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PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Decoding CD4+ T cell transcriptome in giant cell arteritis: Novel pathways and altered cross-talk with monocytes Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Material and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Study cohort Destination: mk:H2_1 Item: Title: 2.2 Sample collection Destination: mk:H2_2 Item: Title: 2.3 RNA-seq and data processing Destination: mk:H2_3 Item: Title: 2.4 Gene expression and enrichment analyses Destination: mk:H2_4 Item: Title: 2.5 DNA methylation profiling Destination: mk:H2_5 Item: Title: 2.6 Integration of gene expression with DNA methylation Destination: mk:H2_6 Item: Title: 2.7 Cell-cell communication Destination: mk:H2_7 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Gene expression deregulation in GCA CD4+ T cells Destination: mk:H2_8 Item: Title: 3.2 GC treatment modulates the transcriptome of CD4+ T cells from GCA patients Destination: mk:H2_9 Item: Title: 3.3 Modest effects of DNA methylation on gene expression alterations Destination: mk:H2_10 Item: Title: 3.4 Potential altered cell-cell communication between CD4+ T cells and CD14+ monocytes in GCA pathogenesis Destination: mk:H2_11 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: 5 Conclusions Destination: mk:H1_5 Item: Title: Funding Destination: mk:H1_6 Item: Title: Ethics approval and consent to participate Destination: mk:H1_7 Item: Title: CRediT authorship contribution statement Destination: mk:H1_8 Item: Title: Data availability Destination: datalink4 Item: Title: Acknowledgements Destination: mk:HH1_5 Item: Title: Appendix A Supplementary data Destination: mk:H1_9 Item: Title: References Destination: mk:HH2_1 Info: Title: Decoding CD4+ T cell transcriptome in giant cell arteritis: Novel pathways and altered cross-talk with monocytes Author: Elkyn Estupiñán-Moreno Subject: Journal of 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Cid Ana Márquez Javier Martin Esteban Ballestar Lourdes Ortiz-Fernández journal Journal of Autoimmunity © 2024 The Authors. 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