d664cf6d759037ec2b3e50663cc885a4 TreGen_a2024v40n6p540.pdf a5fceb57714aa9d1bf1f9216f29bbb0b9338a68c TreGen_a2024v40n6p540.pdf 12a3712511bfdbf3ab1e52bf6815833b1816c739a0d3adcd6a144f798938b99b TreGen_a2024v40n6p540.pdf Title: Genetic adaptations for the oceanic success of fish eggs Subject: Trends in Genetics, 40 (2024) 540-554. doi:10.1016/j.tig.2024.01.004 Keywords: adaptive radiation; yolk proteolysis; vitellogenin; aquaporin; trafficking; oocyte hydration Author: Roderick Nigel Finn Creator: Elsevier CreationDate: Tue May 21 04:01:26 2024 CEST ModDate: Tue May 21 04:01:26 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 15 Encrypted: no Page size: 603.779 x 782.362 pts Page rot: 0 File size: 4267969 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LGABJL+AdvTTb0eaa911 Type 1C WinAnsi yes yes no 760 0 LGABPC+AdvTT1895a33e+03 Type 1C Custom yes yes yes 783 0 LGABPD+AdvTT739e07da Type 1C WinAnsi yes yes no 789 0 LGABJM+AdvOTb8f60ac3 Type 1C WinAnsi yes yes no 761 0 LGABJN+AdvOTb8f60ac3+fb Type 1C Custom yes yes yes 762 0 LGABKN+AdvTT1895a33e Type 1C WinAnsi yes yes no 763 0 LGABNN+AdvTT5d017813 Type 1C WinAnsi yes yes no 764 0 LGABNO+AdvTT5d017813+fb Type 1C Custom yes yes yes 765 0 LGABNP+AdvTT1895a33e+fb Type 1C Custom yes yes yes 766 0 LGABOA+AdvTTe0754e31.B Type 1C WinAnsi yes yes no 767 0 LGABPB+AdvTT1895a33e+20 Type 1C Custom yes yes yes 777 0 LGACNO+Helvetica-Bold Type 1C WinAnsi yes yes no 550 0 LGADJL+AdvTTc685db85 Type 1C WinAnsi yes yes no 553 0 LGAHJD+Helvetica-Bold Type 1C WinAnsi yes yes no 557 0 LGAKLB+AdvTTc685db85+fb Type 1C Custom yes yes yes 561 0 LGACNO+Helvetica-Bold Type 1C WinAnsi yes yes no 563 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-13 02:48:48 CEST RepresentationInformation: TreGen_a2024v40n6p540.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-12 19:02:45 CEST Size: 4267969 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 843 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Genetic adaptations for the oceanic success of fish eggs Destination: maintitle Children: Item: Title: Adaptive radiation in the oceanic environment Destination: s0005 Item: Title: Physiological mechanisms for oocyte hydration Destination: s0010 Children: Item: Title: Evolution of yolk precursors Destination: s0015 Item: Title: Unique forms of Vtg evolved in vertebrates Destination: s0020 Item: Title: Mechanisms of differential proteolysis of yolk proteins during oocyte hydration Destination: s0025 Item: Title: Aquaporins mediate oocyte hydration in pelagophil teleosts Destination: s0030 Children: Item: Title: Selective retention of aqp1ab-type genes in pelagophils Destination: s0035 Item: Title: Molecular regulation of water channel trafficking Destination: s0040 Item: Title: Concluding remarks Destination: s0045 Item: Title: Acknowledgments Destination: s0050 Item: Title: Declaration of interests Destination: s0055 Item: Title: Supplemental information Destination: s0065 Item: Title: References Destination: section13 Info: Title: Genetic adaptations for the oceanic success of fish eggs Author: Roderick Nigel Finn Subject: Trends in Genetics, 40 (2024) 540-554. doi:10.1016/j.tig.2024.01.004 Keywords: adaptive radiation; yolk proteolysis; vitellogenin; aquaporin; trafficking; oocyte hydration Creator: Elsevier CreationDate: Tue May 21 04:01:26 CEST 2024 ModDate: Tue May 21 04:01:26 CEST 2024 ID: 0xa3767bfae8e2d8060e164150b00e327e, 0x3bfa3a0c5a19ed43b142e87221adf484 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1452 ImageHeight: 1153 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1452 ImageHeight: 959 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1820 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1452 ImageHeight: 1514 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1501 ImageHeight: 2339 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1965 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: LGACNO+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: LGACNO+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABPB+AdvTT1895a33e+20 FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: LGABPB+AdvTT1895a33e+20 Flags: Symbolic FontBBox: -197, -145, 1395, 739 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LGADJL+AdvTTc685db85 FontSubset: true FirstChar: 40 LastChar: 233 FontDescriptor: FontName: LGADJL+AdvTTc685db85 Flags: Nonsymbolic FontBBox: -135, -197, 968, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGAHJD+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: LGAHJD+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABPC+AdvTT1895a33e+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: LGABPC+AdvTT1895a33e+03 Flags: Symbolic FontBBox: -354, -218, 781, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LGAKLB+AdvTTc685db85+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LGAKLB+AdvTTc685db85+fb Flags: Symbolic FontBBox: 9, 0, 458, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LGACNO+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: LGACNO+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABPD+AdvTT739e07da FontSubset: true FirstChar: 40 LastChar: 242 FontDescriptor: FontName: LGABPD+AdvTT739e07da Flags: Nonsymbolic FontBBox: -20, -208, 906, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABJL+AdvTTb0eaa911 FontSubset: true FirstChar: 82 LastChar: 119 FontDescriptor: FontName: LGABJL+AdvTTb0eaa911 Flags: Nonsymbolic FontBBox: -31, -229, 968, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABJM+AdvOTb8f60ac3 FontSubset: true FirstChar: 71 LastChar: 117 FontDescriptor: FontName: LGABJM+AdvOTb8f60ac3 Flags: Nonsymbolic FontBBox: -41, -208, 885, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABJN+AdvOTb8f60ac3+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LGABJN+AdvOTb8f60ac3+fb Flags: Symbolic FontBBox: 0, 0, 500, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LGABKN+AdvTT1895a33e FontSubset: true FirstChar: 34 LastChar: 250 FontDescriptor: FontName: LGABKN+AdvTT1895a33e Flags: Nonsymbolic FontBBox: -62, -197, 895, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABNN+AdvTT5d017813 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: LGABNN+AdvTT5d017813 Flags: Nonsymbolic FontBBox: -41, -218, 937, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LGABNO+AdvTT5d017813+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LGABNO+AdvTT5d017813+fb Flags: Symbolic FontBBox: 0, 0, 489, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LGABNP+AdvTT1895a33e+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LGABNP+AdvTT1895a33e+fb Flags: Symbolic FontBBox: 0, 0, 375, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LGABOA+AdvTTe0754e31.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: LGABOA+AdvTTe0754e31.B Flags: Nonsymbolic FontBBox: -41, -208, 937, 968 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.tig.2024.01.004 Genetic adaptations for the oceanic success of fish eggs Roderick Nigel Finn Joan Cerdà adaptive radiation yolk proteolysis vitellogenin aquaporin trafficking oocyte hydration Trends in Genetics, 40 (2024) 540-554. doi:10.1016/j.tig.2024.01.004 The Authors journal Trends in Genetics © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 0168-9525 40 6 June 2024 540-554 540 554 10.1016/j.tig.2024.01.004 https://doi.org/10.1016/j.tig.2024.01.004 2010-04-23 true 10.1016/j.tig.2024.01.004 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.tig.2024.01.004 noindex 2010-04-23 true elsevier.com sciencedirect.com Elsevier 2024-05-21T02:01:26Z 2024-05-21T02:01:26Z 2024-05-21T02:01:26Z True 1 https://www.elsevier.com/tdm/tdmrep-policy.json adaptive radiation; yolk proteolysis; vitellogenin; aquaporin; trafficking; oocyte hydration uuid:80a77fce-63e8-4424-b638-9280ec488449 uuid:e08d6705-4eb7-48de-bb47-89b66a906e83 Pages: Page: Label: 540 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 147, 580, 156, 589 Annotation: Subtype: Link Rect: 157, 582, 162, 593 Destination: 705 Annotation: Subtype: Link Rect: 164, 582, 169, 593 Destination: 705 Annotation: Subtype: Link Rect: 171, 578, 175, 589 Destination: 705 Annotation: Subtype: Link Rect: 254, 580, 263, 589 Annotation: Subtype: Link Rect: 264, 582, 269, 593 Destination: 705 Annotation: Subtype: Link Rect: 271, 582, 276, 593 Destination: 705 Annotation: Subtype: Link Rect: 278, 578, 282, 589 Destination: 705 Annotation: Subtype: Link Rect: 211, 366, 234, 375 Destination: 1 Annotation: Subtype: Link Rect: 252, 354, 285, 363 Destination: 1 Annotation: Subtype: Link Rect: 57, 330, 71, 339 Destination: 269 Annotation: Subtype: Link Rect: 260, 319, 265, 328 Destination: 269 Annotation: Subtype: Link Rect: 267, 319, 272, 328 Destination: 269 Annotation: Subtype: Link Rect: 366, 295, 370, 304 Destination: 269 Annotation: Subtype: Link Rect: 373, 295, 378, 304 Destination: 269 Annotation: Subtype: Link Rect: 206, 247, 211, 256 Destination: 269 Annotation: Subtype: Link Rect: 341, 235, 346, 244 Destination: 269 Annotation: Subtype: Link Rect: 318, 211, 328, 220 Destination: 269 Annotation: Subtype: Link Rect: 387, 115, 410, 124 Destination: 269 Annotation: Subtype: Link Rect: 111, 67, 121, 76 Destination: 269 Annotation: Subtype: Link Rect: 205, 46, 311, 52 Annotation: Subtype: Link Rect: 349, 37, 466, 43 Annotation: Subtype: Link Rect: 518, 32, 547, 61 Annotation: Subtype: Link Rect: 55, 720, 136, 735 Page: Label: 541 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 382, 70, 392, 79 Destination: 269 Annotation: Subtype: Link Rect: 98, 638, 106, 645 Destination: 398 Annotation: Subtype: Link Rect: 110, 628, 131, 635 Destination: 1 Annotation: Subtype: Link Rect: 186, 609, 194, 616 Destination: 398 Annotation: Subtype: Link Rect: 170, 581, 178, 588 Destination: 398 Annotation: Subtype: Link Rect: 128, 562, 135, 569 Destination: 398 Annotation: Subtype: Link Rect: 214, 524, 225, 531 Destination: 269 Annotation: Subtype: Link Rect: 59, 221, 411, 511 Annotation: Subtype: Link Rect: 139, 190, 146, 197 Destination: 398 Annotation: Subtype: Link Rect: 148, 190, 155, 197 Destination: 398 Annotation: Subtype: Link Rect: 375, 190, 409, 197 Annotation: Subtype: Link Rect: 369, 181, 411, 188 Annotation: Subtype: Link Rect: 59, 172, 126, 178 Annotation: Subtype: Link Rect: 130, 172, 220, 178 Annotation: Subtype: Link Rect: 224, 172, 312, 178 Annotation: Subtype: Link Rect: 316, 172, 396, 178 Annotation: Subtype: Link Rect: 59, 162, 117, 169 Annotation: Subtype: Link Rect: 465, 720, 547, 735 Page: Label: 542 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 285, 632, 294, 641 Destination: 269 Annotation: Subtype: Link Rect: 297, 632, 306, 641 Destination: 269 Annotation: Subtype: Link Rect: 122, 608, 132, 617 Destination: 269 Annotation: Subtype: Link Rect: 388, 560, 398, 569 Destination: 269 Annotation: Subtype: Link Rect: 97, 525, 112, 534 Destination: 269 Annotation: Subtype: Link Rect: 310, 513, 320, 522 Destination: 269 Annotation: Subtype: Link Rect: 322, 513, 332, 522 Destination: 269 Annotation: Subtype: Link Rect: 244, 453, 266, 462 Destination: 31 Annotation: Subtype: Link Rect: 100, 429, 105, 438 Destination: 269 Annotation: Subtype: Link Rect: 107, 429, 117, 438 Destination: 269 Annotation: Subtype: Link Rect: 120, 429, 130, 438 Destination: 269 Annotation: Subtype: Link Rect: 337, 429, 347, 438 Destination: 269 Annotation: Subtype: Link Rect: 166, 227, 174, 234 Destination: 398 Annotation: Subtype: Link Rect: 179, 227, 200, 234 Destination: 59 Annotation: Subtype: Link Rect: 377, 208, 385, 215 Destination: 269 Annotation: Subtype: Link Rect: 108, 180, 115, 186 Destination: 398 Annotation: Subtype: Link Rect: 356, 170, 364, 177 Destination: 398 Annotation: Subtype: Link Rect: 61, 132, 69, 139 Destination: 398 Annotation: Subtype: Link Rect: 71, 132, 79, 139 Destination: 398 Annotation: Subtype: Link Rect: 216, 85, 234, 92 Destination: 398 Annotation: Subtype: Link Rect: 55, 719, 136, 734 Page: Label: 543 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 341, 250, 351, 259 Destination: 269 Annotation: Subtype: Link Rect: 57, 202, 86, 211 Destination: 81 Annotation: Subtype: Link Rect: 401, 190, 411, 199 Destination: 269 Annotation: Subtype: Link Rect: 158, 142, 181, 151 Destination: 31 Annotation: Subtype: Link Rect: 246, 118, 256, 127 Destination: 269 Annotation: Subtype: Link Rect: 259, 118, 268, 127 Destination: 269 Annotation: Subtype: Link Rect: 55, 82, 140, 91 Destination: 254 Annotation: Subtype: Link Rect: 147, 82, 171, 91 Destination: 269 Annotation: Subtype: Link Rect: 59, 421, 411, 665 Annotation: Subtype: Link Rect: 465, 720, 547, 735 Page: Label: 544 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 55, 221, 415, 670 Annotation: Subtype: Link Rect: 349, 170, 366, 177 Destination: 1 Annotation: Subtype: Link Rect: 338, 151, 413, 158 Annotation: Subtype: Link Rect: 128, 142, 180, 149 Annotation: Subtype: Link Rect: 100, 104, 108, 111 Destination: 398 Annotation: Subtype: Link Rect: 316, 95, 324, 102 Destination: 269 Annotation: Subtype: Link Rect: 72, 76, 76, 83 Destination: 269 Annotation: Subtype: Link Rect: 189, 66, 197, 73 Destination: 398 Annotation: Subtype: Link Rect: 55, 719, 136, 734 Page: Label: 545 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 57, 644, 67, 653 Destination: 269 Annotation: Subtype: Link Rect: 69, 644, 93, 653 Destination: 269 Annotation: Subtype: Link Rect: 57, 620, 81, 629 Destination: 269 Annotation: Subtype: Link Rect: 401, 525, 410, 534 Destination: 269 Annotation: Subtype: Link Rect: 57, 477, 68, 486 Destination: 269 Annotation: Subtype: Link Rect: 70, 477, 80, 486 Destination: 269 Annotation: Subtype: Link Rect: 87, 477, 118, 486 Destination: 81 Annotation: Subtype: Link Rect: 364, 465, 388, 474 Destination: 269 Annotation: Subtype: Link Rect: 378, 405, 388, 414 Destination: 269 Annotation: Subtype: Link Rect: 312, 297, 322, 306 Destination: 269 Annotation: Subtype: Link Rect: 226, 273, 257, 283 Destination: 81 Annotation: Subtype: Link Rect: 299, 250, 309, 259 Destination: 269 Annotation: Subtype: Link Rect: 331, 226, 340, 235 Destination: 398 Annotation: Subtype: Link Rect: 57, 202, 67, 211 Destination: 269 Annotation: Subtype: Link Rect: 57, 166, 88, 175 Destination: 81 Annotation: Subtype: Link Rect: 57, 94, 79, 103 Destination: 31 Annotation: Subtype: Link Rect: 465, 720, 547, 735 Page: Label: 546 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 211, 644, 221, 653 Destination: 269 Annotation: Subtype: Link Rect: 223, 644, 247, 653 Destination: 398 Annotation: Subtype: Link Rect: 238, 620, 248, 629 Destination: 398 Annotation: Subtype: Link Rect: 250, 620, 260, 629 Destination: 398 Annotation: Subtype: Link Rect: 389, 596, 413, 605 Destination: 398 Annotation: Subtype: Link Rect: 57, 584, 90, 593 Destination: 81 Annotation: Subtype: Link Rect: 375, 572, 384, 581 Destination: 398 Annotation: Subtype: Link Rect: 387, 572, 410, 581 Destination: 398 Annotation: Subtype: Link Rect: 371, 560, 404, 569 Destination: 81 Annotation: Subtype: Link Rect: 132, 537, 164, 546 Destination: 81 Annotation: Subtype: Link Rect: 250, 513, 281, 522 Destination: 81 Annotation: Subtype: Link Rect: 262, 465, 272, 474 Destination: 398 Annotation: Subtype: Link Rect: 327, 429, 337, 438 Destination: 269 Annotation: Subtype: Link Rect: 339, 429, 349, 438 Destination: 398 Annotation: Subtype: Link Rect: 105, 345, 115, 354 Destination: 398 Annotation: Subtype: Link Rect: 229, 321, 239, 330 Destination: 398 Annotation: Subtype: Link Rect: 294, 273, 316, 283 Destination: 161 Annotation: Subtype: Link Rect: 76, 262, 86, 271 Destination: 398 Annotation: Subtype: Link Rect: 88, 262, 98, 271 Destination: 398 Annotation: Subtype: Link Rect: 400, 250, 410, 259 Destination: 398 Annotation: Subtype: Link Rect: 198, 214, 209, 223 Destination: 398 Annotation: Subtype: Link Rect: 232, 214, 261, 223 Destination: 188 Annotation: Subtype: Link Rect: 278, 214, 301, 223 Destination: 161 Annotation: Subtype: Link Rect: 162, 166, 172, 175 Destination: 398 Annotation: Subtype: Link Rect: 175, 166, 185, 175 Destination: 398 Annotation: Subtype: Link Rect: 128, 118, 153, 127 Destination: 398 Annotation: Subtype: Link Rect: 58, 94, 68, 103 Destination: 398 Annotation: Subtype: Link Rect: 55, 719, 136, 734 Page: Label: 547 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 251, 620, 281, 629 Destination: 218 Annotation: Subtype: Link Rect: 360, 596, 370, 605 Destination: 398 Annotation: Subtype: Link Rect: 233, 560, 265, 569 Destination: 218 Annotation: Subtype: Link Rect: 74, 501, 106, 510 Destination: 218 Annotation: Subtype: Link Rect: 103, 429, 112, 438 Destination: 398 Annotation: Subtype: Link Rect: 115, 429, 124, 438 Destination: 398 Annotation: Subtype: Link Rect: 103, 417, 112, 426 Destination: 398 Annotation: Subtype: Link Rect: 115, 417, 124, 426 Destination: 398 Annotation: Subtype: Link Rect: 127, 417, 137, 426 Destination: 398 Annotation: Subtype: Link Rect: 131, 393, 141, 402 Destination: 398 Annotation: Subtype: Link Rect: 143, 393, 153, 402 Destination: 398 Annotation: Subtype: Link Rect: 221, 297, 231, 306 Destination: 398 Annotation: Subtype: Link Rect: 128, 236, 135, 243 Destination: 398 Annotation: Subtype: Link Rect: 61, 217, 82, 224 Destination: 188 Annotation: Subtype: Link Rect: 282, 198, 290, 205 Destination: 398 Annotation: Subtype: Link Rect: 61, 131, 69, 138 Destination: 398 Annotation: Subtype: Link Rect: 268, 112, 275, 119 Destination: 398 Annotation: Subtype: Link Rect: 327, 94, 335, 101 Destination: 398 Annotation: Subtype: Link Rect: 227, 75, 235, 82 Destination: 398 Annotation: Subtype: Link Rect: 465, 720, 547, 735 Page: Label: 548 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 341, 129, 351, 138 Destination: 398 Annotation: Subtype: Link Rect: 59, 288, 411, 665 Annotation: Subtype: Link Rect: 82, 239, 90, 246 Destination: 398 Annotation: Subtype: Link Rect: 55, 719, 136, 734 Page: Label: 549 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 55, 97, 415, 670 Annotation: Subtype: Link Rect: 465, 720, 547, 735 Page: Label: 550 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 301, 608, 311, 617 Destination: 398 Annotation: Subtype: Link Rect: 379, 560, 410, 569 Destination: 238 Annotation: Subtype: Link Rect: 190, 297, 200, 306 Destination: 398 Annotation: Subtype: Link Rect: 247, 250, 257, 259 Destination: 398 Annotation: Subtype: Link Rect: 154, 226, 164, 235 Destination: 398 Annotation: Subtype: Link Rect: 345, 163, 363, 170 Destination: 1 Annotation: Subtype: Link Rect: 365, 125, 373, 132 Destination: 398 Annotation: Subtype: Link Rect: 57, 106, 65, 113 Destination: 398 Annotation: Subtype: Link Rect: 117, 68, 125, 75 Destination: 269 Annotation: Subtype: Link Rect: 126, 68, 134, 75 Destination: 269 Annotation: Subtype: Link Rect: 341, 68, 348, 75 Destination: 269 Annotation: Subtype: Link Rect: 350, 68, 358, 75 Destination: 398 Annotation: Subtype: Link Rect: 55, 719, 136, 734 Page: Label: 551 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 55, 186, 415, 670 Annotation: Subtype: Link Rect: 283, 164, 290, 171 Destination: 398 Annotation: Subtype: Link Rect: 292, 164, 300, 171 Destination: 398 Annotation: Subtype: Link Rect: 465, 720, 547, 735 Page: Label: 552 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 266, 632, 298, 641 Destination: 238 Annotation: Subtype: Link Rect: 153, 584, 163, 593 Destination: 398 Annotation: Subtype: Link Rect: 165, 584, 175, 593 Destination: 398 Annotation: Subtype: Link Rect: 166, 489, 176, 498 Destination: 398 Annotation: Subtype: Link Rect: 145, 453, 155, 462 Destination: 398 Annotation: Subtype: Link Rect: 400, 441, 410, 450 Destination: 398 Annotation: Subtype: Link Rect: 104, 417, 134, 426 Destination: 81 Annotation: Subtype: Link Rect: 55, 719, 136, 734 Page: Label: 553 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 271, 577, 393, 584 Annotation: Subtype: Link Rect: 67, 545, 228, 551 Annotation: Subtype: Link Rect: 67, 537, 91, 543 Annotation: Subtype: Link Rect: 67, 529, 228, 535 Annotation: Subtype: Link Rect: 67, 521, 228, 527 Annotation: Subtype: Link Rect: 67, 513, 175, 519 Annotation: Subtype: Link Rect: 67, 505, 228, 511 Annotation: Subtype: Link Rect: 67, 497, 228, 503 Annotation: Subtype: Link Rect: 67, 489, 130, 495 Annotation: Subtype: Link Rect: 67, 481, 228, 487 Annotation: Subtype: Link Rect: 67, 473, 188, 479 Annotation: Subtype: Link Rect: 66, 465, 228, 471 Annotation: Subtype: Link Rect: 66, 457, 228, 463 Annotation: Subtype: Link Rect: 66, 449, 106, 455 Annotation: Subtype: Link Rect: 67, 441, 228, 447 Annotation: Subtype: Link Rect: 67, 433, 200, 439 Annotation: Subtype: Link Rect: 66, 425, 228, 431 Annotation: Subtype: Link Rect: 66, 417, 198, 423 Annotation: Subtype: Link Rect: 66, 409, 228, 415 Annotation: Subtype: Link Rect: 66, 401, 228, 407 Annotation: Subtype: Link Rect: 66, 393, 228, 399 Annotation: Subtype: Link Rect: 66, 385, 146, 391 Annotation: Subtype: Link Rect: 67, 377, 228, 383 Annotation: Subtype: Link Rect: 67, 369, 228, 375 Annotation: Subtype: Link Rect: 67, 361, 225, 367 Annotation: Subtype: Link Rect: 67, 353, 228, 359 Annotation: Subtype: Link Rect: 67, 345, 228, 351 Annotation: Subtype: Link Rect: 67, 338, 166, 344 Annotation: Subtype: Link Rect: 66, 330, 228, 336 Annotation: Subtype: Link Rect: 66, 322, 228, 328 Annotation: Subtype: Link Rect: 66, 314, 140, 320 Annotation: Subtype: Link Rect: 67, 306, 228, 312 Annotation: Subtype: Link Rect: 67, 298, 228, 304 Annotation: Subtype: Link Rect: 67, 290, 150, 296 Annotation: Subtype: Link Rect: 67, 282, 228, 288 Annotation: Subtype: Link Rect: 67, 274, 228, 280 Annotation: Subtype: Link Rect: 67, 266, 172, 272 Annotation: Subtype: Link Rect: 66, 258, 228, 264 Annotation: Subtype: Link Rect: 66, 250, 228, 256 Annotation: Subtype: Link Rect: 66, 242, 206, 248 Annotation: Subtype: Link Rect: 67, 234, 228, 240 Annotation: Subtype: Link Rect: 67, 226, 228, 232 Annotation: Subtype: Link Rect: 66, 218, 228, 224 Annotation: Subtype: Link Rect: 66, 210, 228, 216 Annotation: Subtype: Link Rect: 66, 202, 228, 208 Annotation: Subtype: Link Rect: 66, 194, 228, 200 Annotation: Subtype: Link Rect: 67, 186, 228, 192 Annotation: Subtype: Link Rect: 67, 178, 228, 184 Annotation: Subtype: Link Rect: 67, 170, 228, 176 Annotation: Subtype: Link Rect: 67, 162, 114, 168 Annotation: Subtype: Link Rect: 67, 154, 228, 160 Annotation: Subtype: Link Rect: 67, 146, 180, 152 Annotation: Subtype: Link Rect: 66, 138, 228, 144 Annotation: Subtype: Link Rect: 66, 130, 196, 136 Annotation: Subtype: Link Rect: 66, 122, 228, 128 Annotation: Subtype: Link Rect: 66, 114, 228, 120 Annotation: Subtype: Link Rect: 66, 106, 210, 112 Annotation: Subtype: Link Rect: 66, 98, 228, 104 Annotation: Subtype: Link Rect: 66, 90, 216, 96 Annotation: Subtype: Link Rect: 67, 82, 228, 88 Annotation: Subtype: Link Rect: 67, 75, 228, 81 Annotation: Subtype: Link Rect: 251, 545, 413, 551 Annotation: Subtype: Link Rect: 251, 537, 275, 543 Annotation: Subtype: Link Rect: 251, 529, 412, 535 Annotation: Subtype: Link Rect: 251, 521, 387, 527 Annotation: Subtype: Link Rect: 251, 513, 412, 519 Annotation: Subtype: Link Rect: 251, 505, 412, 511 Annotation: Subtype: Link Rect: 251, 497, 319, 503 Annotation: Subtype: Link Rect: 251, 489, 413, 495 Annotation: Subtype: Link Rect: 251, 481, 413, 487 Annotation: Subtype: Link Rect: 251, 473, 412, 479 Annotation: Subtype: Link Rect: 251, 465, 277, 471 Annotation: Subtype: Link Rect: 251, 457, 413, 463 Annotation: Subtype: Link Rect: 251, 449, 413, 455 Annotation: Subtype: Link Rect: 251, 441, 311, 447 Annotation: Subtype: Link Rect: 251, 433, 412, 439 Annotation: Subtype: Link Rect: 251, 425, 389, 431 Annotation: Subtype: Link Rect: 251, 417, 412, 423 Annotation: Subtype: Link Rect: 251, 409, 412, 415 Annotation: Subtype: Link Rect: 251, 401, 317, 407 Annotation: Subtype: Link Rect: 251, 393, 412, 399 Annotation: Subtype: Link Rect: 251, 385, 412, 391 Annotation: Subtype: Link Rect: 251, 377, 380, 383 Annotation: Subtype: Link Rect: 251, 369, 413, 375 Annotation: Subtype: Link Rect: 251, 361, 386, 367 Annotation: Subtype: Link Rect: 251, 353, 412, 359 Annotation: Subtype: Link Rect: 251, 345, 413, 351 Annotation: Subtype: Link Rect: 251, 338, 383, 344 Annotation: Subtype: Link Rect: 251, 330, 413, 336 Annotation: Subtype: Link Rect: 251, 322, 411, 328 Annotation: Subtype: Link Rect: 251, 314, 412, 320 Annotation: Subtype: Link Rect: 251, 306, 412, 312 Annotation: Subtype: Link Rect: 251, 298, 412, 304 Annotation: Subtype: Link Rect: 251, 290, 280, 296 Annotation: Subtype: Link Rect: 251, 282, 412, 288 Annotation: Subtype: Link Rect: 251, 274, 413, 280 Annotation: Subtype: Link Rect: 251, 266, 367, 272 Annotation: Subtype: Link Rect: 251, 258, 412, 264 Annotation: Subtype: Link Rect: 251, 250, 413, 256 Annotation: Subtype: Link Rect: 251, 242, 345, 248 Annotation: Subtype: Link Rect: 251, 234, 412, 240 Annotation: Subtype: Link Rect: 251, 226, 412, 232 Annotation: Subtype: Link Rect: 251, 218, 318, 224 Annotation: Subtype: Link Rect: 251, 210, 412, 216 Annotation: Subtype: Link Rect: 251, 202, 393, 208 Annotation: Subtype: Link Rect: 251, 194, 412, 200 Annotation: Subtype: Link Rect: 251, 186, 413, 192 Annotation: Subtype: Link Rect: 251, 178, 386, 184 Annotation: Subtype: Link Rect: 251, 170, 412, 176 Annotation: Subtype: Link Rect: 251, 162, 413, 168 Annotation: Subtype: Link Rect: 251, 154, 304, 160 Annotation: Subtype: Link Rect: 251, 146, 413, 152 Annotation: Subtype: Link Rect: 251, 138, 412, 144 Annotation: Subtype: Link Rect: 251, 130, 357, 136 Annotation: Subtype: Link Rect: 251, 122, 412, 128 Annotation: Subtype: Link Rect: 251, 114, 412, 120 Annotation: Subtype: Link Rect: 251, 106, 330, 112 Annotation: Subtype: Link Rect: 251, 98, 413, 104 Annotation: Subtype: Link Rect: 251, 90, 407, 96 Annotation: Subtype: Link Rect: 251, 82, 412, 88 Annotation: Subtype: Link Rect: 251, 75, 392, 81 Annotation: Subtype: Link Rect: 465, 720, 547, 735 Page: Label: 554 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 66, 661, 228, 667 Annotation: Subtype: Link Rect: 66, 653, 216, 659 Annotation: Subtype: Link Rect: 66, 645, 228, 651 Annotation: Subtype: Link Rect: 66, 637, 228, 643 Annotation: Subtype: Link Rect: 66, 629, 214, 635 Annotation: Subtype: Link Rect: 66, 621, 228, 627 Annotation: Subtype: Link Rect: 66, 613, 228, 619 Annotation: Subtype: Link Rect: 66, 605, 220, 611 Annotation: Subtype: Link Rect: 67, 597, 228, 603 Annotation: Subtype: Link Rect: 67, 589, 228, 595 Annotation: Subtype: Link Rect: 67, 584, 74, 590 Annotation: Subtype: Link Rect: 74, 581, 228, 587 Annotation: Subtype: Link Rect: 67, 573, 210, 579 Annotation: Subtype: Link Rect: 67, 565, 228, 571 Annotation: Subtype: Link Rect: 67, 557, 228, 563 Annotation: Subtype: Link Rect: 67, 549, 228, 555 Annotation: Subtype: Link Rect: 67, 541, 134, 547 Annotation: Subtype: Link Rect: 66, 533, 228, 539 Annotation: Subtype: Link Rect: 66, 525, 228, 531 Annotation: Subtype: Link Rect: 66, 517, 228, 523 Annotation: Subtype: Link Rect: 66, 509, 212, 515 Annotation: Subtype: Link Rect: 66, 501, 228, 507 Annotation: Subtype: Link Rect: 66, 493, 228, 499 Annotation: Subtype: Link Rect: 66, 485, 228, 491 Annotation: Subtype: Link Rect: 67, 477, 228, 483 Annotation: Subtype: Link Rect: 67, 470, 228, 475 Annotation: Subtype: Link Rect: 67, 462, 228, 468 Annotation: Subtype: Link Rect: 67, 454, 88, 460 Annotation: Subtype: Link Rect: 67, 446, 228, 452 Annotation: Subtype: Link Rect: 67, 438, 228, 444 Annotation: Subtype: Link Rect: 67, 430, 221, 436 Annotation: Subtype: Link Rect: 67, 422, 228, 428 Annotation: Subtype: Link Rect: 67, 414, 228, 420 Annotation: Subtype: Link Rect: 67, 406, 225, 412 Annotation: Subtype: Link Rect: 66, 398, 228, 404 Annotation: Subtype: Link Rect: 66, 390, 228, 396 Annotation: Subtype: Link Rect: 66, 382, 228, 388 Annotation: Subtype: Link Rect: 66, 374, 210, 380 Annotation: Subtype: Link Rect: 66, 366, 228, 372 Annotation: Subtype: Link Rect: 66, 358, 228, 364 Annotation: Subtype: Link Rect: 66, 350, 228, 356 Annotation: Subtype: Link Rect: 66, 342, 158, 348 Annotation: Subtype: Link Rect: 67, 334, 228, 340 Annotation: Subtype: Link Rect: 67, 326, 228, 332 Annotation: Subtype: Link Rect: 67, 318, 141, 324 Annotation: Subtype: Link Rect: 67, 310, 228, 316 Annotation: Subtype: Link Rect: 67, 302, 228, 308 Annotation: Subtype: Link Rect: 67, 294, 139, 300 Annotation: Subtype: Link Rect: 67, 286, 228, 292 Annotation: Subtype: Link Rect: 67, 278, 228, 284 Annotation: Subtype: Link Rect: 66, 270, 228, 276 Annotation: Subtype: Link Rect: 66, 262, 227, 268 Annotation: Subtype: Link Rect: 67, 254, 228, 260 Annotation: Subtype: Link Rect: 67, 246, 140, 252 Annotation: Subtype: Link Rect: 67, 238, 228, 244 Annotation: Subtype: Link Rect: 67, 230, 228, 236 Annotation: Subtype: Link Rect: 67, 222, 160, 228 Annotation: Subtype: Link Rect: 66, 214, 228, 220 Annotation: Subtype: Link Rect: 66, 207, 228, 212 Annotation: Subtype: Link Rect: 66, 199, 216, 205 Annotation: Subtype: Link Rect: 66, 191, 228, 197 Annotation: Subtype: Link Rect: 66, 183, 228, 189 Annotation: Subtype: Link Rect: 66, 175, 140, 181 Annotation: Subtype: Link Rect: 67, 167, 228, 173 Annotation: Subtype: Link Rect: 67, 159, 228, 165 Annotation: Subtype: Link Rect: 67, 151, 197, 157 Annotation: Subtype: Link Rect: 67, 143, 228, 149 Annotation: Subtype: Link Rect: 67, 135, 228, 141 Annotation: Subtype: Link Rect: 67, 127, 88, 133 Annotation: Subtype: Link Rect: 67, 119, 228, 125 Annotation: Subtype: Link Rect: 67, 111, 228, 117 Annotation: Subtype: Link Rect: 67, 103, 82, 109 Annotation: Subtype: Link Rect: 251, 661, 413, 667 Annotation: Subtype: Link Rect: 251, 653, 413, 659 Annotation: Subtype: Link Rect: 251, 645, 329, 651 Annotation: Subtype: Link Rect: 251, 637, 413, 643 Annotation: Subtype: Link Rect: 251, 629, 308, 635 Annotation: Subtype: Link Rect: 251, 621, 412, 627 Annotation: Subtype: Link Rect: 251, 613, 369, 619 Annotation: Subtype: Link Rect: 251, 605, 412, 611 Annotation: Subtype: Link Rect: 251, 597, 412, 603 Annotation: Subtype: Link Rect: 251, 589, 375, 595 Annotation: Subtype: Link Rect: 251, 581, 413, 587 Annotation: Subtype: Link Rect: 251, 573, 413, 579 Annotation: Subtype: Link Rect: 251, 565, 412, 571 Annotation: Subtype: Link Rect: 251, 557, 371, 563 Annotation: Subtype: Link Rect: 251, 549, 413, 555 Annotation: Subtype: Link Rect: 251, 541, 413, 547 Annotation: Subtype: Link Rect: 251, 533, 413, 539 Annotation: Subtype: Link Rect: 251, 525, 344, 531 Annotation: Subtype: Link Rect: 251, 517, 412, 523 Annotation: Subtype: Link Rect: 251, 509, 412, 515 Annotation: Subtype: Link Rect: 251, 501, 409, 507 Annotation: Subtype: Link Rect: 251, 493, 412, 499 Annotation: Subtype: Link Rect: 251, 485, 412, 491 Annotation: Subtype: Link Rect: 251, 477, 355, 483 Annotation: Subtype: Link Rect: 251, 470, 413, 475 Annotation: Subtype: Link Rect: 251, 462, 412, 468 Annotation: Subtype: Link Rect: 251, 454, 315, 460 Annotation: Subtype: Link Rect: 251, 446, 412, 452 Annotation: Subtype: Link Rect: 251, 438, 404, 444 Annotation: Subtype: Link Rect: 251, 430, 413, 436 Annotation: Subtype: Link Rect: 251, 422, 327, 428 Annotation: Subtype: Link Rect: 251, 414, 412, 420 Annotation: Subtype: Link Rect: 251, 406, 412, 412 Annotation: Subtype: Link Rect: 251, 398, 392, 404 Annotation: Subtype: Link Rect: 251, 390, 412, 396 Annotation: Subtype: Link Rect: 251, 382, 413, 388 Annotation: Subtype: Link Rect: 251, 374, 360, 380 Annotation: Subtype: Link Rect: 251, 366, 412, 372 Annotation: Subtype: Link Rect: 251, 358, 412, 364 Annotation: Subtype: Link Rect: 251, 350, 367, 356 Annotation: Subtype: Link Rect: 251, 342, 412, 348 Annotation: Subtype: Link Rect: 251, 334, 375, 340 Annotation: Subtype: Link Rect: 251, 326, 412, 332 Annotation: Subtype: Link Rect: 251, 318, 401, 324 Annotation: Subtype: Link Rect: 251, 310, 412, 316 Annotation: Subtype: Link Rect: 251, 302, 412, 308 Annotation: Subtype: Link Rect: 251, 294, 364, 300 Annotation: Subtype: Link Rect: 251, 286, 413, 292 Annotation: Subtype: Link Rect: 251, 278, 388, 284 Annotation: Subtype: Link Rect: 251, 270, 412, 276 Annotation: Subtype: Link Rect: 251, 262, 412, 268 Annotation: Subtype: Link Rect: 251, 254, 412, 260 Annotation: Subtype: Link Rect: 251, 246, 273, 252 Annotation: Subtype: Link Rect: 251, 238, 413, 244 Annotation: Subtype: Link Rect: 251, 230, 413, 236 Annotation: Subtype: Link Rect: 251, 222, 317, 228 Annotation: Subtype: Link Rect: 251, 214, 412, 220 Annotation: Subtype: Link Rect: 251, 207, 316, 212 Annotation: Subtype: Link Rect: 251, 199, 412, 205 Annotation: Subtype: Link Rect: 251, 191, 412, 197 Annotation: Subtype: Link Rect: 251, 183, 311, 189 Annotation: Subtype: Link Rect: 251, 175, 412, 181 Annotation: Subtype: Link Rect: 251, 167, 309, 173 Annotation: Subtype: Link Rect: 251, 159, 413, 165 Annotation: Subtype: Link Rect: 251, 151, 413, 157 Annotation: Subtype: Link Rect: 251, 143, 268, 149 Annotation: Subtype: Link Rect: 251, 135, 413, 141 Annotation: Subtype: Link Rect: 251, 127, 402, 133 Annotation: Subtype: Link Rect: 251, 119, 413, 125 Annotation: Subtype: Link Rect: 251, 111, 413, 117 Annotation: Subtype: Link Rect: 251, 103, 288, 109 Annotation: Subtype: Link Rect: 55, 719, 136, 734 Checksum: 35186088 Type: CRC32 Checksum: d664cf6d759037ec2b3e50663cc885a4 Type: MD5 Checksum: a5fceb57714aa9d1bf1f9216f29bbb0b9338a68c Type: SHA-1 Checksum: 12a3712511bfdbf3ab1e52bf6815833b1816c739a0d3adcd6a144f798938b99b Type: SHA-256