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Title:           A framework for the clinical implementation of optical genome mapping in hematologic malignancies
Subject:         American J Hematol 2024.99:642-661
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     Item: 
      Title: A framework for the clinical implementation of optical genome mapping in hematologic malignancies
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       Item: 
        Title: 1  INTRODUCTION
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         Item: 
          Title: 1.1  Conventional cytogenetic testing
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         Item: 
          Title: 1.2  Optical Genome Mapping-The technique
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          Title: 1.3  Concordance studies between conventional cytogenetics and OGM
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         Item: 
          Title: 1.4  The OGM framework
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        Title: 2  VALIDATION
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         Item: 
          Title: 2.1  Clinical utility
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         Item: 
          Title: 2.2  Proof of principle
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          Title: 2.3  Method validation
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           Item: 
            Title: 2.3.1  Validation cohort size and specimen type
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            Title: 2.3.2  Expected test performance
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            Title: 2.3.3  Reproducibility
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            Title: 2.3.4  Limit of detection
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          Title: 2.4  Clinical validation
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          Title: 2.5  Implementation
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        Title: 3  QUALITY CONTROL CONSIDERATIONS
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         Item: 
          Title: 3.1  Samples
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          Title: 3.2  Pre-analytical phase
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            Title: 3.2.1  Cell input, DNA concentration, and DNA isolation
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          Title: 3.3  Analytic phase-Quality control parameters
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            Title: 3.3.1  Bioinformatic assembly pipelines
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          Title: 3.4  Post-analytic quality parameters
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            Title: 3.4.1  Sub-optimal analyses
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            Title: 3.4.2  Low quality samples, clinical necessity, and irreplaceable samples
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        Title: 4  DATA EVALUATION, INTERPRETATION, AND REPORTING
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          Title: 4.1  General considerations
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          Title: 4.2  Using the rare variant assembly
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         Item: 
          Title: 4.3  Phases of analysis
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         Item: 
          Title: 4.4  Criteria for variant review
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            Title: 4.4.1  Intra- and inter-chromosomal fusions (i.e., translocation, large insertions, and inversions)
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           Item: 
            Title: 4.4.2  Unbalanced SVs called by the SV algorithm (i.e., deletions, duplications and insertions <500kb)
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            Title: 4.4.3  Large CNA calls (>500kb) and aneuploidies
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          Title: 4.5  Enumerating ``cytogenetically visible´´ events
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          Title: 4.6  Loss of heterozygosity and ploidy analysis
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          Title: 4.7  Classification of variants using a 4-Tier system
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          Title: 4.8  Filtering variants with disease specific region files
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          Title: 4.9  OGM clinical report
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        Title: 5  DISCUSSION
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          Title: 5.1  Harmonization of clinical variant reporting
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          Title: 5.2  Loss of heterozygosity and ploidy
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          Title: 5.3  Genomic complexity and complex karyotypes
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        Title: 6  CONCLUSIONS
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       Item: 
        Title: ACKNOWLEDGMENTS
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       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
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         Item: 
          Title: DATA AVAILABILITY STATEMENT
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       Item: 
        Title: REFERENCES
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   Type: CRC32
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