6b7b772b9ed369e411bcdca552bd507a  301888.pdf
df7c9ab33a62878658d5e8e24c0eeceb22bd4fcf  301888.pdf
d4f09d02355106ba9dc9f19790d743d42bc67bc181680df7573cb2359a7921b4  301888.pdf

Title:           p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response
Subject:         Nature Communications, doi:10.1038/s41467-024-46666-1
Keywords:        
Author:          François Serra
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Mon Apr  1 10:51:37 2024 CEST
ModDate:         Mon Apr  1 17:25:48 2024 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           19
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       2943974 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EJJDMC+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no     651  0
EJJEBC+AdvOT511ca30e.B               Type 1C           WinAnsi          yes yes no      65  0
EJJANO+AdvOT13119950                 Type 1C           WinAnsi          yes yes no      67  0
EJJANP+AdvOT89719618                 Type 1C           WinAnsi          yes yes no      68  0
EJJAOA+AdvOTa2fa4214.B               Type 1C           WinAnsi          yes yes no    1107  0
EJJDIB+AdvOTdd63dae3                 Type 1C           WinAnsi          yes yes no      69  0
EJJDJC+AdvOTdd63dae3+fb              Type 1C           Custom           yes yes yes     71  0
EJJDJD+AdvOTcc1f6510.I               Type 1C           WinAnsi          yes yes no      73  0
EJJEDD+AdvOT8608a8d1+22              Type 1C           Custom           yes yes yes     63  0
EJJEED+AdvOT3d287b35.B               Type 1C           WinAnsi          yes yes no      64  0
EJJEDC+AdvOTdd63dae3+20              Type 1C           Custom           yes yes yes     66  0
EJJEEE+AdvOT70e1938e                 Type 1C           WinAnsi          yes yes no      70  0
EJJEEF+AdvOT8608a8d1                 Type 1C           WinAnsi          yes yes no      72  0
EJJFCB+ArialNarrow                   Type 1C           Custom           yes yes yes     89  0
EJJFNO+AdvOTdd63dae3+22              Type 1C           Custom           yes yes yes    104  0
EJKLPH+ArialNarrow-Italic            Type 1C           WinAnsi          yes yes no     162  0
EJLHED+ArialNarrow-Bold              Type 1C           WinAnsi          yes yes no     223  0
ArialMT                              Type 1C           WinAnsi          yes no  no     306  0
EJLJPD+AdvOTcc1f6510.I+20            Type 1C           WinAnsi          yes yes no     307  0
Arial-BoldMT                         Type 1C           WinAnsi          yes no  no     308  0
EJMABB+AdvOT3d287b35.B+fb            Type 1C           Custom           yes yes yes    339  0
EJMKKB+AdvOTdd63dae3+03              Type 1C           Custom           yes yes yes    523  0
EJMLKL+AdvOT70e1938e+fb              Type 1C           Custom           yes yes yes    596  0
EJMMFL+AdvOT0c200bf0+20              Type 1C           WinAnsi          yes yes no     652  0
EJMMDK+AdvMacMthSyN                  Type 1C           Custom           yes yes yes    653  0
EJMMFK+AdvOT23e3f5cb.I               Type 1C           WinAnsi          yes yes no     654  0
EJMMDJ+AdvP4C4E46                    Type 1C           Custom           yes yes yes    655  0
EJMMLK+AdvOT0c200bf0+fb              Type 1C           Custom           yes yes yes    668  0
EJMNHH+AdvOT0c200bf0+03              Type 1C           Custom           yes yes yes    679  0
EJMNHG+AdvOT0c200bf0+22              Type 1C           Custom           yes yes no     680  0
EJMNPG+AdvOT13119950+20              Type 1C           WinAnsi          yes yes no     716  0
EJMNOG+AdvOT0c200bf0+01              Type 1C           Custom           yes yes no     717  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-24 02:46:13 CEST
 RepresentationInformation: 301888.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-10-23 08:57:14 CEST
  Size: 2943974
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1233
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: p53 activation drives two waves of dramatic changes in genome compartments and’TADs
          Destination: B1
         Item: 
          Title: Early and late genome organization changes are triggered by p53 binding directly and indirectly
          Destination: B2
         Item: 
          Title: Promoter interactome is highly rewired by p53 activation
          Destination: B3
         Item: 
          Title: p53 controls transcription of previously non-associated genes located a few hundred kilobases’away
          Destination: B4
         Item: 
          Title: p53 binding at enhancers leads to neo-loop formation with distal gene promoters
          Destination: B5
         Item: 
          Title: Cohesin is required for the p53-mediated transcriptional response
          Destination: B6
         Item: 
          Title: CRISPR-Cas9-based functional validation of new p53 direct target’genes
          Destination: B7
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Cell culture
          Destination: B8
         Item: 
          Title: p53 binding site CRISPR-targeting
          Destination: B9
         Item: 
          Title: Cell cycle analysis by’FACs
          Destination: B10
         Item: 
          Title: Western’blot
          Destination: B11
         Item: 
          Title: In situ Hi-C and PCHi-C libraries generation
          Destination: B12
         Item: 
          Title: ChIP-seq library preparation
          Destination: B13
         Item: 
          Title: RNA-seq library preparation
          Destination: B14
         Item: 
          Title: qRT-PCR
          Destination: B15
         Item: 
          Title: Hi-C processing
          Destination: B16
         Item: 
          Title: ChIP-seq processing
          Destination: B17
         Item: 
          Title: RNA-seq processing
          Destination: B18
         Item: 
          Title: Definition of promoters and enhancers
          Destination: B19
         Item: 
          Title: Definition of functional p53 binding’sites
          Destination: B20
         Item: 
          Title: PCHi-C processing
          Destination: B21
         Item: 
          Title: Definition of p53 target’genes
          Destination: B22
         Item: 
          Title: Gene set enrichment analysis
          Destination: B23
         Item: 
          Title: Statistical methods and figures
          Destination: B24
         Item: 
          Title: Data visualization
          Destination: B25
         Item: 
          Title: Reporting summary
          Destination: B26
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: Code availability
        Destination: M2
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response
    Author: François Serra
    Subject: Nature Communications, doi:10.1038/s41467-024-46666-1
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Mon Apr 01 11:21:37 CEST 2024
    ModDate: Mon Apr 01 17:25:48 CEST 2024
   ID: 0x052cad6341f6f653c5ef151f58464403, 0x8939d8454e173e4b0a32c7ad00ae79d3
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 799
      ImageHeight: 666
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 251
      ImageHeight: 541
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 44
      ImageHeight: 96
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 44
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 44
      ImageHeight: 96
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 44
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 44
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 44
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 44
      ImageHeight: 96
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 44
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 44
      ImageHeight: 96
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 44
      ImageHeight: 96
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 44
      ImageHeight: 96
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 44
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 44
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 44
      ImageHeight: 96
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 518
      ImageHeight: 399
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 518
      ImageHeight: 399
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 389
      ImageHeight: 531
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 518
      ImageHeight: 266
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 389
      ImageHeight: 531
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 518
      ImageHeight: 435
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 216
      ImageHeight: 27
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 25
      ImageHeight: 198
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 86
      ImageHeight: 18
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: EJJEED+AdvOT3d287b35.B
      FontSubset: true
      FirstChar: 45
      LastChar: 124
      FontDescriptor: 
       FontName: EJJEED+AdvOT3d287b35.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 1000, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJEBC+AdvOT511ca30e.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: EJJEBC+AdvOT511ca30e.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 979, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJEDC+AdvOTdd63dae3+20
      FontSubset: true
      FirstChar: 2
      LastChar: 150
      FontDescriptor: 
       FontName: EJJEDC+AdvOTdd63dae3+20
       Flags: Symbolic
       FontBBox: -197, -125, 1322, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJJANO+AdvOT13119950
      FontSubset: true
      FirstChar: 38
      LastChar: 243
      FontDescriptor: 
       FontName: EJJANO+AdvOT13119950
       Flags: Nonsymbolic
       FontBBox: -31, -218, 947, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJANP+AdvOT89719618
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: EJJANP+AdvOT89719618
       Flags: Nonsymbolic
       FontBBox: -20, -218, 927, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJDIB+AdvOTdd63dae3
      FontSubset: true
      FirstChar: 33
      LastChar: 215
      FontDescriptor: 
       FontName: EJJDIB+AdvOTdd63dae3
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -218, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJEEE+AdvOT70e1938e
      FontSubset: true
      FirstChar: 45
      LastChar: 122
      FontDescriptor: 
       FontName: EJJEEE+AdvOT70e1938e
       Flags: Nonsymbolic
       FontBBox: -114, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJDJC+AdvOTdd63dae3+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EJJDJC+AdvOTdd63dae3+fb
       Flags: Symbolic
       FontBBox: 19, 0, 812, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJJEEF+AdvOT8608a8d1
      FontSubset: true
      FirstChar: 181
      LastChar: 181
      FontDescriptor: 
       FontName: EJJEEF+AdvOT8608a8d1
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJDJD+AdvOTcc1f6510.I
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: EJJDJD+AdvOTcc1f6510.I
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1020, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJDMC+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 38
      LastChar: 246
      FontDescriptor: 
       FontName: EJJDMC+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJMKKB+AdvOTdd63dae3+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EJMKKB+AdvOTdd63dae3+03
       Flags: Symbolic
       FontBBox: -156, -197, 833, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJMMFL+AdvOT0c200bf0+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: EJMMFL+AdvOT0c200bf0+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1083, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJMNPG+AdvOT13119950+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: EJMNPG+AdvOT13119950+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1156, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJMMDK+AdvMacMthSyN
      FontSubset: true
      FirstChar: 1
      LastChar: 240
      FontDescriptor: 
       FontName: EJMMDK+AdvMacMthSyN
       Flags: Symbolic
       FontBBox: 0, -947, 1239, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJMNOG+AdvOT0c200bf0+01
      FontSubset: true
      FirstChar: 20
      LastChar: 20
      FontDescriptor: 
       FontName: EJMNOG+AdvOT0c200bf0+01
       Flags: Nonsymbolic
       FontBBox: -41, -218, 947, 1104
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: EJMMFK+AdvOT23e3f5cb.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: EJMMFK+AdvOT23e3f5cb.I
       Flags: Nonsymbolic
       FontBBox: -62, -208, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJMMDJ+AdvP4C4E46
      FontSubset: true
      FirstChar: 1
      LastChar: 114
      FontDescriptor: 
       FontName: EJMMDJ+AdvP4C4E46
       Flags: Symbolic
       FontBBox: -15, 0, 218, 40
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJJAOA+AdvOTa2fa4214.B
      FontSubset: true
      FirstChar: 51
      LastChar: 122
      FontDescriptor: 
       FontName: EJJAOA+AdvOTa2fa4214.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJMABB+AdvOT3d287b35.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EJMABB+AdvOT3d287b35.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 875, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJMLKL+AdvOT70e1938e+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EJMLKL+AdvOT70e1938e+fb
       Flags: Symbolic
       FontBBox: 9, 0, 854, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJJFCB+ArialNarrow
      FontSubset: true
      FirstChar: 2
      LastChar: 122
      FontDescriptor: 
       FontName: EJJFCB+ArialNarrow
       Flags: Symbolic
       FontBBox: -182, -307, 1000, 1086
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJMMLK+AdvOT0c200bf0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EJMMLK+AdvOT0c200bf0+fb
       Flags: Symbolic
       FontBBox: 19, 0, 604, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJLHED+ArialNarrow-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: EJLHED+ArialNarrow-Bold
       Flags: Nonsymbolic
       FontBBox: -137, -307, 1000, 1109
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJKLPH+ArialNarrow-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: EJKLPH+ArialNarrow-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -214, -307, 1000, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJMNHH+AdvOT0c200bf0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EJMNHH+AdvOT0c200bf0+03
       Flags: Symbolic
       FontBBox: -156, -177, 802, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJJFNO+AdvOTdd63dae3+22
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: EJJFNO+AdvOTdd63dae3+22
       Flags: Symbolic
       FontBBox: -62, -250, 1083, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EJMNHG+AdvOT0c200bf0+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: EJMNHG+AdvOT0c200bf0+22
       Flags: Nonsymbolic
       FontBBox: -10, -250, 645, 885
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ArialMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJLJPD+AdvOTcc1f6510.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: EJLJPD+AdvOTcc1f6510.I+20
       Flags: Nonsymbolic
       FontBBox: -250, -125, 1291, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EJJEDD+AdvOT8608a8d1+22
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EJJEDD+AdvOT8608a8d1+22
       Flags: Symbolic
       FontBBox: 0, -322, 1218, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41467-024-46666-1</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>François Serra</rdf:li>
               <rdf:li>Andrea Nieto-Aliseda</rdf:li>
               <rdf:li>Lucía Fanlo-Escudero</rdf:li>
               <rdf:li>Llorenç Rovirosa</rdf:li>
               <rdf:li>Mónica Cabrera-Pasadas</rdf:li>
               <rdf:li>Aleksey Lazarenkov</rdf:li>
               <rdf:li>Blanca Urmeneta</rdf:li>
               <rdf:li>Alvaro Alcalde-Merino</rdf:li>
               <rdf:li>Emanuele M. Nola</rdf:li>
               <rdf:li>Andrei L. Okorokov</rdf:li>
               <rdf:li>Peter Fraser</rdf:li>
               <rdf:li>Mariona Graupera</rdf:li>
               <rdf:li>Sandra D. Castillo</rdf:li>
               <rdf:li>Jose L. Sardina</rdf:li>
               <rdf:li>Alfonso Valencia</rdf:li>
               <rdf:li>Biola M. Javierre</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-024-46666-1</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2024-04-01T17:25:48+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2024-04-01T14:21:37+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2024-04-01T17:25:48+02:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:f6246891-7076-4289-b134-a20dbe4de9e1</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:ab4a4e82-7d31-4558-bf9d-4aca36b96b96</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:60fb6288-f803-41d3-abbb-aa1ccccf0c51</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-04-01T14:22:50+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 278, 552, 280, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 278, 552, 280, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 287, 550, 288, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 279, 550, 287, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 287, 550, 289, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 393, 552, 395, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 393, 552, 395, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 550, 403, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 394, 550, 402, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 550, 404, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 552, 510, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 552, 510, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 518, 550, 519, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 550, 518, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 518, 550, 519, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 395, 527, 396, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 395, 527, 396, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 525, 405, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 395, 525, 404, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 525, 405, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 300, 514, 301, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 300, 514, 301, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 309, 512, 310, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 300, 512, 309, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 309, 512, 310, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 514, 372, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 514, 372, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 512, 381, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 512, 380, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 512, 381, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 467, 514, 469, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 467, 514, 469, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 476, 512, 477, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 512, 476, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 476, 512, 478, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 501, 295, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 501, 295, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 500, 303, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 294, 500, 302, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 500, 304, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 455, 501, 457, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 455, 501, 457, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 500, 465, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 456, 500, 464, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 500, 466, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 287, 488, 289, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 287, 488, 289, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 296, 487, 297, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 288, 487, 296, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 296, 487, 298, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 169, 134, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 452, 234, 455, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 480, 137, 483, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: -2, 479, 50, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 486, 50, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 74, 48, 187, 55
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 208, 737, 211, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 153, 694, 156, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 254, 630, 257, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 79, 598, 82, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 289, 555, 292, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 206, 416, 209, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 211, 416, 216, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 242, 384, 247, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 248, 384, 253, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 256, 384, 261, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 106, 362, 111, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 92, 352, 97, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 166, 341, 171, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 157, 319, 160, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 163, 319, 166, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 389, 690, 392, 698
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 509, 572, 513, 580
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 414, 529, 417, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 462, 497, 465, 505
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 324, 476, 327, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 338, 341, 343, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 535, 315, 540, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 415, 272, 419, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 375, 229, 379, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 320, 165, 325, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 324, 79, 328, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 240, 127, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 77, 101, 82, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 113, 90, 117, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 402, 122, 405, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 342, 95, 348, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 62, 76, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 79, 62, 85, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 347, 154, 352, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 418, 133, 422, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 535, 47, 539, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 224, 476, 228, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 110, 465, 114, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 152, 401, 156, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 107, 341, 112, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 134, 341, 139, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 188, 341, 193, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 162, 298, 167, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 168, 298, 173, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 155, 240, 158, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 268, 122, 273, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 275, 79, 279, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 513, 454, 518, 463
       Flags: Print
       AppearanceDictionary: true
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 553, 287, 559, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 512, 266, 517, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 526, 229, 530, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 454, 212, 459, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 496, 212, 502, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 524, 212, 529, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 553, 212, 559, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 329, 202, 334, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 533, 202, 539, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 375, 165, 379, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 510, 112, 514, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 463, 95, 468, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 552, 95, 558, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 324, 79, 328, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 96, 122, 100, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 114, 90, 118, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 164, 58, 168, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 252, 62, 257, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 324, 112, 327, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 369, 79, 372, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 168, 197, 172, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 262, 154, 266, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 447, 337, 451, 345
       Flags: Print
       AppearanceDictionary: true
       Destination: 344
      Annotation: 
       Subtype: Link
       Rect: 546, 304, 551, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 344
      Annotation: 
       Subtype: Link
       Rect: 508, 255, 513, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 323, 229, 328, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 344
      Annotation: 
       Subtype: Link
       Rect: 551, 133, 555, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 322, 122, 327, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 344
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 197, 63, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 87, 197, 92, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 344
      Annotation: 
       Subtype: Link
       Rect: 165, 73, 170, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 456, 212, 462, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 324, 79, 328, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 362, 47, 366, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 72, 105, 77, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 98, 101, 103, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 220, 69, 224, 77
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 459, 112, 463, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 419, 95, 424, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 450, 90, 454, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 481, 73, 486, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 342, 52, 347, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 460, 47, 465, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 216, 358, 220, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 266, 315, 270, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 273, 229, 277, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 153, 191, 158, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 161, 191, 166, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 231, 52, 237, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 363, 491, 369, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 371, 491, 376, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 330, 169, 336, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 373, 169, 378, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 324, 148, 330, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 332, 148, 338, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 311, 127, 316, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 370, 105, 375, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 377, 105, 382, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 390, 73, 396, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 411, 62, 417, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 126, 416, 129, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 132, 416, 134, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 136, 416, 141, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 64, 384, 69, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 264, 315, 268, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 194, 244, 199, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 218, 212, 224, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 225, 212, 230, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 83, 73, 88, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 89, 73, 94, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 439, 737, 445, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 597
      Annotation: 
       Subtype: Link
       Rect: 347, 694, 352, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 437, 684, 442, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 419, 647, 423, 655
       Flags: Print
       AppearanceDictionary: true
       Destination: 408
      Annotation: 
       Subtype: Link
       Rect: 448, 619, 453, 624
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 553, 587, 559, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 378, 512, 383, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 548, 469, 553, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 556, 469, 561, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 536, 459, 541, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 330, 330, 335, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 337, 330, 342, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 343, 330, 349, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 537, 319, 542, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 553, 287, 559, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 149, 469, 154, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 246, 469, 252, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 210, 454, 294, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 444, 55, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 200, 433, 294, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 422, 67, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 172, 422, 291, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 126, 137, 131, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 522, 390, 531, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 88, 79, 167, 88
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 334, 641, 340, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 458, 501, 464, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 534, 497, 561, 505
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 486, 470, 495
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 438, 480, 443, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 468, 465, 556, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 491, 133, 500, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 480, 95, 485, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 337, 62, 343, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 465, 62, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 94, 319, 99, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 134, 298, 139, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 251, 287, 256, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 239, 277, 244, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 253, 180, 259, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 98, 159, 103, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 166, 105, 172, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 137, 95, 142, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 332, 726, 338, 731
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 530, 716, 538, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 364, 694, 369, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 336, 684, 342, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 508, 491, 513, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 515, 491, 522, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 523, 491, 531, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 342, 437, 347, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 332, 384, 340, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 533, 330, 541, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 483, 202, 490, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 488, 159, 493, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 669
      Annotation: 
       Subtype: Link
       Rect: 522, 62, 530, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 662, 166, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 180, 523, 188, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 72, 469, 79, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 112, 448, 120, 453
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 114, 437, 121, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 124, 437, 130, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 199, 319, 206, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 286, 319, 292, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 86, 266, 92, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 228, 244, 235, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 178, 234, 185, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 130, 52, 137, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 470, 737, 476, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 688
      Annotation: 
       Subtype: Link
       Rect: 390, 669, 558, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 308, 658, 476, 666
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 436, 508, 561, 516
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 497, 353, 505
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 352, 454, 481, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 489, 454, 561, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 444, 363, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 374, 444, 522, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 534, 444, 561, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 433, 414, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 527, 133, 554, 141
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 122, 445, 130
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 17
     Thumb: true
    Page: 
     Label: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 221, 401, 287, 409
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 390, 103, 398
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 111, 358, 241, 366
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 90, 679, 240, 687
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 487, 286, 495
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 476, 104, 484
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 113, 454, 277, 462
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 444, 99, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 216, 433, 282, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 422, 146, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 77, 341, 82, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 664
      Annotation: 
       Subtype: Link
       Rect: 306, 508, 465, 516
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 401, 421, 409
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 456, 230, 561, 237
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 219, 365, 227
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 22e9b77f
   Type: CRC32
  Checksum: 6b7b772b9ed369e411bcdca552bd507a
   Type: MD5
  Checksum: df7c9ab33a62878658d5e8e24c0eeceb22bd4fcf
   Type: SHA-1
  Checksum: d4f09d02355106ba9dc9f19790d743d42bc67bc181680df7573cb2359a7921b4
   Type: SHA-256