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Title:           Clinicopathological correlates in the frontotemporal lobar degeneration–motor neuron disease spectrum
Subject:         DOI: 10.1093/brain/awae011; Brain, 147, 7, 2024-01-16.; Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease (MND) that shares a common clinical, genetic and pathologic spectrum with frontotemporal dementia (FTD). It is highly heterogeneous in its presentation and features. Up to 50% of patients with MND develop cognitive-behavioural symptoms during the course of the disease, meeting criteria for FTD in 10%–15% of cases. In the absence of a precise biomarker, neuropathology is still a valuable tool to understand disease nosology, reach a definite diagnostic confirmation and help define specific subgroups of patients with common phenotypic, genetic and biomarker profiles. However, few neuropathological series have been published, and the frequency of frontotemporal lobar degeneration (FTLD) in MND is difficult to estimate.In this work we describe a large clinicopathological series of MND patients, analysing the frequency of concurrent FTLD changes and tr
Keywords:        amyotrophic lateral sclerosis; motor neuron disease; frontotemporal dementia; neuropathology
Author:          Álvaro Carbayo
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      Title: Clinicopathological correlates in thefrontotemporal lobar degeneration motorneuron disease spectrum
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        Title: Introduction
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        Title: Materials and methods
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          Title: Case selection
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          Title: Neuropathological work-up
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          Title: Clinical classification
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          Title: Neuropathology
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            Title: Clinical characteristics according to the neuropathologic groups: MND versus FTLD-MND
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              Title: Motor symptoms
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              Title: Cognitive and behavioural symptoms
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              Title: Clinicopathological diagnostic correlation
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              Title: Survival analysis
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              Title: Genetics
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              Title: Family history
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  Checksum: ff4d9501
   Type: CRC32
  Checksum: 717f1dca87a500c752545f01222c52f1
   Type: MD5
  Checksum: 5d9b6ab2f325a466c3c428e8b6772d1104291961
   Type: SHA-1
  Checksum: 0618e1e6536db1147f3e24fc95237940630a6fa7c87aa902ee056fc08316c365
   Type: SHA-256