d04fd7aa91250d12bec7f481a8ed4ca9 FroCelInf_a2024v14p1346565.pdf 6be520b1705e14d3d5abf1c8c02697ab493b4ef5 FroCelInf_a2024v14p1346565.pdf 674e9571def0b99499aa06c3ccaed26c2173b1a883d4052e55cf6fdb64b02066 FroCelInf_a2024v14p1346565.pdf Title: The Mla system and its role in maintaining outer membrane barrier function in Stenotrophomonas maltophilia Subject: Stenotrophomonas maltophilia are ubiquitous Gram-negative bacteria found in both natural and clinical environments. Keywords: Stenotrophomonas maltophilia, Mla system, biofilm, chelating agents, membrane permeability Author: Xavier Coves CreationDate: Thu Feb 22 03:59:31 2024 CET ModDate: Thu Feb 22 03:59:31 2024 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 5787531 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IOGCNC+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 1153 0 IOFOJB+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 1139 0 IOFOJC+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 1140 0 IOFOKD+AdvPSA18C Type 1C WinAnsi yes yes no 1141 0 IOFOKE+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 1142 0 IOFOKF+AdvPSA323 Type 1C WinAnsi yes yes no 1143 0 IOFOKG+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 1144 0 IOFOKH+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 1145 0 IOFOKI+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 1154 0 IOFOLI+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 1155 0 IOFOLJ+AdvTTc8b77491.I Type 1C WinAnsi yes yes no 1156 0 IOFOLK+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 1157 0 IOGDFA+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 536 0 IOGDFB+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 513 0 IOGDFC+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 531 0 IOGDGD+AdvTT58d178b9+03 Type 1C Custom yes yes yes 527 0 IOGDGE+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 529 0 IOGDHE+AdvOT1ef757c0+20 Type 1C Custom yes yes yes 530 0 IOGDHF+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 518 0 IOGDMF+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 537 0 IOGDNF+AdvOTd877c31c+22 Type 1C Custom yes yes yes 542 0 IOGDPF+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 543 0 IOGECF+AdvOTd877c31c Type 1C WinAnsi yes yes no 546 0 IOGGFJ+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 549 0 IOGKOO+AdvTT9b12cd41+22 Type 1C Custom yes yes no 550 0 IOGLBO+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 551 0 IOGLEN+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 554 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-17 02:57:38 CEST RepresentationInformation: FroCelInf_a2024v14p1346565.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-16 19:57:45 CEST Size: 5787531 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1245 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The Mla system and its role in maintaining outer membrane barrier function in Stenotrophomonas maltophilia Destination: bmark_-989908100 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Materials and methods Destination: s2 Children: Item: Title: 2.1 Bacterial strains and growth conditions Destination: s2_1 Item: Title: 2.2 Construction of markerless deletion mutants and complementation Destination: s2_2 Item: Title: 2.3 Construction of fluorescently labelled strains Destination: s2_3 Item: Title: 2.4 Growth curves and competition assays Destination: s2_4 Item: Title: 2.5 Plating efficiency assay Destination: s2_5 Item: Title: 2.6 Antimicrobial susceptibility testing Destination: s2_6 Item: Title: 2.7 NPN outer membrane permeability assay Destination: s2_7 Item: Title: 2.8 Bioassay for diffusible signal factor detection Destination: s2_8 Item: Title: 2.9 Congo red agar plate assay Destination: s2_9 Item: Title: 2.10 Biofilm formation assays Destination: s2_10 Item: Title: 2.11 Electron microscopy of bacterial cells Destination: s2_11 Item: Title: 2.12 Recombinant MlaC expression and purification Destination: s2_12 Item: Title: 2.13 Delipidation of purified MlaC protein Destination: s2_13 Item: Title: 2.14 Mass spectrometry and E. coli phospholipid identification Destination: s2_14 Item: Title: 2.15 Biophysical characterization of phospholipid binding to MlaC protein Destination: s2_15 Item: Title: 2.16 Bioinformatics analysis Destination: s2_16 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 The mla operon in S. maltophilia Destination: s3_1 Item: Title: 3.2 Sequence and structural analysis of S. maltophilia MlaC Destination: s3_2 Item: Title: 3.3 Phospholipid cargo in protein MlaC of S. maltophilia Destination: s3_3 Item: Title: 3.4 The Mla system of S. maltophilia contributes to the maintenance of the OM barrier Destination: s3_4 Item: Title: 3.5 The absence of the Mla system affects the cell morphology of S. maltophilia in the presence of EDTA Destination: s3_5 Item: Title: 3.6 Impaired biofilm formation by the Mla system mutant both in mono- and co-culture with P. aeruginosa Destination: s3_6 Item: Title: 4 Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Author contributions Destination: s6 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: The Mla system and its role in maintaining outer membrane barrier function in Stenotrophomonas maltophilia Author: Xavier Coves Subject: Stenotrophomonas maltophilia are ubiquitous Gram-negative bacteria found in both natural and clinical environments. Keywords: Stenotrophomonas maltophilia, Mla system, biofilm, chelating agents, membrane permeability CreationDate: Thu Feb 22 03:59:31 CET 2024 ModDate: Thu Feb 22 03:59:31 CET 2024 ID: 0x0fcdf30039e83e605e2d1ca2846c96db, 0xff07cb511dc6b349968036300f9dbc73 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1417 ImageHeight: 816 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1902 ImageHeight: 1084 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1299 ImageHeight: 1070 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1476 ImageHeight: 1159 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1417 ImageHeight: 472 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1864 ImageHeight: 897 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: IOGCNC+AdvTT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: IOGCNC+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOGDFB+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: IOGDFB+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOKI+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IOFOKI+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOFOLI+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: IOFOLI+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOLJ+AdvTTc8b77491.I FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: IOFOLJ+AdvTTc8b77491.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 1020, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOLK+AdvTT2c8ce45a+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IOFOLK+AdvTT2c8ce45a+fb Flags: Symbolic FontBBox: 0, 0, 947, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOGDHF+AdvOT3f84ef53 FontSubset: true FirstChar: 68 LastChar: 109 FontDescriptor: FontName: IOGDHF+AdvOT3f84ef53 Flags: Serif, Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOGDGD+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: IOGDGD+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOGDGE+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: IOGDGE+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: IOGDHE+AdvOT1ef757c0+20 FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: IOGDHE+AdvOT1ef757c0+20 Flags: Symbolic FontBBox: -135, -187, 1010, 833 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOGDFC+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IOGDFC+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOGDFA+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: IOGDFA+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOGDMF+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IOGDMF+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOGDNF+AdvOTd877c31c+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IOGDNF+AdvOTd877c31c+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOGDPF+AdvTTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: IOGDPF+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOGECF+AdvOTd877c31c FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: IOGECF+AdvOTd877c31c Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOGGFJ+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 65 LastChar: 69 FontDescriptor: FontName: IOGGFJ+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOGKOO+AdvTT9b12cd41+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: IOGKOO+AdvTT9b12cd41+22 Flags: Nonsymbolic FontBBox: 0, -156, 552, 697 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IOGLBO+AdvOTb65e897d.B FontSubset: true FirstChar: 46 LastChar: 56 FontDescriptor: FontName: IOGLBO+AdvOTb65e897d.B Flags: Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOGLEN+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IOGLEN+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOFOJB+AdvTTd3a5f740 FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: IOFOJB+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOJC+AdvTT749c1f5a.I FontSubset: true FirstChar: 45 LastChar: 118 FontDescriptor: FontName: IOFOJC+AdvTT749c1f5a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOKD+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: IOFOKD+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOKE+AdvTT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: IOFOKE+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOKF+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: IOFOKF+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFOKG+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: IOFOKG+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: IOFOKH+AdvTTd168d80a.I FontSubset: true FirstChar: 45 LastChar: 117 FontDescriptor: FontName: IOFOKH+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf Xavier Coves Uwe Mamat Oscar Conchillo-Solé Pol Huedo Marc Bravo Andromeda-Celeste Gómez Ines Krohn Wolfgang R. Streit Ulrich E. Schaible Isidre Gibert Xavier Daura Daniel Yero Stenotrophomonas maltophilia are ubiquitous Gram-negative bacteria found in both natural and clinical environments. Copyright © 2024 Coves, Mamat, Conchillo-Solé, Huedo, Bravo, Gómez, Krohn, Streit, Schaible, Gibert, Daura and Yero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The Mla system and its role in maintaining outer membrane barrier function in Stenotrophomonas maltophilia Stenotrophomonas maltophilia Mla system biofilm chelating agents membrane permeability Stenotrophomonas maltophilia, Mla system, biofilm, chelating agents, membrane permeability True https://www.frontiersin.org/legal/copyright-statement 2024-02-22T10:59:31+08:00 2024-02-22T10:59:31+08:00 2024-02-22T10:59:31+08:00 uuid:ba3bae96-4056-4f27-a4ce-512896d8d27f uuid:2d6b24d3-c266-49e4-b30d-cdae23ba58ed Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 510, 706 Annotation: Subtype: Link Rect: 221, 660, 504, 681 Annotation: Subtype: Link Rect: 221, 635, 396, 656 Annotation: Subtype: Link Rect: 221, 610, 520, 631 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 510, 128, 517 Annotation: Subtype: Link Rect: 60, 490, 125, 497 Annotation: Subtype: Link Rect: 49, 369, 156, 375 Annotation: Subtype: Link Rect: 155, 319, 180, 326 Annotation: Subtype: Link Rect: 49, 309, 168, 317 Annotation: Subtype: Link Rect: 454, 802, 510, 809 Annotation: Subtype: Link Rect: 471, 793, 527, 800 Annotation: Subtype: Link Rect: 451, 783, 542, 790 Annotation: Subtype: Link Rect: 49, 789, 328, 806 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 135, 694, 210, 703 Destination: 402 Annotation: Subtype: Link Rect: 103, 669, 152, 678 Destination: 402 Annotation: Subtype: Link Rect: 53, 619, 148, 628 Destination: 402 Annotation: Subtype: Link Rect: 113, 569, 217, 578 Destination: 461 Annotation: Subtype: Link Rect: 222, 569, 269, 578 Destination: 402 Annotation: Subtype: Link Rect: 143, 519, 216, 528 Destination: 461 Annotation: Subtype: Link Rect: 52, 431, 147, 440 Destination: 402 Annotation: Subtype: Link Rect: 152, 431, 209, 440 Destination: 378 Annotation: Subtype: Link Rect: 214, 431, 262, 440 Destination: 402 Annotation: Subtype: Link Rect: 241, 406, 290, 415 Destination: 402 Annotation: Subtype: Link Rect: 49, 394, 66, 403 Destination: 402 Annotation: Subtype: Link Rect: 52, 344, 125, 353 Destination: 461 Annotation: Subtype: Link Rect: 96, 294, 147, 303 Destination: 461 Annotation: Subtype: Link Rect: 152, 294, 200, 303 Destination: 402 Annotation: Subtype: Link Rect: 187, 231, 254, 240 Destination: 402 Annotation: Subtype: Link Rect: 259, 231, 290, 240 Destination: 461 Annotation: Subtype: Link Rect: 49, 219, 66, 228 Destination: 461 Annotation: Subtype: Link Rect: 70, 219, 168, 228 Destination: 461 Annotation: Subtype: Link Rect: 172, 219, 237, 228 Destination: 402 Annotation: Subtype: Link Rect: 164, 156, 245, 165 Destination: 461 Annotation: Subtype: Link Rect: 251, 156, 290, 165 Destination: 378 Annotation: Subtype: Link Rect: 49, 144, 66, 153 Destination: 378 Annotation: Subtype: Link Rect: 444, 719, 543, 728 Destination: 461 Annotation: Subtype: Link Rect: 304, 706, 383, 715 Destination: 402 Annotation: Subtype: Link Rect: 444, 656, 495, 665 Destination: 461 Annotation: Subtype: Link Rect: 358, 619, 458, 628 Destination: 461 Annotation: Subtype: Link Rect: 307, 569, 377, 578 Destination: 402 Annotation: Subtype: Link Rect: 381, 569, 442, 578 Destination: 461 Annotation: Subtype: Link Rect: 417, 556, 524, 565 Destination: 461 Annotation: Subtype: Link Rect: 338, 531, 399, 540 Destination: 461 Annotation: Subtype: Link Rect: 404, 531, 472, 540 Destination: 402 Annotation: Subtype: Link Rect: 477, 531, 543, 540 Destination: 378 Annotation: Subtype: Link Rect: 304, 519, 387, 528 Destination: 402 Annotation: Subtype: Link Rect: 393, 519, 453, 528 Destination: 461 Annotation: Subtype: Link Rect: 307, 481, 414, 490 Destination: 461 Annotation: Subtype: Link Rect: 419, 481, 485, 490 Destination: 402 Annotation: Subtype: Link Rect: 483, 444, 543, 453 Destination: 402 Annotation: Subtype: Link Rect: 304, 431, 374, 440 Destination: 402 Annotation: Subtype: Link Rect: 378, 431, 440, 440 Destination: 461 Annotation: Subtype: Link Rect: 514, 194, 543, 203 Destination: 51 Annotation: Subtype: Link Rect: 384, 181, 444, 190 Destination: 378 Annotation: Subtype: Link Rect: 510, 106, 545, 115 Destination: 378 Annotation: Subtype: Link Rect: 304, 94, 321, 103 Destination: 378 Annotation: Subtype: Link Rect: 512, 69, 545, 78 Destination: 461 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 304, 313, 346, 322 Destination: 461 Annotation: Subtype: Link Rect: 485, 144, 545, 153 Destination: 402 Annotation: Subtype: Link Rect: 304, 132, 322, 140 Destination: 402 Annotation: Subtype: Link Rect: 326, 132, 393, 140 Destination: 378 Annotation: Subtype: Link Rect: 243, 646, 258, 654 Destination: 378 Annotation: Subtype: Link Rect: 240, 637, 271, 644 Destination: 378 Annotation: Subtype: Link Rect: 243, 578, 263, 585 Destination: 461 Annotation: Subtype: Link Rect: 240, 568, 271, 575 Destination: 461 Annotation: Subtype: Link Rect: 243, 508, 258, 515 Destination: 461 Annotation: Subtype: Link Rect: 240, 499, 271, 506 Destination: 461 Annotation: Subtype: Link Rect: 243, 446, 270, 453 Destination: 402 Annotation: Subtype: Link Rect: 240, 437, 254, 444 Destination: 402 Annotation: Subtype: Link Rect: 243, 420, 272, 427 Destination: 461 Annotation: Subtype: Link Rect: 240, 411, 272, 418 Destination: 461 Annotation: Subtype: Link Rect: 240, 401, 254, 408 Destination: 461 Annotation: Subtype: Link Rect: 243, 341, 256, 348 Destination: 461 Annotation: Subtype: Link Rect: 240, 332, 271, 339 Destination: 461 Annotation: Subtype: Link Rect: 243, 272, 263, 279 Destination: 402 Annotation: Subtype: Link Rect: 240, 262, 271, 269 Destination: 402 Annotation: Subtype: Link Rect: 243, 165, 278, 172 Destination: 402 Annotation: Subtype: Link Rect: 240, 156, 281, 163 Destination: 402 Annotation: Subtype: Link Rect: 243, 130, 253, 137 Destination: 378 Annotation: Subtype: Link Rect: 240, 120, 271, 127 Destination: 378 Annotation: Subtype: Link Rect: 498, 683, 527, 690 Destination: 402 Annotation: Subtype: Link Rect: 496, 673, 526, 680 Destination: 402 Annotation: Subtype: Link Rect: 496, 664, 516, 671 Destination: 402 Annotation: Subtype: Link Rect: 496, 654, 526, 661 Destination: 402 Annotation: Subtype: Link Rect: 498, 638, 519, 645 Destination: 402 Annotation: Subtype: Link Rect: 496, 628, 526, 635 Destination: 402 Annotation: Subtype: Link Rect: 498, 576, 522, 583 Destination: 402 Annotation: Subtype: Link Rect: 496, 566, 526, 573 Destination: 402 Annotation: Subtype: Link Rect: 498, 417, 518, 424 Destination: 461 Annotation: Subtype: Link Rect: 496, 407, 526, 414 Destination: 461 Annotation: Subtype: Link Rect: 498, 372, 518, 379 Destination: 461 Annotation: Subtype: Link Rect: 496, 362, 526, 369 Destination: 461 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 192, 756, 227, 765 Destination: 51 Annotation: Subtype: Link Rect: 234, 756, 238, 765 Destination: 114 Annotation: Subtype: Link Rect: 253, 381, 280, 390 Destination: 114 Annotation: Subtype: Link Rect: 170, 269, 244, 278 Destination: 461 Annotation: Subtype: Link Rect: 261, 181, 290, 190 Destination: 402 Annotation: Subtype: Link Rect: 49, 169, 120, 178 Destination: 402 Annotation: Subtype: Link Rect: 52, 144, 120, 153 Destination: 461 Annotation: Subtype: Link Rect: 472, 669, 540, 678 Destination: 378 Annotation: Subtype: Link Rect: 351, 606, 444, 615 Destination: 402 Annotation: Subtype: Link Rect: 435, 569, 527, 578 Destination: 402 Annotation: Subtype: Link Rect: 425, 556, 525, 565 Destination: 402 Annotation: Subtype: Link Rect: 307, 531, 334, 540 Destination: 114 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 270, 112, 290, 121 Destination: 402 Annotation: Subtype: Link Rect: 49, 99, 66, 108 Destination: 402 Annotation: Subtype: Link Rect: 238, 99, 290, 108 Destination: 461 Annotation: Subtype: Link Rect: 49, 87, 290, 96 Destination: 461 Annotation: Subtype: Link Rect: 49, 74, 208, 83 Destination: 461 Annotation: Subtype: Link Rect: 171, 187, 214, 193 Destination: 461 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 142, 544, 285, 553 Destination: 402 Annotation: Subtype: Link Rect: 145, 531, 201, 540 Destination: 402 Annotation: Subtype: Link Rect: 205, 531, 285, 540 Destination: 402 Annotation: Subtype: Link Rect: 129, 131, 196, 140 Destination: 402 Annotation: Subtype: Link Rect: 347, 431, 404, 440 Destination: 461 Annotation: Subtype: Link Rect: 471, 69, 540, 78 Destination: 402 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 165, 169, 193, 178 Destination: 114 Annotation: Subtype: Link Rect: 430, 294, 500, 303 Destination: 461 Annotation: Subtype: Link Rect: 519, 294, 545, 303 Destination: 402 Annotation: Subtype: Link Rect: 304, 281, 347, 290 Destination: 402 Annotation: Subtype: Link Rect: 450, 281, 542, 290 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 269, 594, 290, 603 Annotation: Subtype: Link Rect: 49, 581, 111, 590 Annotation: Subtype: Link Rect: 52, 556, 195, 565 Annotation: Subtype: Link Rect: 203, 544, 285, 553 Destination: 402 Annotation: Subtype: Link Rect: 52, 519, 113, 528 Destination: 402 Annotation: Subtype: Link Rect: 229, 519, 285, 528 Destination: 378 Annotation: Subtype: Link Rect: 229, 494, 287, 503 Destination: 402 Annotation: Subtype: Link Rect: 82, 469, 160, 478 Destination: 461 Annotation: Subtype: Link Rect: 83, 444, 146, 453 Destination: 461 Annotation: Subtype: Link Rect: 220, 444, 287, 453 Destination: 402 Annotation: Subtype: Link Rect: 105, 419, 183, 428 Annotation: Subtype: Link Rect: 83, 369, 146, 378 Destination: 461 Annotation: Subtype: Link Rect: 264, 369, 290, 378 Annotation: Subtype: Link Rect: 49, 356, 136, 365 Annotation: Subtype: Link Rect: 247, 356, 290, 365 Destination: 461 Annotation: Subtype: Link Rect: 49, 344, 89, 353 Destination: 461 Annotation: Subtype: Link Rect: 188, 344, 258, 353 Destination: 402 Annotation: Subtype: Link Rect: 175, 306, 290, 315 Annotation: Subtype: Link Rect: 49, 294, 83, 303 Annotation: Subtype: Link Rect: 243, 219, 287, 228 Destination: 402 Annotation: Subtype: Link Rect: 252, 206, 290, 215 Destination: 461 Annotation: Subtype: Link Rect: 49, 194, 66, 203 Destination: 461 Annotation: Subtype: Link Rect: 138, 181, 290, 190 Destination: 461 Annotation: Subtype: Link Rect: 49, 169, 122, 178 Destination: 461 Annotation: Subtype: Link Rect: 307, 744, 400, 753 Destination: 378 Annotation: Subtype: Link Rect: 439, 619, 520, 628 Destination: 378 Annotation: Subtype: Link Rect: 376, 581, 442, 590 Destination: 402 Annotation: Subtype: Link Rect: 448, 544, 540, 553 Destination: 378 Annotation: Subtype: Link Rect: 307, 369, 395, 378 Destination: 378 Annotation: Subtype: Link Rect: 307, 344, 406, 353 Destination: 378 Annotation: Subtype: Link Rect: 411, 344, 416, 353 Destination: 378 Annotation: Subtype: Link Rect: 484, 331, 540, 340 Destination: 461 Annotation: Subtype: Link Rect: 438, 294, 479, 303 Destination: 198 Annotation: Subtype: Link Rect: 307, 206, 392, 215 Destination: 378 Annotation: Subtype: Link Rect: 359, 194, 471, 203 Destination: 461 Annotation: Subtype: Link Rect: 480, 181, 545, 190 Destination: 402 Annotation: Subtype: Link Rect: 304, 169, 361, 178 Destination: 402 Annotation: Subtype: Link Rect: 357, 131, 445, 140 Destination: 378 Annotation: Subtype: Link Rect: 491, 119, 545, 128 Destination: 378 Annotation: Subtype: Link Rect: 304, 106, 335, 115 Destination: 378 Annotation: Subtype: Link Rect: 394, 106, 479, 115 Destination: 378 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 203, 443, 239, 452 Destination: 198 Annotation: Subtype: Link Rect: 49, 418, 134, 427 Destination: 378 Annotation: Subtype: Link Rect: 154, 418, 241, 427 Destination: 378 Annotation: Subtype: Link Rect: 49, 330, 139, 339 Destination: 378 Annotation: Subtype: Link Rect: 144, 330, 148, 339 Destination: 378 Annotation: Subtype: Link Rect: 178, 305, 239, 314 Destination: 402 Annotation: Subtype: Link Rect: 221, 268, 277, 277 Destination: 461 Annotation: Subtype: Link Rect: 52, 93, 168, 102 Destination: 402 Annotation: Subtype: Link Rect: 179, 68, 265, 77 Destination: 378 Annotation: Subtype: Link Rect: 270, 68, 274, 77 Destination: 378 Annotation: Subtype: Link Rect: 308, 280, 402, 289 Destination: 378 Annotation: Subtype: Link Rect: 408, 280, 431, 289 Destination: 378 Annotation: Subtype: Link Rect: 353, 243, 445, 252 Destination: 378 Annotation: Subtype: Link Rect: 502, 143, 540, 152 Destination: 224 Annotation: Subtype: Link Rect: 451, 68, 488, 77 Destination: 224 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 162, 681, 210, 690 Destination: 224 Annotation: Subtype: Link Rect: 166, 494, 253, 503 Destination: 378 Annotation: Subtype: Link Rect: 308, 744, 337, 753 Destination: 246 Annotation: Subtype: Link Rect: 443, 706, 479, 715 Destination: 254 Annotation: Subtype: Link Rect: 517, 669, 543, 678 Destination: 246 Annotation: Subtype: Link Rect: 405, 494, 441, 503 Destination: 254 Annotation: Subtype: Link Rect: 363, 419, 396, 428 Destination: 254 Annotation: Subtype: Link Rect: 457, 406, 540, 415 Destination: 378 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 53, 225, 94, 234 Destination: 276 Annotation: Subtype: Link Rect: 157, 200, 193, 209 Destination: 276 Annotation: Subtype: Link Rect: 111, 137, 180, 146 Destination: 378 Annotation: Subtype: Link Rect: 52, 125, 158, 134 Destination: 402 Annotation: Subtype: Link Rect: 343, 377, 379, 386 Destination: 276 Annotation: Subtype: Link Rect: 307, 339, 357, 348 Destination: 276 Annotation: Subtype: Link Rect: 308, 314, 363, 323 Destination: 276 Annotation: Subtype: Link Rect: 307, 264, 394, 273 Destination: 378 Annotation: Subtype: Link Rect: 340, 137, 369, 146 Destination: 276 Annotation: Subtype: Link Rect: 340, 100, 370, 109 Destination: 276 Annotation: Subtype: Link Rect: 373, 75, 458, 84 Destination: 378 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 85, 349, 196, 358 Destination: 378 Annotation: Subtype: Link Rect: 98, 324, 171, 333 Destination: 402 Annotation: Subtype: Link Rect: 119, 311, 188, 320 Destination: 378 Annotation: Subtype: Link Rect: 307, 374, 338, 383 Destination: 293 Annotation: Subtype: Link Rect: 407, 299, 494, 308 Destination: 378 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 52, 731, 83, 740 Destination: 293 Annotation: Subtype: Link Rect: 52, 681, 148, 690 Destination: 378 Annotation: Subtype: Link Rect: 52, 644, 87, 653 Destination: 293 Annotation: Subtype: Link Rect: 177, 531, 288, 540 Destination: 461 Annotation: Subtype: Link Rect: 49, 519, 131, 528 Destination: 402 Annotation: Subtype: Link Rect: 52, 444, 150, 453 Destination: 461 Annotation: Subtype: Link Rect: 155, 444, 264, 453 Destination: 461 Annotation: Subtype: Link Rect: 94, 369, 161, 378 Destination: 402 Annotation: Subtype: Link Rect: 484, 681, 545, 690 Destination: 461 Annotation: Subtype: Link Rect: 304, 669, 353, 678 Destination: 461 Annotation: Subtype: Link Rect: 359, 669, 430, 678 Destination: 402 Annotation: Subtype: Link Rect: 435, 669, 543, 678 Destination: 402 Annotation: Subtype: Link Rect: 304, 656, 374, 665 Destination: 378 Annotation: Subtype: Link Rect: 380, 656, 464, 665 Destination: 402 Annotation: Subtype: Link Rect: 470, 656, 531, 665 Destination: 461 Annotation: Subtype: Link Rect: 537, 656, 545, 665 Destination: 402 Annotation: Subtype: Link Rect: 304, 644, 365, 653 Destination: 402 Annotation: Subtype: Link Rect: 307, 569, 423, 578 Destination: 461 Annotation: Subtype: Link Rect: 365, 494, 426, 503 Destination: 461 Annotation: Subtype: Link Rect: 355, 444, 414, 453 Destination: 461 Annotation: Subtype: Link Rect: 307, 369, 373, 378 Destination: 378 Annotation: Subtype: Link Rect: 377, 369, 443, 378 Destination: 402 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 269, 756, 290, 765 Destination: 402 Annotation: Subtype: Link Rect: 49, 744, 87, 753 Destination: 402 Annotation: Subtype: Link Rect: 91, 744, 158, 753 Destination: 402 Annotation: Subtype: Link Rect: 161, 744, 221, 753 Destination: 461 Annotation: Subtype: Link Rect: 228, 731, 285, 740 Destination: 461 Annotation: Subtype: Link Rect: 149, 706, 221, 715 Destination: 402 Annotation: Subtype: Link Rect: 193, 669, 251, 678 Destination: 461 Annotation: Subtype: Link Rect: 52, 644, 122, 653 Destination: 461 Annotation: Subtype: Link Rect: 109, 594, 185, 603 Destination: 402 Annotation: Subtype: Link Rect: 192, 594, 272, 603 Destination: 402 Annotation: Subtype: Link Rect: 146, 531, 216, 540 Destination: 402 Annotation: Subtype: Link Rect: 222, 531, 285, 540 Destination: 461 Annotation: Subtype: Link Rect: 265, 469, 290, 478 Destination: 402 Annotation: Subtype: Link Rect: 49, 456, 90, 465 Destination: 402 Annotation: Subtype: Link Rect: 96, 456, 162, 465 Destination: 402 Annotation: Subtype: Link Rect: 168, 319, 228, 328 Destination: 461 Annotation: Subtype: Link Rect: 233, 319, 290, 328 Destination: 461 Annotation: Subtype: Link Rect: 49, 306, 66, 315 Destination: 461 Annotation: Subtype: Link Rect: 72, 306, 132, 315 Destination: 378 Annotation: Subtype: Link Rect: 82, 294, 159, 303 Destination: 461 Annotation: Subtype: Link Rect: 195, 231, 256, 240 Destination: 461 Annotation: Subtype: Link Rect: 88, 194, 174, 203 Destination: 461 Annotation: Subtype: Link Rect: 113, 156, 195, 165 Destination: 461 Annotation: Subtype: Link Rect: 201, 156, 285, 165 Destination: 461 Annotation: Subtype: Link Rect: 52, 106, 125, 115 Destination: 402 Annotation: Subtype: Link Rect: 307, 719, 374, 728 Destination: 402 Annotation: Subtype: Link Rect: 354, 619, 434, 628 Destination: 402 Annotation: Subtype: Link Rect: 344, 556, 422, 565 Destination: 402 Annotation: Subtype: Link Rect: 427, 556, 497, 565 Destination: 461 Annotation: Subtype: Link Rect: 352, 481, 428, 490 Destination: 461 Annotation: Subtype: Link Rect: 433, 481, 495, 490 Destination: 461 Annotation: Subtype: Link Rect: 517, 456, 545, 465 Destination: 402 Annotation: Subtype: Link Rect: 304, 444, 384, 453 Destination: 402 Annotation: Subtype: Link Rect: 521, 394, 545, 403 Destination: 402 Annotation: Subtype: Link Rect: 304, 381, 343, 390 Destination: 402 Annotation: Subtype: Link Rect: 348, 381, 418, 390 Destination: 378 Annotation: Subtype: Link Rect: 491, 319, 545, 328 Destination: 402 Annotation: Subtype: Link Rect: 304, 306, 322, 315 Destination: 402 Annotation: Subtype: Link Rect: 325, 306, 386, 315 Destination: 402 Annotation: Subtype: Link Rect: 462, 181, 545, 190 Destination: 461 Annotation: Subtype: Link Rect: 304, 169, 321, 178 Destination: 461 Annotation: Subtype: Link Rect: 325, 169, 384, 178 Destination: 378 Annotation: Subtype: Link Rect: 419, 119, 504, 128 Destination: 461 Annotation: Subtype: Link Rect: 510, 119, 545, 128 Destination: 461 Annotation: Subtype: Link Rect: 304, 106, 321, 115 Destination: 461 Annotation: Subtype: Link Rect: 509, 94, 545, 103 Destination: 461 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 49, 756, 66, 765 Destination: 461 Annotation: Subtype: Link Rect: 118, 744, 194, 753 Destination: 461 Annotation: Subtype: Link Rect: 102, 669, 191, 678 Destination: 378 Annotation: Subtype: Link Rect: 315, 328, 545, 337 Annotation: Subtype: Link Rect: 304, 315, 405, 324 Annotation: Subtype: Link Rect: 266, 225, 290, 232 Annotation: Subtype: Link Rect: 49, 217, 98, 224 Annotation: Subtype: Link Rect: 85, 190, 152, 197 Annotation: Subtype: Link Rect: 162, 155, 224, 162 Annotation: Subtype: Link Rect: 85, 112, 151, 119 Annotation: Subtype: Link Rect: 264, 77, 290, 84 Annotation: Subtype: Link Rect: 49, 69, 103, 76 Annotation: Subtype: Link Rect: 351, 225, 406, 232 Annotation: Subtype: Link Rect: 371, 181, 452, 188 Annotation: Subtype: Link Rect: 509, 153, 545, 160 Annotation: Subtype: Link Rect: 304, 145, 356, 152 Annotation: Subtype: Link Rect: 394, 117, 477, 124 Annotation: Subtype: Link Rect: 400, 89, 488, 96 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 266, 758, 290, 765 Annotation: Subtype: Link Rect: 49, 750, 120, 757 Annotation: Subtype: Link Rect: 62, 715, 119, 722 Annotation: Subtype: Link Rect: 266, 688, 290, 695 Annotation: Subtype: Link Rect: 49, 680, 92, 687 Annotation: Subtype: Link Rect: 162, 661, 228, 668 Annotation: Subtype: Link Rect: 62, 626, 121, 633 Annotation: Subtype: Link Rect: 147, 591, 199, 598 Annotation: Subtype: Link Rect: 266, 572, 290, 579 Annotation: Subtype: Link Rect: 49, 564, 88, 571 Annotation: Subtype: Link Rect: 151, 537, 207, 544 Annotation: Subtype: Link Rect: 158, 475, 221, 482 Annotation: Subtype: Link Rect: 62, 448, 156, 455 Annotation: Subtype: Link Rect: 127, 413, 210, 420 Annotation: Subtype: Link Rect: 207, 378, 280, 385 Annotation: Subtype: Link Rect: 202, 359, 261, 366 Annotation: Subtype: Link Rect: 126, 332, 198, 339 Annotation: Subtype: Link Rect: 82, 305, 134, 312 Annotation: Subtype: Link Rect: 194, 278, 278, 285 Annotation: Subtype: Link Rect: 223, 251, 283, 258 Annotation: Subtype: Link Rect: 161, 216, 242, 223 Annotation: Subtype: Link Rect: 171, 189, 236, 196 Annotation: Subtype: Link Rect: 96, 162, 190, 169 Annotation: Subtype: Link Rect: 62, 127, 152, 134 Annotation: Subtype: Link Rect: 62, 92, 136, 99 Annotation: Subtype: Link Rect: 405, 742, 496, 749 Annotation: Subtype: Link Rect: 522, 707, 545, 714 Annotation: Subtype: Link Rect: 304, 699, 361, 706 Annotation: Subtype: Link Rect: 522, 672, 545, 679 Annotation: Subtype: Link Rect: 304, 664, 361, 671 Annotation: Subtype: Link Rect: 519, 637, 545, 644 Annotation: Subtype: Link Rect: 304, 629, 352, 636 Annotation: Subtype: Link Rect: 429, 602, 524, 609 Annotation: Subtype: Link Rect: 361, 567, 428, 574 Annotation: Subtype: Link Rect: 387, 548, 478, 555 Annotation: Subtype: Link Rect: 317, 521, 412, 528 Annotation: Subtype: Link Rect: 317, 486, 428, 493 Annotation: Subtype: Link Rect: 351, 467, 436, 474 Annotation: Subtype: Link Rect: 375, 440, 459, 447 Annotation: Subtype: Link Rect: 373, 405, 421, 412 Annotation: Subtype: Link Rect: 334, 370, 427, 377 Annotation: Subtype: Link Rect: 441, 343, 514, 350 Annotation: Subtype: Link Rect: 462, 316, 535, 323 Annotation: Subtype: Link Rect: 487, 289, 545, 296 Annotation: Subtype: Link Rect: 304, 281, 323, 288 Annotation: Subtype: Link Rect: 470, 262, 539, 269 Annotation: Subtype: Link Rect: 331, 235, 412, 242 Annotation: Subtype: Link Rect: 459, 208, 514, 215 Annotation: Subtype: Link Rect: 331, 154, 394, 161 Annotation: Subtype: Link Rect: 519, 135, 545, 142 Annotation: Subtype: Link Rect: 304, 127, 363, 134 Annotation: Subtype: Link Rect: 520, 100, 545, 107 Annotation: Subtype: Link Rect: 304, 92, 388, 99 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 109, 742, 181, 749 Annotation: Subtype: Link Rect: 210, 715, 273, 722 Annotation: Subtype: Link Rect: 210, 680, 290, 687 Annotation: Subtype: Link Rect: 221, 653, 290, 660 Annotation: Subtype: Link Rect: 62, 618, 135, 625 Annotation: Subtype: Link Rect: 216, 591, 277, 598 Annotation: Subtype: Link Rect: 62, 556, 153, 563 Annotation: Subtype: Link Rect: 135, 529, 190, 536 Annotation: Subtype: Link Rect: 169, 510, 263, 517 Annotation: Subtype: Link Rect: 99, 483, 172, 490 Annotation: Subtype: Link Rect: 216, 456, 282, 463 Annotation: Subtype: Link Rect: 198, 421, 248, 428 Annotation: Subtype: Link Rect: 199, 394, 256, 401 Annotation: Subtype: Link Rect: 106, 359, 175, 366 Annotation: Subtype: Link Rect: 161, 324, 234, 331 Annotation: Subtype: Link Rect: 194, 297, 263, 304 Annotation: Subtype: Link Rect: 165, 270, 237, 277 Annotation: Subtype: Link Rect: 196, 243, 279, 250 Annotation: Subtype: Link Rect: 159, 216, 223, 223 Annotation: Subtype: Link Rect: 62, 189, 155, 196 Annotation: Subtype: Link Rect: 393, 734, 488, 741 Annotation: Subtype: Link Rect: 462, 715, 535, 722 Annotation: Subtype: Link Rect: 334, 680, 429, 687 Annotation: Subtype: Link Rect: 317, 653, 409, 660 Annotation: Subtype: Link Rect: 443, 626, 524, 633 Annotation: Subtype: Link Rect: 453, 591, 545, 598 Annotation: Subtype: Link Rect: 304, 583, 337, 590 Annotation: Subtype: Link Rect: 341, 564, 437, 571 Annotation: Subtype: Link Rect: 522, 537, 545, 544 Annotation: Subtype: Link Rect: 304, 529, 348, 536 Annotation: Subtype: Link Rect: 522, 510, 545, 517 Annotation: Subtype: Link Rect: 304, 502, 336, 509 Annotation: Subtype: Link Rect: 317, 475, 408, 482 Annotation: Subtype: Link Rect: 358, 448, 439, 455 Annotation: Subtype: Link Rect: 522, 429, 545, 436 Annotation: Subtype: Link Rect: 304, 421, 352, 428 Annotation: Subtype: Link Rect: 522, 394, 545, 401 Annotation: Subtype: Link Rect: 304, 386, 350, 393 Annotation: Subtype: Link Rect: 439, 359, 525, 366 Annotation: Subtype: Link Rect: 317, 324, 378, 331 Annotation: Subtype: Link Rect: 317, 297, 398, 304 Annotation: Subtype: Link Rect: 382, 261, 463, 268 Annotation: Subtype: Link Rect: 423, 225, 496, 232 Annotation: Subtype: Link Rect: 445, 189, 522, 196 Annotation: Subtype: Link Rect: 451, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 5702f6d8 Type: CRC32 Checksum: d04fd7aa91250d12bec7f481a8ed4ca9 Type: MD5 Checksum: 6be520b1705e14d3d5abf1c8c02697ab493b4ef5 Type: SHA-1 Checksum: 674e9571def0b99499aa06c3ccaed26c2173b1a883d4052e55cf6fdb64b02066 Type: SHA-256