f0762b30ee3a87ee986bf96c87f199f6  MolCan_a2024v23p21.pdf
8f6bbc30d21500a78e947f8d383d7423a62f7fbb  MolCan_a2024v23p21.pdf
921264c685e247c71baa7325d9a852894f538fa1d9bf373b046a56db05e7b120  MolCan_a2024v23p21.pdf

Title:           The DNA damage sensor ATM kinase interacts with the
Subject:         Molecular Cancer, https://doi.org/10.1186/s12943-024-01933-z
Keywords:        MDM2;Synonymous mutations;RNA secondary structure;Genotoxic stress;MRN complex;DNA Damage Sensing;Precision medicine
Author:           Konstantinos Karakostis 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Sat Jan 20 10:46:55 2024 CET
ModDate:         Tue Jan 23 07:03:30 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           12
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       2414268 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     43  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     44  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     45  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  no     319  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     78  0
MyriadPro-LightIt                    Type 1C           Custom           yes no  yes     77  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     49  0
WarnockPro-It                        Type 1C           Custom           yes no  yes     46  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     47  0
UBJBIK+STIXMath-Regular              Type 1C           Custom           yes yes yes     48  0
TKSQUM+STIX-Regular                  Type 1C           Custom           yes yes yes     79  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    273  0
JUTTOU+WarnockPro-Bold               Type 1C           WinAnsi          yes yes yes    185  0
AMAFOY+Code2000                      CID TrueType      Identity-H       yes yes yes    227  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-09-13 02:48:51 CEST
 RepresentationInformation: MolCan_a2024v23p21.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-09-12 16:55:35 CEST
  Size: 2414268
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 407
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusion 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Plasmids, recombinant proteins and cell lines
         Item: 
          Title: RNA Binding assay (co-immunoprecipitation)
         Item: 
          Title: Immunochemistry, Proximity Ligation Assay (PLA)
         Item: 
          Title: In vitro RNA–Protein (RPI) ELISA and Protein–Protein (PPI) sandwich ELISA
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: The p53 mRNA interacts with ATM kinase in normal conditions, but following DNA damage activated MDMX competes for the p53 mRNA preventing its association with the NBS1 protein of the MRN complex
         Item: 
          Title: The FAT and the PI3K domains of ATM bind the p53 mRNA
         Item: 
          Title: Phosphorylation events on ATM act synergistically to control the interaction of the FAT and PI3K domains with MDM2 for the trafficking of this complex to the cytoplasm
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: The DNA damage sensor ATM kinase interacts with the
    Author:  Konstantinos Karakostis 
    Subject: Molecular Cancer, https://doi.org/10.1186/s12943-024-01933-z
    Keywords: MDM2;Synonymous mutations;RNA secondary structure;Genotoxic stress;MRN complex;DNA Damage Sensing;Precision medicine
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sat Jan 20 10:46:55 CET 2024
    ModDate: Tue Jan 23 07:03:30 CET 2024
   ID: 0x96f27d555dbbbeb7240071a392c21d87, 0xfb850b30e7b239c7386cfccc9d250dcd
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 39
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 81
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 74
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1217
      ImageHeight: 2199
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1673
      ImageHeight: 2363
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: AMAFOY+Code2000
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: UBJBIK+STIXMath-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: UBJBIK+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JUTTOU+WarnockPro-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: JUTTOU+WarnockPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -183, -599, 1614, 1030
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular2
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TKSQUM+STIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 44
      FontDescriptor: 
       FontName: TKSQUM+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: AMAFOY+Code2000
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: AMAFOY+Code2000
       Flags: Serif, Symbolic
       FontBBox: -1111, -295, 2107, 977
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2024-01-20T09:46:55</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2024-01-23T07:03:30+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-01-23T07:03:30+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>MDM2;Synonymous mutations;RNA secondary structure;Genotoxic stress;MRN complex;DNA Damage Sensing;Precision medicine</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s12943-024-01933-z</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Molecular Cancer, https://doi.org/10.1186/s12943-024-01933-z</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>MDM2</rdf:li>
               <rdf:li>Synonymous mutations</rdf:li>
               <rdf:li>RNA secondary structure</rdf:li>
               <rdf:li>Genotoxic stress</rdf:li>
               <rdf:li>MRN complex</rdf:li>
               <rdf:li>DNA Damage Sensing</rdf:li>
               <rdf:li>Precision medicine</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The DNA damage sensor ATM kinase interacts with the</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Konstantinos Karakostis </rdf:li>
               <rdf:li> Laurence Malbert-Colas </rdf:li>
               <rdf:li> Aikaterini Thermou </rdf:li>
               <rdf:li> Borek Vojtesek </rdf:li>
               <rdf:li> Robin Fåhraeus </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12943-024-01933-z</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s12943-024-01933-z</prism:url>
         <prism:doi>10.1186/s12943-024-01933-z</prism:doi>
         <prism:issn>1476-4598</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Molecular Cancer</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12943-024-01933-z</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:fa5921d8-7d0e-4d21-876d-5d1d05d0c11d</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:852b8009-0e67-46ea-a3f7-a37c44d9c640</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:fa5921d8-7d0e-4d21-876d-5d1d05d0c11d</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-01-23T02:08:37Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 66, 330, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 66, 530, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 58, 276, 50
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 78, 631, 83, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 59, 535, 64, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 101, 487, 106, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 283, 487, 288, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 56, 475, 61, 463
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 159, 355, 164, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 169, 355, 174, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 130, 271, 134, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 139, 271, 144, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 219, 151, 224, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 280, 103, 285, 91
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 512, 680, 517, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 523, 680, 533, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 327, 608, 332, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 337, 608, 342, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 347, 608, 357, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 362, 608, 372, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 377, 608, 387, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 429, 500, 434, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 439, 500, 443, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 405, 344, 510, 332
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 308, 140, 495, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 169, 584, 269, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 101, 463, 204, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 146, 415, 226, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 476, 704, 538, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 304, 692, 341, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 468, 500, 473, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 478, 500, 483, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 328, 404, 333, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 438, 368, 443, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
     Thumb: true
    Page: 
     Sequence: 4
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 191, 597, 196, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 243, 465, 248, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 111, 453, 116, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 208, 453, 213, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 201, 417, 206, 404
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 175, 405, 180, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 275, 405, 280, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 79, 321, 84, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 181, 321, 186, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 175, 273, 180, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 275, 273, 280, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 178, 177, 183, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 275, 177, 279, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 131, 141, 136, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 231, 141, 236, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 197, 105, 207, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 307, 681, 312, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 338, 681, 343, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 434, 681, 439, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 528, 561, 532, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 392, 549, 396, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 326, 381, 331, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 428, 381, 433, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 372, 237, 377, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 468, 237, 473, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 325, 201, 330, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 178, 705, 183, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 278, 705, 283, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 146, 693, 151, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 136, 633, 141, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 181, 561, 186, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 278, 561, 283, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 139, 549, 144, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 112, 429, 117, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 211, 429, 216, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 77, 381, 82, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 92, 357, 97, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 364, 501, 369, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 465, 501, 470, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 430, 429, 435, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 526, 429, 531, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 389, 417, 394, 404
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 390, 393, 395, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 488, 393, 492, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 693, 82, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 172, 693, 177, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 190, 561, 195, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 209, 453, 214, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 75, 441, 80, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 176, 441, 181, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 153, 261, 158, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 253, 261, 258, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 274, 153, 279, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 337, 621, 342, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 523, 429, 533, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 307, 393, 312, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 523, 357, 533, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 503, 345, 508, 332
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 503, 177, 508, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 208, 525, 213, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 213, 477, 218, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 224, 477, 234, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 248, 441, 253, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 259, 441, 269, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 275, 441, 285, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 84, 381, 94, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 100, 381, 110, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 112, 357, 122, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 219, 357, 229, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 240, 309, 245, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 194, 297, 204, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 88, 273, 98, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 258
      Annotation: 
       Subtype: Link
       Rect: 174, 261, 179, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 253, 165, 258, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 469, 453, 474, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 441, 165, 451, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 258
      Annotation: 
       Subtype: Link
       Rect: 510, 129, 520, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 258
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 224, 681, 229, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 78, 561, 83, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 179, 561, 184, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 234
      Annotation: 
       Subtype: Link
       Rect: 275, 429, 285, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 258
      Annotation: 
       Subtype: Link
       Rect: 149, 405, 159, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 258
      Annotation: 
       Subtype: Link
       Rect: 59, 369, 69, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 258
      Annotation: 
       Subtype: Link
       Rect: 326, 525, 331, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 248, 658, 281, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 649, 155, 641
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 240, 606, 243, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 128, 597, 131, 589
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 255, 597, 258, 589
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 151, 588, 155, 580
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 260, 588, 263, 580
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 151, 579, 155, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 172, 364, 176, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 187, 324, 191, 316
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
  Checksum: 522349c5
   Type: CRC32
  Checksum: f0762b30ee3a87ee986bf96c87f199f6
   Type: MD5
  Checksum: 8f6bbc30d21500a78e947f8d383d7423a62f7fbb
   Type: SHA-1
  Checksum: 921264c685e247c71baa7325d9a852894f538fa1d9bf373b046a56db05e7b120
   Type: SHA-256