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A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function Subject: European J of Heart Fail 2024.26:707-729 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 22.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Fri May 17 10:33:05 2024 CEST ModDate: Fri May 2 10:34:36 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 23 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1207992 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GillSansStd Type 1C Custom yes no yes 83 0 GillSansStd-Bold Type 1C Custom yes no yes 84 0 UniversLTStd Type 1C Custom yes no yes 85 0 UniversLTStd-Bold Type 1C Custom yes no yes 103 0 STIXMath-Bold Type 1C Custom yes no yes 1355 0 STIXMath-Regular Type 1C Custom yes no yes 86 0 GillSansStd-Italic Type 1C Custom yes no yes 80 0 UniversLTStd-Obl Type 1C Custom yes no yes 81 0 STIXMath-Italic Type 1C Custom yes no yes 82 0 Times-Roman Type 1 WinAnsi no no no 5 0 STIXMathCalligraphy-Regular Type 1C Custom yes no yes 135 0 STIXMathSans-Regular Type 1C Custom yes no yes 164 0 STIXMath-BoldItalic Type 1C Custom yes no yes 312 0 STIXMathTyperwriter-Regular Type 1C Custom yes no yes 313 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-05-03 02:58:12 CEST RepresentationInformation: EurJouHeaFai_a2024v26.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-05-02 11:51:13 CEST Size: 1207992 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'ejhf3236-supitem-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3236-note-0005' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3236-note-0006' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3236-note-0012' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3236-note-0005' cannot be found ID: PDF-HUL-122 Offset: 1032566 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3236-note-0012' cannot be found ID: PDF-HUL-122 Offset: 1032566 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3236-note-0006' cannot be found ID: PDF-HUL-122 Offset: 1032566 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3236-supitem-0001' cannot be found ID: PDF-HUL-122 Offset: 1032566 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function Destination: section*.1 Item: Title: Introduction Destination: section*.2 Item: Title: Current status on the definition, pathophysiology, and treatment of pulmonary hypertension associated with left heart failure Destination: section*.3 Item: Title: Definition Destination: section*.4 Item: Title: Pathophysiology Destination: section*.5 Item: Title: Treatment Destination: section*.6 Item: Title: The need to improve phenotyping of pulmonary hypertension associated with left heart failure Destination: section*.7 Item: Title: Clinical features Destination: section*.8 Item: Title: Pulmonary function and gas exchange Destination: section*.9 Item: Title: Imaging Destination: section*.10 Item: Title: Haemodynamics Destination: section*.11 Item: Title: Venous blood distribution Destination: section*.12 Item: Title: Biomarkers and omic profiling Destination: section*.13 Item: Title: Moving towards collaborative, multi-level phenotyping Destination: section*.14 Item: Title: The need to improve pre-clinical models of pulmonary hypertension associated with left heart failure Destination: section*.15 Item: Title: The need to improve early-phase clinical trials in pulmonary hypertension associated with left heart failure Destination: section*.16 Item: Title: Tested drugs Destination: section*.17 Item: Title: Trial design Destination: section*.18 Item: Title: Patient selection Destination: section*.19 Item: Title: Endpoint selection Destination: section*.20 Item: Title: Involvement of patient associations Destination: section*.21 Item: Title: Leveraging the evidence from animal models Destination: section*.22 Item: Title: Conclusions Destination: section*.23 Item: Title: Supplementary Information Destination: section*.24 Item: Title: Acknowledgements Destination: section*.25 Item: Title: Funding Destination: section*.26 Item: Title: 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