FontName: GJEINP+AdvOT0c200bf0+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1083, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GJEJCO+AdvOT0c200bf0+01
      FontSubset: true
      FirstChar: 1
      LastChar: 157
      FontDescriptor: 
       FontName: GJEJCO+AdvOT0c200bf0+01
       Flags: Symbolic
       FontBBox: -41, -218, 947, 1104
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GIMACG+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 38
      LastChar: 252
      FontDescriptor: 
       FontName: GIMACG+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GINEAE+AdvOT23e3f5cb.I
      FontSubset: true
      FirstChar: 43
      LastChar: 122
      FontDescriptor: 
       FontName: GINEAE+AdvOT23e3f5cb.I
       Flags: Nonsymbolic
       FontBBox: -62, -208, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GINEAF+AdvMacMthSyN
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GINEAF+AdvMacMthSyN
       Flags: Symbolic
       FontBBox: 0, -947, 1239, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: GINEAD+AdvOT13119950+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GINEAD+AdvOT13119950+fb
       Flags: Symbolic
       FontBBox: 9, 0, 666, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GIOJPB+AdvOT8608a8d1
      FontSubset: true
      FirstChar: 181
      LastChar: 181
      FontDescriptor: 
       FontName: GIOJPB+AdvOT8608a8d1
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GIOJOA+AdvOT3d287b35.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GIOJOA+AdvOT3d287b35.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 875, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2020/06/23-02:37:56        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41467-024-50930-9</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Birgit Stallmeyer</rdf:li>
               <rdf:li>Clara Bühlmann</rdf:li>
               <rdf:li>Rytis Stakaitis</rdf:li>
               <rdf:li>Ann-Kristin Dicke</rdf:li>
               <rdf:li>Farah Ghieh</rdf:li>
               <rdf:li>Luisa Meier</rdf:li>
               <rdf:li>Ansgar Zoch</rdf:li>
               <rdf:li>David MacKenzie MacLeod</rdf:li>
               <rdf:li>Johanna Steingröver</rdf:li>
               <rdf:li>Özlem Okutman</rdf:li>
               <rdf:li>Daniela Fietz</rdf:li>
               <rdf:li>Adrian Pilatz</rdf:li>
               <rdf:li>Antoni Riera-Escamilla</rdf:li>
               <rdf:li>Miguel J. Xavier</rdf:li>
               <rdf:li>Christian Ruckert</rdf:li>
               <rdf:li>Sara Persio</rdf:li>
               <rdf:li>Nina Neuhaus</rdf:li>
               <rdf:li>Ali Sami Gurbuz</rdf:li>
               <rdf:li>Ahmet Şalvarci</rdf:li>
               <rdf:li>Nicolas May</rdf:li>
               <rdf:li>Kevin McEleny</rdf:li>
               <rdf:li>Corinna Friedrich</rdf:li>
               <rdf:li>Godfried Heijden</rdf:li>
               <rdf:li>Margot J. Wyrwoll</rdf:li>
               <rdf:li>Sabine Kliesch</rdf:li>
               <rdf:li>Joris A. Veltman</rdf:li>
               <rdf:li>Csilla Krausz</rdf:li>
               <rdf:li>Stéphane Viville</rdf:li>
               <rdf:li>Donald F. Conrad</rdf:li>
               <rdf:li>Dónal O’Carroll</rdf:li>
               <rdf:li>Frank Tüttelmann</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-024-50930-9</rdf:li>
            </rdf:Alt>
         </dc:description>
         <prism:doi>10.1038/s41467-024-50930-9</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41467-024-50930-9</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Nature Communications</prism:publicationName>
         <prism:copyright>© 2024, The Author(s)</prism:copyright>
         <prism:issn>2041-1723</prism:issn>
         <pdfx:doi>10.1038/s41467-024-50930-9</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41467-024-50930-9</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2024-08-05T16:05:34+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2024-08-02T19:24:28+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2024-08-05T16:05:34+02:00</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords></pdf:Keywords>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:0e29e370-18dd-4246-8f39-b77d4ae3b5e8</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:4b03efd7-fcd9-4628-b064-725c1149dce0</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:d7ed6e15-b9fc-4fdb-b9d0-8d4b66893098</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-08-02T19:25:33+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Rytis Stakaitis</author:name>
                  <author:orcid>http://orcid.org/0000-0001-5946-1731</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Ann-Kristin Dicke</author:name>
                  <author:orcid>http://orcid.org/0000-0002-2171-0525</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Johanna Steingröver</author:name>
                  <author:orcid>http://orcid.org/0009-0007-2272-026X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Daniela Fietz</author:name>
                  <author:orcid>http://orcid.org/0000-0002-7945-1810</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Adrian Pilatz</author:name>
                  <author:orcid>http://orcid.org/0000-0001-8072-1841</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Antoni Riera-Escamilla</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4485-3094</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Miguel J. Xavier</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0709-7223</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Nina Neuhaus</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0181-6194</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Godfried Heijden</author:name>
                  <author:orcid>http://orcid.org/0000-0001-5894-7027</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Sabine Kliesch</author:name>
                  <author:orcid>http://orcid.org/0000-0002-7561-4870</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Joris A. Veltman</author:name>
                  <author:orcid>http://orcid.org/0000-0002-3218-8250</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Stéphane Viville</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5088-3003</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Donald F. Conrad</author:name>
                  <author:orcid>http://orcid.org/0000-0003-3828-8970</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Dónal O’Carroll</author:name>
                  <author:orcid>http://orcid.org/0000-0002-8626-2217</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Frank Tüttelmann</author:name>
                  <author:orcid>http://orcid.org/0000-0003-2745-9965</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 432, 552, 434, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 432, 552, 434, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 441, 550, 442, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 432, 550, 441, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 441, 550, 442, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 552, 532, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 552, 532, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 550, 541, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 550, 540, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 550, 541, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 305, 527, 306, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 305, 527, 306, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 314, 525, 315, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 305, 525, 314, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 314, 525, 315, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 527, 463, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 527, 463, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 471, 525, 472, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 525, 471, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 471, 525, 472, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 527, 537, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 527, 537, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 544, 525, 545, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 525, 544, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 544, 525, 545, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 514, 315, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 514, 315, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 512, 323, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 512, 322, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 512, 323, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 514, 405, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 514, 405, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 512, 414, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 512, 413, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 512, 414, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 347, 501, 349, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 347, 501, 349, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 356, 500, 357, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 347, 500, 356, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 356, 500, 357, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 325, 476, 326, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 325, 476, 326, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 334, 474, 335, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 325, 474, 334, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 334, 474, 335, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 501, 476, 502, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 501, 476, 502, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 510, 474, 511, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 501, 474, 510, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 510, 474, 511, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 463, 288, 472
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 463, 288, 472
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 462, 296, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 287, 462, 295, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 462, 297, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 453, 463, 454, 472
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 453, 463, 454, 472
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 462, 463, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 453, 462, 462, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 462, 463, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 450, 293, 460
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 450, 293, 460
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 301, 449, 302, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 449, 301, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 301, 449, 302, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 450, 379, 460
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 450, 379, 460
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 449, 388, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 449, 387, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 449, 388, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 485, 450, 486, 460
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 485, 450, 486, 460
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 494, 449, 495, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 485, 449, 494, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 494, 449, 495, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 195, 169, 197, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 198, 169, 201, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 251, 116, 254, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 290, 95, 292, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 325, 148, 328, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 330, 148, 333, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 470, 116, 473, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 474, 116, 476, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 537, 105, 540, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 556, 95, 559, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: -2, 479, 50, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 486, 50, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 48, 382, 55
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 716, 126, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 129, 716, 134, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 148, 705, 152, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 153, 705, 158, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 173, 662, 178, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 111, 587, 115, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 117, 587, 121, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 252, 555, 255, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 145, 534, 150, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 66, 480, 71, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 74, 480, 79, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 223, 437, 229, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 231, 437, 237, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 159, 405, 164, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 167, 405, 172, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 289, 212, 294, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 58, 144, 61, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 133, 122, 136, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 57, 58, 60, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 175, 47, 178, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 529, 690, 532, 698
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 551, 690, 554, 698
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 404, 662, 409, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 410, 662, 415, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 492, 465, 496, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 536, 341, 541, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 437, 319, 442, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 389, 294, 393, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 531, 283, 536, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 464, 251, 469, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 353, 208, 358, 216
       Flags: Print
       AppearanceDictionary: true
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 372, 148, 377, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 547, 144, 552, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 360, 116, 365, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 491, 101, 496, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 382, 58, 386, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 139
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 308, 74, 495, 81
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 272, 95, 276, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 257, 73, 262, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 435, 133, 439, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 463, 133, 467, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 89, 201, 93, 205
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 90, 193, 94, 197
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 149, 101, 153, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 540, 95, 545, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 401, 73, 407, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 322, 47, 326, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 572, 109, 580
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 87, 369, 92, 377
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 57, 337, 62, 345
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 249, 341, 254, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 255, 341, 260, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 59, 251, 63, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 138, 180, 142, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 136, 144, 140, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 212, 73, 218, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 270, 62, 275, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 206, 52, 211, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 489, 540, 493, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 380, 476, 384, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 454, 427, 459, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 409, 358, 414, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 426, 229, 429, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 450, 229, 455, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 466, 208, 471, 216
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 555, 176, 559, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 365, 144, 369, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 392, 144, 396, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
     Thumb: true
    Page: 
     Label: 7
     Thumb: true
    Page: 
     Label: 8
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 139, 711, 144, 720
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 160, 497, 164, 505
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 216, 262, 220, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 170, 90, 174, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 283, 58, 287, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 526, 598, 531, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 532, 598, 537, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 538, 598, 543, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 544, 598, 550, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 553, 598, 559, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 373, 587, 378, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 403, 587, 409, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 437, 587, 442, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 443, 587, 449, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 496, 587, 502, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 372, 561, 376, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 378, 544, 384, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 385, 544, 391, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 333, 352, 339, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 459, 234, 465, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 466, 234, 470, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 512, 191, 517, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 547, 191, 552, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 554, 191, 559, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 334, 180, 339, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 340, 180, 346, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 369, 180, 374, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 409, 180, 415, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 454, 180, 459, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 488, 180, 494, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 495, 180, 500, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 501, 180, 506, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 555, 180, 561, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 397, 127, 402, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 536, 127, 542, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 482, 116, 488, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 488, 69, 493, 77
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 517, 73, 522, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 265, 105, 270, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 509, 105, 514, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 515, 105, 520, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 416, 604, 555, 611
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 594, 354, 601
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 67, 673, 73, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 55, 641, 58, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 59, 641, 64, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 177, 555, 182, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 99, 480, 104, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 218, 469, 223, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 283, 427, 286, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 287, 427, 292, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 187, 373, 190, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 282, 287, 288, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 289, 287, 294, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 250, 277, 257, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 100, 255, 103, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 104, 255, 110, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 93, 73, 98, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 366, 726, 370, 731
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 372, 726, 377, 731
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 455, 705, 461, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 481, 651, 486, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 336, 384, 341, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 325, 202, 331, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 423, 169, 428, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 373, 148, 378, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 441, 105, 446, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 286, 534, 292, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 93, 437, 98, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 87, 427, 93, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 199, 416, 205, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 177, 362, 182, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 161, 277, 166, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 218, 272, 294, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 262, 52, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 55, 266, 60, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 63, 266, 68, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 211, 251, 294, 259
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 240, 140, 248
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 140, 244, 145, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 147, 244, 151, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 83, 212, 89, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 95, 208, 166, 216
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 149, 159, 154, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 424, 694, 430, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 354, 491, 360, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 491, 148, 496, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 240, 379, 252, 388
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 99, 358, 294, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 347, 185, 355
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 187, 352, 193, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 195, 352, 200, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 98, 191, 104, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 142, 116, 148, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 115, 73, 120, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 488
      Annotation: 
       Subtype: Link
       Rect: 523, 651, 529, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 72, 673, 77, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 289, 641, 294, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 190, 619, 193, 624
       Flags: Print
       AppearanceDictionary: true
       Destination: 426
      Annotation: 
       Subtype: Link
       Rect: 97, 598, 103, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 499
      Annotation: 
       Subtype: Link
       Rect: 123, 369, 294, 377
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 358, 70, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 157, 358, 294, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 347, 105, 355
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 201, 347, 294, 355
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 337, 149, 345
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 103, 229, 173, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 194, 229, 267, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 165, 294, 173
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 154, 126, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 154, 294, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 144, 130, 152
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 144, 294, 152
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 133, 123, 141
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 133, 294, 141
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 122, 127, 131
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 268, 122, 294, 131
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 112, 162, 120
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 268, 112, 294, 120
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 101, 163, 109
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 268, 101, 294, 109
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 90, 165, 98
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 42, 79, 187, 88
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 347, 484, 355
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 437, 197, 551, 205
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 187, 365, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 360, 165, 516, 173
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 701, 516, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 536, 701, 540, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 306, 465, 468, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 358, 421, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 456, 187, 561, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 176, 365, 184
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 145, 604, 263, 612
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: a5cedfe4
   Type: CRC32
  Checksum: e2f4730c93ebb48bffad088d12a66c9a
   Type: MD5
  Checksum: 16e79374612f433ad5802320e6e3f687f89b4de3
   Type: SHA-1
  Checksum: ecb27b0d61d95560b910b1c2da34e4434a09ed1d51e34014bee28a8c2882ab10
   Type: SHA-256