9ec372c947a605d22216f5a4ea551e7b  301876.pdf
3298685d6e432974dcb7355634c344ba273642e2  301876.pdf
278155a965cfff4195d96eb1b94b7786f6e0437d3e772771cbfc5f39c09653fb  301876.pdf

Title:           Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2
Subject:         DOI: 10.1093/nar/gkae051 , 52, 7, 7-2-2024. Abstract: MeCP2 is a general regulator of transcription involved in the repression/activation of genes depending on the local epigenetic context. It acts as a chromatin regulator and binds with exquisite specificity to gene promoters. The set of epigenetic marks recognized by MeCP2 has been already established (mainly, cytosine modifications in CpG and CpA), as well as many of the constituents of its interactome. We unveil a new set of interactions for MeCP2 with the four canonical nucleosomal histones. MeCP2 interacts with high affinity with H2A, H2B, H3 and H4. In addition, Rett syndrome associated mutations in MeCP2 and histone epigenetic marks modulate these interactions. Given the abundance and the structural/functional relevance of histones and their involvement in epigenetic regulation, this new set of interactions and its modulating elements provide a new addition to the ‘alphabet’ for this epigenetic reader.
Keywords:        
Author:          Ortega-Alarcon David, Claveria-Gimeno Rafael, Vega Sonia, Kalani Ladan, Jorge-Torres OlgaC., Esteller Manel, Ausio Juan, Abian Olga, Velazquez-Campoy Adrian
Creator:         OUP
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CreationDate:    Thu Apr 18 08:10:31 2024 CEST
ModDate:         Wed Oct 16 13:31:42 2024 CEST
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Jhove (Rel. 1.28.0, 2023-05-18)
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      Title: Graphical abstract
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      Title: Introduction
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     Item: 
      Title: Materials and methods
      Destination: section.4.4.0
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      Title: Results
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      Title: Data availability
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      Title: Funding
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      Title: Conflict of interest statement
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     Item: 
      Title: References
      Destination: section.12.27.0
   Info: 
    Title: Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2
    Author: Ortega-Alarcon David, Claveria-Gimeno Rafael, Vega Sonia, Kalani Ladan, Jorge-Torres OlgaC., Esteller Manel, Ausio Juan, Abian Olga, Velazquez-Campoy Adrian
    Subject: DOI: 10.1093/nar/gkae051 , 52, 7, 7-2-2024. Abstract: MeCP2 is a general regulator of transcription involved in the repression/activation of genes depending on the local epigenetic context. It acts as a chromatin regulator and binds with exquisite specificity to gene promoters. The set of epigenetic marks recognized by MeCP2 has been already established (mainly, cytosine modifications in CpG and CpA), as well as many of the constituents of its interactome. We unveil a new set of interactions for MeCP2 with the four canonical nucleosomal histones. MeCP2 interacts with high affinity with H2A, H2B, H3 and H4. In addition, Rett syndrome associated mutations in MeCP2 and histone epigenetic marks modulate these interactions. Given the abundance and the structural/functional relevance of histones and their involvement in epigenetic regulation, this new set of interactions and its modulating elements provide a new addition to the ‘alphabet’ for this epigenetic reader.
    Keywords: 
    Creator: OUP
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